TW429250B - Novel heterocyclic derivatives and pharmaceutical use thereof - Google Patents

Novel heterocyclic derivatives and pharmaceutical use thereof

Info

Publication number
TW429250B
TW429250B TW085112125A TW85112125A TW429250B TW 429250 B TW429250 B TW 429250B TW 085112125 A TW085112125 A TW 085112125A TW 85112125 A TW85112125 A TW 85112125A TW 429250 B TW429250 B TW 429250B
Authority
TW
Taiwan
Prior art keywords
alkyl group
group
alkyl
carboxyl
alkoxyl
Prior art date
Application number
TW085112125A
Other languages
English (en)
Inventor
Shoji Kamiya
Hiroaki Shirahase
Hiroshi Matsui
Shohei Nakamura
Katsuo Wada
Original Assignee
Kyoto Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyoto Pharmaceutical Co Ltd filed Critical Kyoto Pharmaceutical Co Ltd
Application granted granted Critical
Publication of TW429250B publication Critical patent/TW429250B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrrole Compounds (AREA)
TW085112125A 1995-10-05 1996-10-04 Novel heterocyclic derivatives and pharmaceutical use thereof TW429250B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP25908295 1995-10-05
JP5801896 1996-03-14
JP19433196 1996-07-24

Publications (1)

Publication Number Publication Date
TW429250B true TW429250B (en) 2001-04-11

Family

ID=27296460

Family Applications (1)

Application Number Title Priority Date Filing Date
TW085112125A TW429250B (en) 1995-10-05 1996-10-04 Novel heterocyclic derivatives and pharmaceutical use thereof

Country Status (20)

Country Link
US (3) USRE38970E1 (zh)
EP (1) EP0866059B1 (zh)
KR (1) KR100388345B1 (zh)
CN (2) CN1097043C (zh)
AT (1) ATE210116T1 (zh)
BR (1) BR9610846A (zh)
CZ (1) CZ292632B6 (zh)
DE (1) DE69617731T2 (zh)
DK (1) DK0866059T3 (zh)
ES (1) ES2164920T3 (zh)
HK (2) HK1015781A1 (zh)
HU (1) HUP9900617A3 (zh)
IL (1) IL123939A (zh)
NO (1) NO310818B1 (zh)
NZ (1) NZ318874A (zh)
PL (1) PL190034B1 (zh)
PT (1) PT866059E (zh)
TR (1) TR199800655T2 (zh)
TW (1) TW429250B (zh)
WO (1) WO1997012860A1 (zh)

