BR9610846A - New heterocyclic derivatives and pharmaceutical use thereof - Google Patents

New heterocyclic derivatives and pharmaceutical use thereof

Info

Publication number
BR9610846A
BR9610846A BR9610846A BR9610846A BR9610846A BR 9610846 A BR9610846 A BR 9610846A BR 9610846 A BR9610846 A BR 9610846A BR 9610846 A BR9610846 A BR 9610846A BR 9610846 A BR9610846 A BR 9610846A
Authority
BR
Brazil
Prior art keywords
pharmaceutical use
heterocyclic derivatives
new heterocyclic
arteriosclerosis
useful
Prior art date
Application number
BR9610846A
Other languages
Portuguese (pt)
Inventor
Shoji Kamiya
Hiroaki Shirahase
Hiroshi Matsui
Shohei Nakamura
Katsuo Wada
Original Assignee
Kyoto Pharma Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyoto Pharma Ind filed Critical Kyoto Pharma Ind
Publication of BR9610846A publication Critical patent/BR9610846A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Abstract

A heterocyclic derivative of the formula (I) <CHEM> wherein each symbol is as defined in the specification, and pharmaceutically acceptable salts thereof. The compound (I) of the present invention and pharmaceutically acceptable salts thereof exhibit superior ACAT inhibitory activity and lipoperoxidation inhibitory activity in mammals, and are useful as ACAT inhibitors and lipoperoxidation inhibitors. Specifically, they are useful for the prophylaxis and treatment of arteriosclerosis, hyperlipemia, arteriosclerosis in diabetes, and cerebrovascular and cardiovascular ischemic diseases.
BR9610846A 1995-10-05 1996-09-30 New heterocyclic derivatives and pharmaceutical use thereof BR9610846A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP25908295 1995-10-05
JP5801896 1996-03-14
JP19433196 1996-07-24
PCT/JP1996/002852 WO1997012860A1 (en) 1995-10-05 1996-09-30 Novel heterocyclic derivatives and medicinal use thereof

Publications (1)

Publication Number Publication Date
BR9610846A true BR9610846A (en) 1999-07-13

Family

ID=27296460

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9610846A BR9610846A (en) 1995-10-05 1996-09-30 New heterocyclic derivatives and pharmaceutical use thereof

Country Status (20)

