PE20050473A1 - Nuevos derivados de pirimidin-2-amina - Google Patents

Nuevos derivados de pirimidin-2-amina

Info

Publication number
PE20050473A1
PE20050473A1 PE2004000948A PE2004000948A PE20050473A1 PE 20050473 A1 PE20050473 A1 PE 20050473A1 PE 2004000948 A PE2004000948 A PE 2004000948A PE 2004000948 A PE2004000948 A PE 2004000948A PE 20050473 A1 PE20050473 A1 PE 20050473A1
Authority
PE
Peru
Prior art keywords
amine
pyrimidin
pyridin
substituents
halogen
Prior art date
Application number
PE2004000948A
Other languages
English (en)
Inventor
Trias Cristina Esteve
Juan Bernat Vidal
Original Assignee
Almirall Prodesfarma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Prodesfarma Sa filed Critical Almirall Prodesfarma Sa
Publication of PE20050473A1 publication Critical patent/PE20050473A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

REFERIDA A UN COMPUESTO DE FORMULA I DONDE R1 ES ARILO O HETEROARILO MONOCICLICO SUSTITUIDO O NO CON 1-3 SUSTITUYENTES COMO -OH, HALOGENO, -SH, ENTRE OTROS; R2 ES HETEROARILO MONOCICLICO CON N EN EL ANILLO Y ADICIONALMENTE SUSTITUIDO O NO POR 1-3 SUSTITUYENTES COMO HALOGENO, -SH, NITRO, ENTRE OTROS; R3 ES GRUPO HETEROARILO MONOCICLICO O POLICICLICO SUSTITUIDO O NO POR 1-3 SUSTITUYENTES COMO HALOGENO, OXO, ALCOXI, ENTRE OTROS. TAMBIEN REFERIDA A UNA COMPOSICION FARMACEUTICA QUE CONTIENE DICHO COMPUESTO CUYO PREFERIDOS SON: 4'-(2-FURIL)-N-PIRIDIN-3-IL-4,5'-BIPIRIMIDIN-2'-AMINA; N-PIRIDIN-3-IL-4'-TIEN-2-IL-4,5'-BIPIRIMIDIN-2'-AMINA Y 5-PIRIDAZIN-4-IL-N-PIRIDIN-3-IL-4-(2-TIENIL)PIRIMIDIN-2-AMINA. DICHO COMPUESTO ES UTIL EN EL TRATAMIENTO DE ASMA, ATEROSCLEROSIS, RETINOPATIA, ENTRE OTRAS
PE2004000948A 2003-10-02 2004-09-28 Nuevos derivados de pirimidin-2-amina PE20050473A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200302275A ES2229928B1 (es) 2003-10-02 2003-10-02 Nuevos derivados de pirimidin-2-amina.

Publications (1)

Publication Number Publication Date
PE20050473A1 true PE20050473A1 (es) 2005-08-24

Family

ID=34507890

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2004000948A PE20050473A1 (es) 2003-10-02 2004-09-28 Nuevos derivados de pirimidin-2-amina

Country Status (24)