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AR008331A1 (es) * 1997-01-23 1999-12-29 Smithkline Beecham Corp Compuestos antagonistas de un receptor de il-8, uso de los mismos para la fabricacion de medicamentos, procedimiento para su obtencion, composicionesfarmaceuticas que los contienen
US5929250A (en) * 1997-01-23 1999-07-27 Smithkline Beecham Corporation IL-8 receptor antagonists
AR015425A1 (es) * 1997-09-05 2001-05-02 Smithkline Beecham Corp Compuestos de benzotiazol, composicion farmaceutica que los contiene, su uso en la manufactura de un medicamento, procedimiento para su preparacion,compuestos intermediarios y procedimiento para su preparacion
WO1999052875A1 (en) * 1998-04-08 1999-10-21 Takeda Chemical Industries, Ltd. Amine compounds, their production and their use as somatostatin receptor antagonists or agonists
WO2000005216A1 (en) * 1998-07-23 2000-02-03 Smithkline Beecham Corporation Il-8 receptor antagonists
FR2783519B1 (fr) 1998-09-23 2003-01-24 Sod Conseils Rech Applic Nouveaux derives d'amidines, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
WO2002020009A1 (fr) * 2000-09-01 2002-03-14 Sankyo Company, Limited Compositions medicales
TW200600497A (en) * 2001-02-02 2006-01-01 Sankyo Co Preparation of indoline derivative
WO2002072147A1 (fr) * 2001-03-14 2002-09-19 Sankyo Company, Limited Compositions medicinales contenant un inhibiteur de transporteur d'acide biliaire
EP2335700A1 (en) * 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C virus polymerase inhibitors with a heterobicylic structure
MXPA04001878A (es) * 2001-08-28 2004-06-15 Sankyo Co Composiciones medicinales que comprenden antagonista del receptor de angiotensina ii.
US20050119314A1 (en) * 2002-04-05 2005-06-02 Sankyo Company, Limited Pharmaceutical composition comprising an ACAT inhibitor and an insulin resistance reducing agent
WO2003084572A1 (fr) * 2002-04-05 2003-10-16 Sankyo Company, Limited Composition médicale comprenant un inhibiteur de l'acat et agent améliorant la résistance à l'insuline
JP2004002365A (ja) * 2002-04-05 2004-01-08 Sankyo Co Ltd Ａｃａｔ阻害剤とインシュリン抵抗性改善剤とからなる医薬組成物
DE60332851D1 (de) * 2002-07-17 2010-07-15 Kyoto Pharma Ind Indolinverbindung und deren medizinische verwendung
IL166312A0 (en) * 2002-07-18 2006-01-15 Sankyo Co A pharmaceutical composition containing an adp receptor antagonist and an acat inhibitor
US20050192245A1 (en) * 2002-07-18 2005-09-01 Sankyo Company, Limited Medicinal composition for treating arteriosclerosis
US7223785B2 (en) * 2003-01-22 2007-05-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7098231B2 (en) * 2003-01-22 2006-08-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
WO2005051298A2 (en) 2003-11-19 2005-06-09 Metabasis Therapeutics, Inc. Novel phosphorus-containing thyromimetics
WO2005077359A1 (ja) * 2004-02-17 2005-08-25 Sankyo Company, Limited インドリン化合物を含有する安定化された医薬組成物
DK1718608T3 (da) * 2004-02-20 2013-10-14 Boehringer Ingelheim Int Virale polymeraseinhibitorer
ES2439229T3 (es) 2004-10-06 2014-01-22 The Brigham And Women's Hospital, Inc. Relevancia de niveles logrados de marcadores de inflamación sistémica tras el tratamiento
MX2007005129A (es) * 2004-10-27 2007-09-11 Daiichi Sankyo Co Ltd Compuesto de benceno que tiene 2 o mas sustituyentes.
US8076365B2 (en) * 2005-08-12 2011-12-13 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
WO2007146230A2 (en) * 2006-06-14 2007-12-21 Merck & Co., Inc. Non-nucleoside reverse transcriptase inhibitors
FR2918890A1 (fr) * 2007-07-19 2009-01-23 Galderma Res & Dev Utilisation du pactimibe pour la preparation d'un medicament destine a prevenir ou a traiter une maladie due a un dysfonctionnement des glandes sebacees chez l'homme ou l'animal
WO2010093601A1 (en) 2009-02-10 2010-08-19 Metabasis Therapeutics, Inc. Novel sulfonic acid-containing thyromimetics, and methods for their use
US8343706B2 (en) * 2010-01-25 2013-01-01 International Business Machines Corporation Fluorine-free fused ring heteroaromatic photoacid generators and resist compositions containing the same
WO2011161964A1 (ja) * 2010-06-24 2011-12-29 興和株式会社 Ａｃａｔ阻害剤を有効成分とするインスリン抵抗性改善剤
US9650375B2 (en) * 2013-03-14 2017-05-16 Merck Sharp & Dohme Corp. Indole derivatives useful as anti-diabetic agents
JP2018052818A (ja) * 2015-01-28 2018-04-05 武田薬品工業株式会社 スルホンアミド化合物
CN108440373B (zh) * 2018-03-23 2021-05-14 昆明学院 一种铁催化的氰烷基吲哚啉及其制备方法