Country Link
US (3) US6063806A (en)
EP (1) EP0866059B1 (en)
KR (1) KR100388345B1 (en)
CN (2) CN1097043C (en)
AT (1) ATE210116T1 (en)
BR (1) BR9610846A (en)
CZ (1) CZ292632B6 (en)
DE (1) DE69617731T2 (en)
DK (1) DK0866059T3 (en)
ES (1) ES2164920T3 (en)
HK (2) HK1048989B (en)
HU (1) HUP9900617A3 (en)
IL (1) IL123939A (en)
NO (1) NO310818B1 (en)
NZ (1) NZ318874A (en)
PL (1) PL190034B1 (en)
PT (1) PT866059E (en)
TR (1) TR199800655T2 (en)
TW (1) TW429250B (en)
WO (1) WO1997012860A1 (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3720395B2 (en) 1994-09-20 2005-11-24 京都薬品工業株式会社 Novel heterocyclic derivative, production method thereof and pharmaceutical use thereof
AR008331A1 (en) * 1997-01-23 1999-12-29 Smithkline Beecham Corp ANTAGONIST COMPOUNDS OF AN IL-8 RECEPTOR, USE OF THE SAME FOR THE MANUFACTURE OF MEDICINES, PROCEDURE FOR THEIR OBTAINING, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM
US5929250A (en) * 1997-01-23 1999-07-27 Smithkline Beecham Corporation IL-8 receptor antagonists
AR015425A1 (en) * 1997-09-05 2001-05-02 Smithkline Beecham Corp BENZOTIAZOL COMPOUNDS, PHARMACEUTICAL COMPOSITION CONTAINING THEM, ITS USE IN THE MANUFACTURE OF A MEDICINAL PRODUCT, PROCEDURE FOR PREPARATION, INTERMEDIARY COMPOUNDS AND PROCEDURE FOR PREPARATION
CA2327695A1 (en) 1998-04-08 1999-10-21 Takeda Chemical Industries, Ltd. Amine compounds, their production and their use as somatostatin receptor antagonists or agonists
WO2000005216A1 (en) * 1998-07-23 2000-02-03 Smithkline Beecham Corporation Il-8 receptor antagonists
FR2783519B1 (en) * 1998-09-23 2003-01-24 Sod Conseils Rech Applic NOVEL AMIDINE DERIVATIVES, THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
AU8254101A (en) * 2000-09-01 2002-03-22 Sankyo Co Medicinal compositions
TW200600497A (en) * 2001-02-02 2006-01-01 Sankyo Co Preparation of indoline derivative
WO2002072147A1 (en) * 2001-03-14 2002-09-19 Sankyo Company, Limited Medicinal compositions containing bile acid transporter inhibitor
EP2335700A1 (en) * 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C virus polymerase inhibitors with a heterobicylic structure
PL368843A1 (en) * 2001-08-28 2005-04-04 Sankyo Company, Limited Medicinal compositions containing angiotensin ii receptor antagonist
US20050119314A1 (en) * 2002-04-05 2005-06-02 Sankyo Company, Limited Pharmaceutical composition comprising an ACAT inhibitor and an insulin resistance reducing agent
BR0308871A (en) * 2002-04-05 2005-01-04 Sankyo Co Pharmaceutical Composition
JP2004002365A (en) * 2002-04-05 2004-01-08 Sankyo Co Ltd Pharmaceutical composition composed of acat inhibitor and insulin-resistant improving agent
RU2318808C2 (en) * 2002-07-17 2008-03-10 Киото Фармасьютикал Индастриз, Лтд. Novel indoline compound and its using in medicine
PL373383A1 (en) * 2002-07-18 2005-08-22 Sankyo Company, Limited Medicinal composition for treating arteriosclerosis
US20050192245A1 (en) * 2002-07-18 2005-09-01 Sankyo Company, Limited Medicinal composition for treating arteriosclerosis
US7098231B2 (en) * 2003-01-22 2006-08-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7223785B2 (en) * 2003-01-22 2007-05-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
BRPI0416639A (en) 2003-11-19 2007-01-16 Metabasis Therapeutics Inc phosphorus-containing thyromimetics
WO2005077359A1 (en) * 2004-02-17 2005-08-25 Sankyo Company, Limited Stabilized pharmaceutical composition containing indoline compound
SG150511A1 (en) * 2004-02-20 2009-03-30 Boehringer Ingelheim Int Viral polymerase inhibitors
US9164104B2 (en) 2004-10-06 2015-10-20 The Brigham And Women's Hospital, Inc. Relevance of achieved levels of markers of systemic inflammation following treatment
WO2006046593A1 (en) * 2004-10-27 2006-05-04 Daiichi Sankyo Company, Limited Benzene compound having 2 or more substituents
EP1915378A4 (en) * 2005-08-12 2009-07-22 Boehringer Ingelheim Int Viral polymerase inhibitors
WO2007146230A2 (en) * 2006-06-14 2007-12-21 Merck & Co., Inc. Non-nucleoside reverse transcriptase inhibitors
FR2918890A1 (en) * 2007-07-19 2009-01-23 Galderma Res & Dev USE OF PACTIMIBE FOR THE PREPARATION OF A MEDICAMENT FOR THE PREVENTION OR TREATMENT OF DISEASE DUE TO DYSFUNCTION OF SEBATED GLANDS IN MAN OR ANIMAL
US20120046364A1 (en) 2009-02-10 2012-02-23 Metabasis Therapeutics, Inc. Novel Sulfonic Acid-Containing Thyromimetics, and Methods for Their Use
US8343706B2 (en) * 2010-01-25 2013-01-01 International Business Machines Corporation Fluorine-free fused ring heteroaromatic photoacid generators and resist compositions containing the same
WO2011161964A1 (en) * 2010-06-24 2011-12-29 興和株式会社 Agent for improving insulin resistance with acat inhibitor as active component
EP2970119B1 (en) * 2013-03-14 2021-11-03 Merck Sharp & Dohme Corp. Novel indole derivatives useful as anti-diabetic agents
JP2018052818A (en) * 2015-01-28 2018-04-05 武田薬品工業株式会社 Sulfonamide compound
CN108440373B (en) * 2018-03-23 2021-05-14 昆明学院 Iron-catalyzed cyanoalkylindoline and preparation method thereof

