AR034557A1 - Derivados de (2-azabiclo[2.2.1]hept-7-il)metanol como agonistas de receptores nicotinicos de acetilcolina - Google Patents
Derivados de (2-azabiclo[2.2.1]hept-7-il)metanol como agonistas de receptores nicotinicos de acetilcolinaInfo
- Publication number
- AR034557A1 AR034557A1 ARP010104304A ARP010104304A AR034557A1 AR 034557 A1 AR034557 A1 AR 034557A1 AR P010104304 A ARP010104304 A AR P010104304A AR P010104304 A ARP010104304 A AR P010104304A AR 034557 A1 AR034557 A1 AR 034557A1
- Authority
- AR
- Argentina
- Prior art keywords
- groups
- substances
- substituted
- unsubstituted
- group
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Toxicology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Abstract
Sustancias de la fórmula general (1) donde: la línea punteada representa un enlace doble opcional; X se selecciona del grupo formado por NH, NR4, O y S; R1 se selecciona del grupo formado por hidrógeno, grupo alquilo C1-10 lineales y ramificados, sustituidos e insustituidos, grupos arilo C5-10 sustituidos e insustituidos, grupos heteroarilo C4-10 sustituidos e insustituidos, grupos acilo, tioacilo, carbonilcarboxi, carbamoilo N-organil sustituidos y organosulfonilo; R2, R3 y R4 se seleccionan independientemente entre sí del grupo formado por grupos alquilo C1-10, arilo C5-12 y heteroarilo C4-12, donde estos grupos son insustituidos o presentan uno o varios sustituyentes que se seleccionan independientemente entre sí del grupo formado por halógenos, grupos alcoxi, ariloxi, nitro, alcoxicarbonilo C1-5, alquilo o acilo eventualmente sustituidos con flúor y grupos ciano; o una sal fisiológicamente inofensiva de los mismos. También se describen los métodos de obtención de las sustancias de fórmula (1), los compuestos intermediarios a partir de los cuales se obtienen las sustancias de fórmula (1), los medicamentos que contienen dichas sustancias y el uso de las mismas para la preparación de un medicamento. Las sustancias de fórmula (1) pueden ser usadas específicamente para el tratamiento de enfermedades en las que una estimulación de los receptores nicotínicos de acetilcolina provocan una mejoría del cuadro clínico.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10044905A DE10044905A1 (de) | 2000-09-12 | 2000-09-12 | (2-Azabicyclo[2.2.1]hept-7-yl)methanol-Derivate als nikontinische Acetylcholinrezeptor Agonisten |
Publications (1)
Publication Number | Publication Date |
---|---|
AR034557A1 true AR034557A1 (es) | 2004-03-03 |
Family
ID=7655825
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP010104304A AR034557A1 (es) | 2000-09-12 | 2001-09-12 | Derivados de (2-azabiclo[2.2.1]hept-7-il)metanol como agonistas de receptores nicotinicos de acetilcolina |
Country Status (15)
Country | Link |
---|---|
US (1) | US7008955B2 (es) |
EP (1) | EP1317430B1 (es) |
JP (1) | JP2004509106A (es) |
CN (1) | CN1455770A (es) |
AR (1) | AR034557A1 (es) |
AT (1) | ATE295835T1 (es) |
AU (1) | AU2001285945A1 (es) |
CA (1) | CA2421936A1 (es) |
DE (2) | DE10044905A1 (es) |
ES (1) | ES2240506T3 (es) |
HU (1) | HUP0302971A2 (es) |
MX (1) | MXPA03002076A (es) |
PT (1) | PT1317430E (es) |
WO (1) | WO2002022578A1 (es) |
ZA (1) | ZA200302829B (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10118551A1 (de) * | 2001-04-14 | 2002-10-17 | Merck Patent Gmbh | Nikotinische Acetylcholinrezeptor Liganden |
DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
