NO933837L - 4-aryl-3- (heteroarylureido) quinoline derivatives - Google Patents
4-aryl-3- (heteroarylureido) quinoline derivativesInfo
- Publication number
- NO933837L NO933837L NO933837A NO933837A NO933837L NO 933837 L NO933837 L NO 933837L NO 933837 A NO933837 A NO 933837A NO 933837 A NO933837 A NO 933837A NO 933837 L NO933837 L NO 933837L
- Authority
- NO
- Norway
- Prior art keywords
- heteroarylureido
- aryl
- quinoline derivatives
- compounds
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Det beskrives forbindelser med formel (I) og farmasøytisk akseptable salter derav, hvor R1, R2, R3, R4, m, X og Q er som definert i beskrivelsen, og nye mellom- produkter benyttet ved syntese av slike forbindelser. For- bindelsene med formel (I) er ir.hibiz.orer av acyl-koenzym A: kolesterol-acyltransferase og er anvendelige som hypolipidemiske og antiarerosklerotiske midler.Compounds of formula (I) and pharmaceutically acceptable salts thereof are described, wherein R 1, R 2, R 3, R 4, m, X and Q are as defined in the specification, and novel intermediates used in the synthesis of such compounds. The compounds of formula (I) are inhibitors of acyl-coenzyme A: cholesterol-acyltransferase and are useful as hypolipidemic and anti-aarosclerotic agents.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US69232391A | 1991-04-26 | 1991-04-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
NO933837L true NO933837L (en) | 1993-10-25 |
Family
ID=24780107
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO933837A NO933837L (en) | 1991-04-26 | 1993-10-25 | 4-aryl-3- (heteroarylureido) quinoline derivatives |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0590094A1 (en) |
JP (1) | JPH0776215B2 (en) |
CN (1) | CN1066068A (en) |
AU (1) | AU1879792A (en) |
BR (1) | BR9205939A (en) |
CA (1) | CA2108014A1 (en) |
CZ (1) | CZ395592A3 (en) |
DE (1) | DE9290049U1 (en) |
FI (1) | FI934710A (en) |
HU (1) | HUT65748A (en) |
IE (1) | IE921330A1 (en) |
IL (1) | IL101627A0 (en) |
MX (1) | MX9201916A (en) |
NO (1) | NO933837L (en) |
NZ (1) | NZ242493A (en) |
PT (1) | PT100426A (en) |
TW (1) | TW197436B (en) |
WO (1) | WO1992019614A1 (en) |
YU (1) | YU44592A (en) |
ZA (1) | ZA922976B (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU3323393A (en) * | 1992-01-23 | 1993-09-01 | Pfizer Inc. | 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents |
US5565472A (en) * | 1992-12-21 | 1996-10-15 | Pfizer Inc. | 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents |
NZ264063A (en) * | 1993-08-13 | 1995-11-27 | Nihon Nohyaku Co Ltd | N-(2-phenylpyrid-3-yl)- and n-(4-phenylpyrimidin-5-yl)-n'-phenylurea derivatives and pharmaceutical compositions |
US5843957A (en) * | 1995-05-19 | 1998-12-01 | Sumitomo Pharmaceuticals Company, Ltd. | Naphthyridine derivatives |
CA2222687A1 (en) * | 1995-05-31 | 1996-12-05 | Masami Muraoka | Novel naphthyridine derivatives |
KR20000057268A (en) * | 1996-11-26 | 2000-09-15 | 다께우찌 마사야쓰 | Novel naphthyridine derivatives |
AU2547399A (en) | 1998-02-25 | 1999-09-15 | Sumitomo Pharmaceuticals Company, Limited | Pyridone derivatives and process for producing the same |
US6452008B2 (en) | 1998-02-25 | 2002-09-17 | Sumitomo Pharmaceuticals Company, Limited | Pyridone derivatives and process for preparing the same |
CA2547518A1 (en) | 2003-12-12 | 2005-06-30 | Wyeth | Quinolines useful in treating cardiovascular disease |
CN103601677B (en) * | 2013-11-19 | 2015-11-18 | 清华大学 | Prepare the method for 2-alkylthio quinoline |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE892088L (en) * | 1988-07-12 | 1990-01-12 | William Henry Deryk Morris | Quinoline derivatives, their production and use |
WO1991004027A1 (en) * | 1989-09-15 | 1991-04-04 | Pfizer Inc. | New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat) |
TW205037B (en) * | 1989-10-06 | 1993-05-01 | Takeda Pharm Industry Co Ltd |
-
1992
- 1992-03-16 CZ CS923955A patent/CZ395592A3/en unknown
- 1992-03-16 JP JP4510186A patent/JPH0776215B2/en not_active Expired - Lifetime
- 1992-03-16 AU AU18797/92A patent/AU1879792A/en not_active Abandoned
- 1992-03-16 EP EP92923349A patent/EP0590094A1/en not_active Withdrawn
- 1992-03-16 WO PCT/US1992/001801 patent/WO1992019614A1/en not_active Application Discontinuation
- 1992-03-16 BR BR9205939A patent/BR9205939A/en not_active Application Discontinuation
- 1992-03-16 DE DE9290049U patent/DE9290049U1/en not_active Expired - Lifetime
- 1992-03-16 HU HU9303025A patent/HUT65748A/en active IP Right Revival
- 1992-03-16 CA CA002108014A patent/CA2108014A1/en not_active Abandoned
- 1992-03-17 TW TW081102005A patent/TW197436B/zh active
- 1992-03-24 ZA ZA922976A patent/ZA922976B/en unknown
- 1992-04-16 IL IL101627A patent/IL101627A0/en unknown
- 1992-04-24 PT PT100426A patent/PT100426A/en not_active Application Discontinuation
- 1992-04-24 YU YU44592A patent/YU44592A/en unknown
- 1992-04-24 IE IE133092A patent/IE921330A1/en not_active Application Discontinuation
- 1992-04-24 MX MX9201916A patent/MX9201916A/en not_active IP Right Cessation
- 1992-04-24 NZ NZ242493A patent/NZ242493A/en unknown
- 1992-04-25 CN CN92103010A patent/CN1066068A/en active Pending
-
1993
- 1993-10-25 FI FI934710A patent/FI934710A/en unknown
- 1993-10-25 NO NO933837A patent/NO933837L/en unknown
Also Published As
Publication number | Publication date |
---|---|
JPH06501025A (en) | 1994-01-27 |
HU9303025D0 (en) | 1994-01-28 |
IL101627A0 (en) | 1992-12-30 |
FI934710A0 (en) | 1993-10-25 |
WO1992019614A1 (en) | 1992-11-12 |
ZA922976B (en) | 1993-10-25 |
HUT65748A (en) | 1994-07-28 |
AU1879792A (en) | 1992-12-21 |
EP0590094A1 (en) | 1994-04-06 |
IE921330A1 (en) | 1992-11-04 |
PT100426A (en) | 1993-08-31 |
CZ395592A3 (en) | 1994-02-16 |
CN1066068A (en) | 1992-11-11 |
BR9205939A (en) | 1994-09-27 |
TW197436B (en) | 1993-01-01 |
YU44592A (en) | 1994-12-28 |
NZ242493A (en) | 1994-08-26 |
CA2108014A1 (en) | 1992-10-27 |
JPH0776215B2 (en) | 1995-08-16 |
FI934710A (en) | 1993-10-25 |
DE9290049U1 (en) | 1994-01-05 |
MX9201916A (en) | 1992-11-01 |
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