CL2021001266A1 - Síntesis mejorada del intermedio clave del compuesto inhibidor de g12c de kras - Google Patents

Síntesis mejorada del intermedio clave del compuesto inhibidor de g12c de kras

Info

Publication number
CL2021001266A1
CL2021001266A1 CL2021001266A CL2021001266A CL2021001266A1 CL 2021001266 A1 CL2021001266 A1 CL 2021001266A1 CL 2021001266 A CL2021001266 A CL 2021001266A CL 2021001266 A CL2021001266 A CL 2021001266A CL 2021001266 A1 CL2021001266 A1 CL 2021001266A1
Authority
CL
Chile
Prior art keywords
kras
key
inhibitor compound
compound intermediate
improved synthesis
Prior art date
Application number
CL2021001266A
Other languages
English (en)
Inventor
Andrew Thomas Parsons
Brian Mcneil Cochran
Iv William Powazinik
Marc Anthony Caporini
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of CL2021001266A1 publication Critical patent/CL2021001266A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/24—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/06—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a un proceso escalable, eficaz, mejorado para preparar compuestos intermedios, tal como un compuesto 5M, que tiene la estructura útil para la síntesis de compuestos que inhiben las mutaciones de G12C de KRAS tales como
CL2021001266A 2018-11-16 2021-05-14 Síntesis mejorada del intermedio clave del compuesto inhibidor de g12c de kras CL2021001266A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862768802P 2018-11-16 2018-11-16

Publications (1)

Publication Number Publication Date
CL2021001266A1 true CL2021001266A1 (es) 2021-11-26

Family

ID=68887130

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2021001266A CL2021001266A1 (es) 2018-11-16 2021-05-14 Síntesis mejorada del intermedio clave del compuesto inhibidor de g12c de kras

Country Status (25)

Country Link
US (2) US11299491B2 (es)
EP (2) EP3880670B1 (es)
JP (1) JP2020090482A (es)
KR (1) KR20210093276A (es)
CN (1) CN113015724A (es)
AR (1) AR117101A1 (es)
AU (1) AU2019381817A1 (es)
BR (1) BR112021009384A2 (es)
CA (1) CA3117221A1 (es)
CL (1) CL2021001266A1 (es)
DK (1) DK3880670T3 (es)
EA (1) EA202191381A1 (es)
ES (1) ES2953752T3 (es)
FI (1) FI3880670T3 (es)
HU (1) HUE062656T2 (es)
IL (1) IL282682A (es)
LT (1) LT3880670T (es)
MA (1) MA54233A (es)
MX (2) MX2021005598A (es)
PL (1) PL3880670T3 (es)
PT (1) PT3880670T (es)
SG (1) SG11202104927QA (es)
SI (1) SI3880670T1 (es)
TW (1) TW202035354A (es)
WO (1) WO2020102730A1 (es)

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CN114605406B (zh) * 2021-09-18 2023-05-26 都创(上海)医药开发有限公司 Amg510化合物的晶型及其制备方法和用途
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