DE69532216D1 - 1-Acetyl-5-Bromo-4,6-Dimethylindolin - Google Patents

1-Acetyl-5-Bromo-4,6-Dimethylindolin

Info

Publication number
DE69532216D1
DE69532216D1 DE1995632216 DE69532216A DE69532216D1 DE 69532216 D1 DE69532216 D1 DE 69532216D1 DE 1995632216 DE1995632216 DE 1995632216 DE 69532216 A DE69532216 A DE 69532216A DE 69532216 D1 DE69532216 D1 DE 69532216D1
Authority
DE
Germany
Prior art keywords
dimethylindoline
bromo
acetyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE1995632216
Other languages
English (en)
Other versions
DE69532216T2 (de
Inventor
Hiroshi Matsui
Shoji Kamiya
Hiroaki Shirahase
Shohei Nakamura
Katsuo Wada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP22516694A priority Critical patent/JP3720395B2/ja
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Application granted granted Critical
Publication of DE69532216D1 publication Critical patent/DE69532216D1/de
Anticipated expiration legal-status Critical
Application status is Expired - Fee Related legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/08Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C07D215/06Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/24Oxygen atoms attached in position 8
    • C07D215/26Alcohols; Ethers thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S514/00Drug, bio-affecting and body treating compositions
    • Y10S514/824Arteriosclerosis
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S514/00Drug, bio-affecting and body treating compositions
    • Y10S514/866Diabetes
DE1995632216 1994-09-20 1995-09-20 1-Acetyl-5-Bromo-4,6-Dimethylindolin Expired - Fee Related DE69532216D1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP22516694A JP3720395B2 (ja) 1994-09-20 1994-09-20 新規ヘテロ環誘導体、その製造方法およびその医薬用途

Publications (1)

Publication Number Publication Date
DE69532216D1 true DE69532216D1 (de) 2004-01-08

Family

ID=16824983

Family Applications (4)

Application Number Title Priority Date Filing Date
DE1995631213 Expired - Fee Related DE69531213D1 (de) 1994-09-20 1995-09-20 Neue heterocyclische verbindungen, verfahren zu deren herstellung sowie medizinische verwendung
DE1995632216 Expired - Fee Related DE69532216D1 (de) 1994-09-20 1995-09-20 1-Acetyl-5-Bromo-4,6-Dimethylindolin
DE1995631213 Expired - Lifetime DE69531213T2 (de) 1994-09-20 1995-09-20 Neue heterocyclische verbindungen, verfahren zu deren herstellung sowie medizinische verwendung
DE1995632216 Expired - Lifetime DE69532216T2 (de) 1994-09-20 1995-09-20 1-Acetyl-5-Bromo-4,6-Dimethylindolin

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE1995631213 Expired - Fee Related DE69531213D1 (de) 1994-09-20 1995-09-20 Neue heterocyclische verbindungen, verfahren zu deren herstellung sowie medizinische verwendung

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE1995631213 Expired - Lifetime DE69531213T2 (de) 1994-09-20 1995-09-20 Neue heterocyclische verbindungen, verfahren zu deren herstellung sowie medizinische verwendung
DE1995632216 Expired - Lifetime DE69532216T2 (de) 1994-09-20 1995-09-20 1-Acetyl-5-Bromo-4,6-Dimethylindolin

Country Status (13)

Country Link
US (4) US5990150A (de)
EP (2) EP1136474B1 (de)
JP (1) JP3720395B2 (de)
KR (1) KR100365503B1 (de)
AT (2) AT255091T (de)
AU (1) AU693261B2 (de)
CA (1) CA2200472A1 (de)
DE (4) DE69531213D1 (de)
DK (2) DK1136474T3 (de)
ES (2) ES2200003T3 (de)
HK (1) HK1040513A1 (de)
PT (2) PT782986E (de)
WO (1) WO1996009287A1 (de)

