ATE453646T1 - 3-substituierte n-(aryl- oder heteroaryl)pyrazoä1,5-aüpyrimidine als kinaseinhibitoren - Google Patents
3-substituierte n-(aryl- oder heteroaryl)pyrazoä1,5-aüpyrimidine als kinaseinhibitorenInfo
- Publication number
- ATE453646T1 ATE453646T1 AT07723895T AT07723895T ATE453646T1 AT E453646 T1 ATE453646 T1 AT E453646T1 AT 07723895 T AT07723895 T AT 07723895T AT 07723895 T AT07723895 T AT 07723895T AT E453646 T1 ATE453646 T1 AT E453646T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- heteroaryl
- aryl
- substituted
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0606805.0A GB0606805D0 (en) | 2006-04-04 | 2006-04-04 | Organic compounds |
PCT/EP2007/002954 WO2007113000A1 (en) | 2006-04-04 | 2007-04-02 | 3-SUBSTITUTED N-(ARYL- OR HETEROARYL)-PYRAZO[1,5-a]PYRIMIDINES AS KINASE INHIBITORS |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE453646T1 true ATE453646T1 (de) | 2010-01-15 |
Family
ID=36539336
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT07723895T ATE453646T1 (de) | 2006-04-04 | 2007-04-02 | 3-substituierte n-(aryl- oder heteroaryl)pyrazoä1,5-aüpyrimidine als kinaseinhibitoren |
Country Status (16)
Country | Link |
---|---|
US (1) | US20090275593A1 (de) |
EP (1) | EP2004653B1 (de) |
JP (1) | JP2009532401A (de) |
KR (1) | KR20090024110A (de) |
CN (1) | CN101460500A (de) |
AT (1) | ATE453646T1 (de) |
AU (1) | AU2007233928A1 (de) |
BR (1) | BRPI0710293A2 (de) |
CA (1) | CA2646166A1 (de) |
DE (1) | DE602007004093D1 (de) |
ES (1) | ES2339174T3 (de) |
GB (1) | GB0606805D0 (de) |
MX (1) | MX2008012820A (de) |
PL (1) | PL2004653T3 (de) |
PT (1) | PT2004653E (de) |
WO (1) | WO2007113000A1 (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010033941A1 (en) | 2008-09-22 | 2010-03-25 | Array Biopharma Inc. | Substituted imidazo[1,2b]pyridazine compounds as trk kinase inhibitors |
UY32192A (es) | 2008-10-22 | 2011-05-31 | Array Biopharma Inc | COMPUESTOS PIRAZOLO[1,5-a]PIRIMIDINA SUSTITUIDA COMO INHIBIDORES DE TRK CINASA |
AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
HUE035337T2 (en) | 2010-05-20 | 2018-05-02 | Array Biopharma Inc | Macrocyclic compounds as TRK kinase inhibitors |
WO2014081996A1 (en) * | 2012-11-23 | 2014-05-30 | Glaxosmithkline Llc | Novel compounds as diacylglycerol acyltransferase inhibitors |
KR102649887B1 (ko) | 2014-11-16 | 2024-03-22 | 어레이 바이오파마 인크. | (s)-n-(5-((r)-2-(2,5-디플루오로페닐)-피롤리딘-1-일)-피라졸로[1,5-a]피리미딘-3-일)-3-히드록시피롤리딘-1-카르복스아미드 히드로겐 술페이트의 결정질 형태 |
TN2018000138A1 (en) | 2015-10-26 | 2019-10-04 | Array Biopharma Inc | Point mutations in trk inhibitor-resistant cancer and methods relating to the same |
MX2018012163A (es) | 2016-04-04 | 2019-07-08 | Loxo Oncology Inc | Formulaciones liquidas de (s)-n-(5-((r)-2-(2,5-difluorofenil)-pirr olidin-1-il)-pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidina- 1-carboxamida. |
US10045991B2 (en) | 2016-04-04 | 2018-08-14 | Loxo Oncology, Inc. | Methods of treating pediatric cancers |
JP7443057B2 (ja) | 2016-05-18 | 2024-03-05 | ロクソ オンコロジー, インコーポレイテッド | (S)-N-(5-((R)-2-(2,5-ジフルオロフェニル)ピロリジン-1-イル)-ピラゾロ[1,5-a]ピリミジン-3-イル)-3-ヒドロキシピロリジン-1-カルボキサミドの調製 |
JOP20190092A1 (ar) | 2016-10-26 | 2019-04-25 | Array Biopharma Inc | عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها |
JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
CA3121202A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
CN114751910B (zh) * | 2022-05-17 | 2023-02-24 | 重庆文理学院 | 一种可诱导细胞巨泡式死亡的化合物及其制备方法和应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR049769A1 (es) * | 2004-01-22 | 2006-09-06 | Novartis Ag | Derivados de pirazolo(1,5-a)pirimidin 7-il-amina para utilizarse en el tratamiento de enfermedades dependientes de la quinasa de proteina |
GB0515026D0 (en) * | 2005-07-21 | 2005-08-31 | Novartis Ag | Organic compounds |
-
2006
- 2006-04-04 GB GBGB0606805.0A patent/GB0606805D0/en not_active Ceased
-
2007
- 2007-04-02 PT PT07723895T patent/PT2004653E/pt unknown
- 2007-04-02 PL PL07723895T patent/PL2004653T3/pl unknown
- 2007-04-02 BR BRPI0710293-3A patent/BRPI0710293A2/pt not_active IP Right Cessation
- 2007-04-02 DE DE602007004093T patent/DE602007004093D1/de not_active Expired - Fee Related
- 2007-04-02 EP EP07723895A patent/EP2004653B1/de active Active
- 2007-04-02 KR KR1020087026941A patent/KR20090024110A/ko not_active Application Discontinuation
- 2007-04-02 JP JP2009503472A patent/JP2009532401A/ja active Pending
- 2007-04-02 MX MX2008012820A patent/MX2008012820A/es not_active Application Discontinuation
- 2007-04-02 WO PCT/EP2007/002954 patent/WO2007113000A1/en active Application Filing
- 2007-04-02 CA CA002646166A patent/CA2646166A1/en not_active Abandoned
- 2007-04-02 CN CNA2007800206411A patent/CN101460500A/zh active Pending
- 2007-04-02 ES ES07723895T patent/ES2339174T3/es active Active
- 2007-04-02 US US12/296,154 patent/US20090275593A1/en not_active Abandoned
- 2007-04-02 AT AT07723895T patent/ATE453646T1/de active
- 2007-04-02 AU AU2007233928A patent/AU2007233928A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
KR20090024110A (ko) | 2009-03-06 |
CA2646166A1 (en) | 2007-10-11 |
PL2004653T3 (pl) | 2010-06-30 |
AU2007233928A1 (en) | 2007-10-11 |
US20090275593A1 (en) | 2009-11-05 |
PT2004653E (pt) | 2010-03-31 |
EP2004653A1 (de) | 2008-12-24 |
MX2008012820A (es) | 2008-10-15 |
DE602007004093D1 (de) | 2010-02-11 |
JP2009532401A (ja) | 2009-09-10 |
BRPI0710293A2 (pt) | 2011-08-09 |
ES2339174T3 (es) | 2010-05-17 |
GB0606805D0 (en) | 2006-05-17 |
CN101460500A (zh) | 2009-06-17 |
EP2004653B1 (de) | 2009-12-30 |
WO2007113000A1 (en) | 2007-10-11 |
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