PL3880670T3 - Ulepszona synteza kluczowego związku pośredniego dla związku inhibitora kras g12c - Google Patents

Ulepszona synteza kluczowego związku pośredniego dla związku inhibitora kras g12c

Info

Publication number
PL3880670T3
PL3880670T3 PL19820938.9T PL19820938T PL3880670T3 PL 3880670 T3 PL3880670 T3 PL 3880670T3 PL 19820938 T PL19820938 T PL 19820938T PL 3880670 T3 PL3880670 T3 PL 3880670T3
Authority
PL
Poland
Prior art keywords
kras
inhibitor compound
key intermediate
improved synthesis
synthesis
Prior art date
Application number
PL19820938.9T
Other languages
English (en)
Inventor
Andrew Thomas PARSONS
Brian McNeil COCHRAN
IV William POWAZINIK
Marc Anthony Caporini
Original Assignee
Amgen Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc. filed Critical Amgen Inc.
Publication of PL3880670T3 publication Critical patent/PL3880670T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/24—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/06—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PL19820938.9T 2018-11-16 2019-11-15 Ulepszona synteza kluczowego związku pośredniego dla związku inhibitora kras g12c PL3880670T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862768802P 2018-11-16 2018-11-16
PCT/US2019/061815 WO2020102730A1 (en) 2018-11-16 2019-11-15 Improved synthesis of key intermediate of kras g12c inhibitor compound

Publications (1)

Publication Number Publication Date
PL3880670T3 true PL3880670T3 (pl) 2023-10-02

Family

ID=68887130

Family Applications (1)

Application Number Title Priority Date Filing Date
PL19820938.9T PL3880670T3 (pl) 2018-11-16 2019-11-15 Ulepszona synteza kluczowego związku pośredniego dla związku inhibitora kras g12c

Country Status (25)

Country Link
US (2) US11299491B2 (pl)
EP (2) EP4234546A3 (pl)
JP (1) JP2020090482A (pl)
KR (1) KR20210093276A (pl)
CN (1) CN113015724A (pl)
AR (1) AR117101A1 (pl)
AU (1) AU2019381817A1 (pl)
BR (1) BR112021009384A2 (pl)
CA (1) CA3117221A1 (pl)
CL (1) CL2021001266A1 (pl)
DK (1) DK3880670T3 (pl)
EA (1) EA202191381A1 (pl)
ES (1) ES2953752T3 (pl)
FI (1) FI3880670T3 (pl)
HU (1) HUE062656T2 (pl)
IL (1) IL282682A (pl)
LT (1) LT3880670T (pl)
MA (1) MA54233A (pl)
MX (2) MX2021005598A (pl)
PL (1) PL3880670T3 (pl)
PT (1) PT3880670T (pl)
SG (1) SG11202104927QA (pl)
SI (1) SI3880670T1 (pl)
TW (1) TW202035354A (pl)
WO (1) WO2020102730A1 (pl)

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CN110366550A (zh) 2016-12-22 2019-10-22 美国安进公司 作为用于治疗肺癌、胰腺癌或结直肠癌的KRAS G12C抑制剂的苯并异噻唑、异噻唑并[3,4-b]吡啶、喹唑啉、酞嗪、吡啶并[2,3-d]哒嗪和吡啶并[2,3-d]嘧啶衍生物
JOP20190272A1 (ar) 2017-05-22 2019-11-21 Amgen Inc مثبطات kras g12c وطرق لاستخدامها
AR112797A1 (es) 2017-09-08 2019-12-11 Amgen Inc Inhibidores de kras g12c y métodos para utilizarlos
US11090304B2 (en) 2018-05-04 2021-08-17 Amgen Inc. KRAS G12C inhibitors and methods of using the same
CA3099118A1 (en) 2018-05-04 2019-11-07 Amgen Inc. Kras g12c inhibitors and methods of using the same
CA3099045A1 (en) 2018-05-10 2019-11-14 Amgen Inc. Kras g12c inhibitors for the treatment of cancer
CA3098885A1 (en) 2018-06-01 2019-12-05 Amgen Inc. Kras g12c inhibitors and methods of using the same
AU2019336588B2 (en) 2018-06-12 2022-07-28 Amgen Inc. KRAS G12C inhibitors encompassing a piperazine ring and use thereof in the treatment of cancer
JP2020090482A (ja) 2018-11-16 2020-06-11 アムジエン・インコーポレーテツド Ｋｒａｓ ｇ１２ｃ阻害剤化合物の重要な中間体の改良合成法
JP7377679B2 (ja) 2018-11-19 2023-11-10 アムジエン・インコーポレーテツド がん治療のためのｋｒａｓｇ１２ｃ阻害剤及び１種以上の薬学的に活性な追加の薬剤を含む併用療法
AU2019384118A1 (en) 2018-11-19 2021-05-27 Amgen Inc. KRAS G12C inhibitors and methods of using the same
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JP2023505100A (ja) 2019-11-27 2023-02-08 レボリューション メディシンズ インコーポレイテッド 共有ｒａｓ阻害剤及びその使用
WO2021185233A1 (en) * 2020-03-17 2021-09-23 Jacobio Pharmaceuticals Co., Ltd. Kras mutant protein inhibitors
JP2023528623A (ja) 2020-06-02 2023-07-05 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング がんを治療するための縮合環化２－アミノ－３－シアノチオフェン及び誘導体
WO2021244555A1 (zh) * 2020-06-02 2021-12-09 上海喆邺生物科技有限公司 一种手性中间体及其制备方法
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CN115942936A (zh) 2020-06-24 2023-04-07 勃林格殷格翰国际有限公司 包含sos1抑制剂和kras g12c抑制剂的抗癌组合疗法
CN113929676A (zh) * 2020-07-14 2022-01-14 浙江海正药业股份有限公司 吡啶并杂环类衍生物及其制备方法和用途
WO2022028346A1 (zh) 2020-08-02 2022-02-10 上海喆邺生物科技有限公司 一种芳香类化合物及其在抗肿瘤药物中的应用
IL301062A (en) 2020-09-03 2023-05-01 Revolution Medicines Inc Use of SOS1 inhibitors to treat malignancies with SHP2 mutations
JP2023544775A (ja) * 2020-10-07 2023-10-25 アムジエン・インコーポレーテツド ７－クロロ－６－フルオロ－１－（２－イソプロピル－４－メチルピリジン－３－イル）ピリド［２，３－ｄ］ピリミジン－２，４（１Ｈ，３Ｈ）－ジオンのアトロプ異性体をラセミ化及び単離するためのプロセス
MX2023005823A (es) 2020-11-20 2023-05-31 Amgen Inc Procedimiento para preparar 7-cloro-6-fluoro-1-(2-isopropil-4-meti lpiridin-3-il)pirido[2,3-d]pirimidino-2,4(1h,3h)-diona.
CN117479942A (zh) 2021-04-09 2024-01-30 勃林格殷格翰国际有限公司 抗癌疗法
WO2022246069A1 (en) 2021-05-19 2022-11-24 Teva Pharmaceuticals International Gmbh Process for preparation of sotorasib and solid state form thereof
CN114605406B (zh) * 2021-09-18 2023-05-26 都创(上海)医药开发有限公司 Amg510化合物的晶型及其制备方法和用途
WO2023117681A1 (en) 2021-12-22 2023-06-29 Boehringer Ingelheim International Gmbh Heteroaromatic compounds for the treatment of cancer
WO2023172858A1 (en) 2022-03-07 2023-09-14 Amgen Inc. A process for preparing 4-methyl-2-propan-2-yl-pyridine-3-carbonitrile
CN115466259B (zh) * 2022-08-16 2023-12-05 山东大学 一种kras g12c抑制剂索托拉西布的制备方法

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