MX2021006533A - Sintesis del (s)-6-hidroxitriptofano y derivados del mismo. - Google Patents
Sintesis del (s)-6-hidroxitriptofano y derivados del mismo.Info
- Publication number
- MX2021006533A MX2021006533A MX2021006533A MX2021006533A MX2021006533A MX 2021006533 A MX2021006533 A MX 2021006533A MX 2021006533 A MX2021006533 A MX 2021006533A MX 2021006533 A MX2021006533 A MX 2021006533A MX 2021006533 A MX2021006533 A MX 2021006533A
- Authority
- MX
- Mexico
- Prior art keywords
- derivatives
- synthesis
- synthesizing
- amanitin
- relates
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/22—Organic complexes
- B01J31/2282—Unsaturated compounds used as ligands
- B01J31/2295—Cyclic compounds, e.g. cyclopentadienyls
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
- B01J31/2404—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring
- B01J31/2409—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring with more than one complexing phosphine-P atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
- B01J2231/60—Reduction reactions, e.g. hydrogenation
- B01J2231/64—Reductions in general of organic substrates, e.g. hydride reductions or hydrogenations
- B01J2231/641—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes
- B01J2231/645—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes of C=C or C-C triple bonds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
- B01J2531/80—Complexes comprising metals of Group VIII as the central metal
- B01J2531/82—Metals of the platinum group
- B01J2531/822—Rhodium
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Peptides Or Proteins (AREA)
- Indole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
La presente invención se refiere a nuevos procedimientos y compuestos para sintetizar derivados de amanitina. La invención se refiere en particular a procedimientos para sintetizar derivados del (S)-hidroxitriptófano que se pueden usar como bloques de construcción en la síntesis de derivados de amanitina o conjugados amatoxina-fármaco. La invención se refiere también a compuestos intermedios de dichas rutas de síntesis para su uso en la síntesis de derivados de amanitina y conjugados amatoxina-fármaco, así como al uso de catalizadores particulares adecuados para mediar en dichas rutas de síntesis.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP18211747 | 2018-12-11 | ||
PCT/EP2019/084544 WO2020120525A1 (en) | 2018-12-11 | 2019-12-11 | Synthesis of (s)-6-hydroxytryptophan and derivatives thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021006533A true MX2021006533A (es) | 2021-07-21 |
Family
ID=64664928
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021006533A MX2021006533A (es) | 2018-12-11 | 2019-12-11 | Sintesis del (s)-6-hidroxitriptofano y derivados del mismo. |
Country Status (15)
Country | Link |
---|---|
US (1) | US20220024870A1 (es) |
EP (1) | EP3894390A1 (es) |
JP (1) | JP2022513621A (es) |
KR (1) | KR20210102200A (es) |
CN (1) | CN113166057A (es) |
AR (1) | AR117958A1 (es) |
AU (1) | AU2019396560A1 (es) |
BR (1) | BR112021009851A2 (es) |
CA (1) | CA3118031A1 (es) |
CL (1) | CL2021001434A1 (es) |
CO (1) | CO2021007237A2 (es) |
IL (1) | IL282566A (es) |
MX (1) | MX2021006533A (es) |
SG (1) | SG11202104455XA (es) |
WO (1) | WO2020120525A1 (es) |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2138507A1 (en) * | 2008-06-23 | 2009-12-30 | Helmholtz-Zentrum für Infektionsforschung GmbH | Method for producing intermediates for the production of novel macrocycles that are inhibitors of the proteasomic degradation of p27, such as argyrin and derivatives thereof, and uses of said macrocycles |
WO2011073173A1 (en) * | 2009-12-14 | 2011-06-23 | Helmholtz-Zentrum für Infektionsforschung GmbH | Improved method for producing intermediates for the production of macrocycles that are inhibitors of the proteasomic degradation of p27, such as argyrin and derivatives thereof |
US11066445B2 (en) * | 2017-06-23 | 2021-07-20 | Bristol-Myers Squibb Company | Immunomodulators acting as antagonists of PD-1 |
EP3665173A1 (en) * | 2017-08-07 | 2020-06-17 | Heidelberg Pharma Research GmbH | Novel method for synthesizing amanitins |
-
2019
- 2019-12-11 KR KR1020217014029A patent/KR20210102200A/ko not_active Application Discontinuation
- 2019-12-11 EP EP19817704.0A patent/EP3894390A1/en active Pending
- 2019-12-11 AR ARP190103621A patent/AR117958A1/es unknown
- 2019-12-11 US US17/312,308 patent/US20220024870A1/en active Pending
- 2019-12-11 BR BR112021009851-8A patent/BR112021009851A2/pt unknown
- 2019-12-11 JP JP2021528949A patent/JP2022513621A/ja active Pending
- 2019-12-11 MX MX2021006533A patent/MX2021006533A/es unknown
- 2019-12-11 AU AU2019396560A patent/AU2019396560A1/en active Pending
- 2019-12-11 CA CA3118031A patent/CA3118031A1/en active Pending
- 2019-12-11 WO PCT/EP2019/084544 patent/WO2020120525A1/en unknown
- 2019-12-11 SG SG11202104455XA patent/SG11202104455XA/en unknown
- 2019-12-11 CN CN201980081834.0A patent/CN113166057A/zh active Pending
-
2021
- 2021-04-22 IL IL282566A patent/IL282566A/en unknown
- 2021-06-01 CO CONC2021/0007237A patent/CO2021007237A2/es unknown
- 2021-06-01 CL CL2021001434A patent/CL2021001434A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
US20220024870A1 (en) | 2022-01-27 |
CN113166057A (zh) | 2021-07-23 |
IL282566A (en) | 2021-06-30 |
BR112021009851A2 (pt) | 2021-08-17 |
AU2019396560A1 (en) | 2021-06-17 |
EP3894390A1 (en) | 2021-10-20 |
CA3118031A1 (en) | 2020-06-18 |
CL2021001434A1 (es) | 2021-12-03 |
JP2022513621A (ja) | 2022-02-09 |
WO2020120525A1 (en) | 2020-06-18 |
SG11202104455XA (en) | 2021-05-28 |
KR20210102200A (ko) | 2021-08-19 |
AR117958A1 (es) | 2021-09-08 |
CO2021007237A2 (es) | 2021-06-21 |
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