CA2233842A1 - Novel heterocyclic derivatives having indoline, indole or tetrahydroquinoline ring and pharmaceutical use thereof - Google Patents
Novel heterocyclic derivatives having indoline, indole or tetrahydroquinoline ring and pharmaceutical use thereofInfo
- Publication number
- CA2233842A1 CA2233842A1 CA002233842A CA2233842A CA2233842A1 CA 2233842 A1 CA2233842 A1 CA 2233842A1 CA 002233842 A CA002233842 A CA 002233842A CA 2233842 A CA2233842 A CA 2233842A CA 2233842 A1 CA2233842 A1 CA 2233842A1
- Authority
- CA
- Canada
- Prior art keywords
- indoline
- indole
- pharmaceutical use
- heterocyclic derivatives
- novel heterocyclic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000623 heterocyclic group Chemical group 0.000 title abstract 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 3
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 title 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 title 1
- 125000000147 tetrahydroquinolinyl group Chemical group N1(CCCC2=CC=CC=C12)* 0.000 title 1
- 206010003210 Arteriosclerosis Diseases 0.000 abstract 2
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 230000002248 lipoperoxidative effect Effects 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 201000005577 familial hyperlipidemia Diseases 0.000 abstract 1
- 208000023589 ischemic disease Diseases 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A heterocyclic derivative of the formula (I) (see formula I) wherein each symbol is as defined in the specification, and pharmaceutically acceptable salts thereof. The compound (I) of the present invention and pharmaceutically acceptable salts thereof exhibit superior ACAT inhibitory activity and lipoperoxidation inhibitory activity in mammals, and are useful as ACAT inhibitors and lipoperoxidation inhibitors. Specifically, they are useful for the prophylaxis and treatment of arteriosclerosis, hyperlipemia, arteriosclerosis in diabetes, and cerebrovascular and cardiovascular ischemic diseases.
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP259082/1995 | 1995-10-05 | ||
| JP25908295 | 1995-10-05 | ||
| JP5801896 | 1996-03-14 | ||
| JP58018/1996 | 1996-03-14 | ||
| JP19433196 | 1996-07-24 | ||
| JP194331/1996 | 1996-07-24 | ||
| PCT/JP1996/002852 WO1997012860A1 (en) | 1995-10-05 | 1996-09-30 | Novel heterocyclic derivatives and medicinal use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2233842A1 true CA2233842A1 (en) | 1997-04-10 |
| CA2233842C CA2233842C (en) | 2006-04-11 |
Family
ID=36178155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002233842A Expired - Fee Related CA2233842C (en) | 1995-10-05 | 1996-09-30 | Novel heterocyclic derivatives having indoline, indole or tetrahydroquinoline ring and pharmaceutical use thereof |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2233842C (en) |
-
1996
- 1996-09-30 CA CA002233842A patent/CA2233842C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2233842C (en) | 2006-04-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |