ES2164920T3 - Nuevos derivados heterociclicos y uso medicinal de los mismos. - Google Patents
Nuevos derivados heterociclicos y uso medicinal de los mismos.Info
- Publication number
- ES2164920T3 ES2164920T3 ES96932060T ES96932060T ES2164920T3 ES 2164920 T3 ES2164920 T3 ES 2164920T3 ES 96932060 T ES96932060 T ES 96932060T ES 96932060 T ES96932060 T ES 96932060T ES 2164920 T3 ES2164920 T3 ES 2164920T3
- Authority
- ES
- Spain
- Prior art keywords
- same
- medicinal use
- lipoperoxidation
- acat
- useful
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 206010003210 Arteriosclerosis Diseases 0.000 abstract 2
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 230000002248 lipoperoxidative effect Effects 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrrole Compounds (AREA)
Abstract
LA INVENCION SE REFIERE UN DERIVADO HETEROCICLICO DE FORMULA (I): DONDE CADA SIMBOLO ES TAL Y COMO SE DEFINE EN LA DESCRIPCION, ASI COMO LAS SALES FARMACEUTICAMENTE ACEPTABLES DEL MISMO. DICHO COMPUESTO Y SUS CITADAS SALES PRESENTAN UNA ACTIVIDAD INHIBIDORA SUPERIOR DE ACAT Y ACTIVIDAD INHIBIDORA DE LA LIPOPEROXIDACION EN MAMIFEROS, Y SON UTILES COMO INHIBIDORES DE ACAT Y DE LA LIPOPEROXIDACION. ESPECIFICAMENTE, SON UTILES PARA LA PROFILAXIS Y TRATAMIENTO DE LA ARTERIOSCLEROSIS, HIPERLIPERMIA, ARTERIOSCLEROSIS DERIVADA DE DIABETES, ASI COMO ENFERMEDADES ISQUEMICAS CEREBROVASCULARES Y CARDIOVASCULARES.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP25908295 | 1995-10-05 | ||
JP5801896 | 1996-03-14 | ||
JP19433196 | 1996-07-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2164920T3 true ES2164920T3 (es) | 2002-03-01 |
Family
ID=27296460
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96932060T Expired - Lifetime ES2164920T3 (es) | 1995-10-05 | 1996-09-30 | Nuevos derivados heterociclicos y uso medicinal de los mismos. |
Country Status (20)
Country | Link |
---|---|
US (3) | US6063806A (es) |
EP (1) | EP0866059B1 (es) |
KR (1) | KR100388345B1 (es) |
CN (2) | CN1097043C (es) |
AT (1) | ATE210116T1 (es) |
BR (1) | BR9610846A (es) |
CZ (1) | CZ292632B6 (es) |
DE (1) | DE69617731T2 (es) |
DK (1) | DK0866059T3 (es) |
ES (1) | ES2164920T3 (es) |
HK (2) | HK1015781A1 (es) |
HU (1) | HUP9900617A3 (es) |
IL (1) | IL123939A (es) |
NO (1) | NO310818B1 (es) |
NZ (1) | NZ318874A (es) |
PL (1) | PL190034B1 (es) |
PT (1) | PT866059E (es) |
TR (1) | TR199800655T2 (es) |
TW (1) | TW429250B (es) |
WO (1) | WO1997012860A1 (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3720395B2 (ja) * | 1994-09-20 | 2005-11-24 | 京都薬品工業株式会社 | 新規ヘテロ環誘導体、その製造方法およびその医薬用途 |
US5929250A (en) * | 1997-01-23 | 1999-07-27 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
AR008331A1 (es) * | 1997-01-23 | 1999-12-29 | Smithkline Beecham Corp | Compuestos antagonistas de un receptor de il-8, uso de los mismos para la fabricacion de medicamentos, procedimiento para su obtencion, composicionesfarmaceuticas que los contienen |
AR015425A1 (es) * | 1997-09-05 | 2001-05-02 | Smithkline Beecham Corp | Compuestos de benzotiazol, composicion farmaceutica que los contiene, su uso en la manufactura de un medicamento, procedimiento para su preparacion,compuestos intermediarios y procedimiento para su preparacion |
CA2327695A1 (en) * | 1998-04-08 | 1999-10-21 | Takeda Chemical Industries, Ltd. | Amine compounds, their production and their use as somatostatin receptor antagonists or agonists |
HUP0102863A3 (en) * | 1998-07-23 | 2002-05-28 | Smithkline Beecham Corp | Il-8 receptor antagonists benzimidazole derivatives, process for their preparation and medicaments containing them |
FR2783519B1 (fr) * | 1998-09-23 | 2003-01-24 | Sod Conseils Rech Applic | Nouveaux derives d'amidines, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant |
HUP0301728A3 (en) * | 2000-09-01 | 2004-05-28 | Sankyo Co | Hmg-coa reductase inhibiting pharmaceutical compositions and their use |
TW200600497A (en) | 2001-02-02 | 2006-01-01 | Sankyo Co | Preparation of indoline derivative |
WO2002072147A1 (fr) * | 2001-03-14 | 2002-09-19 | Sankyo Company, Limited | Compositions medicinales contenant un inhibiteur de transporteur d'acide biliaire |
EP2335700A1 (en) * | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C virus polymerase inhibitors with a heterobicylic structure |
CA2459017A1 (en) * | 2001-08-28 | 2003-03-13 | Sankyo Company, Limited | Medicinal compositions containing angiotensin ii receptor antagonist |
JP2004002365A (ja) * | 2002-04-05 | 2004-01-08 | Sankyo Co Ltd | Acat阻害剤とインシュリン抵抗性改善剤とからなる医薬組成物 |
EP1493448A4 (en) * | 2002-04-05 | 2007-12-05 | Sankyo Co | MEDICAL COMPOSITION WITH ACAT HEMMER AND AGENT TO IMPROVE INSULIN RESISTANCE |
US20050119314A1 (en) * | 2002-04-05 | 2005-06-02 | Sankyo Company, Limited | Pharmaceutical composition comprising an ACAT inhibitor and an insulin resistance reducing agent |
ATE469884T1 (de) * | 2002-07-17 | 2010-06-15 | Kyoto Pharma Ind | Indolinverbindung und deren medizinische verwendung |
US20050192245A1 (en) * | 2002-07-18 | 2005-09-01 | Sankyo Company, Limited | Medicinal composition for treating arteriosclerosis |
WO2004009119A1 (ja) * | 2002-07-18 | 2004-01-29 | Sankyo Company, Limited | 動脈硬化症治療のための医薬組成物 |
US7223785B2 (en) * | 2003-01-22 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
US7098231B2 (en) * | 2003-01-22 | 2006-08-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
EP2428516A1 (en) | 2003-11-19 | 2012-03-14 | Metabasis Therapeutics, Inc. | Novel phosphorus-containing thyromimetics |
WO2005077359A1 (ja) * | 2004-02-17 | 2005-08-25 | Sankyo Company, Limited | インドリン化合物を含有する安定化された医薬組成物 |
PT1718608E (pt) * | 2004-02-20 | 2013-08-01 | Boehringer Ingelheim Int | Inibidores da polimerase viral |
CA2624601C (en) | 2004-10-06 | 2018-07-03 | The Brigham And Women's Hospital, Inc. | Relevance of achieved levels of markers of systemic inflammation following treatment |
US7923573B2 (en) * | 2004-10-27 | 2011-04-12 | Daiichi Sankyo Company, Limited | Benzene compound having 2 or more substituents |
US8076365B2 (en) * | 2005-08-12 | 2011-12-13 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
WO2007146230A2 (en) * | 2006-06-14 | 2007-12-21 | Merck & Co., Inc. | Non-nucleoside reverse transcriptase inhibitors |