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4803218A (en) * 1982-09-29 1989-02-07 Mcneilab, Inc. 3-aminoalkyl-1H-indole-5-urea and amide derivatives
US4956372A (en) * 1987-10-02 1990-09-11 Kyorin Pharmaceutical Co., Ltd. Cyclic anthranilic acid derivatives and process for their preparation
CN1021819C (en) 1988-01-20 1993-08-18 山之内制药株式会社 Process for diurea derivatives useful as medicaments
JPH02117651A (en) * 1988-01-20 1990-05-02 Yamanouchi Pharmaceut Co Ltd Diurea derivative and its production
IE892088L (en) 1988-07-12 1990-01-12 William Henry Deryk Morris Quinoline derivatives, their production and use
JPH0753714B2 (en) * 1988-07-12 1995-06-07 武田薬品工業株式会社 ACAT inhibitor, quinoline derivative and method for producing the same
US4958485A (en) 1988-12-22 1990-09-25 Springs Industries, Inc. Corespun yarn for fire resistant safety apparel
US5153226A (en) * 1989-08-31 1992-10-06 Warner-Lambert Company Acat inhibitors for treating hypocholesterolemia
FR2654335A1 (en) 1989-11-10 1991-05-17 Oreal TINCTORIAL COMPOSITIONS FOR KERATIN FIBERS CONTAINING OXIDATION COLORING PRECURSORS AND 4-HYDROXYINDOLE DERIVED COUPLERS, AND METHOD OF DYING USING SAME.
DE69105786T2 (en) * 1990-03-12 1995-04-27 Yamanouchi Pharma Co Ltd Urea derivatives, their preparation and pharmaceutical compositions containing them.
JPH0466568A (en) * 1990-06-29 1992-03-02 Takeda Chem Ind Ltd Central antioxidant compound
US5143919A (en) 1990-08-17 1992-09-01 Takeda Chemical Industries, Ltd. Thienopyridine derivatives and their pharmaceutical use
JP3086295B2 (en) * 1990-08-17 2000-09-11 武田薬品工業株式会社 Thienopyridine derivatives, their preparation and ACAT inhibitors
GB9025848D0 (en) 1990-11-28 1991-01-09 Erba Carlo Spa Imidazol-2-yl derivatives of substituted bicyclic compounds and process for their preparation
FR2673625B1 (en) 1991-03-08 1993-05-07 Adir NOVEL ACYLAMINOPHENOL DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
FR2674522B1 (en) * 1991-03-26 1993-07-16 Lipha NOVEL INDOLE DERIVATIVES, PREPARATION METHODS AND MEDICAMENTS CONTAINING THEM.
IL101785A0 (en) 1991-05-10 1992-12-30 Fujisawa Pharmaceutical Co Urea derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
CN1068000A (en) * 1991-06-27 1993-01-13 重庆人民广播电台 Dynamic balance switch, amplitude modulation, floating carrier brodcasting tv transmitter
CA2121391A1 (en) * 1993-04-28 1994-10-29 Atsuyuki Kojima Indoloylguanidine derivatives
US5952354A (en) 1993-07-21 1999-09-14 American Home Products Corporation Tris carbamic acid esters: inhibitors of cholesterol absorption
JP3720395B2 (en) * 1994-09-20 2005-11-24 京都薬品工業株式会社 Novel heterocyclic derivative, production method thereof and pharmaceutical use thereof
JPH08208602A (en) * 1994-10-18 1996-08-13 Sumitomo Pharmaceut Co Ltd Indoloylguanidine derivative
CA2160600A1 (en) * 1994-10-18 1996-04-19 Masahumi Kitano Indoloylguanidine derivatives
US5767129A (en) * 1995-08-24 1998-06-16 Warner-Lambert Company Substituted quinolines and isoquinolines as calcium channel blockers, their preparation and the use thereof
DE69702725T2 (en) * 1996-03-04 2000-12-07 Fuji Photo Film Co Ltd Processing composition for silver halide photographic light-sensitive material, developer and processing method using the same

