BR9610846A - Novos derivados heterocíclicos e uso farmacêutico dos mesmos - Google Patents

Novos derivados heterocíclicos e uso farmacêutico dos mesmos

Info

Publication number
BR9610846A
BR9610846A BR9610846A BR9610846A BR9610846A BR 9610846 A BR9610846 A BR 9610846A BR 9610846 A BR9610846 A BR 9610846A BR 9610846 A BR9610846 A BR 9610846A BR 9610846 A BR9610846 A BR 9610846A
Authority
BR
Brazil
Prior art keywords
pharmaceutical use
heterocyclic derivatives
new heterocyclic
arteriosclerosis
useful
Prior art date
Application number
BR9610846A
Other languages
English (en)
Inventor
Shoji Kamiya
Hiroaki Shirahase
Hiroshi Matsui
Shohei Nakamura
Katsuo Wada
Original Assignee
Kyoto Pharma Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyoto Pharma Ind filed Critical Kyoto Pharma Ind
Publication of BR9610846A publication Critical patent/BR9610846A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
BR9610846A 1995-10-05 1996-09-30 Novos derivados heterocíclicos e uso farmacêutico dos mesmos BR9610846A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP25908295 1995-10-05
JP5801896 1996-03-14
JP19433196 1996-07-24
PCT/JP1996/002852 WO1997012860A1 (fr) 1995-10-05 1996-09-30 Nouveaux derives heterocycliques et leur utilisation medicinale

Publications (1)

Publication Number Publication Date
BR9610846A true BR9610846A (pt) 1999-07-13

Family

ID=27296460

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9610846A BR9610846A (pt) 1995-10-05 1996-09-30 Novos derivados heterocíclicos e uso farmacêutico dos mesmos

Country Status (20)

Country Link
US (3) US6063806A (pt)
EP (1) EP0866059B1 (pt)
KR (1) KR100388345B1 (pt)
CN (2) CN1097043C (pt)
AT (1) ATE210116T1 (pt)
BR (1) BR9610846A (pt)
CZ (1) CZ292632B6 (pt)
DE (1) DE69617731T2 (pt)
DK (1) DK0866059T3 (pt)
ES (1) ES2164920T3 (pt)
HK (2) HK1015781A1 (pt)
HU (1) HUP9900617A3 (pt)
IL (1) IL123939A (pt)
NO (1) NO310818B1 (pt)
NZ (1) NZ318874A (pt)
PL (1) PL190034B1 (pt)
PT (1) PT866059E (pt)
TR (1) TR199800655T2 (pt)
TW (1) TW429250B (pt)
WO (1) WO1997012860A1 (pt)