FR2918890A1 (fr) * | 2007-07-19 | 2009-01-23 | Galderma Res & Dev | Utilisation du pactimibe pour la preparation d'un medicament destine a prevenir ou a traiter une maladie due a un dysfonctionnement des glandes sebacees chez l'homme ou l'animal |
WO2010093601A1 (en) | 2009-02-10 | 2010-08-19 | Metabasis Therapeutics, Inc. | Novel sulfonic acid-containing thyromimetics, and methods for their use |
US8343706B2 (en) * | 2010-01-25 | 2013-01-01 | International Business Machines Corporation | Fluorine-free fused ring heteroaromatic photoacid generators and resist compositions containing the same |
WO2011161964A1 (ja) * | 2010-06-24 | 2011-12-29 | 興和株式会社 | Acat阻害剤を有効成分とするインスリン抵抗性改善剤 |
US9650375B2 (en) * | 2013-03-14 | 2017-05-16 | Merck Sharp & Dohme Corp. | Indole derivatives useful as anti-diabetic agents |
JP2018052818A (ja) * | 2015-01-28 | 2018-04-05 | 武田薬品工業株式会社 | スルホンアミド化合物 |
CN108440373B (zh) * | 2018-03-23 | 2021-05-14 | 昆明学院 | 一种铁催化的氰烷基吲哚啉及其制备方法 |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4803218A (en) * | 1982-09-29 | 1989-02-07 | Mcneilab, Inc. | 3-aminoalkyl-1H-indole-5-urea and amide derivatives |
US4956372A (en) * | 1987-10-02 | 1990-09-11 | Kyorin Pharmaceutical Co., Ltd. | Cyclic anthranilic acid derivatives and process for their preparation |
CN1021819C (zh) | 1988-01-20 | 1993-08-18 | 山之内制药株式会社 | 作为药物有用的双脲衍生物的制备方法 |
JPH02117651A (ja) * | 1988-01-20 | 1990-05-02 | Yamanouchi Pharmaceut Co Ltd | ジウレア誘導体及びその製造法 |
IE892088L (en) | 1988-07-12 | 1990-01-12 | William Henry Deryk Morris | Quinoline derivatives, their production and use |
JPH0753714B2 (ja) * | 1988-07-12 | 1995-06-07 | 武田薬品工業株式会社 | Acat阻害剤、キノリン誘導体及びその製造法 |
US4958485A (en) | 1988-12-22 | 1990-09-25 | Springs Industries, Inc. | Corespun yarn for fire resistant safety apparel |
US5153226A (en) * | 1989-08-31 | 1992-10-06 | Warner-Lambert Company | Acat inhibitors for treating hypocholesterolemia |
FR2654335A1 (fr) | 1989-11-10 | 1991-05-17 | Oreal | Compositions tinctoriales pour fibres keratiniques contenant des precurseurs de colorants par oxydation et des coupleurs derives du 4-hydroxyindole, et procede de teinture les mettant en óoeuvre. |
DK0447116T3 (da) | 1990-03-12 | 1995-05-15 | Yamanouchi Pharma Co Ltd | Urinstof-derivater, deres fremstilling samt lægemidler indeholdende sådanne derivater |
JPH0466568A (ja) * | 1990-06-29 | 1992-03-02 | Takeda Chem Ind Ltd | 中枢性抗酸化剤化合物 |
JP3086295B2 (ja) * | 1990-08-17 | 2000-09-11 | 武田薬品工業株式会社 | チエノピリジン誘導体、その製造法およびacat阻害剤 |
US5143919A (en) | 1990-08-17 | 1992-09-01 | Takeda Chemical Industries, Ltd. | Thienopyridine derivatives and their pharmaceutical use |
GB9025848D0 (en) | 1990-11-28 | 1991-01-09 | Erba Carlo Spa | Imidazol-2-yl derivatives of substituted bicyclic compounds and process for their preparation |
FR2673625B1 (fr) * | 1991-03-08 | 1993-05-07 | Adir | Nouveaux derives d'acylaminophenol, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
FR2674522B1 (fr) * | 1991-03-26 | 1993-07-16 | Lipha | Nouveaux derives de l'indole, procedes de preparation et medicaments les contenant. |
