ATE365550T1 - Verwendung von einem protein kinase hemmer wie z.b. genistein bei der behandlung von diabetischer retinopathie - Google Patents

Verwendung von einem protein kinase hemmer wie z.b. genistein bei der behandlung von diabetischer retinopathie

Info

Publication number
ATE365550T1
ATE365550T1 AT99911365T AT99911365T ATE365550T1 AT E365550 T1 ATE365550 T1 AT E365550T1 AT 99911365 T AT99911365 T AT 99911365T AT 99911365 T AT99911365 T AT 99911365T AT E365550 T1 ATE365550 T1 AT E365550T1
Authority
AT
Austria
Prior art keywords
diabetic retinopathy
genistein
treatment
protein kinase
kinase inhibitor
Prior art date
Application number
AT99911365T
Other languages
English (en)
Inventor
Juan Jr Eugene De
Original Assignee
Univ Johns Hopkins Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09041931 external-priority patent/US5919813C1/en
Priority claimed from US09/042,440 external-priority patent/US5980929A/en
Application filed by Univ Johns Hopkins Med filed Critical Univ Johns Hopkins Med
Application granted granted Critical
Publication of ATE365550T1 publication Critical patent/ATE365550T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
AT99911365T 1998-03-13 1999-03-12 Verwendung von einem protein kinase hemmer wie z.b. genistein bei der behandlung von diabetischer retinopathie ATE365550T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09041931 US5919813C1 (en) 1998-03-13 1998-03-13 Use of a protein tyrosine kinase pathway inhibitor in the treatment of diabetic retinopathy
US09/042,440 US5980929A (en) 1998-03-13 1998-03-13 Use of a protein tyrosine kinase pathway inhibitor in the treatment of retinal ischmemia or ocular inflammation

Publications (1)

Publication Number Publication Date
ATE365550T1 true ATE365550T1 (de) 2007-07-15

Family

ID=26718704

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99911365T ATE365550T1 (de) 1998-03-13 1999-03-12 Verwendung von einem protein kinase hemmer wie z.b. genistein bei der behandlung von diabetischer retinopathie

Country Status (7)

Country Link
EP (2) EP1806135A3 (de)
JP (2) JP2002506028A (de)
AT (1) ATE365550T1 (de)
AU (1) AU756515B2 (de)
CA (1) CA2321560C (de)
DE (1) DE69936381T2 (de)
WO (1) WO1999045920A2 (de)

Families Citing this family (26)

