AU2001285945A1 - (2-azabicyclo(2.2.1)hept-7-yl)methanol derivatives as nicotinic acetylcholine receptor agonists - Google Patents

(2-azabicyclo(2.2.1)hept-7-yl)methanol derivatives as nicotinic acetylcholine receptor agonists

Info

Publication number
AU2001285945A1
AU2001285945A1 AU2001285945A AU8594501A AU2001285945A1 AU 2001285945 A1 AU2001285945 A1 AU 2001285945A1 AU 2001285945 A AU2001285945 A AU 2001285945A AU 8594501 A AU8594501 A AU 8594501A AU 2001285945 A1 AU2001285945 A1 AU 2001285945A1
Authority
AU
Australia
Prior art keywords
azabicyclo
hept
receptor agonists
acetylcholine receptor
nicotinic acetylcholine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001285945A
Inventor
Joachim Leibrock
Kai Schiemann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of AU2001285945A1 publication Critical patent/AU2001285945A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
AU2001285945A 2000-09-12 2001-09-11 (2-azabicyclo(2.2.1)hept-7-yl)methanol derivatives as nicotinic acetylcholine receptor agonists Abandoned AU2001285945A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10044905A DE10044905A1 (en) 2000-09-12 2000-09-12 (2-Azabicyclo [2.2.1] hept-7-yl) methanol derivatives as nicontinic acetylcholine receptor agonists
DE10044905 2000-09-12
PCT/EP2001/010491 WO2002022578A1 (en) 2000-09-12 2001-09-11 (2-azabicyclo[2.2.1]hept-7-yl)methanol derivatives as nicotinic acetylcholine receptor agonists

Publications (1)

Publication Number Publication Date
AU2001285945A1 true AU2001285945A1 (en) 2002-03-26

Family

ID=7655825

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001285945A Abandoned AU2001285945A1 (en) 2000-09-12 2001-09-11 (2-azabicyclo(2.2.1)hept-7-yl)methanol derivatives as nicotinic acetylcholine receptor agonists

Country Status (15)

Country Link
US (1) US7008955B2 (en)
EP (1) EP1317430B1 (en)
JP (1) JP2004509106A (en)
CN (1) CN1455770A (en)
AR (1) AR034557A1 (en)
AT (1) ATE295835T1 (en)
AU (1) AU2001285945A1 (en)
CA (1) CA2421936A1 (en)
DE (2) DE10044905A1 (en)
ES (1) ES2240506T3 (en)
HU (1) HUP0302971A2 (en)
MX (1) MXPA03002076A (en)
PT (1) PT1317430E (en)
WO (1) WO2002022578A1 (en)
ZA (1) ZA200302829B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10118551A1 (en) * 2001-04-14 2002-10-17 Merck Patent Gmbh New 2-aza-bicyclo (2.2.1) heptane derivatives, are nicotinic acetyl choline receptor ligands useful for e.g. treating schizophrenia, depression or neurodegenerative diseases
DE10164139A1 (en) 2001-12-27 2003-07-10 Bayer Ag 2-heteroaryl carboxamides
JP2005522456A (en) * 2002-02-15 2005-07-28 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー Azabicyclosubstituted benzoylamides and thioamides for the treatment of CNS related disorders
EP1611128A2 (en) * 2003-03-28 2006-01-04 Pharmacia & Upjohn Company LLC Positive allosteric modulators of the nicotinic acetylcholine receptor
PL2540297T3 (en) 2008-11-19 2015-12-31 Forum Pharmaceuticals Inc Treatment of Cognitive Disorders with (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide and pharmaceutically acceptable salts thereof
BRPI1014793A2 (en) * 2009-05-11 2016-04-05 Envivo Pharmaceuticals Inc treatment of cognition disorders with certain alpha-7-nicotinic acid receptors in combination with acetyl cholinesterase inhibitors
PL3029039T3 (en) 2010-05-17 2018-04-30 Forum Pharmaceuticals Inc. Pharmaceutical formulations comprising crystalline forms of (r)-7-chloro-n-(quinuclidin-3-yl)benzo(b)thiophene-2-carboxamide hydrochloride monohydrate
AU2013259871A1 (en) 2012-05-08 2014-11-20 Forum Pharmaceuticals Inc. Methods of maintaining, treating or improving cognitive function

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9020051D0 (en) 1990-09-13 1990-10-24 Pfizer Ltd Muscarinic receptor antagonists
US5817679A (en) * 1993-04-01 1998-10-06 University Of Virginia 7-Azabicyclo 2.2.1!-heptane and -heptene derivatives as cholinergic receptor ligands
US6117889A (en) * 1994-04-01 2000-09-12 University Of Virginia 7-Azabicyclo-[2.2.1]-heptane and -heptene derivatives as analgesics and anti-inflammatory agents
CA2287223A1 (en) 1997-04-26 1998-11-05 Tomohiro Toyoda 2-azabicyclo compounds
GB9822945D0 (en) 1998-10-20 1998-12-16 Isis Innovations Ltd Epibatidine analogues

Also Published As

Publication number Publication date
EP1317430B1 (en) 2005-05-18
JP2004509106A (en) 2004-03-25
CA2421936A1 (en) 2003-03-11
ES2240506T3 (en) 2005-10-16
EP1317430A1 (en) 2003-06-11
CN1455770A (en) 2003-11-12
US20040039045A1 (en) 2004-02-26
DE50106266D1 (en) 2005-06-23
AR034557A1 (en) 2004-03-03
PT1317430E (en) 2005-09-30
MXPA03002076A (en) 2003-06-24
ZA200302829B (en) 2004-08-13
DE10044905A1 (en) 2002-03-21
US7008955B2 (en) 2006-03-07
HUP0302971A2 (en) 2003-12-29
ATE295835T1 (en) 2005-06-15
WO2002022578A1 (en) 2002-03-21

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Legal Events

Date Code Title Description
MK4 Application lapsed section 142(2)(d) - no continuation fee paid for the application