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US4956372A (en) * 1987-10-02 1990-09-11 Kyorin Pharmaceutical Co., Ltd. Cyclic anthranilic acid derivatives and process for their preparation
JPH02117651A (ja) * 1988-01-20 1990-05-02 Yamanouchi Pharmaceut Co Ltd ジウレア誘導体及びその製造法
CN1021819C (zh) 1988-01-20 1993-08-18 山之内制药株式会社 作为药物有用的双脲衍生物的制备方法
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US5153226A (en) * 1989-08-31 1992-10-06 Warner-Lambert Company Acat inhibitors for treating hypocholesterolemia
FR2654335A1 (fr) 1989-11-10 1991-05-17 Oreal Compositions tinctoriales pour fibres keratiniques contenant des precurseurs de colorants par oxydation et des coupleurs derives du 4-hydroxyindole, et procede de teinture les mettant en óoeuvre.
DE69105786T2 (de) 1990-03-12 1995-04-27 Yamanouchi Pharma Co Ltd Harnstoffderivate, deren Herstellung sowie diese enthaltende pharmazeutische Zusammensetzungen.
JPH0466568A (ja) * 1990-06-29 1992-03-02 Takeda Chem Ind Ltd 中枢性抗酸化剤化合物
JP3086295B2 (ja) * 1990-08-17 2000-09-11 武田薬品工業株式会社 チエノピリジン誘導体、その製造法およびａｃａｔ阻害剤
US5143919A (en) 1990-08-17 1992-09-01 Takeda Chemical Industries, Ltd. Thienopyridine derivatives and their pharmaceutical use
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FR2673625B1 (fr) * 1991-03-08 1993-05-07 Adir Nouveaux derives d'acylaminophenol, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2674522B1 (fr) * 1991-03-26 1993-07-16 Lipha Nouveaux derives de l'indole, procedes de preparation et medicaments les contenant.
IL101785A0 (en) 1991-05-10 1992-12-30 Fujisawa Pharmaceutical Co Urea derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
CN1068000A (zh) * 1991-06-27 1993-01-13 重庆人民广播电台 动平衡开关调幅浮动载波广播电视发射机
CA2121391A1 (en) * 1993-04-28 1994-10-29 Atsuyuki Kojima Indoloylguanidine derivatives
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JP3720395B2 (ja) 1994-09-20 2005-11-24 京都薬品工業株式会社 新規ヘテロ環誘導体、その製造方法およびその医薬用途
JPH08208602A (ja) * 1994-10-18 1996-08-13 Sumitomo Pharmaceut Co Ltd インドロイルグアニジン誘導体
CA2160600A1 (en) * 1994-10-18 1996-04-19 Masahumi Kitano Indoloylguanidine derivatives
US5767129A (en) * 1995-08-24 1998-06-16 Warner-Lambert Company Substituted quinolines and isoquinolines as calcium channel blockers, their preparation and the use thereof
US5994040A (en) * 1996-03-04 1999-11-30 Fuji Photo Film Co., Ltd. Processing composition for silver halide photographic light-sensitive material, developer and processing method using the same

Also Published As

Publication number Publication date
USRE38970E1 (en) 2006-02-07
ATE210116T1 (de) 2001-12-15
IL123939A (en) 2001-11-25
HK1048989A1 (en) 2003-04-25
DK0866059T3 (da) 2002-03-25
NO981485D0 (no) 1998-04-01
CN1193018C (zh) 2005-03-16
AU708571B2 (en) 1999-08-05
NO981485L (no) 1998-06-02
NZ318874A (en) 1999-09-29
PL326000A1 (en) 1998-08-17
CN1097043C (zh) 2002-12-25
PL190034B1 (pl) 2005-10-31
KR19990063987A (ko) 1999-07-26
BR9610846A (pt) 1999-07-13
ES2164920T3 (es) 2002-03-01
CN1203587A (zh) 1998-12-30
CN1361100A (zh) 2002-07-31
HK1015781A1 (en) 1999-10-22
EP0866059A1 (en) 1998-09-23
US6200988B1 (en) 2001-03-13
HUP9900617A3 (en) 2001-12-28
HK1048989B (zh) 2005-10-28
TR199800655T2 (xx) 1999-09-21
DE69617731D1 (de) 2002-01-17
KR100388345B1 (ko) 2004-03-30
EP0866059A4 (en) 1998-12-02
AU7097796A (en) 1997-04-28
WO1997012860A1 (fr) 1997-04-10
US6063806A (en) 2000-05-16
HUP9900617A2 (hu) 1999-06-28
NO310818B1 (no) 2001-09-03
DE69617731T2 (de) 2002-08-08
CZ292632B6 (cs) 2003-11-12
PT866059E (pt) 2002-03-28
EP0866059B1 (en) 2001-12-05
CZ99698A3 (cs) 1998-08-12

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Legal Events

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GD4A Issue of patent certificate for granted invention patent
MM4A Annulment or lapse of patent due to non-payment of fees