AU2002223084A1 - Nitrogen substituted 1,2,4-triazolo(3,4-a)phthalazine derivatives for enhancing cognition - Google Patents

Nitrogen substituted 1,2,4-triazolo(3,4-a)phthalazine derivatives for enhancing cognition

Info

Publication number
AU2002223084A1
AU2002223084A1 AU2002223084A AU2308402A AU2002223084A1 AU 2002223084 A1 AU2002223084 A1 AU 2002223084A1 AU 2002223084 A AU2002223084 A AU 2002223084A AU 2308402 A AU2308402 A AU 2308402A AU 2002223084 A1 AU2002223084 A1 AU 2002223084A1
Authority
AU
Australia
Prior art keywords
triazolo
nitrogen substituted
phthalazine derivatives
enhancing cognition
cognition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002223084A
Inventor
Mark Stuart Chambers
Philip Jones
Angus Murray Macleod
Robert James Maxey
Helen Jane Szekeres
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Original Assignee
Merck Sharp and Dohme Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme Ltd filed Critical Merck Sharp and Dohme Ltd
Publication of AU2002223084A1 publication Critical patent/AU2002223084A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2002223084A 2000-11-23 2001-11-22 Nitrogen substituted 1,2,4-triazolo(3,4-a)phthalazine derivatives for enhancing cognition Abandoned AU2002223084A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0028583 2000-11-23
GBGB0028583.3A GB0028583D0 (en) 2000-11-23 2000-11-23 Therapeutic compounds
PCT/GB2001/005164 WO2002042305A1 (en) 2000-11-23 2001-11-22 Nitrogen substituted 1,2,4-triazolo[3,4-a]phthalazine derivatives for enhancing cognition

Publications (1)

Publication Number Publication Date
AU2002223084A1 true AU2002223084A1 (en) 2002-06-03

Family

ID=9903734

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002223084A Abandoned AU2002223084A1 (en) 2000-11-23 2001-11-22 Nitrogen substituted 1,2,4-triazolo(3,4-a)phthalazine derivatives for enhancing cognition

Country Status (4)

Country Link
US (1) US6900209B2 (en)
AU (1) AU2002223084A1 (en)
GB (1) GB0028583D0 (en)
WO (1) WO2002042305A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1657240A4 (en) 2003-08-18 2009-04-08 Fujifilm Finechemicals Co Ltd Pyridyltetrahydropyridines, pyridylpiperidines, and process for the production of both
WO2005041971A1 (en) * 2003-10-21 2005-05-12 Merck & Co., Inc. Triazolo-pyridazine compounds and derivatives thereof useful in the treatment of neuropathic pain
BRPI0514586A (en) * 2004-09-02 2008-06-17 Altana Pharma Ag triazolphtalazine
AU2006204451C1 (en) * 2005-01-05 2012-05-24 Takeda Gmbh Triazolophthalazines as PDE2-inhibitors
KR20070095986A (en) * 2005-01-05 2007-10-01 니코메드 게엠베하 Triazolophthalazines as pde2-inhibitors
WO2010013849A1 (en) 2008-08-01 2010-02-04 日本ケミファ株式会社 Gpr119 agonist
US8557815B2 (en) 2009-08-14 2013-10-15 Concert Pharmaceuticals, Inc. Substituted triazolophthalazine derivatives
KR20150123967A (en) * 2010-11-05 2015-11-04 에프. 호프만-라 로슈 아게 Use of active pharmaceutical compounds for the treatment of central nervous system conditions
EP2457569A1 (en) * 2010-11-05 2012-05-30 F. Hoffmann-La Roche AG Use of active pharmaceutical compounds for the treatment of central nervous system conditions
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
CN106854207B (en) * 2015-12-08 2019-10-29 上海赛默罗生物科技有限公司 Dai piperazine analog derivative, preparation method, pharmaceutical composition and purposes
CN107344936B (en) * 2016-05-06 2022-06-03 上海赛默罗生物科技有限公司 Triazolopyridazine derivative, preparation method, pharmaceutical composition and application thereof
AU2019233183B2 (en) * 2018-03-12 2024-02-01 Shanghai SIMR Biotechnology Co., Ltd Phthalazine isoxazole alkoxy derivatives, preparation method thereof, pharmaceutical composition and use thereof
US20230088214A1 (en) * 2019-06-19 2023-03-23 Biomarin Pharmaceutical Inc. Glycolate oxidase inhibitors for the treatment of disease
WO2023073364A1 (en) 2021-10-25 2023-05-04 C4X Discovery Limited Tetrahydroisoquinoline compounds that are keap1 binders

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH21834A (en) 1982-01-18 1988-03-17 Lepetit Spa New 6-substituted-s-triazolo(3,4-a)phthalazine derivatives
IT1194310B (en) 1983-07-12 1988-09-14 Lepetit Spa TRIAZOLE DERIVATIVES (3,4-A) FTALAZINICI 3,6-DISOSTITUITI
US5145684A (en) * 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
US5182290A (en) * 1991-08-27 1993-01-26 Neurogen Corporation Certain oxazoloquinolinones; a new class of GABA brain receptor ligands
US5212310A (en) * 1991-12-19 1993-05-18 Neurogen Corporation Certain aryl fused imidazopyrimidines; a new class of GABA brain receptor ligands
US5306819A (en) * 1992-08-27 1994-04-26 Neurogen Corporation Certain aryl a cycloalkyl fused imidazopyrazinols; and new class of GABA brain receptor ligands
GB9503601D0 (en) 1995-02-23 1995-04-12 Merck Sharp & Dohme Method of treatment and method of manufacture of medicament
DE19617862A1 (en) 1996-04-23 1997-10-30 Schering Ag New phenyl-azolo:phthalazine compounds
EA002436B1 (en) 1996-07-25 2002-04-25 Мерк Шарп Энд Домэ Лимитед Substituted triazolo-pyridazine derivatives as ligands for gaba receptors
AU732455C (en) * 1997-05-08 2002-09-05 Merck Sharp & Dohme Limited Substituted 1,2,4-triazolo{3,4-a}phthalazine derivatives as gaba alpha 5 ligands
GB9715977D0 (en) * 1997-07-29 1997-10-01 Merck Sharp & Dohme Therapeutic agents

Also Published As

Publication number Publication date
WO2002042305A1 (en) 2002-05-30
US20040043982A1 (en) 2004-03-04
GB0028583D0 (en) 2001-01-10
US6900209B2 (en) 2005-05-31

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