AR015425A1 - Compuestos de benzotiazol, composicion farmaceutica que los contiene, su uso en la manufactura de un medicamento, procedimiento para su preparacion,compuestos intermediarios y procedimiento para su preparacion - Google Patents

Compuestos de benzotiazol, composicion farmaceutica que los contiene, su uso en la manufactura de un medicamento, procedimiento para su preparacion,compuestos intermediarios y procedimiento para su preparacion

Info

Publication number
AR015425A1
AR015425A1 ARP980104362A ARP980104362A AR015425A1 AR 015425 A1 AR015425 A1 AR 015425A1 AR P980104362 A ARP980104362 A AR P980104362A AR P980104362 A ARP980104362 A AR P980104362A AR 015425 A1 AR015425 A1 AR 015425A1
Authority
AR
Argentina
Prior art keywords
cr8r8
optionally substituted
integer
alkyl
value
Prior art date
Application number
ARP980104362A
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English (en)
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of AR015425A1 publication Critical patent/AR015425A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Transplantation (AREA)
  • Psychiatry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compuestos de benzotiazol utiles para el tratamiento de estados de enfermedad que ocurren por mediacion de la quimioquina, Interleuquina-8 (IL-8) de laformula (I)en la que: Res -NH -C(X)-NH-(CR13R14)v - Z; Z es W, hereroarilo opcionalmente sustituido,cicloalquilo de C5-8 opcionalmente sustituido,alquilo C1-10opcionalmente sustituido,alquenilo C2-10 opcionalmente sustituido, o un alquinilo C2-10 opcionalmente sustituido, X es =O, o =S; A es CR20R21; R1 se seleccionaindependientemente entre H; halogeno; nitro, ciano; alquilo de C1-10 halosustituido;alquilo de C1-10;alquenilo de C2-10;alcoxi de C1-10; alcoxi de C1-10halosustituido; azida; (CR8R8)qS(O)tR4, hidroxi; hidroxialquilo de C1-4; arilo; arilalquilo de C1-4; ariloxi; arilalquiloxi de C1-4; heteroarilo, heteroarilalquilo; heterocíclico; heterociclicoalquilo de C1-4; heteroarilalquiloxi de C1-4; arilalquenilo de C2-10; heteroarilalquenilo de C2-10; heterociclicoalqueniloC2-10; (CR8R8)qNR4R5; alquenilo de C2-10C(O)NR4R5; (CR8R8)qC(O)NR4R5; (CR8R8)qC(O)NR4R10; S(O)3H; S(O)3R8; (CR8R8)qC(O)R11; alquenilo de C2-10C(O)R11;alquenilo de C2-10C(O)OR11; (CR8R8)qC(O)OR11; (CR8R8)qC(O)OR12; (CR8R8)qOC(O)R11; (CR8R8)qNR4C(O)R11; (CR8R8)qC(NR4)NR4R5; (CR8R8)qNR4C(NR5)R11;(CR8R8)qNHS(O)2R17;(CR8R8)qS-(O)2-NR4R5; o dos restos R1 juntos pueden formar O-(CH2)sO o un anillo saturado o insaturado de 5 a 6 miembros, y en el que losanillos arilo, heteroarilo y heterocíclico pueden estar opcionalmente sustituidos; n es un numero entero que tiene un valor de 1 a 3; m es un numero entero quetiene un valor de 1 o 3; q es O o un numero entero que tiene un valor de 1 a 10; t es 0, o un numero entero que tiene un valor de 1 o 2; s es un numero enteroque tiene un valor de 1 a 3; v es 0 o un numero entero que tiene un valor de 1 a 4; R4 y R5 son independientemente hidrogeno, alquilo de C1-4 opcionalmentesustituido, arilo opcionalmente sustituido, arilalquilo de C1-4 opcionalmente sustituido, heteroarilo opcionalmente sustituido, heteroarilalquilo de C1-4opcionalmente sustituido, heterocíclico, heterocíclico alquilo de C1-4, o R4 y R5 junto con el nitrogeno al que están unidos forman un anillo de 5 a 7 miembros
ARP980104362A 1997-09-05 1998-09-01 Compuestos de benzotiazol, composicion farmaceutica que los contiene, su uso en la manufactura de un medicamento, procedimiento para su preparacion,compuestos intermediarios y procedimiento para su preparacion AR015425A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5799897P 1997-09-05 1997-09-05