Also Published As

Publication number Publication date
CN1361100A (en) 2002-07-31
CN1097043C (en) 2002-12-25
CZ292632B6 (en) 2003-11-12
AU708571B2 (en) 1999-08-05
WO1997012860A1 (en) 1997-04-10
ATE210116T1 (en) 2001-12-15
CZ99698A3 (en) 1998-08-12
HK1015781A1 (en) 1999-10-22
EP0866059A1 (en) 1998-09-23
PT866059E (en) 2002-03-28
TR199800655T2 (en) 1999-09-21
USRE38970E1 (en) 2006-02-07
NO310818B1 (en) 2001-09-03
TW429250B (en) 2001-04-11
HUP9900617A3 (en) 2001-12-28
EP0866059B1 (en) 2001-12-05
KR100388345B1 (en) 2004-03-30
ES2164920T3 (en) 2002-03-01
PL190034B1 (en) 2005-10-31
CN1193018C (en) 2005-03-16
HK1048989A1 (en) 2003-04-25
DE69617731D1 (en) 2002-01-17
CN1203587A (en) 1998-12-30
NO981485L (en) 1998-06-02
KR19990063987A (en) 1999-07-26
DK0866059T3 (en) 2002-03-25
US6063806A (en) 2000-05-16
HUP9900617A2 (en) 1999-06-28
PL326000A1 (en) 1998-08-17
AU7097796A (en) 1997-04-28
NO981485D0 (en) 1998-04-01
US6200988B1 (en) 2001-03-13
HK1048989B (en) 2005-10-28
DE69617731T2 (en) 2002-08-08
NZ318874A (en) 1999-09-29
IL123939A (en) 2001-11-25
EP0866059A4 (en) 1998-12-02

Similar Documents

Publication Publication Date Title
BR9610846A (en) New heterocyclic derivatives and pharmaceutical use thereof
DE69532216D1 (en) 1-acetyl-5-bromo-4,6-dimethylindoline
ATE223378T1 (en) PROLINEAMIDE DERIVATIVES
PT958296E (en) HETEROCYCLIC COMPOUNDS PROCESS FOR THEIR PREPARATION PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND ITS UTILIZATION IN THE TREATMENT OF RELATED DIABETES AND DISEASES
ATE226574T1 (en) 4,6-DIARYLPYRIMIDINE DERIVATIVES AND SALTS THEREOF
FI931011A (en) HETEROCYCLIC KETONDERIVAT CONDENSERS, DERAS FRAMSTAELLNING OCH ANVAENDNING
NO933837L (en) 4-aryl-3- (heteroarylureido) quinoline derivatives
DE69600231T2 (en) N-arylalkylphenylacetamide derivatives
ATE322479T1 (en) BENZAMIDINE DERIVATIVES
RU95106652A (en) Optically active derivatives of carboxamide, analgetic agent
CA2233842A1 (en) Novel heterocyclic derivatives having indoline, indole or tetrahydroquinoline ring and pharmaceutical use thereof
DK0784973T3 (en) Quinoxaline derivatives for the treatment of tinnitus

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 30/09/1996, OBSERVADAS AS CONDICOES LEGAIS.

B24C Patent annual fee: request for for restoration

Free format text: REFERENTE A 13A, 14A E 15A ANUIDADE(S).

B24H Lapse because of non-payment of annual fees (definitively: art 78 iv lpi)
B24F Patent annual fee: publication cancelled

Free format text: ANULADA A PUBLICACAO CODIGO 24.8 NA RPI NO 2259 DE 22/04/2014 POR TER SIDO INDEVIDA.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE AS 13A, 14A E 15A ANUIDADES.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2607 DE 22-12-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.