EA201070841A1 - НОВЫЕ ПИРАЗОЛО[3,4-d]ПИРИМИДИНОВЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ПРОТИВОРАКОВЫХ ЛЕКАРСТВЕННЫХ СРЕДСТВ - Google Patents

НОВЫЕ ПИРАЗОЛО[3,4-d]ПИРИМИДИНОВЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ПРОТИВОРАКОВЫХ ЛЕКАРСТВЕННЫХ СРЕДСТВ

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Publication number
EA201070841A1
EA201070841A1 EA201070841A EA201070841A EA201070841A1 EA 201070841 A1 EA201070841 A1 EA 201070841A1 EA 201070841 A EA201070841 A EA 201070841A EA 201070841 A EA201070841 A EA 201070841A EA 201070841 A1 EA201070841 A1 EA 201070841A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyrimidine derivatives
treatment medicines
new pyrazolo
humans
relates
Prior art date
Application number
EA201070841A
Other languages
English (en)
Inventor
Дурга Прасад Конаканчи
Субба Рао Пула
Лакшми Анантханени
Рамакришна Пилли
Муддасани Пулла Редди
Бхуджанга Рао Адибхатла Кали Сатиа
Наннапанени Венкайах Човдари
Original Assignee
Натко Фарма Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Натко Фарма Лимитед filed Critical Натко Фарма Лимитед
Publication of EA201070841A1 publication Critical patent/EA201070841A1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Изобретение относится к замещенным пиразоло[3,4-d]пиримидиновым производным формулы I или их фармацевтически приемлемым солям, которые обладают антипролиферативной активностью, такой как противораковая активность, и таким образом полезны при лечении человека или животного. Изобретение также относится к способам получения замещенных пиразоло[3,4-d]пиримидиновых производных, к фармацевтическим композициям, содержащим эти соединения, и их применению в производстве лекарственных средств для обеспечения антипролиферативного эффекта у теплокровного животного, такого как человек.
EA201070841A 2008-01-11 2009-01-12 НОВЫЕ ПИРАЗОЛО[3,4-d]ПИРИМИДИНОВЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ПРОТИВОРАКОВЫХ ЛЕКАРСТВЕННЫХ СРЕДСТВ EA201070841A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN109CH2008 2008-01-11
PCT/IN2009/000037 WO2009098715A2 (en) 2008-01-11 2009-01-12 Novel pyrazolo [3, 4 -d] pyrimidine derivatives as anti -cancer agents

Publications (1)

Publication Number Publication Date
EA201070841A1 true EA201070841A1 (ru) 2011-02-28

Family

ID=40933862

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201070841A EA201070841A1 (ru) 2008-01-11 2009-01-12 НОВЫЕ ПИРАЗОЛО[3,4-d]ПИРИМИДИНОВЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ПРОТИВОРАКОВЫХ ЛЕКАРСТВЕННЫХ СРЕДСТВ

Country Status (18)

Country Link
US (1) US8349847B2 (ru)
EP (1) EP2247596A2 (ru)
JP (1) JP2011509290A (ru)
KR (1) KR20100116607A (ru)
CN (1) CN101965350A (ru)
AP (1) AP2010005347A0 (ru)
AU (1) AU2009211004C1 (ru)
BR (1) BRPI0906475A2 (ru)
CA (1) CA2711777A1 (ru)
CO (1) CO6382174A2 (ru)
EA (1) EA201070841A1 (ru)
GE (1) GEP20135780B (ru)
IL (1) IL206811A0 (ru)
MA (1) MA32009B1 (ru)
MX (1) MX2010007523A (ru)
NZ (1) NZ586642A (ru)
WO (1) WO2009098715A2 (ru)
ZA (1) ZA201004823B (ru)

