AR050518A1 - Proceso de amonolisis para la preparacion de intermedarios para inhibidores de dpp iv - Google Patents

Proceso de amonolisis para la preparacion de intermedarios para inhibidores de dpp iv

Info

Publication number
AR050518A1
AR050518A1 ARP050103337A ARP050103337A AR050518A1 AR 050518 A1 AR050518 A1 AR 050518A1 AR P050103337 A ARP050103337 A AR P050103337A AR P050103337 A ARP050103337 A AR P050103337A AR 050518 A1 AR050518 A1 AR 050518A1
Authority
AR
Argentina
Prior art keywords
formula
dpp
inhibitors
preparation
amonolisis
Prior art date
Application number
ARP050103337A
Other languages
English (en)
Inventor
Gabriel M Galvin
Susan D Boettger
Saibaba Racha
Jingyang Zhu
Jack Melton
Boguslaw Mudryk
Padam M Sharma
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AR050518A1 publication Critical patent/AR050518A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered

Abstract

Un proceso para preparar el intermediario de formula (1) de conformidad con la secuencia de reaccion de formula (2); los productos se usan en la preparacion de inhibidores de DPP IV para el tratamiento de diabetes. Reivindicacion 1: Proceso para preparar un compuesto intermediario de la formula (1), caracterizado porque comprende: a) proporcionar un éster de la formula (3), donde R1 es etilo o metilo; b) hacer reaccionar el éster de formula (3) con una fuente de amoníaco y una base para formar el intermediario de formula (1).
ARP050103337A 2004-08-11 2005-08-11 Proceso de amonolisis para la preparacion de intermedarios para inhibidores de dpp iv AR050518A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60051004P 2004-08-11 2004-08-11

Publications (1)

Publication Number Publication Date
AR050518A1 true AR050518A1 (es) 2006-11-01

Family

ID=35908106

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050103337A AR050518A1 (es) 2004-08-11 2005-08-11 Proceso de amonolisis para la preparacion de intermedarios para inhibidores de dpp iv

Country Status (5)

Country Link
US (1) US20060035954A1 (es)
AR (1) AR050518A1 (es)
PE (1) PE20060641A1 (es)
TW (1) TW200618796A (es)
WO (1) WO2006020664A2 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2349588C2 (ru) * 2004-08-26 2009-03-20 Пфайзер Продактс Инк. Способы получения производных изотиазола
PE20090696A1 (es) * 2007-04-20 2009-06-20 Bristol Myers Squibb Co Formas cristalinas de saxagliptina y procesos para preparar las mismas
GB2465132B (en) * 2007-09-21 2012-06-06 Lupin Ltd Compounds as dipeptidyl peptidase IV (DPP IV) inhibitors
WO2010115974A1 (en) * 2009-04-09 2010-10-14 Sandoz Ag Crystal forms of saxagliptin
EA201291169A1 (ru) 2010-05-05 2013-04-30 Ассия Кемикал Индастриз Лтд. Промежуточные соединения саксаглиптина, полиморфы саксаглиптина и способы их получения
US8410288B2 (en) 2010-10-04 2013-04-02 Teva Pharmaceutical Industries Ltd. Polymorphs of Saxagliptin hydrochloride and processes for preparing them
WO2012162507A1 (en) 2011-05-24 2012-11-29 Apicore, Llc Process for preparing saxagliptin and its novel intermediates useful in the synthesis thereof
WO2013175395A2 (en) * 2012-05-21 2013-11-28 Dr. Reddys Laboratories Limited Improved process for preparation of saxagliptin and its salts
US9199933B2 (en) * 2012-05-30 2015-12-01 Ramamohan Rao Davuluri Process for preparation of (1S, 3S, 5S)-2-[(2S)-2-amino-2-(3-hydroxy-I-adamantyl) acetyl]-2-azabicyclo [3.1.0] hexane-3-carbonitrile
CN103265473A (zh) * 2013-06-04 2013-08-28 上海同昌生物医药科技有限公司 一种生产沙格列汀的方法
CN103274968B (zh) * 2013-06-04 2015-05-20 上海同昌生物医药科技有限公司 一种生产金刚烷胺化合物的方法
CZ2014177A3 (cs) 2014-03-24 2015-10-07 Zentiva, K.S. Způsob výroby saxagliptinu
CN103951588B (zh) * 2014-04-30 2016-10-05 淮海工学院 一种合成沙格列汀中间体n-叔丁氧羰基-3-羟基-1-金刚烷基-d-甘氨酸的方法
CN105315189A (zh) * 2014-05-29 2016-02-10 上海医药工业研究院 一种制备（5s）-5-氨基羰基-4,5-二氢-1h-吡咯-1-羧酸-1（1,1-二甲基乙基）酯的方法
KR102533388B1 (ko) * 2016-12-13 2023-05-19 코르테바 애그리사이언스 엘엘씨 벤질 4-아미노-3-클로로-5-플루오로-6-(4-클로로-2-플루오로-3-메톡시페닐)피콜리네이트 제조 방법
CN111170927B (zh) * 2020-04-10 2020-08-04 上海翰森生物医药科技有限公司 一种沙格列汀中间体的制备方法
CN112961162B (zh) * 2021-03-30 2022-09-30 泉州师范学院 有机无机杂化锰卤化物发光材料及其制备方法
WO2023114200A2 (en) * 2021-12-14 2023-06-22 Alexion Pharmaceuticals, Inc. Methods for the synthesis of complement factor d inhibitors and intermediates thereof
CN114605307A (zh) * 2022-03-10 2022-06-10 浙江新和成股份有限公司 胺化反应及其催化剂
CN114605308B (zh) * 2022-03-18 2023-12-19 阜新孚隆宝医药科技有限公司 一种帕罗韦德的氮杂双环医药中间体的制备方法及中间体
CN114634441B (zh) * 2022-05-16 2022-07-26 南京海辰药业股份有限公司 一种合成6,6-二甲基-3-氮杂双环[3,1,0]己烷的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6395767B2 (en) * 2000-03-10 2002-05-28 Bristol-Myers Squibb Company Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method
US7420079B2 (en) * 2002-12-09 2008-09-02 Bristol-Myers Squibb Company Methods and compounds for producing dipeptidyl peptidase IV inhibitors and intermediates thereof
US7470810B2 (en) * 2004-01-21 2008-12-30 Bristol-Myers Squibb Company Alkyl and aryl-thiotrifluoroacetates and process
TW200538122A (en) * 2004-03-31 2005-12-01 Bristol Myers Squibb Co Process for preparing a dipeptidyl peptidase Ⅳ inhibitor and intermediates employed therein

Also Published As

Publication number Publication date
TW200618796A (en) 2006-06-16
PE20060641A1 (es) 2006-07-09
US20060035954A1 (en) 2006-02-16
WO2006020664A2 (en) 2006-02-23
WO2006020664A3 (en) 2006-12-28

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