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AR008331A1 (es) * 1997-01-23 1999-12-29 Smithkline Beecham Corp Compuestos antagonistas de un receptor de il-8, uso de los mismos para la fabricacion de medicamentos, procedimiento para su obtencion, composicionesfarmaceuticas que los contienen
US5929250A (en) * 1997-01-23 1999-07-27 Smithkline Beecham Corporation IL-8 receptor antagonists
AR015425A1 (es) * 1997-09-05 2001-05-02 Smithkline Beecham Corp Compuestos de benzotiazol, composicion farmaceutica que los contiene, su uso en la manufactura de un medicamento, procedimiento para su preparacion,compuestos intermediarios y procedimiento para su preparacion
AU5265599A (en) 1998-04-08 1999-11-01 Takeda Chemical Industries Ltd. Amine compounds, their production and their use as somatostatin receptor antagonists or agonists
CA2338741A1 (en) * 1998-07-23 2000-02-03 Smithkline Beecham Corporation Il-8 receptor antagonists
FR2783519B1 (fr) * 1998-09-23 2003-01-24 Sod Conseils Rech Applic Nouveaux derives d'amidines, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
WO2002020009A1 (fr) * 2000-09-01 2002-03-14 Sankyo Company, Limited Compositions medicales
TW200600497A (en) * 2001-02-02 2006-01-01 Sankyo Co Preparation of indoline derivative
WO2002072147A1 (fr) * 2001-03-14 2002-09-19 Sankyo Company, Limited Compositions medicinales contenant un inhibiteur de transporteur d'acide biliaire
EP2335700A1 (en) * 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C virus polymerase inhibitors with a heterobicylic structure
BR0212254A (pt) * 2001-08-28 2004-10-19 Sankyo Co Composição farmaceutica
JP2004002365A (ja) * 2002-04-05 2004-01-08 Sankyo Co Ltd Ａｃａｔ阻害剤とインシュリン抵抗性改善剤とからなる医薬組成物
US20050119314A1 (en) * 2002-04-05 2005-06-02 Sankyo Company, Limited Pharmaceutical composition comprising an ACAT inhibitor and an insulin resistance reducing agent
KR20040099394A (ko) * 2002-04-05 2004-11-26 상꾜 가부시키가이샤 Ａｃａｔ 저해제 및 인슐린 저항성 개선제를 함유하는의약 조성물
AU2003252638B8 (en) * 2002-07-17 2009-03-05 Kyoto Pharmaceutical Industries, Ltd. Novel indoline compound and medicinal use thereof
US20050192245A1 (en) * 2002-07-18 2005-09-01 Sankyo Company, Limited Medicinal composition for treating arteriosclerosis
KR20050025604A (ko) * 2002-07-18 2005-03-14 상꾜 가부시키가이샤 동맥 경화증 치료를 위한 의약 조성물
US7223785B2 (en) * 2003-01-22 2007-05-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7098231B2 (en) * 2003-01-22 2006-08-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
CA2546601A1 (en) 2003-11-19 2005-06-09 Metabasis Therapeutics, Inc. Novel phosphorus-containing thyromimetics
WO2005077359A1 (ja) * 2004-02-17 2005-08-25 Sankyo Company, Limited インドリン化合物を含有する安定化された医薬組成物
EP1718608B1 (en) * 2004-02-20 2013-07-17 Boehringer Ingelheim International GmbH Viral polymerase inhibitors
EP2343553A1 (en) 2004-10-06 2011-07-13 The Brigham and Women's Hospital Relevance of achieved levels of markers of systemic inflammation following treatment
EP1806332A4 (en) * 2004-10-27 2010-03-31 Daiichi Sankyo Co Ltd BENZENE COMPOUND HAVING TWO OR MORE TWO SUBSTITUENTS
JP5015154B2 (ja) * 2005-08-12 2012-08-29 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ウイルスポリメラーゼインヒビター
WO2007146230A2 (en) * 2006-06-14 2007-12-21 Merck & Co., Inc. Non-nucleoside reverse transcriptase inhibitors
FR2918890A1 (fr) * 2007-07-19 2009-01-23 Galderma Res & Dev Utilisation du pactimibe pour la preparation d'un medicament destine a prevenir ou a traiter une maladie due a un dysfonctionnement des glandes sebacees chez l'homme ou l'animal
WO2010093601A1 (en) 2009-02-10 2010-08-19 Metabasis Therapeutics, Inc. Novel sulfonic acid-containing thyromimetics, and methods for their use
US8343706B2 (en) * 2010-01-25 2013-01-01 International Business Machines Corporation Fluorine-free fused ring heteroaromatic photoacid generators and resist compositions containing the same
WO2011161964A1 (ja) * 2010-06-24 2011-12-29 興和株式会社 Ａｃａｔ阻害剤を有効成分とするインスリン抵抗性改善剤
WO2014139388A1 (en) * 2013-03-14 2014-09-18 Merck Sharp & Dohme Corp. Novel indole derivatives useful as anti-diabetic agents
JP2018052818A (ja) * 2015-01-28 2018-04-05 武田薬品工業株式会社 スルホンアミド化合物
CN108440373B (zh) * 2018-03-23 2021-05-14 昆明学院 一种铁催化的氰烷基吲哚啉及其制备方法

