AR052580A1 - Antagonistas del receptor de pgd2 para el tratamiento de enfermedades inflamatorias - Google Patents

Antagonistas del receptor de pgd2 para el tratamiento de enfermedades inflamatorias

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Publication number
AR052580A1
AR052580A1 ARP060100701A ARP060100701A AR052580A1 AR 052580 A1 AR052580 A1 AR 052580A1 AR P060100701 A ARP060100701 A AR P060100701A AR P060100701 A ARP060100701 A AR P060100701A AR 052580 A1 AR052580 A1 AR 052580A1
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AR
Argentina
Prior art keywords
monocyclic
group
bicyclic
aromatic
optionally substituted
Prior art date
Application number
ARP060100701A
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English (en)
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Millennium Pharm Inc
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36593677&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR052580(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc
Publication of AR052580A1 publication Critical patent/AR052580A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P17/00—Drugs for dermatological disorders
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    • A61P19/00—Drugs for skeletal disorders
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P27/16—Otologicals
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/02—Immunomodulators
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    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Reivindicacion No. 1:Un compuesto caracterizado porque está representado por la siguiente formula estructural (1) o una sal farmacéuticamente aceptable del mismo, donde : El anillo A es un anillo arilo o heteroarilo, de 5-6 miembros, condensado, opcionalmente sustituido; Y es >C(Rx)- o >N-; X1 es -C(=O)-, -SO2-, -CONR-, -C«2- o -CO2-, R1 es un grupo opcionalmente sustituido seleccionado entre un grupo alifático, un arilo monocíclico o bicíclico, un heteroarilo monocíclico o bicíclico, un heterociclilo monocíclico o bicíclico no aromático o un grupo carbociclilo monocíclico o bicíclico no aromático; R2 es un grupo alquilo C1-3, un grupo haloalquilo C1-3 o un grupo cicloalquilo C3-6, o un grupo opcionalmente sustituido seleccionado entre un grupo cicloalquilo C3-8, un grupo heterocíclico monocíclico no aromático, un arilo monocíclico o un grupo heteroarilo monocíclico; R4 es -[C(R7)2]m-B; o R3 y R4 se forman junto con el átomo de nitrogeno situado entre ellos para formar un grupo heteroarilo monocíclico o bicíclico, opcionalmente sustituido o un grupo heterocíclico no aromático; o Rx y R4 se toman junto con los átomos de carbono y nitrogeno situados entre ellos para formar un grupo heterocíclico que contiene nitrogeno, no aromático, monocíclico, opcionalmente sustituido; R5 es -OH, -O(grupo alifático C1-4)-COOR' o -N(R')2; R6 es -OH, -O(grupo alifático C1-4), N(R')2, -C(O)R', -COOR', C(O)N(R')2 o un grupo opcionalmente sustituido seleccionado ente un cicloalquilo monocíclico, un arilo monocíclico, un heteroarilo monocíclico o un grupo heterocíclico no aromático monocíclico; cada R7 es independientemente hidrogeno o un grupo alifático C1-4 o N(R')2 es un grupo heterocíclico que contiene nitrogeno, no aromático, monocíclico; m es cero o uno; y B es -H, -C(R7)3, -C(R7)3-C(R7)3 o un grupo opcionalmente sustituido seleccionado ente un cicloalquilo monocíclico o bicíclico, un arilo monocíclico o bicíclico, un heteroarilo monocíclico o bicíclico o un grupo heterocíclico no aromático, monocíclico o bicíclico, con la condicion de que los compuestos de formula(1) sean distintos de los compuestos en los que X1 es -COO- y R1 es etilo y el anillo A está sustituido con: a) dos apariciones de OMe, a) dos apariciones de Me, o c) una aparicion de CF3.
ARP060100701A 2005-02-24 2006-02-24 Antagonistas del receptor de pgd2 para el tratamiento de enfermedades inflamatorias AR052580A1 (es)

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US65592705P 2005-02-24 2005-02-24

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Country Status (26)

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US (1) US7951950B2 (es)
EP (1) EP1861372A1 (es)
JP (1) JP2008543726A (es)
KR (1) KR20070114762A (es)
CN (1) CN101146776A (es)
AR (1) AR052580A1 (es)
AU (1) AU2006216713A1 (es)
BR (1) BRPI0608553A2 (es)
CA (1) CA2598133A1 (es)
CR (1) CR9378A (es)
DO (1) DOP2006000054A (es)
GT (1) GT200600093A (es)
IL (1) IL185422A0 (es)
MA (1) MA29330B1 (es)
MX (1) MX2007010215A (es)
NI (1) NI200700221A (es)
NO (1) NO20074388L (es)
PE (1) PE20061013A1 (es)
RU (1) RU2007135224A (es)
SV (1) SV2007002429A (es)
TN (1) TNSN07325A1 (es)
TW (1) TW200640869A (es)
UA (1) UA90706C2 (es)
UY (1) UY29397A1 (es)
WO (1) WO2006091674A1 (es)
ZA (1) ZA200707498B (es)

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ZA200707498B (en) 2008-11-26
CA2598133A1 (en) 2006-08-31
DOP2006000054A (es) 2006-08-31
UA90706C2 (ru) 2010-05-25
EP1861372A1 (en) 2007-12-05
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KR20070114762A (ko) 2007-12-04
CN101146776A (zh) 2008-03-19
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UY29397A1 (es) 2006-10-02
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US7951950B2 (en) 2011-05-31
US20060241109A1 (en) 2006-10-26
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IL185422A0 (en) 2008-01-06
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