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JP3720395B2 (ja) 1994-09-20 2005-11-24 京都薬品工業株式会社 新規ヘテロ環誘導体、その製造方法およびその医薬用途
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US6861448B2 (en) * 1998-01-14 2005-03-01 Virtual Drug Development, Inc. NAD synthetase inhibitors and uses thereof
WO1999036422A1 (en) 1998-01-14 1999-07-22 The Uab Research Foundation Methods of synthesizing and screening inhibitors of bacterial nad synthetase enzyme, compounds thereof, and methods of treating bacterial and microbial infections with inhibitors of bacterial nad synthetase enzyme
JP2002521368A (ja) * 1998-07-23 2002-07-16 スミスクライン・ビーチャム・コーポレイション Il−8受容体アンタゴニスト
FR2783519B1 (fr) * 1998-09-23 2003-01-24 Sod Conseils Rech Applic Nouveaux derives d'amidines, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
US6673827B1 (en) 1999-06-29 2004-01-06 The Uab Research Foundation Methods of treating fungal infections with inhibitors of NAD synthetase enzyme
MXPA03001857A (es) * 2000-09-01 2003-06-04 Sankyo Co Composicones medicinales.
TW200600497A (en) * 2001-02-02 2006-01-01 Sankyo Co Preparation of indoline derivative
WO2002072147A1 (en) * 2001-03-14 2002-09-19 Sankyo Company, Limited Medicinal compositions containing bile acid transporter inhibitor
WO2003020315A1 (fr) * 2001-08-28 2003-03-13 Sankyo Company, Limited Compositions medicinales contenant un antagoniste du recepteur d'angiotensine ii
US7205329B2 (en) * 2003-05-30 2007-04-17 Microbia, Inc. Modulators of CRTH2 activity
US20050119314A1 (en) * 2002-04-05 2005-06-02 Sankyo Company, Limited Pharmaceutical composition comprising an ACAT inhibitor and an insulin resistance reducing agent
DK1541553T3 (da) * 2002-07-17 2010-09-20 Kyoto Pharma Ind Indolinforbindelse samt medicinsk anvendelse deraf
US20050234030A1 (en) * 2004-04-20 2005-10-20 Wilmin Bartolini Modulators of CRTH2, COX-2 and FAAH
US20070161698A1 (en) * 2003-05-30 2007-07-12 Microbia, Inc. Modulators of CRTH2 Activity
US20050234244A1 (en) * 2004-04-20 2005-10-20 Wilmin Bartolini Synthesis of COX-2 and FAAH inhibitors
US20050032747A1 (en) * 2003-07-01 2005-02-10 Wilmin Bartolini COX-2 and FAAH inhibitors
WO2005037227A2 (en) * 2003-10-16 2005-04-28 Microbia, Inc. Selective cox-2 inhibitors
KR20060109926A (ko) 2003-11-19 2006-10-23 메타베이시스 테라퓨틱스, 인크. 새로운 인-함유 갑상선 호르몬 모방약들
AU2005294165B2 (en) 2004-10-06 2012-02-02 The Brigham And Women's Hospital, Inc. Relevance of achieved levels of markers of systemic inflammation following treatment
AU2005297984B2 (en) * 2004-10-27 2009-11-12 Daiichi Sankyo Company, Limited Benzene compound having 2 or more substituents
US20060046841A1 (en) * 2004-11-12 2006-03-02 Walker Jay S Budget-based flat rate play contract parameters
US8022188B2 (en) * 2006-04-24 2011-09-20 Abbott Laboratories Immunosuppressant binding antibodies and methods of obtaining and using same
US7883855B2 (en) 2006-07-21 2011-02-08 Abbott Laboratories Immunosuppressant drug extraction reagent for immunoassays
CA2673314C (en) 2006-12-29 2014-03-11 Abbott Laboratories Non-denaturing lysis reagent for use with capture-in-solution immunoassay
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EP2118656B1 (de) 2006-12-29 2012-08-29 Abbott Laboratories Verbessertes testverfahren für immunsuppressiva
JP5134692B2 (ja) * 2007-12-19 2013-01-30 アボット・ラボラトリーズAbbott Laboratories 免疫アッセイのための免疫抑制剤薬剤抽出試薬
US20120046364A1 (en) 2009-02-10 2012-02-23 Metabasis Therapeutics, Inc. Novel Sulfonic Acid-Containing Thyromimetics, and Methods for Their Use

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HU9900617A3 (en) * 1995-10-05 2001-12-28 Kyoto Pharma Ind Novel indole-, indoline- or tetrahydrokinoline derivatives as acat and lipid peroxidation inhibitors, use thereof, pharmaceutical compositions containing these compounds

Also Published As

Publication number Publication date
HK1040513A1 (en) 2004-06-18
US6414012B1 (en) 2002-07-02
AU3532495A (en) 1996-04-09
DE69532216T2 (de) 2004-09-16
JP3720395B2 (ja) 2005-11-24
DE69531213T2 (de) 2004-04-15
DK1136474T3 (da) 2004-02-23
CA2200472A1 (en) 1996-03-28
US6127403A (en) 2000-10-03
ES2200003T3 (es) 2004-03-01
EP0782986B1 (de) 2003-07-02
US20010014740A1 (en) 2001-08-16
PT782986E (pt) 2003-11-28
DK0782986T3 (da) 2003-10-06
WO1996009287A1 (fr) 1996-03-28
US5990150A (en) 1999-11-23
US6489475B2 (en) 2002-12-03
EP1136474B1 (de) 2003-11-26
EP1136474A1 (de) 2001-09-26
KR970706252A (ko) 1997-11-03
DK782986T3 (de)
PT1136474E (pt) 2004-04-30
EP0782986A1 (de) 1997-07-09
AT255091T (de) 2003-12-15
KR100365503B1 (ko) 2003-06-12
EP0782986A4 (de) 2000-04-05
AT244220T (de) 2003-07-15
JPH0892210A (ja) 1996-04-09
DE69531213D1 (de) 2003-08-07
ES2206367T3 (es) 2004-05-16
AU693261B2 (en) 1998-06-25

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