CO6382174A2 - Nuevos derivados de pirazolo[3,4-d]pirimidina como farmacos anticancer. - Google Patents
Nuevos derivados de pirazolo[3,4-d]pirimidina como farmacos anticancer.Info
- Publication number
- CO6382174A2 CO6382174A2 CO10098749A CO10098749A CO6382174A2 CO 6382174 A2 CO6382174 A2 CO 6382174A2 CO 10098749 A CO10098749 A CO 10098749A CO 10098749 A CO10098749 A CO 10098749A CO 6382174 A2 CO6382174 A2 CO 6382174A2
- Authority
- CO
- Colombia
- Prior art keywords
- trifluoromethyl
- heterocyclyl
- aryl
- alkylamino
- independently selected
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1.- Derivados de pirazolo[3,4-d]pirimidina sustituida de la fórmula I,y sales farmacéuticamente aceptables de los mismos, caracterizados porque n y m son 1, 2 ó 3; W es un enlace individual, alquenilo, alquinilo, NH, S, SO,SO2, O, C=O, o un grupo amida:cada R1 se selecciona independientemente de hidrógeno, halo, hidroxi, amino, hidroxiamino, carboxi, nitro, guanidino, ureido, carbamoilo, ciano y trifluorometilo,o cada R1 se selecciona independientemente del grupo que consiste de C3-C6cicloalquilo, C1-C6alcoxi, C3-C6cicloalcoxi, (C1-C6)alcoxicarbonilo, ariloxi, heteroariloxi, C1-C6tioalcoxi, C3-C6tiocicloalcoxi, tioariloxi, tioheteroariloxi, nitro, amino, N-mono(C1-C6)alquilamino, N,N-di(C1-C6)alquilamino, formamido, amido, acetamido, hidroxilamino, C1-C6alcoxiamino, hidrazino, trifluorometilo, trifluorometoxi, C2-C6alquenilo, C2-C6alquinilo, arilo, heterociclilo, arilo fusionado, heteroarilo fusionado y heterociclilo fusionado; o cada R1 se selecciona independientemente de R3-sulfonilamino, ftalimido- (C1-C4)-alquilsulfonilamino, benzamido, bencenosulfonilamino, 3-fenilureido, 2-oxopirrolidin-1-ilo, 2,5-dioxopirrolidin-1-ilo, y C2-C4alcanoilamino, y en donde el sustituyente bencenosulfonilamino o fenilo o fenoxi o anilino o fenilsulfanilo en R1 puede tener opcionalmente uno o dos halógenos, (C1-C4)alquilo, ciano, metanosulfonilo o sustituyentes (C1-C4)alcoxi, o cualquiera de dos R1 tomados conjuntamente con los carbonos a los cuales están unidos comprende un anillo de 5-8 miembros que comprende al menos uno o dos heteroátomos seleccionados de oxígeno, azufre y nitrógeno; en donde los grupos alquilo y porciones alquilo de los grupos alcoxi o alquilamino en R1 pueden ser de cadena recta o si comprenden al menos tres carbonos pueden estar ramificados o ser cíclicos y en donde R3 se selecciona de C1-C6alquilo y C3-C6cicloalquilo;R2 se selecciona del grupo que consiste de hidrógeno, C1-C6alquilo, C3-C6cicloalquilo, C1-C6alcoxicarbonilo, arilo, heteroarilo, C1-C6tioalquilo, trifluorometilo, trifluorometoxi, heterociclilo, ...
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN109CH2008 | 2008-01-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6382174A2 true CO6382174A2 (es) | 2012-02-15 |
Family
ID=40933862
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO10098749A CO6382174A2 (es) | 2008-01-11 | 2010-08-11 | Nuevos derivados de pirazolo[3,4-d]pirimidina como farmacos anticancer. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8349847B2 (es) |
| EP (1) | EP2247596A2 (es) |
| JP (1) | JP2011509290A (es) |
| KR (1) | KR20100116607A (es) |
| CN (1) | CN101965350A (es) |
| AP (1) | AP2010005347A0 (es) |
| AU (1) | AU2009211004C1 (es) |
| BR (1) | BRPI0906475A2 (es) |
| CA (1) | CA2711777A1 (es) |
| CO (1) | CO6382174A2 (es) |
| EA (1) | EA201070841A1 (es) |
| GE (1) | GEP20135780B (es) |
| IL (1) | IL206811A0 (es) |
| MA (1) | MA32009B1 (es) |
| MX (1) | MX2010007523A (es) |
| NZ (1) | NZ586642A (es) |
| WO (1) | WO2009098715A2 (es) |
| ZA (1) | ZA201004823B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2448938T1 (sl) | 2009-06-29 | 2014-08-29 | Incyte Corporation Experimental Station | Pirimidinoni kot zaviralci pi3k |
