AR117958A1 - Síntesis del (s)-6-hidroxitriptófano y derivados del mismo - Google Patents

Síntesis del (s)-6-hidroxitriptófano y derivados del mismo

Info

Publication number
AR117958A1
AR117958A1 ARP190103621A ARP190103621A AR117958A1 AR 117958 A1 AR117958 A1 AR 117958A1 AR P190103621 A ARP190103621 A AR P190103621A AR P190103621 A ARP190103621 A AR P190103621A AR 117958 A1 AR117958 A1 AR 117958A1
Authority
AR
Argentina
Prior art keywords
synthesis
hydroxyptophan
derivatives
hdp
acetyloxy
Prior art date
Application number
ARP190103621A
Other languages
English (en)
Inventor
Mller Christoph Dr
Werner-Simon Susanne Dr
Simon Werner Dr
Original Assignee
Heidelberg Pharma Res Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heidelberg Pharma Res Gmbh filed Critical Heidelberg Pharma Res Gmbh
Publication of AR117958A1 publication Critical patent/AR117958A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/22—Organic complexes
    • B01J31/2282—Unsaturated compounds used as ligands
    • B01J31/2295—Cyclic compounds, e.g. cyclopentadienyls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
    • B01J31/2404—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring
    • B01J31/2409—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring with more than one complexing phosphine-P atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/60—Reduction reactions, e.g. hydrogenation
    • B01J2231/64—Reductions in general of organic substrates, e.g. hydride reductions or hydrogenations
    • B01J2231/641—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes
    • B01J2231/645—Hydrogenation of organic substrates, i.e. H2 or H-transfer hydrogenations, e.g. Fischer-Tropsch processes of C=C or C-C triple bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/822—Rhodium

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Reivindicación 1: Procedimiento para la síntesis del (S)-6-acetiloxi-N-terc-butoxicarbonil-triptófano (HDP 30.2550) o del (S)-6-hidroxitriptófano, comprendiendo dicho procedimiento al menos una etapa de hidrogenación enantioselectiva de un compuesto precursor olefínico mediante el uso de al menos un catalizador quiral. Reivindicación 7: El procedimiento de acuerdo con cualquiera de las reivindicaciones 1 - 6, en el que dicho procedimiento comprende el uso de al menos un compuesto de partida o un compuesto intermedio seleccionado entre el grupo que consiste en: los compuestos del grupo de fórmulas (1). Reivindicación 8: El procedimiento para la síntesis del (S)-6-acetiloxi-N-terc-butoxicarbonil-triptófano (HDP 30.2550) de acuerdo con cualquiera de las reivindicaciones 1 - 7, en el que dicho procedimiento comprende al menos las etapas: del esquema (2). Reivindicación 9: El procedimiento para la síntesis del (S)-6-hidroxitriptófano de acuerdo con cualquiera de las reivindicaciones 1 - 7, en el que dicho procedimiento comprende al menos las etapas: del esquema (3).
ARP190103621A 2018-12-11 2019-12-11 Síntesis del (s)-6-hidroxitriptófano y derivados del mismo AR117958A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP18211747 2018-12-11

Publications (1)

Publication Number Publication Date
AR117958A1 true AR117958A1 (es) 2021-09-08

Family

ID=64664928

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP190103621A AR117958A1 (es) 2018-12-11 2019-12-11 Síntesis del (s)-6-hidroxitriptófano y derivados del mismo

Country Status (15)

Country Link
US (1) US20220024870A1 (es)
EP (1) EP3894390A1 (es)
JP (1) JP2022513621A (es)
KR (1) KR20210102200A (es)
CN (1) CN113166057A (es)
AR (1) AR117958A1 (es)
AU (1) AU2019396560B2 (es)
BR (1) BR112021009851A2 (es)
CA (1) CA3118031A1 (es)
CL (1) CL2021001434A1 (es)
CO (1) CO2021007237A2 (es)
IL (1) IL282566A (es)
MX (1) MX2021006533A (es)
SG (1) SG11202104455XA (es)
WO (1) WO2020120525A1 (es)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4073795A (en) * 1976-06-22 1978-02-14 Hoffmann-La Roche Inc. Synthesis of tryptophans
EP2138507A1 (en) * 2008-06-23 2009-12-30 Helmholtz-Zentrum für Infektionsforschung GmbH Method for producing intermediates for the production of novel macrocycles that are inhibitors of the proteasomic degradation of p27, such as argyrin and derivatives thereof, and uses of said macrocycles
JP5735977B2 (ja) * 2009-12-14 2015-06-17 ヘルムホルツ−ツェントルム フュア インフェクツィオンスフォルシュンク ゲーエムベーハー ｐ２７のプロテアソーム分解の阻害因子である、アルギリン及びその誘導体等の大員環の製造の中間体を製造する改善された方法
US10138205B2 (en) * 2015-02-19 2018-11-27 University Of Florida Research Foundation, Incorporated Artificial self-sufficient cytochrome P450s
WO2018237153A1 (en) * 2017-06-23 2018-12-27 Bristol-Myers Squibb Company IMMUNOMODULATORS ACTING AS PD-1 ANTAGONISTS
AU2018314668B2 (en) * 2017-08-07 2022-06-02 Heidelberg Pharma Research Gmbh Novel method for synthesizing amanitins
JP2023529455A (ja) * 2020-06-09 2023-07-10 ハイデルベルク ファルマ リサーチ ゲゼルシャフト ミット ベシュレンクテル ハフツング チオエーテル含有ペプチドの合成方法

Also Published As

Publication number Publication date
AU2019396560B2 (en) 2024-10-03
AU2019396560A1 (en) 2021-06-17
CO2021007237A2 (es) 2021-06-21
MX2021006533A (es) 2021-07-21
CN113166057A (zh) 2021-07-23
SG11202104455XA (en) 2021-05-28
CA3118031A1 (en) 2020-06-18
EP3894390A1 (en) 2021-10-20
CL2021001434A1 (es) 2021-12-03
US20220024870A1 (en) 2022-01-27
WO2020120525A1 (en) 2020-06-18
JP2022513621A (ja) 2022-02-09
BR112021009851A2 (pt) 2021-08-17
KR20210102200A (ko) 2021-08-19
IL282566A (en) 2021-06-30

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