HUP0302971A2 - (2-Azabiciklo[2.2.1]hept-7-il)-metanol-származékok, eljárás az előállításukra és nikotinos acetilkolin-receptorok agonistájakénti alkalmazásuk - Google Patents
(2-Azabiciklo[2.2.1]hept-7-il)-metanol-származékok, eljárás az előállításukra és nikotinos acetilkolin-receptorok agonistájakénti alkalmazásukInfo
- Publication number
- HUP0302971A2 HUP0302971A2 HU0302971A HUP0302971A HUP0302971A2 HU P0302971 A2 HUP0302971 A2 HU P0302971A2 HU 0302971 A HU0302971 A HU 0302971A HU P0302971 A HUP0302971 A HU P0302971A HU P0302971 A2 HUP0302971 A2 HU P0302971A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- substituted
- unsubstituted
- atom
- azabicyclo
- Prior art date
Links
- 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 title abstract 2
- 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 title abstract 2
- IWHDRGCABGBUDE-UHFFFAOYSA-N 3-azabicyclo[2.2.1]heptan-7-ylmethanol Chemical class C1CC2NCC1C2CO IWHDRGCABGBUDE-UHFFFAOYSA-N 0.000 title 1
- 239000000018 receptor agonist Substances 0.000 title 1
- 229940044601 receptor agonist Drugs 0.000 title 1
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 abstract 2
- 125000000172 C5-C10 aryl group Chemical group 0.000 abstract 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- GNVMUORYQLCPJZ-UHFFFAOYSA-M Thiocarbamate Chemical compound NC([S-])=O GNVMUORYQLCPJZ-UHFFFAOYSA-M 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000000962 organic group Chemical group 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- 125000003441 thioacyl group Chemical group 0.000 abstract 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N urea group Chemical group NC(=O)N XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Toxicology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Abstract
A találmány olyan betegségek kezelésére alkalmas vegyületekrevonatkozik, amelyeknél a nikotinos acetilkolin-receptorok serkentése akórkép javulását eredményezi. A találmány szerinti anyagok adottesetben szubsztituált (2-azabiciklo[2.2.1]hept-7-il-metil]-egységettartalmaznak, amely karbamát-, tiokarbamát- vagy karbamidegységhezkapcsolódik. A vegyületek az (I) általános képletnek felelnek meg,amelyben X jelentése NH, NR4, -O- vagy -S-, R1 jelentése hidrogénatom,egyenes vagy elágazó szénláncú, szubsztituált vagy szubsztituálatlanC1-C10-alkilcsoport, szubsztituált vagy szubsztituálatlan C5-C10-arilcsoport, szubsztituált vagy szubsztituálatlan C4-C10-heteroarilcsoport, acilcsoport, tioacilcsoport, karbonil-karboxil-csoport, az N-atomon szerves csoporttal szubsztituáIt karbamoilcsoportvagy szerves szulfonilcsoport, R2, R3 és R4 jelentése egymástólfüggetlenül C1-C10-alkilcsoport, C5-C12-arilcsoport vagy C4-C12-heteroarilcsoport, amely csoportok szubsztituálatlanok vagyhalogénatommal, alkoxi-, ariloxi-, nitrocsoporttal, C1-C5-alkoxi-karbonil csoporttal, adott esetben fluoratommal szubsztituáltalkilcsoporttal, adott esetben fluoratommal szubsztituáltacilcsoporttal és/vagy cianocsoporttal egyszeresen vagy többszörösenszubsztituáltak. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10044905A DE10044905A1 (de) | 2000-09-12 | 2000-09-12 | (2-Azabicyclo[2.2.1]hept-7-yl)methanol-Derivate als nikontinische Acetylcholinrezeptor Agonisten |
PCT/EP2001/010491 WO2002022578A1 (de) | 2000-09-12 | 2001-09-11 | (2-azabicyclo[2.2.1]hept-7-yl)methanol-derivate als nikotinische acetylcholinrezeptor agonisten |
Publications (1)
Publication Number | Publication Date |
---|---|
HUP0302971A2 true HUP0302971A2 (hu) | 2003-12-29 |
Family
ID=7655825
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0302971A HUP0302971A2 (hu) | 2000-09-12 | 2001-09-11 | (2-Azabiciklo[2.2.1]hept-7-il)-metanol-származékok, eljárás az előállításukra és nikotinos acetilkolin-receptorok agonistájakénti alkalmazásuk |
Country Status (15)
Country | Link |
---|---|
US (1) | US7008955B2 (hu) |
EP (1) | EP1317430B1 (hu) |
JP (1) | JP2004509106A (hu) |
CN (1) | CN1455770A (hu) |
AR (1) | AR034557A1 (hu) |
AT (1) | ATE295835T1 (hu) |
