AR033306A1 - Compuestos - Google Patents

Compuestos

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Publication number
AR033306A1
AR033306A1 ARP020101610A ARP020101610A AR033306A1 AR 033306 A1 AR033306 A1 AR 033306A1 AR P020101610 A ARP020101610 A AR P020101610A AR P020101610 A ARP020101610 A AR P020101610A AR 033306 A1 AR033306 A1 AR 033306A1
Authority
AR
Argentina
Prior art keywords
optionally substituted
heteroatoms selected
group containing
phenyl
bicyclic
Prior art date
Application number
ARP020101610A
Other languages
English (en)
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0111184A external-priority patent/GB0111184D0/en
Priority claimed from GBGB0111189.7A external-priority patent/GB0111189D0/en
Priority claimed from GB0121303A external-priority patent/GB0121303D0/en
Priority claimed from GB0130331A external-priority patent/GB0130331D0/en
Priority claimed from GB0130392A external-priority patent/GB0130392D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of AR033306A1 publication Critical patent/AR033306A1/es

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Neurology (AREA)
  • Biomedical Technology (AREA)
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  • Diabetes (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
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  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Derivados de N-aroil amino cíclica, uso de una cantidad eficaz de un compuesto de formula (1), en la que: Y representa un enlace, oxígeno, o un grupo (CH2)n, representando n 1, 2 o 3; m representa 1, 2 o 3; p representa 0 o 1; X es NR, siendo R H o alquilo C1-4; Ar1 es arilo, un grupo heteroarilo mono o bicíclico que contiene hasta 3 heteroátomos seleccionados entre N, O y S; pudiendo estar cualquiera de ellos opcionalmente sustituido; Ar2 representa fenilo o un grupo heterociclilo de 5 o 6 miembros que contiene hasta 3 heteroátomos seleccionados entre N, O y S, estando el grupo fenilo o heterociclilo sustituido con R1 y otros sustituyentes opcionales; o Ar2 representa un grupo aromático bicíclico o heteroaromático bicíclico opcionalmente sustituido que contiene hasta 3 heteroátomos seleccionados entre N, O y S; R1 representa hidrogeno, alcoxi C1-4 opcionalmente sustituido, halo, ciano, alquilo C1-6 opcionalmente sustituido, fenilo opcionalmente sustituido, o un grupo heterociclilo de 5 o 6 miembros opcionalmente sustituido que contiene hasta 4 heteroátomos seleccionados entre N, O y S; en la que cuando Y es un enlace Ar2 no puede ser 2-naftilo; cuando Ar1 es arilo, p no es 1; o una sal farmacéuticamente aceptable del mismo para la preparacion de un medicamento para el tratamiento o prevencion de enfermedades o trastornos en los que se requiere un antagonista de un receptor orexin humano; y una composicion farmacéutica que comprende el compuesto.
ARP020101610A 2001-05-05 2002-05-02 Compuestos AR033306A1 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0111184A GB0111184D0 (en) 2001-05-05 2001-05-05 Compounds
GBGB0111189.7A GB0111189D0 (en) 2001-05-05 2001-05-05 Compounds
GB0121303A GB0121303D0 (en) 2001-09-03 2001-09-03 Compounds
GB0130331A GB0130331D0 (en) 2001-12-19 2001-12-19 Compounds
GB0130392A GB0130392D0 (en) 2001-12-19 2001-12-19 Compouds

Publications (1)

Publication Number Publication Date
AR033306A1 true AR033306A1 (es) 2003-12-10

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Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020101610A AR033306A1 (es) 2001-05-05 2002-05-02 Compuestos

Country Status (20)

Country Link
US (4) US7432270B2 (es)
EP (2) EP1385845B1 (es)
JP (1) JP4309135B2 (es)
KR (1) KR20030096348A (es)
CN (1) CN100448874C (es)
AR (1) AR033306A1 (es)
AT (1) ATE383359T1 (es)
AU (1) AU2002253361B2 (es)
BR (1) BR0209334A (es)
CA (1) CA2446396A1 (es)
CZ (1) CZ20032990A3 (es)
DE (1) DE60224521T2 (es)
ES (1) ES2299567T3 (es)
HU (1) HUP0400048A3 (es)
IL (1) IL158463A0 (es)
MX (1) MXPA03010129A (es)
NO (1) NO20034925L (es)
NZ (1) NZ528851A (es)
PL (1) PL366853A1 (es)
WO (1) WO2002090355A1 (es)

Families Citing this family (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1435955A2 (en) * 2001-05-05 2004-07-14 SmithKline Beecham P.L.C. N-aroyl cyclic amine derivatives as orexin receptor antagonists
GB0115862D0 (en) * 2001-06-28 2001-08-22 Smithkline Beecham Plc Compounds
US7470710B2 (en) * 2001-06-28 2008-12-30 Smithkline Beecham P.L.C. N-aroyl cyclic amine derivatives as orexin receptor antagonists
GB0124463D0 (en) * 2001-10-11 2001-12-05 Smithkline Beecham Plc Compounds
GB0130335D0 (en) * 2001-12-19 2002-02-06 Smithkline Beecham Plc Compounds
US7998986B2 (en) 2001-12-21 2011-08-16 Exelixis Patent Company Llc Modulators of LXR
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
US20060040937A1 (en) * 2002-09-18 2006-02-23 Glaxo Group Limited N-aroyl cyclic amines as orexin receptor antagonists
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