CY1113873T1 - Παραγωγα hydroxybenzamide σαν παραγοντες καταστολης της hsp90 - Google Patents

Παραγωγα hydroxybenzamide σαν παραγοντες καταστολης της hsp90

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Publication number
CY1113873T1
CY1113873T1 CY20131100278T CY131100278T CY1113873T1 CY 1113873 T1 CY1113873 T1 CY 1113873T1 CY 20131100278 T CY20131100278 T CY 20131100278T CY 131100278 T CY131100278 T CY 131100278T CY 1113873 T1 CY1113873 T1 CY 1113873T1
Authority
CY
Cyprus
Prior art keywords
hsp90
supporting agents
formula
hydroxybenzamide derivatives
hydroxybenzamide
Prior art date
Application number
CY20131100278T
Other languages
English (en)
Inventor
Martyn Frederickson
John Francis Lyons
Neil Thomas Thompson
Mladen Vinkovic
Brian Williams
Andrew James Woodhead
Alison Jo-Anne Woolford
Original Assignee
Astex Therapeutics Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astex Therapeutics Limited filed Critical Astex Therapeutics Limited
Publication of CY1113873T1 publication Critical patent/CY1113873T1/el

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    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/317—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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    • A61P25/04—Centrally acting analgesics, e.g. opioids
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P33/00—Antiparasitic agents
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    • A61P37/02—Immunomodulators
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
    • C07C59/08—Lactic acid
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
    • C07C65/05—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring o-Hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/313—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of doubly bound oxygen containing functional groups, e.g. carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
    • C07C69/92—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with etherified hydroxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles

Abstract

Η εφεύρεση παρέχει ένα άλας προσθήκης οξέος μιας ένωσης του τύπου (1). Παρέχονται επίσης από την εφεύρεση διαδικασίες για την παρασκευή ενώσεων του τύπου (1) και ανάλογα αλκυλίου (alkyl) αυτών, καινούργια ενδιάμεσα προϊόντα προς χρήση στην διαδικασία και μέθοδοι για την παρασκευή των ενδιάμεσων προϊόντων. Η εφεύρεση παρέχει επίσης νέες ιατρικές χρήσεις των ενώσεων του τύπου (1) και των αναλόγων της αιθυλίου.
CY20131100278T 2006-10-12 2013-04-03 Παραγωγα hydroxybenzamide σαν παραγοντες καταστολης της hsp90 CY1113873T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US82924306P 2006-10-12 2006-10-12
GBGB0620259.2A GB0620259D0 (en) 2006-10-12 2006-10-12 Pharmaceutical compounds
EP07824125A EP2081895B1 (en) 2006-10-12 2007-10-12 Hydrobenzamide derivatives as inhibitors of hsp90

Publications (1)

Publication Number Publication Date
CY1113873T1 true CY1113873T1 (el) 2016-07-27

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CY20131100278T CY1113873T1 (el) 2006-10-12 2013-04-03 Παραγωγα hydroxybenzamide σαν παραγοντες καταστολης της hsp90
CY20181100318T CY1120081T1 (el) 2006-10-12 2018-03-19 Παραγωγα hydroxybenzamide σαν παραγοντες καταστολης της hsp90

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US (2) US8653084B2 (el)
EP (2) EP2546233B1 (el)
JP (1) JP5726416B2 (el)
KR (1) KR101571568B1 (el)
CN (1) CN101848892B (el)
AU (1) AU2007306104B2 (el)
BR (1) BRPI0719879A8 (el)
CA (1) CA2665931C (el)
CY (2) CY1113873T1 (el)
DK (2) DK2081895T3 (el)
ES (2) ES2662359T3 (el)
GB (1) GB0620259D0 (el)
HK (1) HK1128026A1 (el)
HR (2) HRP20130255T1 (el)
HU (1) HUE037268T2 (el)
IL (1) IL197934A (el)
LT (1) LT2546233T (el)
ME (1) ME01874B (el)
MX (1) MX2009003739A (el)
NO (1) NO342242B1 (el)
NZ (1) NZ576110A (el)
PL (2) PL2081895T3 (el)
PT (2) PT2546233T (el)
RS (2) RS52716B (el)
RU (1) RU2490258C2 (el)
SI (2) SI2546233T1 (el)
TW (1) TWI429638B (el)
WO (1) WO2008044034A1 (el)
ZA (1) ZA200902270B (el)

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