AU (1) | AU2001285945A1 (hu) |
CA (1) | CA2421936A1 (hu) |
DE (2) | DE10044905A1 (hu) |
ES (1) | ES2240506T3 (hu) |
HU (1) | HUP0302971A2 (hu) |
MX (1) | MXPA03002076A (hu) |
PT (1) | PT1317430E (hu) |
WO (1) | WO2002022578A1 (hu) |
ZA (1) | ZA200302829B (hu) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10118551A1 (de) * | 2001-04-14 | 2002-10-17 | Merck Patent Gmbh | Nikotinische Acetylcholinrezeptor Liganden |
DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
CA2476417A1 (en) * | 2002-02-15 | 2003-08-28 | Pharmacia & Upjohn Company | Azabicyclo-substituted benzoylamides and thioamides for treatment of cns-related disorders |
WO2004085433A2 (en) * | 2003-03-28 | 2004-10-07 | Pharmacia & Upjohn Company Llc | Positive allosteric modulators of the nicotinic acetylcholine receptor |
KR20180011888A (ko) | 2008-11-19 | 2018-02-02 | 포럼 파마슈티칼즈 인크. | (r)-7-클로로-n-(퀴누클리딘-3-일)벤조[b]티오펜-2-카르복사미드 및 그 약학적으로 허용가능한 염을 이용한 인지 장애의 치료 |
BRPI1014793A2 (pt) * | 2009-05-11 | 2016-04-05 | Envivo Pharmaceuticals Inc | tratamento de distúrbios de cognição com determinados receptores de ácido alfa-7-nicotínico em combinação com inibidores de acetil-colinesterase |
RS54742B1 (sr) | 2010-05-17 | 2016-10-31 | Forum Pharmaceuticals Inc | Kristalni oblik (r)-7-hlor-n-(hinuklidin-3-il)benzo[b]tiofen-2-karboksamid hidrohlorid monohidrata |
WO2013169646A1 (en) | 2012-05-08 | 2013-11-14 | Envivo Pharmaceuticals, Inc. | Methods of maintaining, treating or improving cognitive function |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9020051D0 (en) | 1990-09-13 | 1990-10-24 | Pfizer Ltd | Muscarinic receptor antagonists |
US5817679A (en) | 1993-04-01 | 1998-10-06 | University Of Virginia | 7-Azabicyclo 2.2.1!-heptane and -heptene derivatives as cholinergic receptor ligands |
US6117889A (en) * | 1994-04-01 | 2000-09-12 | University Of Virginia | 7-Azabicyclo-[2.2.1]-heptane and -heptene derivatives as analgesics and anti-inflammatory agents |
WO1998048801A1 (fr) | 1997-04-26 | 1998-11-05 | Sumitomo Pharmaceuticals Co., Ltd. | Composes 2-azabicyclo |
GB9822945D0 (en) | 1998-10-20 | 1998-12-16 | Isis Innovations Ltd | Epibatidine analogues |
-
2000
- 2000-09-12 DE DE10044905A patent/DE10044905A1/de not_active Withdrawn
-
2001
- 2001-09-11 JP JP2002526831A patent/JP2004509106A/ja active Pending
- 2001-09-11 HU HU0302971A patent/HUP0302971A2/hu unknown
- 2001-09-11 AT AT01965274T patent/ATE295835T1/de not_active IP Right Cessation
- 2001-09-11 ES ES01965274T patent/ES2240506T3/es not_active Expired - Lifetime
- 2001-09-11 CA CA002421936A patent/CA2421936A1/en not_active Abandoned
- 2001-09-11 EP EP01965274A patent/EP1317430B1/de not_active Expired - Lifetime
- 2001-09-11 DE DE50106266T patent/DE50106266D1/de not_active Expired - Fee Related
- 2001-09-11 MX MXPA03002076A patent/MXPA03002076A/es not_active Application Discontinuation
- 2001-09-11 CN CN01815520A patent/CN1455770A/zh active Pending
- 2001-09-11 WO PCT/EP2001/010491 patent/WO2002022578A1/de active IP Right Grant
- 2001-09-11 AU AU2001285945A patent/AU2001285945A1/en not_active Abandoned
- 2001-09-11 PT PT01965274T patent/PT1317430E/pt unknown
- 2001-09-11 US US10/380,064 patent/US7008955B2/en not_active Expired - Fee Related
- 2001-09-12 AR ARP010104304A patent/AR034557A1/es unknown
-
2003
- 2003-04-10 ZA ZA200302829A patent/ZA200302829B/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN1455770A (zh) | 2003-11-12 |
JP2004509106A (ja) | 2004-03-25 |
DE10044905A1 (de) | 2002-03-21 |
US7008955B2 (en) | 2006-03-07 |
WO2002022578A1 (de) | 2002-03-21 |
PT1317430E (pt) | 2005-09-30 |
EP1317430A1 (de) | 2003-06-11 |
DE50106266D1 (en) | 2005-06-23 |
ZA200302829B (en) | 2004-08-13 |
CA2421936A1 (en) | 2003-03-11 |
ES2240506T3 (es) | 2005-10-16 |
AU2001285945A1 (en) | 2002-03-26 |
US20040039045A1 (en) | 2004-02-26 |
MXPA03002076A (es) | 2003-06-24 |
EP1317430B1 (de) | 2005-05-18 |
ATE295835T1 (de) | 2005-06-15 |
AR034557A1 (es) | 2004-03-03 |
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