PE20211243A1 - Procedimiento y productos intermedios para la preparacion de bilastina - Google Patents
Procedimiento y productos intermedios para la preparacion de bilastinaInfo
- Publication number
- PE20211243A1 PE20211243A1 PE2021000095A PE2021000095A PE20211243A1 PE 20211243 A1 PE20211243 A1 PE 20211243A1 PE 2021000095 A PE2021000095 A PE 2021000095A PE 2021000095 A PE2021000095 A PE 2021000095A PE 20211243 A1 PE20211243 A1 PE 20211243A1
- Authority
- PE
- Peru
- Prior art keywords
- preparation
- bilastin
- procedure
- intermediate products
- solvate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/62—Halogen-containing esters
- C07C69/63—Halogen-containing esters of saturated acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/39—Preparation of carboxylic acid esters by oxidation of groups which are precursors for the acid moiety of the ester
- C07C67/42—Preparation of carboxylic acid esters by oxidation of groups which are precursors for the acid moiety of the ester by oxidation of secondary alcohols or ketones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
Referido a un procedimiento para preparar un compuesto de formula (III) o un solvato del mismo, en la que X es un grupo saliente; y R1 es alquilo C1-C6; que comprende la transposicion oxidativa de un compuesto de formula (II) o un solvato del mismo. Tambien se refiere a compuestos intermedios de los mismos, y procedimiento para la preparacion de bilastina.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP18382556.1A EP3599235A1 (en) | 2018-07-24 | 2018-07-24 | Process and intermediates for the preparation of bilastine |
PCT/EP2019/069772 WO2020020873A1 (en) | 2018-07-24 | 2019-07-23 | Process and intermediates for the preparation of bilastine |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20211243A1 true PE20211243A1 (es) | 2021-07-13 |
Family
ID=63103892
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2021000095A PE20211243A1 (es) | 2018-07-24 | 2019-07-23 | Procedimiento y productos intermedios para la preparacion de bilastina |
Country Status (27)
Country | Link |
---|---|
US (1) | US11370742B2 (es) |
EP (2) | EP3599235A1 (es) |
JP (1) | JP7145312B2 (es) |
KR (1) | KR20210038905A (es) |
CN (1) | CN112469709A (es) |
AU (1) | AU2019311251B2 (es) |
BR (1) | BR112021001179A2 (es) |
CA (1) | CA3107879A1 (es) |
CL (1) | CL2021000171A1 (es) |
CO (1) | CO2021000940A2 (es) |
CY (1) | CY1124909T1 (es) |
EA (1) | EA202190346A1 (es) |
EC (1) | ECSP21008461A (es) |
ES (1) | ES2901786T3 (es) |
HR (1) | HRP20211994T1 (es) |
HU (1) | HUE056822T2 (es) |
LT (1) | LT3826997T (es) |
MA (1) | MA53370B1 (es) |
MX (1) | MX2021000924A (es) |
PE (1) | PE20211243A1 (es) |
PH (1) | PH12021550144A1 (es) |
PL (1) | PL3826997T3 (es) |
PT (1) | PT3826997T (es) |
SG (1) | SG11202100576WA (es) |
SI (1) | SI3826997T1 (es) |
WO (1) | WO2020020873A1 (es) |
ZA (1) | ZA202101214B (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112110893A (zh) * | 2020-10-28 | 2020-12-22 | 山东齐环医药科技有限公司 | 一种比拉斯汀的制备方法 |
WO2022214921A1 (en) * | 2021-04-10 | 2022-10-13 | Ocimum Labs Private Limited | An improved process for the preparation of intermediates used in the preparation of antihistamine agent |
WO2023037184A2 (en) * | 2021-08-19 | 2023-03-16 | Biophore India Pharmaceuticals Pvt. Ltd | Novel process for the preparation of bilastine and intermediates thereof |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS52108943A (en) * | 1976-03-10 | 1977-09-12 | Teikoku Hormone Mfg Co Ltd | Alkyl phenyl ketone derivative |
WO2009050116A2 (en) * | 2007-10-17 | 2009-04-23 | Basf Se | Adhesion promoting photoinitiators for uv cured coatings over metal surfaces |
EP2240464A4 (en) | 2008-02-12 | 2011-09-14 | Yuhan Corp | PROCESS FOR THE PREPARATION OF 2-METHYL-2'-PHENYLPROPIONIC ACID DERIVATIVES AND NOVEL INTERMEDIATE COMPOUNDS |
CN102675101B (zh) | 2012-05-16 | 2014-01-29 | 王蕾 | 2-(4-卤乙基)苯基-2-甲基丙酸酯的制备方法及合成比拉斯汀的方法 |
CN103159674A (zh) | 2013-04-03 | 2013-06-19 | 苏州安诺生物医药技术有限公司 | 2-苯烷酰胺类化合物及其制备方法、药物组合物和用途 |
CN104151160A (zh) | 2013-05-15 | 2014-11-19 | 重庆华邦制药有限公司 | 用酯类化合物合成2-甲基丙酸酯衍生物的方法 |
WO2014188453A2 (en) * | 2013-05-24 | 2014-11-27 | Msn Laboratories Private Limited | Novel process for the preparation of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl) phenyl]-2-methylpropanoic acid |
CN104326909A (zh) | 2014-09-22 | 2015-02-04 | 暨南大学 | 一种制备α,α-二甲基-4-(2-卤乙基)苯乙酸酯及合成比拉斯汀的方法 |
-
2018
- 2018-07-24 EP EP18382556.1A patent/EP3599235A1/en not_active Withdrawn
-
2019
- 2019-07-23 CA CA3107879A patent/CA3107879A1/en not_active Abandoned
- 2019-07-23 MA MA53370A patent/MA53370B1/fr unknown
- 2019-07-23 WO PCT/EP2019/069772 patent/WO2020020873A1/en active Application Filing
- 2019-07-23 EA EA202190346A patent/EA202190346A1/ru unknown
- 2019-07-23 MX MX2021000924A patent/MX2021000924A/es unknown
- 2019-07-23 HU HUE19742604A patent/HUE056822T2/hu unknown
- 2019-07-23 KR KR1020217005292A patent/KR20210038905A/ko not_active Application Discontinuation
- 2019-07-23 SG SG11202100576WA patent/SG11202100576WA/en unknown
- 2019-07-23 US US17/261,731 patent/US11370742B2/en active Active
- 2019-07-23 PT PT197426042T patent/PT3826997T/pt unknown
- 2019-07-23 PL PL19742604T patent/PL3826997T3/pl unknown
- 2019-07-23 AU AU2019311251A patent/AU2019311251B2/en not_active Ceased
- 2019-07-23 JP JP2021503753A patent/JP7145312B2/ja active Active
- 2019-07-23 ES ES19742604T patent/ES2901786T3/es active Active
- 2019-07-23 EP EP19742604.2A patent/EP3826997B1/en active Active
- 2019-07-23 HR HRP20211994TT patent/HRP20211994T1/hr unknown
- 2019-07-23 BR BR112021001179-0A patent/BR112021001179A2/pt not_active Application Discontinuation
- 2019-07-23 SI SI201930140T patent/SI3826997T1/sl unknown
- 2019-07-23 CN CN201980049580.4A patent/CN112469709A/zh active Pending
- 2019-07-23 LT LTEPPCT/EP2019/069772T patent/LT3826997T/lt unknown
- 2019-07-23 PE PE2021000095A patent/PE20211243A1/es unknown
-
2021
- 2021-01-19 PH PH12021550144A patent/PH12021550144A1/en unknown
- 2021-01-21 CL CL2021000171A patent/CL2021000171A1/es unknown
- 2021-01-28 CO CONC2021/0000940A patent/CO2021000940A2/es unknown
- 2021-02-05 EC ECSENADI20218461A patent/ECSP21008461A/es unknown
- 2021-02-23 ZA ZA2021/01214A patent/ZA202101214B/en unknown
-
2022
- 2022-01-14 CY CY20221100038T patent/CY1124909T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
HRP20211994T1 (hr) | 2022-04-01 |
MA53370B1 (fr) | 2021-12-31 |
WO2020020873A1 (en) | 2020-01-30 |
CA3107879A1 (en) | 2020-01-30 |
ECSP21008461A (es) | 2021-03-31 |
MA53370A (fr) | 2021-06-02 |
JP2021531300A (ja) | 2021-11-18 |
EP3599235A1 (en) | 2020-01-29 |
PT3826997T (pt) | 2022-01-21 |
PL3826997T3 (pl) | 2022-05-30 |
ZA202101214B (en) | 2022-09-28 |
CO2021000940A2 (es) | 2021-02-17 |
EP3826997B1 (en) | 2021-11-10 |
US20210300856A1 (en) | 2021-09-30 |
US11370742B2 (en) | 2022-06-28 |
SI3826997T1 (sl) | 2022-01-31 |
PH12021550144A1 (en) | 2021-09-13 |
ES2901786T3 (es) | 2022-03-23 |
BR112021001179A2 (pt) | 2021-04-27 |
AU2019311251A1 (en) | 2021-03-04 |
AU2019311251B2 (en) | 2021-10-21 |
CY1124909T1 (el) | 2023-01-05 |
HUE056822T2 (hu) | 2022-03-28 |
CL2021000171A1 (es) | 2021-07-09 |
LT3826997T (lt) | 2021-12-27 |
SG11202100576WA (en) | 2021-02-25 |
CN112469709A (zh) | 2021-03-09 |
JP7145312B2 (ja) | 2022-09-30 |
MX2021000924A (es) | 2021-03-31 |
EA202190346A1 (ru) | 2021-05-20 |
KR20210038905A (ko) | 2021-04-08 |
EP3826997A1 (en) | 2021-06-02 |
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