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US8759359B2 (en) * 2009-12-18 2014-06-24 Incyte Corporation Substituted heteroaryl fused derivatives as PI3K inhibitors
AR079529A1 (es) * 2009-12-18 2012-02-01 Incyte Corp Derivados arilo y heteroarilo sustituidos y fundidos como inhibidores de la pi3k
AR081823A1 (es) 2010-04-14 2012-10-24 Incyte Corp DERIVADOS FUSIONADOS COMO INHIBIDORES DE PI3Kd
WO2011163195A1 (en) 2010-06-21 2011-12-29 Incyte Corporation Fused pyrrole derivatives as pi3k inhibitors
CA2822070C (en) 2010-12-20 2019-09-17 Incyte Corporation N-(1-(substituted-phenyl)ethyl)-9h-purin-6-amines as pi3k inhibitors
WO2012125629A1 (en) 2011-03-14 2012-09-20 Incyte Corporation Substituted diamino-pyrimidine and diamino-pyridine derivatives as pi3k inhibitors
WO2012135009A1 (en) 2011-03-25 2012-10-04 Incyte Corporation Pyrimidine-4,6-diamine derivatives as pi3k inhibitors
DK2751109T3 (en) 2011-09-02 2017-01-23 Incyte Holdings Corp HETEROCYCLYLAMINES AS PI3K INHIBITORS
AR090548A1 (es) 2012-04-02 2014-11-19 Incyte Corp Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
CN102746309B (zh) * 2012-07-09 2013-06-05 四川大学 1-N-乙基-4-N-2′-取代酰基肼-1H-吡唑[3,4-d]嘧啶类衍生物及其制备方法和用途
CN102746307B (zh) * 2012-07-09 2013-07-31 四川大学 1-n-苄基别嘌醇衍生物及其制备方法和用途
CN103965202B (zh) * 2014-05-21 2016-01-20 邹宏丽 二环稠合杂环化合物、其制备方法及用途
US10077277B2 (en) 2014-06-11 2018-09-18 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors
TWI748941B (zh) 2015-02-27 2021-12-11 美商英塞特公司 Ｐｉ３ｋ抑制劑之鹽及製備方法
US9988401B2 (en) 2015-05-11 2018-06-05 Incyte Corporation Crystalline forms of a PI3K inhibitor
WO2016183060A1 (en) 2015-05-11 2016-11-17 Incyte Corporation Process for the synthesis of a phosphoinositide 3-kinase inhibitor
CN106008527B (zh) * 2016-06-29 2018-05-15 四川大学华西医院 吡唑并[3,4-d]嘧啶衍生物
CN107698596A (zh) * 2017-11-15 2018-02-16 双鹤药业（商丘）有限责任公司 一种别嘌醇的合成方法
CN115304607B (zh) * 2022-07-06 2023-06-27 华南农业大学 吡唑并嘧啶衍生物的制备方法

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Also Published As

Publication number Publication date
CO6382174A2 (es) 2012-02-15
WO2009098715A4 (en) 2009-12-10
WO2009098715A3 (en) 2009-10-15
JP2011509290A (ja) 2011-03-24
NZ586642A (en) 2012-04-27
US20100298351A1 (en) 2010-11-25
US8349847B2 (en) 2013-01-08
CN101965350A (zh) 2011-02-02
AU2009211004A1 (en) 2009-08-13
AU2009211004A2 (en) 2011-01-27
WO2009098715A2 (en) 2009-08-13
CA2711777A1 (en) 2009-08-13
EP2247596A2 (en) 2010-11-10
IL206811A0 (en) 2010-12-30
KR20100116607A (ko) 2010-11-01
GEP20135780B (en) 2013-03-11
AU2009211004B2 (en) 2011-09-01
MA32009B1 (fr) 2011-01-03
AP2010005347A0 (en) 2010-08-31
ZA201004823B (en) 2011-09-28
BRPI0906475A2 (pt) 2015-07-14
AU2009211004C1 (en) 2013-08-01
MX2010007523A (es) 2010-08-18

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