DE69227583D1 - Arylmorpholine, herstellung und verwendung - Google Patents
Arylmorpholine, herstellung und verwendungInfo
- Publication number
- DE69227583D1 DE69227583D1 DE69227583T DE69227583T DE69227583D1 DE 69227583 D1 DE69227583 D1 DE 69227583D1 DE 69227583 T DE69227583 T DE 69227583T DE 69227583 T DE69227583 T DE 69227583T DE 69227583 D1 DE69227583 D1 DE 69227583D1
- Authority
- DE
- Germany
- Prior art keywords
- arylmorpholine
- production
- human
- depression
- administering
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB919108629A GB9108629D0 (en) | 1991-04-23 | 1991-04-23 | Heterocyclic pharmaceutical compounds,preparation and use |
PCT/GB1992/000733 WO1992018489A1 (en) | 1991-04-23 | 1992-04-22 | Arylmorpholine, preparation and use |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69227583D1 true DE69227583D1 (de) | 1998-12-17 |
DE69227583T2 DE69227583T2 (de) | 1999-04-01 |
Family
ID=10693740
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69227583T Expired - Fee Related DE69227583T2 (de) | 1991-04-23 | 1992-04-22 | Arylmorpholine, herstellung und verwendung |
Country Status (17)
Country | Link |
---|---|
US (2) | US5648347A (de) |
EP (1) | EP0583271B1 (de) |
JP (1) | JP3130040B2 (de) |
AT (1) | ATE173252T1 (de) |
AU (1) | AU668863B2 (de) |
CA (1) | CA2108967C (de) |
DE (1) | DE69227583T2 (de) |
DK (1) | DK0583271T3 (de) |
ES (1) | ES2124256T3 (de) |
FI (1) | FI934680A0 (de) |
GB (1) | GB9108629D0 (de) |
HU (1) | HU219458B (de) |
IE (1) | IE921260A1 (de) |
NZ (1) | NZ242421A (de) |
PT (1) | PT100415B (de) |
WO (1) | WO1992018489A1 (de) |
ZA (1) | ZA922910B (de) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9108629D0 (en) * | 1991-04-23 | 1991-06-12 | Wellcome Found | Heterocyclic pharmaceutical compounds,preparation and use |
US7098206B2 (en) | 1998-01-21 | 2006-08-29 | Smithkline Beecham Corporation | Pharmaceutically active morpholinol |
NZ529316A (en) | 1998-01-21 | 2004-05-28 | Glaxo Group Ltd | Pharmaceutically active morpholinol |
US6998400B2 (en) | 1998-01-22 | 2006-02-14 | Smithkline Beecham Corporation | Pharmaceutically active morpholinol |
US6734213B2 (en) | 1999-01-20 | 2004-05-11 | Smithkline Beecham Corporation | Pharmaceutically active morpholinol |
US6855820B2 (en) | 1999-01-20 | 2005-02-15 | Smithkline Beecham Corporation | Pharmaceutically active morpholinol |
FR2796069B3 (fr) * | 1999-07-09 | 2001-08-24 | Sanofi Synthelabo | Nouveaux procedes de preparation de derives de 2-(2- arylmorpholin-2-yl)ethanol substitues, enantiomeriquement purs, et composes intermediaires utiles dans ces procedes |
US7323462B2 (en) | 2002-12-10 | 2008-01-29 | Pfizer Inc. | Morpholine dopamine agonists |
GB0228787D0 (en) * | 2002-12-10 | 2003-01-15 | Pfizer Ltd | Morpholine dopamine agonists |
CA2508262C (en) * | 2002-12-10 | 2009-12-01 | Pfizer Inc. | Morpholine derivatives for use as dopamine agonists in the treatment of i.a. sexual dysfunction |
EP2571858B1 (de) * | 2010-05-21 | 2018-06-20 | Research Triangle Institute | Phenylmorpholine und analoge davon |
CA2800219C (en) | 2010-05-21 | 2019-03-12 | Research Triangle Institute | 1 - phenylmorpholine derivatives as hydroxybupropion analogues for treating drug dependence |
CN105949142B (zh) * | 2016-05-21 | 2018-03-27 | 南华大学 | 具有抗抑郁活性的单一手性化合物及其制备方法和应用 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2997469A (en) * | 1961-08-22 | Preparation of substituted | ||
GB851311A (en) * | 1958-04-02 | 1960-10-12 | Geigy Ag J R | Morpholine compounds and their production |
US3117967A (en) * | 1962-04-02 | 1964-01-14 | Smith Kline French Lab | 2-biphenylyl-2-hydroxy-morpholinium halides |