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Publication number Priority date Publication date Assignee Title
KR100698449B1 (ko) * 1998-11-23 2007-03-23 노파르티스 아게 안구 혈관신생 질환 치료용 스타우로스포린 유도체의 용도
US6399107B1 (en) 1998-12-22 2002-06-04 Alcon Laboratories, Inc. Use of inhibitors of gag synthesis for the treatment of corneal haze
US6670321B1 (en) 1998-12-30 2003-12-30 The Children's Medical Center Corporation Prevention and treatment for retinal ischemia and edema
JP4920134B2 (ja) * 1999-05-07 2012-04-18 ジョンズ ホプキンス ユニヴァーシティ スクール オヴ メディシン 眼障害の処置におけるプロテインチロシンキナーゼ経路インヒビターの使用
US7943162B2 (en) 1999-10-21 2011-05-17 Alcon, Inc. Drug delivery device
KR100732262B1 (ko) 1999-10-21 2007-06-25 알콘, 인코퍼레이티드 약물 전달 장치
AU775149B2 (en) 1999-10-21 2004-07-22 Alcon Inc. Sub-tenon drug delivery
US6416777B1 (en) 1999-10-21 2002-07-09 Alcon Universal Ltd. Ophthalmic drug delivery device
EP1223950B1 (de) * 1999-10-26 2006-01-04 Immusol, Inc. Ribozym-therapie zur behandlung von proliferativen augenkranheiten
MXPA03011609A (es) 2001-07-23 2004-07-01 Alcon Inc Dispositivo de entrega de droga oftalmica.
CN100349562C (zh) 2001-07-23 2007-11-21 爱尔康公司 眼部药物输送装置
AU2002359635A1 (en) * 2001-12-05 2003-06-17 Mitokor, Inc. Use of polycyclic phenolic compounds for the treatment of opthalmic diseases
GB0302882D0 (en) * 2003-02-07 2003-03-12 Univ Cardiff Improvements in or relating to agents for the treatment of cardiovascular dysfunction and weight loss
US7642061B2 (en) 2003-05-02 2010-01-05 Centre National De La Recherche Scientifique Glut-1 as a receptor for HTLV envelopes and its uses
US9777044B2 (en) 2003-05-02 2017-10-03 Centre National De La Recherche Scientifique (Cnrs) GLUT-1 as a receptor for HTLV envelopes and its uses
US7771742B2 (en) * 2004-04-30 2010-08-10 Allergan, Inc. Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods
US20050261197A1 (en) * 2004-05-19 2005-11-24 Henry Aoki Coffee bean extract, method of extraction and composition containing the same
BRPI0608152A2 (pt) 2005-02-09 2009-11-10 Macusight Inc formulações para tratamento ocular
KR20140093764A (ko) 2006-02-09 2014-07-28 산텐 세이야꾸 가부시키가이샤 안정한 제제와 그 제조 및 사용 방법
CN103127100A (zh) 2006-03-23 2013-06-05 参天制药株式会社 用于与血管通透性有关的疾病或病症的制剂和方法
US20080181972A1 (en) * 2007-01-29 2008-07-31 Valentina Amico Compositions and Methods for Maintaining, Strengthening, Improving, or Promoting Eye Health
US9482677B2 (en) * 2008-02-27 2016-11-01 Scios Inc. Method, composition and device for sampling natriuretic peptides in a biological fluid
CA2749183C (en) 2009-01-09 2017-11-28 Marc Sitbon New receptor binding ligands, their use in the detection of cells with biological interest
US8372036B2 (en) 2009-05-06 2013-02-12 Alcon Research, Ltd. Multi-layer heat assembly for a drug delivery device
US8177747B2 (en) 2009-12-22 2012-05-15 Alcon Research, Ltd. Method and apparatus for drug delivery
CN105343869A (zh) * 2012-02-22 2016-02-24 康德生物医疗技术公司 用于预防或治疗眼科病状的方法和组合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE114661T1 (de) * 1990-04-02 1994-12-15 Pfizer Benzylphosphonsäure-tyrosinkinaseinhibitoren.
JPH08503450A (ja) * 1992-08-06 1996-04-16 ワーナー−ランバート・コンパニー 蛋白チロシンキナーゼを阻害し、かつ抗腫瘍特性を有する２−チオインドール（セレノインドール）および関連ジスルフィド（セレニド）
US5593997A (en) * 1995-05-23 1997-01-14 Pfizer Inc. 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors
US5710173A (en) * 1995-06-07 1998-01-20 Sugen, Inc. Thienyl compounds for inhibition of cell proliferative disorders
US5834513A (en) * 1996-04-25 1998-11-10 Avon Products, Inc. Oxa diacids and related compounds for treating skin conditions

Also Published As

Publication number Publication date
EP1806135A2 (de) 2007-07-11
CA2321560A1 (en) 1999-09-16
WO1999045920A3 (en) 1999-10-21
AU756515B2 (en) 2003-01-16
DE69936381T2 (de) 2007-10-31
JP2010168389A (ja) 2010-08-05
CA2321560C (en) 2007-05-22
EP1806135A3 (de) 2010-11-24
AU3001999A (en) 1999-09-27
JP2002506028A (ja) 2002-02-26
WO1999045920A2 (en) 1999-09-16
DE69936381D1 (de) 2007-08-09
EP1061913B1 (de) 2007-06-27
EP1061913A2 (de) 2000-12-27

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