Country Link
US (1) US20070265273A1 (es)
EP (1) EP1668000A1 (es)
JP (1) JP2007507443A (es)
KR (1) KR20060097010A (es)
CN (1) CN1886402A (es)
AR (1) AR046170A1 (es)
AU (1) AU2004283800B8 (es)
BR (1) BRPI0415324A (es)
CA (1) CA2540765A1 (es)
CO (1) CO5690593A2 (es)
EC (1) ECSP066426A (es)
ES (1) ES2229928B1 (es)
IL (1) IL174771A0 (es)
MX (1) MXPA06003525A (es)
NO (1) NO20061952L (es)
NZ (1) NZ546266A (es)
PE (1) PE20050473A1 (es)
RU (1) RU2006114746A (es)
SG (1) SG149077A1 (es)
TW (1) TW200526645A (es)
UA (1) UA82563C2 (es)
UY (1) UY28529A1 (es)
WO (1) WO2005040155A1 (es)
ZA (1) ZA200602139B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2311462A1 (en) 2004-10-15 2011-04-20 Cv Therapeutics, Inc. Method of preventing and treating airway remodeling and pulmonary inflammation using A2B adenosine receptor antagonists
ES2270715B1 (es) * 2005-07-29 2008-04-01 Laboratorios Almirall S.A. Nuevos derivados de pirazina.
ES2274712B1 (es) 2005-10-06 2008-03-01 Laboratorios Almirall S.A. Nuevos derivados imidazopiridina.
DE102006046410A1 (de) * 2006-09-20 2008-03-27 Eberhard-Karls-Universität Tübingen Universitätsklinikum Arzneimittel zur Prophylaxe oder Behandlung oder Diagnostik von ischämischen Krankheiten
ES2303776B1 (es) * 2006-12-29 2009-08-07 Laboratorios Almirall S.A. Derivados de 5-fenil-6-piridin-4-il-1,3-dihidro-2h-imidazo(4,5-b)piridin-2-ona utiles como antagonistas del receptor de adenosina a2b.
ES2320955B1 (es) 2007-03-02 2010-03-16 Laboratorios Almirall S.A. Nuevos derivados de 3-((1,2,4)triazolo(4,3-a)piridin-7-il)benzamida.
US8273759B2 (en) * 2007-06-08 2012-09-25 Bayer Cropscience Ag Fungicide heterocyclyl-pyrimidinyl-amino derivatives
EA201000104A1 (ru) * 2007-07-26 2010-08-30 Новартис Аг Производные пиримидина, применимые для лечения воспалительных или аллергических патологических состояний
AU2008289037B2 (en) 2007-08-22 2012-03-01 Novartis Ag 5- (4- (haloalkoxy) phenyl) pyrimidine-2-amine compounds and compositions as kinase inhibitors
US8288540B2 (en) 2007-08-22 2012-10-16 Irm Llc 2-heteroarylamino-pyrimidine derivatives as kinase inhibitors
EP2108641A1 (en) 2008-04-11 2009-10-14 Laboratorios Almirall, S.A. New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors
EP2113503A1 (en) 2008-04-28 2009-11-04 Laboratorios Almirall, S.A. New substituted indolin-2-one derivatives and their use as p39 mitogen-activated kinase inhibitors
EP2308866A1 (de) 2009-10-09 2011-04-13 Bayer CropScience AG Phenylpyri(mi)dinylpyrazole und ihre Verwendung als Fungizide
EP2322176A1 (en) 2009-11-11 2011-05-18 Almirall, S.A. New 7-phenyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives
EP2516423A1 (en) 2009-12-21 2012-10-31 Bayer CropScience AG Thienylpyri (mi) dinylazole and their use for controlling phytopathogenic fungi
CN103270026A (zh) 2010-12-21 2013-08-28 诺瓦提斯公司 作为vps34抑制剂的联-杂芳基化合物
MX2021008094A (es) 2019-01-11 2021-09-21 Omeros Corp Metodos y composiciones para el tratamiento del cancer.
CN111825698B (zh) 2019-07-30 2021-10-15 杭州阿诺生物医药科技有限公司 腺苷受体拮抗剂
CN112500416B (zh) 2019-07-30 2021-12-17 厦门宝太生物科技股份有限公司 一种吡唑并三嗪类化合物中间体的制备方法
CN115477653B (zh) * 2022-10-11 2024-04-09 安徽省庆云医药股份有限公司 一种曲拉西利关键中间体及曲拉西利的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US42891A (en) * 1864-05-24 Improvement in water-engines
US22106A (en) * 1858-11-23 Truss-bridge
US275038A (en) * 1883-04-03 Ors to themselves
US23763A (en) * 1859-04-26 Method of adjusting the knives of rotary cutter-heads for planing wood
US176399A (en) * 1876-04-18 Improvement in boxes for packing crackers
GB9309573D0 (en) * 1993-05-10 1993-06-23 Merck Sharp & Dohme Therapeutic agents
US5686470A (en) * 1995-02-10 1997-11-11 Weier; Richard M. 2, 3-substituted pyridines for the treatment of inflammation
ATE284712T1 (de) * 2000-04-26 2005-01-15 Eisai Co Ltd Medizinische zusammensetzungen zur förderung der aktivierung der eingeweide
US6641549B2 (en) * 2001-02-05 2003-11-04 Bsn Medical, Inc. Custom-moldable support for patellar tendinitis
TWI330183B (es) * 2001-10-22 2010-09-11 Eisai R&D Man Co Ltd
US20050043315A1 (en) * 2002-01-02 2005-02-24 Hideo Tsutsumi Aminopyrimidine compounds, processes for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
ES2229928B1 (es) 2006-07-01
EP1668000A1 (en) 2006-06-14
SG149077A1 (en) 2009-01-29
CA2540765A1 (en) 2005-05-06
IL174771A0 (en) 2006-08-20
AU2004283800B2 (en) 2009-05-07
TW200526645A (en) 2005-08-16
US20070265273A1 (en) 2007-11-15
CN1886402A (zh) 2006-12-27
NO20061952L (no) 2006-06-26
WO2005040155A1 (en) 2005-05-06
KR20060097010A (ko) 2006-09-13
UY28529A1 (es) 2005-04-29
ES2229928A1 (es) 2005-04-16
MXPA06003525A (es) 2006-06-08
AU2004283800B8 (en) 2009-06-18
AR046170A1 (es) 2005-11-30
NZ546266A (en) 2008-10-31
ECSP066426A (es) 2006-10-17
RU2006114746A (ru) 2007-11-20
WO2005040155A8 (en) 2006-04-20
BRPI0415324A (pt) 2006-12-05
JP2007507443A (ja) 2007-03-29
CO5690593A2 (es) 2006-10-31
UA82563C2 (uk) 2008-04-25
AU2004283800A1 (en) 2005-05-06
ZA200602139B (en) 2007-06-27