CA2476417A1 (en) * | 2002-02-15 | 2003-08-28 | Pharmacia & Upjohn Company | Azabicyclo-substituted benzoylamides and thioamides for treatment of cns-related disorders |
WO2004085433A2 (en) * | 2003-03-28 | 2004-10-07 | Pharmacia & Upjohn Company Llc | Positive allosteric modulators of the nicotinic acetylcholine receptor |
KR20180011888A (ko) | 2008-11-19 | 2018-02-02 | 포럼 파마슈티칼즈 인크. | (r)-7-클로로-n-(퀴누클리딘-3-일)벤조[b]티오펜-2-카르복사미드 및 그 약학적으로 허용가능한 염을 이용한 인지 장애의 치료 |
BRPI1014793A2 (pt) * | 2009-05-11 | 2016-04-05 | Envivo Pharmaceuticals Inc | tratamento de distúrbios de cognição com determinados receptores de ácido alfa-7-nicotínico em combinação com inibidores de acetil-colinesterase |
RS54742B1 (sr) | 2010-05-17 | 2016-10-31 | Forum Pharmaceuticals Inc | Kristalni oblik (r)-7-hlor-n-(hinuklidin-3-il)benzo[b]tiofen-2-karboksamid hidrohlorid monohidrata |
WO2013169646A1 (en) | 2012-05-08 | 2013-11-14 | Envivo Pharmaceuticals, Inc. | Methods of maintaining, treating or improving cognitive function |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9020051D0 (en) | 1990-09-13 | 1990-10-24 | Pfizer Ltd | Muscarinic receptor antagonists |
US5817679A (en) | 1993-04-01 | 1998-10-06 | University Of Virginia | 7-Azabicyclo 2.2.1!-heptane and -heptene derivatives as cholinergic receptor ligands |
US6117889A (en) * | 1994-04-01 | 2000-09-12 | University Of Virginia | 7-Azabicyclo-[2.2.1]-heptane and -heptene derivatives as analgesics and anti-inflammatory agents |
WO1998048801A1 (fr) | 1997-04-26 | 1998-11-05 | Sumitomo Pharmaceuticals Co., Ltd. | Composes 2-azabicyclo |
GB9822945D0 (en) | 1998-10-20 | 1998-12-16 | Isis Innovations Ltd | Epibatidine analogues |
-
2000
- 2000-09-12 DE DE10044905A patent/DE10044905A1/de not_active Withdrawn
-
2001
- 2001-09-11 JP JP2002526831A patent/JP2004509106A/ja active Pending
- 2001-09-11 HU HU0302971A patent/HUP0302971A2/hu unknown
- 2001-09-11 AT AT01965274T patent/ATE295835T1/de not_active IP Right Cessation
- 2001-09-11 ES ES01965274T patent/ES2240506T3/es not_active Expired - Lifetime
- 2001-09-11 CA CA002421936A patent/CA2421936A1/en not_active Abandoned
- 2001-09-11 EP EP01965274A patent/EP1317430B1/de not_active Expired - Lifetime
- 2001-09-11 DE DE50106266T patent/DE50106266D1/de not_active Expired - Fee Related
- 2001-09-11 MX MXPA03002076A patent/MXPA03002076A/es not_active Application Discontinuation
- 2001-09-11 CN CN01815520A patent/CN1455770A/zh active Pending
- 2001-09-11 WO PCT/EP2001/010491 patent/WO2002022578A1/de active IP Right Grant
- 2001-09-11 AU AU2001285945A patent/AU2001285945A1/en not_active Abandoned
- 2001-09-11 PT PT01965274T patent/PT1317430E/pt unknown
- 2001-09-11 US US10/380,064 patent/US7008955B2/en not_active Expired - Fee Related
- 2001-09-12 AR ARP010104304A patent/AR034557A1/es unknown
-
2003
- 2003-04-10 ZA ZA200302829A patent/ZA200302829B/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN1455770A (zh) | 2003-11-12 |
JP2004509106A (ja) | 2004-03-25 |
DE10044905A1 (de) | 2002-03-21 |
HUP0302971A2 (hu) | 2003-12-29 |
US7008955B2 (en) | 2006-03-07 |
WO2002022578A1 (de) | 2002-03-21 |
PT1317430E (pt) | 2005-09-30 |
EP1317430A1 (de) | 2003-06-11 |
DE50106266D1 (en) | 2005-06-23 |
ZA200302829B (en) | 2004-08-13 |
CA2421936A1 (en) | 2003-03-11 |
ES2240506T3 (es) | 2005-10-16 |
AU2001285945A1 (en) | 2002-03-26 |
US20040039045A1 (en) | 2004-02-26 |
MXPA03002076A (es) | 2003-06-24 |
EP1317430B1 (de) | 2005-05-18 |
ATE295835T1 (de) | 2005-06-15 |
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