Publications (1)

Publication Number Publication Date
AR015425A1 true AR015425A1 (es) 2001-05-02

Family

ID=22014023

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980104362A AR015425A1 (es) 1997-09-05 1998-09-01 Compuestos de benzotiazol, composicion farmaceutica que los contiene, su uso en la manufactura de un medicamento, procedimiento para su preparacion,compuestos intermediarios y procedimiento para su preparacion

Country Status (17)

Country Link
US (1) US6297265B2 (es)
EP (1) EP1003509A4 (es)
JP (1) JP2001514225A (es)
KR (1) KR20010023672A (es)
CN (1) CN1278726A (es)
AR (1) AR015425A1 (es)
AU (1) AU732728B2 (es)
BR (1) BR9812176A (es)
CA (1) CA2302450A1 (es)
CO (1) CO4970747A1 (es)
HU (1) HUP0004646A3 (es)
IL (1) IL134855A0 (es)
NO (1) NO20001100D0 (es)
PL (1) PL339134A1 (es)
TR (1) TR200000611T2 (es)
WO (1) WO1999011264A1 (es)
ZA (1) ZA988100B (es)

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US6498154B1 (en) 1999-05-04 2002-12-24 Wyeth Cyclic regimens using quinazolinone and benzoxazine derivatives
US6380235B1 (en) 1999-05-04 2002-04-30 American Home Products Corporation Benzimidazolones and analogues
US6369056B1 (en) 1999-05-04 2002-04-09 American Home Products Corporation Cyclic urea and cyclic amide derivatives
US6358947B1 (en) 1999-05-04 2002-03-19 American Home Products Corporation Tetracyclic progesterone receptor modulator compounds and methods
US6319912B1 (en) 1999-05-04 2001-11-20 American Home Products Corporation Cyclic regimens using 2,1-benzisothiazoline 2,2-dioxides
US6391907B1 (en) 1999-05-04 2002-05-21 American Home Products Corporation Indoline derivatives
US6339098B1 (en) 1999-05-04 2002-01-15 American Home Products Corporation 2,1-benzisothiazoline 2,2-dioxides
US6380178B1 (en) 1999-05-04 2002-04-30 American Home Products Corporation Cyclic regimens using cyclocarbamate and cyclic amide derivatives
US6355648B1 (en) 1999-05-04 2002-03-12 American Home Products Corporation Thio-oxindole derivatives
US6306851B1 (en) 1999-05-04 2001-10-23 American Home Products Corporation Cyclocarbamate and cyclic amide derivatives
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CN100444839C (zh) * 2002-03-18 2008-12-24 先灵公司 式(i)化合物在制备治疗化学激活物中介的疾病的药物中的应用
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TW200418812A (en) * 2002-10-29 2004-10-01 Smithkline Beecham Corp IL-8 receptor antagonists
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Also Published As

Publication number Publication date
CO4970747A1 (es) 2000-11-07
WO1999011264A1 (en) 1999-03-11
ZA988100B (en) 1999-03-05
AU9566398A (en) 1999-03-22
IL134855A0 (en) 2001-05-20
JP2001514225A (ja) 2001-09-11
HUP0004646A3 (en) 2002-12-28
CA2302450A1 (en) 1999-03-11
EP1003509A4 (en) 2002-11-20
KR20010023672A (ko) 2001-03-26
NO20001100L (no) 2000-03-03
AU732728B2 (en) 2001-04-26
US20010018447A1 (en) 2001-08-30
US6297265B2 (en) 2001-10-02
CN1278726A (zh) 2001-01-03
PL339134A1 (en) 2000-12-04
BR9812176A (pt) 2001-12-18
NO20001100D0 (no) 2000-03-03
HUP0004646A2 (hu) 2001-09-28
TR200000611T2 (tr) 2000-08-21
EP1003509A1 (en) 2000-05-31

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