CO2021000940A2 - Procedimiento y productos intermedios para la preparación de bilastina - Google Patents

Procedimiento y productos intermedios para la preparación de bilastina

Info

Publication number
CO2021000940A2
CO2021000940A2 CONC2021/0000940A CO2021000940A CO2021000940A2 CO 2021000940 A2 CO2021000940 A2 CO 2021000940A2 CO 2021000940 A CO2021000940 A CO 2021000940A CO 2021000940 A2 CO2021000940 A2 CO 2021000940A2
Authority
CO
Colombia
Prior art keywords
bilastine
intermediates
procedure
preparation
iii
Prior art date
Application number
CONC2021/0000940A
Other languages
English (en)
Inventor
Herrero Gonzalo Hernández
Domínguez Neftalí García
Poladura Pablo Morán
García Tania González
González Álvaro Ganza
Cerdeiras Paloma Tato
Original Assignee
Faes Farma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Faes Farma Sa filed Critical Faes Farma Sa
Publication of CO2021000940A2 publication Critical patent/CO2021000940A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/63—Halogen-containing esters of saturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/39—Preparation of carboxylic acid esters by oxidation of groups which are precursors for the acid moiety of the ester
    • C07C67/42—Preparation of carboxylic acid esters by oxidation of groups which are precursors for the acid moiety of the ester by oxidation of secondary alcohols or ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La invención se refiere a un procedimiento para preparar un compuesto de (III) (III) en la que X es un grupo saliente; y R1 es alquilo C1-C6; que comprende la transposición oxidativa de un compuesto de fórmula (II) o un solvato del mismo (II). Los compuestos de fórmula (III) son productos intermedios clave en la síntesis de bilastina.
CONC2021/0000940A 2018-07-24 2021-01-28 Procedimiento y productos intermedios para la preparación de bilastina CO2021000940A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18382556.1A EP3599235A1 (en) 2018-07-24 2018-07-24 Process and intermediates for the preparation of bilastine
PCT/EP2019/069772 WO2020020873A1 (en) 2018-07-24 2019-07-23 Process and intermediates for the preparation of bilastine

Publications (1)

Publication Number Publication Date
CO2021000940A2 true CO2021000940A2 (es) 2021-02-17

Family

ID=63103892

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2021/0000940A CO2021000940A2 (es) 2018-07-24 2021-01-28 Procedimiento y productos intermedios para la preparación de bilastina

Country Status (27)

Country Link
US (1) US11370742B2 (es)
EP (2) EP3599235A1 (es)
JP (1) JP7145312B2 (es)
KR (1) KR20210038905A (es)
CN (1) CN112469709A (es)
AU (1) AU2019311251B2 (es)
BR (1) BR112021001179A2 (es)
CA (1) CA3107879A1 (es)
CL (1) CL2021000171A1 (es)
CO (1) CO2021000940A2 (es)
CY (1) CY1124909T1 (es)
EA (1) EA202190346A1 (es)
EC (1) ECSP21008461A (es)
ES (1) ES2901786T3 (es)
HR (1) HRP20211994T1 (es)
HU (1) HUE056822T2 (es)
LT (1) LT3826997T (es)
MA (1) MA53370B1 (es)
MX (1) MX2021000924A (es)
PE (1) PE20211243A1 (es)
PH (1) PH12021550144A1 (es)
PL (1) PL3826997T3 (es)
PT (1) PT3826997T (es)
SG (1) SG11202100576WA (es)
SI (1) SI3826997T1 (es)
WO (1) WO2020020873A1 (es)
ZA (1) ZA202101214B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112110893A (zh) * 2020-10-28 2020-12-22 山东齐环医药科技有限公司 一种比拉斯汀的制备方法
WO2022214921A1 (en) * 2021-04-10 2022-10-13 Ocimum Labs Private Limited An improved process for the preparation of intermediates used in the preparation of antihistamine agent
WO2023037184A2 (en) * 2021-08-19 2023-03-16 Biophore India Pharmaceuticals Pvt. Ltd Novel process for the preparation of bilastine and intermediates thereof
WO2024116135A1 (en) * 2022-12-01 2024-06-06 Piramal Pharma Limited Process for the preparation of bilastine
CN117024313B (zh) * 2023-08-09 2024-08-30 重庆恩联生物科技有限公司 一种比拉斯汀中间体2-甲基-2-{4-[2-甲基-4-磺酰氧基-乙基]苯基}丙酸甲酯的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52108943A (en) * 1976-03-10 1977-09-12 Teikoku Hormone Mfg Co Ltd Alkyl phenyl ketone derivative
WO2009050116A2 (en) * 2007-10-17 2009-04-23 Basf Se Adhesion promoting photoinitiators for uv cured coatings over metal surfaces
WO2009102155A2 (en) 2008-02-12 2009-08-20 Yuhan Corporation Process for preparation of 2-methyl-2´-phenylpropionic acid derivatives and novel intermediate compounds
CN102675101B (zh) 2012-05-16 2014-01-29 王蕾 2-(4-卤乙基)苯基-2-甲基丙酸酯的制备方法及合成比拉斯汀的方法
CN103159674A (zh) 2013-04-03 2013-06-19 苏州安诺生物医药技术有限公司 2-苯烷酰胺类化合物及其制备方法、药物组合物和用途
CN104151160A (zh) 2013-05-15 2014-11-19 重庆华邦制药有限公司 用酯类化合物合成2-甲基丙酸酯衍生物的方法
WO2014188453A2 (en) * 2013-05-24 2014-11-27 Msn Laboratories Private Limited Novel process for the preparation of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl) phenyl]-2-methylpropanoic acid
CN104326909A (zh) 2014-09-22 2015-02-04 暨南大学 一种制备α,α-二甲基-4-(2-卤乙基)苯乙酸酯及合成比拉斯汀的方法

Also Published As

Publication number Publication date
WO2020020873A1 (en) 2020-01-30
CN112469709A (zh) 2021-03-09
AU2019311251B2 (en) 2021-10-21
MA53370B1 (fr) 2021-12-31
KR20210038905A (ko) 2021-04-08
ECSP21008461A (es) 2021-03-31
US20210300856A1 (en) 2021-09-30
LT3826997T (lt) 2021-12-27
HRP20211994T1 (hr) 2022-04-01
EP3826997B1 (en) 2021-11-10
MX2021000924A (es) 2021-03-31
EP3599235A1 (en) 2020-01-29
ZA202101214B (en) 2022-09-28
HUE056822T2 (hu) 2022-03-28
CL2021000171A1 (es) 2021-07-09
PL3826997T3 (pl) 2022-05-30
SI3826997T1 (sl) 2022-01-31
JP7145312B2 (ja) 2022-09-30
PE20211243A1 (es) 2021-07-13
US11370742B2 (en) 2022-06-28
JP2021531300A (ja) 2021-11-18
AU2019311251A1 (en) 2021-03-04
PH12021550144A1 (en) 2021-09-13
CA3107879A1 (en) 2020-01-30
MA53370A (fr) 2021-06-02
BR112021001179A2 (pt) 2021-04-27
PT3826997T (pt) 2022-01-21
CY1124909T1 (el) 2023-01-05
ES2901786T3 (es) 2022-03-23
SG11202100576WA (en) 2021-02-25
EP3826997A1 (en) 2021-06-02
EA202190346A1 (ru) 2021-05-20

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