YU44592A - DERIVATI 4-ARIL-3- (HETEROARILKARBAMIDO) HINOLINA - Google Patents
DERIVATI 4-ARIL-3- (HETEROARILKARBAMIDO) HINOLINAInfo
- Publication number
- YU44592A YU44592A YU44592A YU44592A YU44592A YU 44592 A YU44592 A YU 44592A YU 44592 A YU44592 A YU 44592A YU 44592 A YU44592 A YU 44592A YU 44592 A YU44592 A YU 44592A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- group
- alkyl
- hydrogen
- aryl
- halogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
DERIVATI 4-ARIL-3-(HETEROARILKARBAMIDO) HINOLINA, opisani su derivti 4-aril-3-(heteroarilkarbmido)hinolina, jedinjenja formule u kojoj R1 je odabrano od vodonika, (C1-C6)alkil, (C6-C12)aralkil grupe pri čemu je aril ostatak odabran od fenil, tienil, furil ili piridil grupe; R2 je odabrano od vodonika, (C1-C6)alkil i (C1-C6)alkoksi grupe; svako R3 i R4 je nezavisno odabrano od vodonika, halogena, (C1-C6)alkil, (C1-C6)alkoksi i (C1-C6)alkiltio grupa koje su po potrebi supstituisane sa jednim ili više atoma halogena; Q je grupa formule: R6 i R7 je odabrano iz grupe koju čine halogen, (C1-C6)alkil, (C1-C6)haloalkil, (C5-C7)cikloalkiltio, (C1-C6)alkilsulfonil; m je nezavisno odabrano od 0 do 4; n je 0 ili 1; 1 je od 0 do 3; B, D, E i G su odabrani iz grupe koju čine azot i ugljenik; X je sumpor ili kiseonik.DERIVATIVES OF 4-Aryl-3- (HETEROARYLIC CARBAMIDO) QUINOLINE, derivatives of 4-aryl-3- (heteroarylcarbamido) quinoline, compounds of formula wherein R1 is selected from hydrogen, (C1-C6) alkyl, (C6-C12) aralkyl groups wherein the aryl residue is selected from the phenyl, thienyl, furyl or pyridyl group; R 2 is selected from hydrogen, (C 1 -C 6) alkyl and (C 1 -C 6) alkoxy group; each R 3 and R 4 is independently selected from hydrogen, halogen, (C 1 -C 6) alkyl, (C 1 -C 6) alkoxy and (C 1 -C 6) alkylthio groups optionally substituted with one or more halogen atoms; Q is a group of the formula: R 6 and R 7 are selected from the group consisting of halogen, (C 1 -C 6) alkyl, (C 1 -C 6) haloalkyl, (C 5 -C 7) cycloalkylthio, (C 1 -C 6) alkylsulfonyl; m is independently selected from 0 to 4; n is 0 or 1; 1 is from 0 to 3; B, D, E and G are selected from the group consisting of nitrogen and carbon; X is sulfur or oxygen.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69232391A | 1991-04-26 | 1991-04-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU44592A true YU44592A (en) | 1994-12-28 |
Family
ID=24780107
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU44592A YU44592A (en) | 1991-04-26 | 1992-04-24 | DERIVATI 4-ARIL-3- (HETEROARILKARBAMIDO) HINOLINA |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0590094A1 (en) |
| JP (1) | JPH0776215B2 (en) |
| CN (1) | CN1066068A (en) |
| AU (1) | AU1879792A (en) |
| BR (1) | BR9205939A (en) |
| CA (1) | CA2108014A1 (en) |
| CZ (1) | CZ395592A3 (en) |
| DE (1) | DE9290049U1 (en) |
| FI (1) | FI934710A0 (en) |
| HU (1) | HUT65748A (en) |
| IE (1) | IE921330A1 (en) |
| IL (1) | IL101627A0 (en) |
| MX (1) | MX9201916A (en) |
| NO (1) | NO933837L (en) |
| NZ (1) | NZ242493A (en) |
| PT (1) | PT100426A (en) |
| TW (1) | TW197436B (en) |
| WO (1) | WO1992019614A1 (en) |
| YU (1) | YU44592A (en) |
| ZA (1) | ZA922976B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2125325T3 (en) * | 1992-01-23 | 1999-03-01 | Pfizer | DERIVATIVES OF 4-PHENYL-3- (HETEROARILUREIDO) -1,2-DIHIDRO-2-OXOQUINOLINA AS ANTIHIPERCOLESTEROLEMICOS AND ANTIATEROSCLEROTIC AGENTS. |
| US5565472A (en) * | 1992-12-21 | 1996-10-15 | Pfizer Inc. | 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents |
| NZ264063A (en) * | 1993-08-13 | 1995-11-27 | Nihon Nohyaku Co Ltd | N-(2-phenylpyrid-3-yl)- and n-(4-phenylpyrimidin-5-yl)-n'-phenylurea derivatives and pharmaceutical compositions |
