NO20052893L - Ftalazinderivater for behandling av inflammatoriske sykdommer - Google Patents

Ftalazinderivater for behandling av inflammatoriske sykdommer

Info

Publication number
NO20052893L
NO20052893L NO20052893A NO20052893A NO20052893L NO 20052893 L NO20052893 L NO 20052893L NO 20052893 A NO20052893 A NO 20052893A NO 20052893 A NO20052893 A NO 20052893A NO 20052893 L NO20052893 L NO 20052893L
Authority
NO
Norway
Prior art keywords
treatment
disease
phthalazine derivatives
inflammatory diseases
preparation
Prior art date
Application number
NO20052893A
Other languages
English (en)
Other versions
NO20052893D0 (no
Inventor
Bernhard Wietfeld
Guido Bold
Jeanette Marjorie Wood
Jorg Frei
Janet Dawson King
Richard Heng
Paul William Manley
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9916064.0A external-priority patent/GB9916064D0/en
Publication of NO20052893L publication Critical patent/NO20052893L/no
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NO20052893D0 publication Critical patent/NO20052893D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Abstract

Det er beskrevet behandling av en inflammatorisk sykdom, spesielt en inflammatorisk reumatoid eller reumatisk sykdom, og/eller smerte med en inhibitor av aktiviteten av VEGF-reseptortyrosinkinase av formel I hvori r er 0 til 2, n er 0 til 3, R1 o g R2 er a) uavhengig i hvert tilfelle en lavere alkyl, b) danner sammen en bro av underformel I* hvori bindingen oppnås via de to terminale C-atomene og m er 0 til 4, eller c) danner sammen en bro av underformel I** hvori ett eller to av ringelementene T1, T2, T3 og T4 er nitrogen, og de andre er i hvert tilfelle CH, og bindingen oppnås via atomer T1 og T4, G er -C(=O)-, -CHF-, -CF2-, lavere alkylen, C2-C6-alkenylen, lavere alkylen eller C3-C6-alkenylen substituert med acyloksy eller hydroksy, -CH2-O-, -CH2-S-, -CH2-NH-, -CH2-O-CH2-, -CH2-S-CH2-, -CH2-NH-CH2-, oksa (-O-), tia (-S-), imino (-NH-), -CH2-O-CH2-, -CH2-S-CH2- eller -CH2-NH-CH2-, A, B, D, E og T er uavhengig N eller CH under den forutsetning at minst én og ikke mer enn tre av disse restene er N, Q er lavere alkyl, lavere alkoksy eller halogen, Ra. og Ra' er hver uavhengig H eller lavere alkyl, X er imino, oksa eller tia, Y er hydrogen, aryl, heteroaryl eller usubstituert eller substituert sykloalkyl, og Z er mono- eller disubstituert amino, halogen, alkyl, substituert alkyl, hydroksy, foretret eller forestret hydroksy, nitro, cyano, karboksy, forestret karboksy, alkanoyl, karbamoyl, N-mono- eller N,N-disubstituert karbamoyl, amidino, guanidino, merkapto, sulfo, fenyltio, fenyl-laverealkyltio, alkylfenyltio, fenylsulfinyl, fenyl-laverealkylsulfinyl, alkylfenylsulfinyl, fenylsulfonyl, fenyl-laverealkylsulfonyl, alkylfenylsulfonyl eller (altemativt eller, i en videre forstand av oppfinnelsen, i tillegg) valgt fra gruppen bestående av ureido, halogen-laverealkyltio, halogen-laverealkansulfonyl, pyrazolyl, lavere-alkylpyrazolyl og C2-C7-alkenyl; hvori dersom mer enn 1 rest Z (m > 2) er til stede - substituentene Z er valgt uavhengig av hverandre; og hvor bindingene angitt i underformel I* med en bølget linje, enten er enkelt- eller dobbeltbindinger; eller et N-oksid av nevnte forbindelse, hvori 1 eller flere N-atomer bærer et oksygenatom; eller et farrnasøytisk akseptabelt salt derav; så vel som nye ftalazinderivater; fremgangsmåter for fremstilling derav; anvendelsen derav i en fremgangsmåte for behandling av det humane eller animalske legeme; anvendelsen derav for behandling av en sykdom, spesielt en sykdom forårsaket ved okular neovaskularisering, så som aldersrelatert makular degenerering eller diabetisk retinopati, eller andre sykdommer som viser respons på inhiberingen av tyrosinkinaser, så som en proliferativ sykdom; en fremgangsmåte for behandling av slik sykdom i pattedyr; og anvendelsen av en slik forbindelse for fremstilling av et farmasøytisk preparat for behandling spesielt av en sykdom som nevnt ovenfor.
NO20052893A 1999-03-30 2005-06-14 Ftalazinderivater for behandling av inflammatoriske sykdommer NO20052893D0 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH60399 1999-03-30
GBGB9916064.0A GB9916064D0 (en) 1999-07-08 1999-07-08 Organic compounds
EP0002767 2000-03-28

Publications (2)

Publication Number Publication Date
NO20052893L true NO20052893L (no) 2001-10-19
NO20052893D0 NO20052893D0 (no) 2005-06-14

Family

ID=25685089

Family Applications (3)

Application Number Title Priority Date Filing Date
NO20014655A NO320849B1 (no) 1999-03-30 2001-09-25 Anvendelse av ftalazinderivat for fremstilling av et farmasoytisk preparat
NO20052893A NO20052893D0 (no) 1999-03-30 2005-06-14 Ftalazinderivater for behandling av inflammatoriske sykdommer
NO20054048A NO20054048L (no) 1999-03-30 2005-08-31 Ftalazinderivater for behandling av inflammatoriske sykdommer

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO20014655A NO320849B1 (no) 1999-03-30 2001-09-25 Anvendelse av ftalazinderivat for fremstilling av et farmasoytisk preparat

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20054048A NO20054048L (no) 1999-03-30 2005-08-31 Ftalazinderivater for behandling av inflammatoriske sykdommer

Country Status (13)

Country Link
US (4) US6686347B2 (no)
EP (1) EP1165085B1 (no)
JP (1) JP4673977B2 (no)
CN (2) CN1221262C (no)
AT (1) ATE329596T1 (no)
AU (1) AU766081B2 (no)
BR (1) BR0009507A (no)
CA (1) CA2366857C (no)
DE (1) DE60028740T2 (no)
ES (1) ES2265929T3 (no)
NO (3) NO320849B1 (no)
PT (1) PT1165085E (no)
WO (1) WO2000059509A1 (no)

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