BR0009507A - Derivados de ftalazina para o tratamento de doenças inflamatórias - Google Patents

Derivados de ftalazina para o tratamento de doenças inflamatórias

Info

Publication number
BR0009507A
BR0009507A BR0009507-9A BR0009507A BR0009507A BR 0009507 A BR0009507 A BR 0009507A BR 0009507 A BR0009507 A BR 0009507A BR 0009507 A BR0009507 A BR 0009507A
Authority
BR
Brazil
Prior art keywords
treatment
disease
phthalazine derivatives
inflammatory diseases
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
BR0009507-9A
Other languages
English (en)
Inventor
Guido Bold
Janet Dawson King
Joerg Frei
Richard Heng
Paul William Manley
Bernhard Wietfeld
Jeanette Marjorie Wood
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9916064.0A external-priority patent/GB9916064D0/en
Application filed by Novartis AG filed Critical Novartis AG
Publication of BR0009507A publication Critical patent/BR0009507A/pt
Pending legal-status Critical Current

Links

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Patente de Invenção: "DERIVADOS DE FTALAZINA PARA O TRATAMENTO DE DOENçAS INFLAMATóRIAS". A presente invenção refere-se ao tratamento de uma doença inflamatória, especialmente uma doença reumatóide ou reumática inflamatória, e/ou dor com um inibidor da atividade de tirosína cinase receptora do VEGF da fórmula I, em que r é de 0 a 2, n é de 0 a 3 R~ 1~ e R~ 2~ a) são independentemente em cada caso uma alquila inferior; b) juntamente formam uma ponte de subfórmula I<sym>, em que a ligação é obtida através de dois átomos C terminais e m é de 0 a 4, ou c) juntamente formam uma ponte de sub fórmula I<sym><sym> em que um ou dois dos membros do anel T~ 1~, T~ 2~, T~ 3~ e T~ 4~ são nitrogênio, e os outros são em cada caso CH, e a ligação é alcançada através de átomos T~ 1~ e T~ 4~; G é -C(=O)-, -CHF-, -CF~ 2~-, alquileno inferior, alquenileno C~ 2~-C~ 6~, alquileno inferior ou alquenileno C~ 3~-C~ 6~ substituído por acilóxi ou hidróxi, -CH~ 2~-O-, -CH~ 2~-S-, -CH~ 2~-NH-, -CH~ 2~-O-CH~ 2~-, -CH~ 2~-S-CH~ 2~-, -CH~ 2~-NH-CH~ 2~-, oxa (-O-), tia (-S-), imino (-NH-), -CH~ 2~-O-CH~ 2~-, -CH~ 2~-S-CH~ 2~-, ou -CH~ 2~-NH-CH~ 2~-; A, B, D, E e T são independentemente N ou CH submetidos à condição de que pelo menos um e não mais do que três destes radicais são N; Q é alquila inferior, alcóxi inferior ou halogênio; R~ a~ e R~ a'~ são cada um independentemente H ou alquila inferior; X é imino, oxa ou tia; Y é hidrogênio, arila, heteroarila, ou cicloalquila não-substituida ou substituída; e Z é amino mono- ou dissubstituído, halogênio, alquila, alquila substituída, hidróxi, hidróxi eterificado ou esterificado, nitro, ciano, carbóxi, carbóxi esterificado, alcanoíla, carbamoíla, carbamoíla N-mono- ou N,Ndissubstituída, amidino, guanidino, mercapto, sulfo, feniltio, alquiltio inferior de fenila, alquilfeniltio, fenilsulfinila, alquilsulfinila inferior de fenila, alquilfenilsulfinila, fenilsulfonila, alquilsulfonila inferior de fenila, alquilfeniisulfonila, ou (alternativamente ou, em um aspecto mais amplo da invenção, além disso) selecionado do grupo consistindo em ureído, alquiltio haio-inferior, alcanossulfonila haio-inferior, pirazolila, pirazolila de alquila inferior e alquenila C~ 2~-C~ 7~; em que - se mais do que 1 radical Z (m <242>2) estiver presente - os substituintes Z são selecionados independentemente um do outro; e em que as ligações caracterizadas na subfórmula I<sym> por uma linha ondulada são ligações únicas ou duplas; ou um N-óxido do dito composto, em que 1 ou mais átomos de N carregam um átomo de oxigênio; ou um sal farmaceuticamente aceitável destes; assim como os novos derivados de ftalazina; processos para a preparação destes; a aplicação destes em um processo para o tratamento do corpo humano ou animal; o uso destes para o tratamento de uma doença, especialmente uma doença causada por neovascularização ocular, tal como degeneração macular relacionada com a idade ou retinopatia diabética, ou outras doenças que respondem à inibição da tirosina cinase, tal como uma doença proliferativa; um método para o tratamento de tal doença em mamíferos; e o uso de um tal composto para a fabricação de uma preparação farmacêutica para o tratamento especialmente de uma doença como acima mencionada.
BR0009507-9A 1999-03-30 2000-03-28 Derivados de ftalazina para o tratamento de doenças inflamatórias Pending BR0009507A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH60399 1999-03-30
GBGB9916064.0A GB9916064D0 (en) 1999-07-08 1999-07-08 Organic compounds
PCT/EP2000/002726 WO2000059509A1 (en) 1999-03-30 2000-03-28 Phthalazine derivatives for treating inflammatory diseases

Publications (1)

Publication Number Publication Date
BR0009507A true BR0009507A (pt) 2002-01-15

Family

ID=25685089

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0009507-9A Pending BR0009507A (pt) 1999-03-30 2000-03-28 Derivados de ftalazina para o tratamento de doenças inflamatórias

Country Status (13)

Country Link
US (4) US6686347B2 (pt)
EP (1) EP1165085B1 (pt)
JP (1) JP4673977B2 (pt)
CN (2) CN1221262C (pt)
AT (1) ATE329596T1 (pt)
AU (1) AU766081B2 (pt)
BR (1) BR0009507A (pt)
CA (1) CA2366857C (pt)
DE (1) DE60028740T2 (pt)
ES (1) ES2265929T3 (pt)
NO (3) NO320849B1 (pt)
PT (1) PT1165085E (pt)
WO (1) WO2000059509A1 (pt)

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