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US4803218A (en) * 1982-09-29 1989-02-07 Mcneilab, Inc. 3-aminoalkyl-1H-indole-5-urea and amide derivatives
US4956372A (en) * 1987-10-02 1990-09-11 Kyorin Pharmaceutical Co., Ltd. Cyclic anthranilic acid derivatives and process for their preparation
JPH02117651A (ja) * 1988-01-20 1990-05-02 Yamanouchi Pharmaceut Co Ltd ジウレア誘導体及びその製造法
CN1021819C (zh) 1988-01-20 1993-08-18 山之内制药株式会社 作为药物有用的双脲衍生物的制备方法
IE892088L (en) 1988-07-12 1990-01-12 William Henry Deryk Morris Quinoline derivatives, their production and use
JPH0753714B2 (ja) * 1988-07-12 1995-06-07 武田薬品工業株式会社 Ａｃａｔ阻害剤、キノリン誘導体及びその製造法
US4958485A (en) 1988-12-22 1990-09-25 Springs Industries, Inc. Corespun yarn for fire resistant safety apparel
US5153226A (en) * 1989-08-31 1992-10-06 Warner-Lambert Company Acat inhibitors for treating hypocholesterolemia
FR2654335A1 (fr) 1989-11-10 1991-05-17 Oreal Compositions tinctoriales pour fibres keratiniques contenant des precurseurs de colorants par oxydation et des coupleurs derives du 4-hydroxyindole, et procede de teinture les mettant en óoeuvre.
ES2068497T3 (es) 1990-03-12 1995-04-16 Yamanouchi Pharma Co Ltd Derivados de urea, su produccion, y composiciones farmaceuticas que los contienen.
JPH0466568A (ja) * 1990-06-29 1992-03-02 Takeda Chem Ind Ltd 中枢性抗酸化剤化合物
JP3086295B2 (ja) * 1990-08-17 2000-09-11 武田薬品工業株式会社 チエノピリジン誘導体、その製造法およびａｃａｔ阻害剤
US5143919A (en) 1990-08-17 1992-09-01 Takeda Chemical Industries, Ltd. Thienopyridine derivatives and their pharmaceutical use
GB9025848D0 (en) 1990-11-28 1991-01-09 Erba Carlo Spa Imidazol-2-yl derivatives of substituted bicyclic compounds and process for their preparation
FR2673625B1 (fr) 1991-03-08 1993-05-07 Adir Nouveaux derives d'acylaminophenol, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2674522B1 (fr) * 1991-03-26 1993-07-16 Lipha Nouveaux derives de l'indole, procedes de preparation et medicaments les contenant.
IL101785A0 (en) 1991-05-10 1992-12-30 Fujisawa Pharmaceutical Co Urea derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
CN1068000A (zh) * 1991-06-27 1993-01-13 重庆人民广播电台 动平衡开关调幅浮动载波广播电视发射机
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US5952354A (en) 1993-07-21 1999-09-14 American Home Products Corporation Tris carbamic acid esters: inhibitors of cholesterol absorption
JP3720395B2 (ja) 1994-09-20 2005-11-24 京都薬品工業株式会社 新規ヘテロ環誘導体、その製造方法およびその医薬用途
CA2160600A1 (en) * 1994-10-18 1996-04-19 Masahumi Kitano Indoloylguanidine derivatives
JPH08208602A (ja) * 1994-10-18 1996-08-13 Sumitomo Pharmaceut Co Ltd インドロイルグアニジン誘導体
US5767129A (en) * 1995-08-24 1998-06-16 Warner-Lambert Company Substituted quinolines and isoquinolines as calcium channel blockers, their preparation and the use thereof
DE69702725T2 (de) * 1996-03-04 2000-12-07 Fuji Photo Film Co Ltd Verarbeitungszusammensetzung für lichtempfindliches photographisches Silberhalogenidmaterial, Entwickler und Verarbeitungsverfahren unter dessen Verwendung

Also Published As

Publication number Publication date
EP0866059A1 (en) 1998-09-23
KR19990063987A (ko) 1999-07-26
DE69617731D1 (de) 2002-01-17
NO981485L (no) 1998-06-02
PT866059E (pt) 2002-03-28
DE69617731T2 (de) 2002-08-08
KR100388345B1 (ko) 2004-03-30
HK1048989A1 (en) 2003-04-25
EP0866059B1 (en) 2001-12-05
EP0866059A4 (en) 1998-12-02
TW429250B (en) 2001-04-11
US6200988B1 (en) 2001-03-13
PL326000A1 (en) 1998-08-17
TR199800655T2 (xx) 1999-09-21
CN1097043C (zh) 2002-12-25
PL190034B1 (pl) 2005-10-31
CN1193018C (zh) 2005-03-16
DK0866059T3 (da) 2002-03-25
USRE38970E1 (en) 2006-02-07
CN1203587A (zh) 1998-12-30
US6063806A (en) 2000-05-16
CZ292632B6 (cs) 2003-11-12
IL123939A (en) 2001-11-25
HK1015781A1 (en) 1999-10-22
CN1361100A (zh) 2002-07-31
AU7097796A (en) 1997-04-28
WO1997012860A1 (fr) 1997-04-10
HUP9900617A2 (hu) 1999-06-28
HK1048989B (zh) 2005-10-28
CZ99698A3 (cs) 1998-08-12
ES2164920T3 (es) 2002-03-01
ATE210116T1 (de) 2001-12-15
NZ318874A (en) 1999-09-29
HUP9900617A3 (en) 2001-12-28
NO310818B1 (no) 2001-09-03
AU708571B2 (en) 1999-08-05
NO981485D0 (no) 1998-04-01

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 30/09/1996, OBSERVADAS AS CONDICOES LEGAIS.

B24C Patent annual fee: request for for restoration

Free format text: REFERENTE A 13A, 14A E 15A ANUIDADE(S).

B24H Lapse because of non-payment of annual fees (definitively: art 78 iv lpi)
B24F Patent annual fee: publication cancelled

Free format text: ANULADA A PUBLICACAO CODIGO 24.8 NA RPI NO 2259 DE 22/04/2014 POR TER SIDO INDEVIDA.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE AS 13A, 14A E 15A ANUIDADES.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2607 DE 22-12-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.