GB1336732A (en) * | 1970-10-28 | 1973-11-07 | Istituto Gentili Spa Pisa | Diethanolamine derivatives |
IE50355B1 (en) * | 1979-10-20 | 1986-04-02 | Wyeth John & Brother Ltd | Morpholine derivatives |
FR2517305B1 (fr) * | 1981-12-01 | 1985-10-25 | Lafon Labor | Nouveaux derives de 2-phenyl-morpholine et leur utilisation en therapeutique |
FR2553410B1 (fr) * | 1983-10-14 | 1986-05-16 | Lafon Labor | Nouveaux derives de 2-tolyl-morpholine utiles en therapeutique |
FR2553411B1 (fr) * | 1983-10-14 | 1986-08-01 | Lafon Labor | Derives de 2-halogenophenyl-morpholine, procede de preparation et utilisation en therapeutique |
FR2553413B1 (fr) * | 1983-10-17 | 1986-03-21 | Lafon Labor | Derives de 4-alkyl-2-hydroxy-3-methyl-2-phenyl-morpholine, procede de preparation et utilisation en therapeutique |
GB8417170D0 (en) * | 1984-07-05 | 1984-08-08 | Wellcome Found | Heterocyclic pharmaceutical compounds |
US4803200A (en) * | 1987-10-02 | 1989-02-07 | A. H. Robins Company, Incorporated | Substituted dialkanolamines, sulfur analogs and condensed 1,4-oxazine derivatives thereof in viral disease treatment |
GB8924528D0 (en) * | 1989-10-31 | 1989-12-20 | Wellcome Found | Heterocyclic pharmaceutical compounds,preparation and use |
GB9108629D0 (en) * | 1991-04-23 | 1991-06-12 | Wellcome Found | Heterocyclic pharmaceutical compounds,preparation and use |
-
1991
- 1991-04-23 GB GB919108629A patent/GB9108629D0/en active Pending
-
1992
- 1992-04-22 IE IE126092A patent/IE921260A1/en not_active IP Right Cessation
- 1992-04-22 AT AT92908819T patent/ATE173252T1/de not_active IP Right Cessation
- 1992-04-22 EP EP92908819A patent/EP0583271B1/de not_active Expired - Lifetime
- 1992-04-22 NZ NZ242421A patent/NZ242421A/en unknown
- 1992-04-22 AU AU15753/92A patent/AU668863B2/en not_active Ceased
- 1992-04-22 ES ES92908819T patent/ES2124256T3/es not_active Expired - Lifetime
- 1992-04-22 CA CA002108967A patent/CA2108967C/en not_active Expired - Fee Related
- 1992-04-22 WO PCT/GB1992/000733 patent/WO1992018489A1/en active IP Right Grant
- 1992-04-22 JP JP04508053A patent/JP3130040B2/ja not_active Expired - Fee Related
- 1992-04-22 DK DK92908819T patent/DK0583271T3/da active
- 1992-04-22 ZA ZA922910A patent/ZA922910B/xx unknown
- 1992-04-22 PT PT100415A patent/PT100415B/pt not_active IP Right Cessation
- 1992-04-22 HU HU9303000A patent/HU219458B/hu not_active IP Right Cessation
- 1992-04-22 DE DE69227583T patent/DE69227583T2/de not_active Expired - Fee Related
-
1993
- 1993-10-22 FI FI934680A patent/FI934680A0/fi not_active IP Right Cessation
-
1995
- 1995-05-19 US US08/444,609 patent/US5648347A/en not_active Expired - Fee Related
-
1997
- 1997-03-28 US US08/828,935 patent/US5760224A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ZA922910B (en) | 1994-01-24 |
US5648347A (en) | 1997-07-15 |
DK0583271T3 (da) | 1999-07-26 |
CA2108967A1 (en) | 1992-10-24 |
FI934680A (fi) | 1993-10-22 |
NZ242421A (en) | 1994-10-26 |
HU9303000D0 (en) | 1994-01-28 |
JP3130040B2 (ja) | 2001-01-31 |
AU668863B2 (en) | 1996-05-23 |
HU219458B (hu) | 2001-04-28 |
ES2124256T3 (es) | 1999-02-01 |
ATE173252T1 (de) | 1998-11-15 |
JPH06506675A (ja) | 1994-07-28 |
EP0583271B1 (de) | 1998-11-11 |
CA2108967C (en) | 2002-10-08 |
AU1575392A (en) | 1992-11-17 |
EP0583271A1 (de) | 1994-02-23 |
FI934680A0 (fi) | 1993-10-22 |
WO1992018489A1 (en) | 1992-10-29 |
PT100415A (pt) | 1993-06-30 |
US5760224A (en) | 1998-06-02 |
IE921260A1 (en) | 1992-11-04 |
GB9108629D0 (en) | 1991-06-12 |
PT100415B (pt) | 1999-08-31 |
DE69227583T2 (de) | 1999-04-01 |
HUT70531A (en) | 1995-10-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |