SI3880670T1 - Izboljšana sinteza ključne vmesne spojine inhibitorske spojine KRAS G12C - Google Patents

Izboljšana sinteza ključne vmesne spojine inhibitorske spojine KRAS G12C

Info

Publication number
SI3880670T1
SI3880670T1 SI201930601T SI201930601T SI3880670T1 SI 3880670 T1 SI3880670 T1 SI 3880670T1 SI 201930601 T SI201930601 T SI 201930601T SI 201930601 T SI201930601 T SI 201930601T SI 3880670 T1 SI3880670 T1 SI 3880670T1
Authority
SI
Slovenia
Prior art keywords
kras
inhibitor compound
key intermediate
improved synthesis
synthesis
Prior art date
Application number
SI201930601T
Other languages
English (en)
Inventor
Andrew Thomas Parsons
Brian Mcneil Cochran
Iv William Powazinik
Marc Anthony Caporini
Original Assignee
Amgen Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc. filed Critical Amgen Inc.
Publication of SI3880670T1 publication Critical patent/SI3880670T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/24—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/06—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SI201930601T 2018-11-16 2019-11-15 Izboljšana sinteza ključne vmesne spojine inhibitorske spojine KRAS G12C SI3880670T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862768802P 2018-11-16 2018-11-16
EP19820938.9A EP3880670B1 (en) 2018-11-16 2019-11-15 Improved synthesis of key intermediate of kras g12c inhibitor compound
PCT/US2019/061815 WO2020102730A1 (en) 2018-11-16 2019-11-15 Improved synthesis of key intermediate of kras g12c inhibitor compound

Publications (1)

Publication Number Publication Date
SI3880670T1 true SI3880670T1 (sl) 2023-10-30

Family

ID=68887130

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201930601T SI3880670T1 (sl) 2018-11-16 2019-11-15 Izboljšana sinteza ključne vmesne spojine inhibitorske spojine KRAS G12C

Country Status (25)

Country Link
US (2) US11299491B2 (sl)
EP (2) EP4234546A3 (sl)
JP (2) JP7516029B2 (sl)
KR (1) KR20210093276A (sl)
CN (1) CN113015724A (sl)
AR (1) AR117101A1 (sl)
AU (1) AU2019381817A1 (sl)
BR (1) BR112021009384A2 (sl)
CA (1) CA3117221A1 (sl)
CL (1) CL2021001266A1 (sl)
DK (1) DK3880670T3 (sl)
EA (1) EA202191381A1 (sl)
ES (1) ES2953752T3 (sl)
FI (1) FI3880670T3 (sl)
HU (1) HUE062656T2 (sl)
IL (1) IL282682A (sl)
LT (1) LT3880670T (sl)
MA (1) MA54233A (sl)
MX (2) MX2021005598A (sl)
PL (1) PL3880670T3 (sl)
PT (1) PT3880670T (sl)
SG (1) SG11202104927QA (sl)
SI (1) SI3880670T1 (sl)
TW (1) TW202035354A (sl)
WO (1) WO2020102730A1 (sl)

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MA52564A (fr) 2018-05-10 2021-03-17 Amgen Inc Inhibiteurs de kras g12c pour le traitement du cancer
MA52765A (fr) 2018-06-01 2021-04-14 Amgen Inc Inhibiteurs de kras g12c et leurs procédés d'utilisation
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JP7516029B2 (ja) 2018-11-16 2024-07-16 アムジエン・インコーポレーテツド Ｋｒａｓ ｇ１２ｃ阻害剤化合物の重要な中間体の改良合成法
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CN113929676A (zh) * 2020-07-14 2022-01-14 浙江海正药业股份有限公司 吡啶并杂环类衍生物及其制备方法和用途
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WO2022042630A1 (en) * 2020-08-26 2022-03-03 InventisBio Co., Ltd. Heteroaryl compounds, preparation methods and uses thereof
MX2023002248A (es) 2020-09-03 2023-05-16 Revolution Medicines Inc Uso de inhibidores de sos1 para tratar neoplasias malignas con mutaciones de shp2.
KR20230083318A (ko) * 2020-10-07 2023-06-09 암젠 인크 7-클로로-6-플루오로-1-(2-이소프로필-4-메틸피리딘-3-일)피리도[2,3-d]피리미딘-2,4(1H,3H)-디온의 회전장애이성질체의 라세미화 및 단리 방법
TW202237598A (zh) 2020-11-20 2022-10-01 美商安進公司 用於製備７—氯—６—氟—１—（２—異丙基—４—甲吡啶—３—基）吡啶并［２，３—ｄ］嘧啶—２，４（１ｈ，３ｈ）—二酮之方法
US20240238294A1 (en) 2021-04-09 2024-07-18 Boehringer Ingelheim International Gmbh Anticancer therapy
US20240254122A1 (en) 2021-05-19 2024-08-01 Teva Pharmaceuticals International Gmbh Process for preparation of sotorasib and solid state form thereof
CN114605406B (zh) * 2021-09-18 2023-05-26 都创(上海)医药开发有限公司 Amg510化合物的晶型及其制备方法和用途
CA3240980A1 (en) 2021-12-01 2023-06-08 Boehringer Ingelheim International Gmbh Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer
CN118339153A (zh) 2021-12-22 2024-07-12 勃林格殷格翰国际有限公司 用于治疗癌症的杂芳族化合物
TW202346267A (zh) 2022-03-07 2023-12-01 美商安進公司 用於製備４－甲基－２－丙－２－基－吡啶－３－甲腈之方法
CN115466259B (zh) * 2022-08-16 2023-12-05 山东大学 一种kras g12c抑制剂索托拉西布的制备方法
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