| US5843957A (en) * | 1995-05-19 | 1998-12-01 | Sumitomo Pharmaceuticals Company, Ltd. | Naphthyridine derivatives |
| NZ308228A (en) * | 1995-05-31 | 1999-11-29 | Sumitomo Pharma | Substituted 1,8-naphthyridine derivatives |
| NZ335766A (en) * | 1996-11-26 | 2000-11-24 | Sumitomo Pharma | Naphthyridine derivatives and use as acyl-CoA cholesterol acyl transferase(ACAT) inhibitor as treatment of hyperlipidemia |
| AU2547399A (en) | 1998-02-25 | 1999-09-15 | Sumitomo Pharmaceuticals Company, Limited | Pyridone derivatives and process for producing the same |
| US6452008B2 (en) | 1998-02-25 | 2002-09-17 | Sumitomo Pharmaceuticals Company, Limited | Pyridone derivatives and process for preparing the same |
| BRPI0417543A (en) * | 2003-12-12 | 2007-03-27 | Wyeth Corp | quinolines useful in treating cardiovascular disease |
| CN103601677B (en) * | 2013-11-19 | 2015-11-18 | 清华大学 | Prepare the method for 2-alkylthio quinoline |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE892088L (en) * | 1988-07-12 | 1990-01-12 | William Henry Deryk Morris | Quinoline derivatives, their production and use |
| MX22406A (en) * | 1989-09-15 | 1994-01-31 | Pfizer | NEW DERIVATIVES OF N-ARIL AND N-HETEROARILAMIDAS AND UREA AS INHIBITORS OF ACIL COENZYME A: ACIL TRANSFERASA DEL COLESTEROL (ACAT). |
| TW205037B (en) * | 1989-10-06 | 1993-05-01 | Takeda Pharm Industry Co Ltd |
-
1992
- 1992-03-16 BR BR9205939A patent/BR9205939A/en not_active Application Discontinuation
- 1992-03-16 AU AU18797/92A patent/AU1879792A/en not_active Abandoned
- 1992-03-16 HU HU9303025A patent/HUT65748A/en active IP Right Revival
- 1992-03-16 JP JP4510186A patent/JPH0776215B2/en not_active Expired - Lifetime
- 1992-03-16 EP EP92923349A patent/EP0590094A1/en not_active Withdrawn
- 1992-03-16 WO PCT/US1992/001801 patent/WO1992019614A1/en not_active Application Discontinuation
- 1992-03-16 CZ CS923955A patent/CZ395592A3/en unknown
- 1992-03-16 DE DE9290049U patent/DE9290049U1/en not_active Expired - Lifetime
- 1992-03-16 CA CA002108014A patent/CA2108014A1/en not_active Abandoned
- 1992-03-17 TW TW081102005A patent/TW197436B/zh active
- 1992-03-24 ZA ZA922976A patent/ZA922976B/en unknown
- 1992-04-16 IL IL101627A patent/IL101627A0/en unknown
- 1992-04-24 NZ NZ242493A patent/NZ242493A/en unknown
- 1992-04-24 MX MX9201916A patent/MX9201916A/en not_active IP Right Cessation
- 1992-04-24 PT PT100426A patent/PT100426A/en not_active Application Discontinuation
- 1992-04-24 IE IE133092A patent/IE921330A1/en not_active Application Discontinuation
- 1992-04-24 YU YU44592A patent/YU44592A/en unknown
- 1992-04-25 CN CN92103010A patent/CN1066068A/en active Pending
-
1993
- 1993-10-25 NO NO933837A patent/NO933837L/en unknown
- 1993-10-25 FI FI934710A patent/FI934710A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUT65748A (en) | 1994-07-28 |
| TW197436B (en) | 1993-01-01 |
| CA2108014A1 (en) | 1992-10-27 |
| HU9303025D0 (en) | 1994-01-28 |
| FI934710A (en) | 1993-10-25 |
| JPH0776215B2 (en) | 1995-08-16 |
| PT100426A (en) | 1993-08-31 |
| NO933837L (en) | 1993-10-25 |
| AU1879792A (en) | 1992-12-21 |
| BR9205939A (en) | 1994-09-27 |
| NZ242493A (en) | 1994-08-26 |
| IL101627A0 (en) | 1992-12-30 |
| ZA922976B (en) | 1993-10-25 |
| CN1066068A (en) | 1992-11-11 |
| FI934710A0 (en) | 1993-10-25 |
| MX9201916A (en) | 1992-11-01 |
| WO1992019614A1 (en) | 1992-11-12 |
| IE921330A1 (en) | 1992-11-04 |
| EP0590094A1 (en) | 1994-04-06 |
| JPH06501025A (en) | 1994-01-27 |
| DE9290049U1 (en) | 1994-01-05 |
| CZ395592A3 (en) | 1994-02-16 |
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