Similar Documents

Publication Publication Date Title
PE20050473A1 (es) Nuevos derivados de pirimidin-2-amina
NO20075623L (no) Benzodioksan- og benzodioksolanderivater og deres anvendelse
BRPI0511933B8 (pt) derivados de quinazolinona, seu uso e seu processo de preparação, e composição farmacêutica
ECSP034865A (es) Resolución óptica de (1-benzilo-4-metilopiperidina-3-il)-metilamina y su uso para la preparación de derivados de pirrolo 2,3-pirimidina como inhibidores de proteina quinasas
NI200700056A (es) Nuevos derivados de sulfamidas de heteroaril benzo-fundido útiles como agentes anticonvulsivos
BR0317268A (pt) Compostos ativadores da pirazina e da piridina glucoquinase 5-substituìda, composição farmacêutica, uso e processo de preparação dos mesmos
BRPI0517423A (pt) composto, composição farmacêutica, método para o tratamento ou prevenção de distúrbios neurológicos e psiquiátricos associados com disfunção do glutamato em um animal, e, uso em um composto
UY27976A1 (es) Piperazinas heterocíclicas sustituídas para el tratamiento de la esquizofrenia
BR0312695A (pt) Derivados de 1h-pirrolidina-2,4-diona espirocìclicos substituìdos por cis-alcóxi
DK1337518T3 (da) Piperazinylpyrazinforbindelser som antagonister for serotonin-5-HT2-receptoren
AR061374A1 (es) Derivados de diamidas de acido antranilico con sus sustituyentes heteroaromaticos y heterociclicos
AR057088A1 (es) Compuestos quimicos
UY29892A1 (es) Nuevos derivados de cromano, composiciones farmaceuticas conteniendolos, procesos de preparacion y aplicaciones
ATE409179T1 (de) Tetralin- und indanderivate und deren anwendungen als 5-ht-antagonisten
CR11220A (es) Derivados de pirimidina 934
PE20001543A1 (es) Derivados de piridopiranoacepinas, su preparacion y su aplicacion en terapeutica
BRPI0713132B8 (pt) compostos derivados de cinamoil-piperazina, método de preparação dos referidos compostos, composições farmacêuticas, seus usos como antagonistas de par-i e produtos
UY28917A1 (es) Derivados de tetrahidroisoquinolilsulfonamidas composiciones farmaceuticas y su uso terapeutico
HRP20070286T3 (en) Substituted diketopiperazines and their use as oxytocyn antagonists
AR059032A1 (es) Combinacion de derivados de triazina y sensibilizadores de insulina
UY28694A1 (es) Nuevos compuestos
ECSP045219A (es) Derivados de quinazolinona y su uso como agonistas cb
CL2003002565A1 (es) Compuestos derivados de 3h-quinazolin-4-ona, su proceso de preparacion, composicion farmaceutica que los contiene, y uso en el tratamiento y prevencion de enfermedades mediadas por inhibidores de mao-b, tales como la enfermedad de alzheimer y demenci
BRPI0418255A (pt) derivados de piperazina e piperidina n-substituìdos
ECSP034531A (es) Derivados sustituidos de c-ciclohexilmetilamina

Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed