MA54233A - Synthèse améliorée d'un intermédiaire clé du composé inhibiteur de kras g12c - Google Patents

Synthèse améliorée d'un intermédiaire clé du composé inhibiteur de kras g12c

Info

Publication number
MA54233A
MA54233A MA054233A MA54233A MA54233A MA 54233 A MA54233 A MA 54233A MA 054233 A MA054233 A MA 054233A MA 54233 A MA54233 A MA 54233A MA 54233 A MA54233 A MA 54233A
Authority
MA
Morocco
Prior art keywords
inhibitor compound
key intermediate
improved synthesis
kras inhibitor
kras
Prior art date
Application number
MA054233A
Other languages
English (en)
Inventor
Marc Anthony Caporini
Brian Mcneil Cochran
Andrew Thomas Parsons
Iv William Powazinik
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MA54233A publication Critical patent/MA54233A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/24—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/06—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
MA054233A 2018-11-16 2019-11-15 Synthèse améliorée d'un intermédiaire clé du composé inhibiteur de kras g12c MA54233A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862768802P 2018-11-16 2018-11-16

Publications (1)

Publication Number Publication Date
MA54233A true MA54233A (fr) 2022-02-23

Family

ID=68887130

Family Applications (1)

Application Number Title Priority Date Filing Date
MA054233A MA54233A (fr) 2018-11-16 2019-11-15 Synthèse améliorée d'un intermédiaire clé du composé inhibiteur de kras g12c

Country Status (25)

Country Link
US (2) US11299491B2 (fr)
EP (2) EP3880670B1 (fr)
JP (1) JP2020090482A (fr)
KR (1) KR20210093276A (fr)
CN (1) CN113015724A (fr)
AR (1) AR117101A1 (fr)
AU (1) AU2019381817A1 (fr)
BR (1) BR112021009384A2 (fr)
CA (1) CA3117221A1 (fr)
CL (1) CL2021001266A1 (fr)
DK (1) DK3880670T3 (fr)
EA (1) EA202191381A1 (fr)
ES (1) ES2953752T3 (fr)
FI (1) FI3880670T3 (fr)
HU (1) HUE062656T2 (fr)
IL (1) IL282682A (fr)
LT (1) LT3880670T (fr)
MA (1) MA54233A (fr)
MX (2) MX2021005598A (fr)
PL (1) PL3880670T3 (fr)
PT (1) PT3880670T (fr)
SG (1) SG11202104927QA (fr)
SI (1) SI3880670T1 (fr)
TW (1) TW202035354A (fr)
WO (1) WO2020102730A1 (fr)

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JOP20190272A1 (ar) 2017-05-22 2019-11-21 Amgen Inc مثبطات kras g12c وطرق لاستخدامها
UY37870A (es) 2017-09-08 2019-03-29 Amgen Inc Inhibidores de kras g12c y métodos para utilizarlos campo de la invención
MA52501A (fr) 2018-05-04 2021-03-10 Amgen Inc Inhibiteurs de kras g12c et leurs procédés d'utilisation
JP7361722B2 (ja) 2018-05-04 2023-10-16 アムジエン・インコーポレーテツド Ｋｒａｓ ｇ１２ｃ阻害剤及び同一物の使用方法
EP3790886A1 (fr) 2018-05-10 2021-03-17 Amgen Inc. Inhibiteurs de kras g12c pour le traitement du cancer
WO2019232419A1 (fr) 2018-06-01 2019-12-05 Amgen Inc. Inhibiteurs de kras g12c et leurs procédés d'utilisation
MA51848A (fr) 2018-06-12 2021-04-21 Amgen Inc Inhibiteurs de kras g12c et leurs procédés d'utilisation
JP2020090482A (ja) 2018-11-16 2020-06-11 アムジエン・インコーポレーテツド Ｋｒａｓ ｇ１２ｃ阻害剤化合物の重要な中間体の改良合成法
WO2020106640A1 (fr) 2018-11-19 2020-05-28 Amgen Inc. Inhibiteurs de kras g12c et leurs procédés d'utilisation
JP7377679B2 (ja) 2018-11-19 2023-11-10 アムジエン・インコーポレーテツド がん治療のためのｋｒａｓｇ１２ｃ阻害剤及び１種以上の薬学的に活性な追加の薬剤を含む併用療法
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WO2021185233A1 (fr) * 2020-03-17 2021-09-23 Jacobio Pharmaceuticals Co., Ltd. Inhibiteurs de protéine mutante kras
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CN115942936A (zh) 2020-06-24 2023-04-07 勃林格殷格翰国际有限公司 包含sos1抑制剂和kras g12c抑制剂的抗癌组合疗法
CN113929676A (zh) * 2020-07-14 2022-01-14 浙江海正药业股份有限公司 吡啶并杂环类衍生物及其制备方法和用途
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IL301062A (en) 2020-09-03 2023-05-01 Revolution Medicines Inc Use of SOS1 inhibitors to treat malignancies with SHP2 mutations
AU2021357815A1 (en) * 2020-10-07 2023-04-20 Amgen Inc. Process for racemizing and isolating atropisomers of 7-chloro-6-fluoro-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidine-2,4(1h,3h)-dione
CA3201663A1 (fr) 2020-11-20 2022-05-27 Amgen Inc. Procede de preparation de 7-chloro-6-fluoro-1-(2-isopropyl-4-methylpyridin-3-yl)pyridof[2,3-d]pyrimidine-2,4 (1h,3h)-dione
EP4319757A1 (fr) 2021-04-09 2024-02-14 Boehringer Ingelheim International GmbH Thérapie anticancéreuse
EP4341260A1 (fr) 2021-05-19 2024-03-27 Teva Pharmaceuticals International GmbH Procédé de préparation du sotorasib et sa forme à l'état solide
CN114605406B (zh) * 2021-09-18 2023-05-26 都创(上海)医药开发有限公司 Amg510化合物的晶型及其制备方法和用途
WO2023117681A1 (fr) 2021-12-22 2023-06-29 Boehringer Ingelheim International Gmbh Composés hétéroaromatiques pour le traitement du cancer
WO2023172858A1 (fr) 2022-03-07 2023-09-14 Amgen Inc. Procédé de préparation de 4-méthyl-2-propan-2-yl-pyridine-3-carbonitrile
CN115466259B (zh) * 2022-08-16 2023-12-05 山东大学 一种kras g12c抑制剂索托拉西布的制备方法

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