IL101785A0 (en) * | 1991-05-10 | 1992-12-30 | Fujisawa Pharmaceutical Co | Urea derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same |
CN1068000A (zh) * | 1991-06-27 | 1993-01-13 | 重庆人民广播电台 | 动平衡开关调幅浮动载波广播电视发射机 |
CA2121391A1 (en) * | 1993-04-28 | 1994-10-29 | Atsuyuki Kojima | Indoloylguanidine derivatives |
US5952354A (en) | 1993-07-21 | 1999-09-14 | American Home Products Corporation | Tris carbamic acid esters: inhibitors of cholesterol absorption |
JP3720395B2 (ja) * | 1994-09-20 | 2005-11-24 | 京都薬品工業株式会社 | 新規ヘテロ環誘導体、その製造方法およびその医薬用途 |
CA2160600A1 (en) * | 1994-10-18 | 1996-04-19 | Masahumi Kitano | Indoloylguanidine derivatives |
JPH08208602A (ja) * | 1994-10-18 | 1996-08-13 | Sumitomo Pharmaceut Co Ltd | インドロイルグアニジン誘導体 |
US5767129A (en) * | 1995-08-24 | 1998-06-16 | Warner-Lambert Company | Substituted quinolines and isoquinolines as calcium channel blockers, their preparation and the use thereof |
DE69702725T2 (de) * | 1996-03-04 | 2000-12-07 | Fuji Photo Film Co., Ltd. | Verarbeitungszusammensetzung für lichtempfindliches photographisches Silberhalogenidmaterial, Entwickler und Verarbeitungsverfahren unter dessen Verwendung |
-
1996
- 1996-09-30 NZ NZ318874A patent/NZ318874A/xx unknown
- 1996-09-30 BR BR9610846A patent/BR9610846A/pt not_active IP Right Cessation
- 1996-09-30 EP EP96932060A patent/EP0866059B1/en not_active Expired - Lifetime
- 1996-09-30 HU HU9900617A patent/HUP9900617A3/hu unknown
- 1996-09-30 US US09/051,202 patent/US6063806A/en not_active Ceased
- 1996-09-30 KR KR10-1998-0702462A patent/KR100388345B1/ko not_active IP Right Cessation
- 1996-09-30 US US10/609,224 patent/USRE38970E1/en not_active Expired - Fee Related
- 1996-09-30 CZ CZ1998996A patent/CZ292632B6/cs not_active IP Right Cessation
- 1996-09-30 WO PCT/JP1996/002852 patent/WO1997012860A1/ja active IP Right Grant
- 1996-09-30 ES ES96932060T patent/ES2164920T3/es not_active Expired - Lifetime
- 1996-09-30 IL IL12393996A patent/IL123939A/en not_active IP Right Cessation
- 1996-09-30 AT AT96932060T patent/ATE210116T1/de not_active IP Right Cessation
- 1996-09-30 TR TR1998/00655T patent/TR199800655T2/xx unknown
- 1996-09-30 CN CN96198670A patent/CN1097043C/zh not_active Expired - Fee Related
- 1996-09-30 PL PL96326000A patent/PL190034B1/pl not_active IP Right Cessation
- 1996-09-30 DE DE69617731T patent/DE69617731T2/de not_active Expired - Fee Related
- 1996-09-30 DK DK96932060T patent/DK0866059T3/da active
- 1996-09-30 PT PT96932060T patent/PT866059E/pt unknown
- 1996-10-04 TW TW085112125A patent/TW429250B/zh not_active IP Right Cessation
-
1998
- 1998-04-01 NO NO19981485A patent/NO310818B1/no unknown
-
1999
- 1999-03-05 HK HK99100913A patent/HK1015781A1/xx not_active IP Right Cessation
- 1999-03-05 HK HK03100740.0A patent/HK1048989B/zh not_active IP Right Cessation
-
2000
- 2000-02-18 US US09/506,839 patent/US6200988B1/en not_active Expired - Fee Related
-
2001
- 2001-11-30 CN CNB011429577A patent/CN1193018C/zh not_active Expired - Fee Related
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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