MX2020010682A - Conjugado de anticuerpo-farmaco anti-receptor 2 del factor de crecimiento epidermal (her2). - Google Patents

Conjugado de anticuerpo-farmaco anti-receptor 2 del factor de crecimiento epidermal (her2).

Info

Publication number
MX2020010682A
MX2020010682A MX2020010682A MX2020010682A MX2020010682A MX 2020010682 A MX2020010682 A MX 2020010682A MX 2020010682 A MX2020010682 A MX 2020010682A MX 2020010682 A MX2020010682 A MX 2020010682A MX 2020010682 A MX2020010682 A MX 2020010682A
Authority
MX
Mexico
Prior art keywords
sup
sub
her2 antibody
tumor
drug conjugate
Prior art date
Application number
MX2020010682A
Other languages
English (en)
Inventor
Masao Yoshida
Takeshi Masuda
Hiroyuki Naito
Koji Morita
Yuki Abe
Yusuke Ogitani
Shinji Ashida
Hideki Miyazaki
Yuji Kasuya
Ichiro Hayakawa
Takashi Nakada
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53756672&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2020010682(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of MX2020010682A publication Critical patent/MX2020010682A/es

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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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Abstract

La presente invención se refiere a un fármaco antitumoral el cual es excelente en N-terminales de efecto antitumoral y seguridad y tiene un excelente efecto terapéutico, se proporciona un conjugado de anticuerpo-fármaco en el cual un compuesto antitumoral representado por la siguiente Fórmula está conjugado a un anticuerpo anti-HER2 mediante un enlazador que tiene una estructura representada por la siguiente fórmula: -L1-L2-LP-NH-(CH2)n1-La-(CH2)n2-C(=O)- en donde el anticuerpo anti-HER2 está conectado al terminal L1, y el compuesto antitumoral está conectado al grupo carbonilo de la porción -(CH2)n2-C(=O)- con el átomo de nitrógeno del grupo amino en la posición 1 como la posición de conexión. (ver Fórmula).
MX2020010682A 2014-01-31 2016-05-18 Conjugado de anticuerpo-farmaco anti-receptor 2 del factor de crecimiento epidermal (her2). MX2020010682A (es)

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