| TW201130842A (en) * | 2009-12-18 | 2011-09-16 | Incyte Corp | Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors |
| WO2011075643A1 (en) * | 2009-12-18 | 2011-06-23 | Incyte Corporation | Substituted heteroaryl fused derivatives as pi3k inhibitors |
| US9193721B2 (en) | 2010-04-14 | 2015-11-24 | Incyte Holdings Corporation | Fused derivatives as PI3Kδ inhibitors |
| US9062055B2 (en) | 2010-06-21 | 2015-06-23 | Incyte Corporation | Fused pyrrole derivatives as PI3K inhibitors |
| ES2764848T3 (es) | 2010-12-20 | 2020-06-04 | Incyte Holdings Corp | N-(1-(fenilo sustituido)etilo)-9H-purina-6-aminas como inhibidores de PI3K |
| US9108984B2 (en) | 2011-03-14 | 2015-08-18 | Incyte Corporation | Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors |
| WO2012135009A1 (en) | 2011-03-25 | 2012-10-04 | Incyte Corporation | Pyrimidine-4,6-diamine derivatives as pi3k inhibitors |
| HUE030869T2 (en) | 2011-09-02 | 2017-06-28 | Incyte Holdings Corp | Heterocyclic amines as inhibitors of PI3K |
| AR090548A1 (es) | 2012-04-02 | 2014-11-19 | Incyte Corp | Azaheterociclobencilaminas biciclicas como inhibidores de pi3k |
| CN102746309B (zh) * | 2012-07-09 | 2013-06-05 | 四川大学 | 1-N-乙基-4-N-2′-取代酰基肼-1H-吡唑[3,4-d]嘧啶类衍生物及其制备方法和用途 |
| CN102746307B (zh) * | 2012-07-09 | 2013-07-31 | 四川大学 | 1-n-苄基别嘌醇衍生物及其制备方法和用途 |
| CN103965202B (zh) * | 2014-05-21 | 2016-01-20 | 邹宏丽 | 二环稠合杂环化合物、其制备方法及用途 |
| WO2015191677A1 (en) | 2014-06-11 | 2015-12-17 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors |
| TWI748941B (zh) | 2015-02-27 | 2021-12-11 | 美商英塞特公司 | Ｐｉ３ｋ抑制劑之鹽及製備方法 |
| WO2016183060A1 (en) | 2015-05-11 | 2016-11-17 | Incyte Corporation | Process for the synthesis of a phosphoinositide 3-kinase inhibitor |
| WO2016183063A1 (en) | 2015-05-11 | 2016-11-17 | Incyte Corporation | Crystalline forms of a pi3k inhibitor |
| CN106008527B (zh) * | 2016-06-29 | 2018-05-15 | 四川大学华西医院 | 吡唑并[3,4-d]嘧啶衍生物 |
| CN107698596A (zh) * | 2017-11-15 | 2018-02-16 | 双鹤药业（商丘）有限责任公司 | 一种别嘌醇的合成方法 |
| CN115304607B (zh) * | 2022-07-06 | 2023-06-27 | 华南农业大学 | 吡唑并嘧啶衍生物的制备方法 |
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| US3000688A (en) | 1961-09-19 | Process for vatting of vat dyestuffs | ||
| US3551428A (en) | 1956-02-10 | 1970-12-29 | Ciba Geigy Corp | New 1- (or 2-) substituted 4-mercapto-pyrazolo(3,4-d)pyrimidines |
| JPS5439096A (en) | 1977-08-27 | 1979-03-24 | Lion Dentifrice Co Ltd | 11phenyll1hhpyrazolo*3*44d*pyrimidinee44 carbonitrile |
| US5877178A (en) | 1991-04-08 | 1999-03-02 | Duquesne University Of The Holy Ghost | Pyrimidine derivatives and methods of making and using these derivatives |
| US5958930A (en) | 1991-04-08 | 1999-09-28 | Duquesne University Of The Holy Ghost | Pyrrolo pyrimidine and furo pyrimidine derivatives |
| US5593997A (en) * | 1995-05-23 | 1997-01-14 | Pfizer Inc. | 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors |
| CA2224435C (en) | 1995-07-06 | 2008-08-05 | Novartis Ag | Pyrrolopyrimidines and processes for the preparation thereof |
| WO1997027199A1 (en) | 1996-01-23 | 1997-07-31 | Novartis Ag | Pyrrolopyrimidines and processes for their preparation |
| CH690773A5 (de) | 1996-02-01 | 2001-01-15 | Novartis Ag | Pyrrolo(2,3-d)pyrimide und ihre Verwendung. |
| US6537999B2 (en) | 1996-06-06 | 2003-03-25 | Duquesne University Of The Holy Ghost | Pyrimidine derivatives and methods of making and using these derivatives |
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| DE19709488A1 (de) | 1997-03-07 | 1998-09-10 | Basf Ag | Verfahren zur N-Alkylierung von Aminen |
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| ITMI992711A1 (it) | 1999-12-27 | 2001-06-27 | Novartis Ag | Composti organici |
| AU2000240570A1 (en) | 2000-03-29 | 2001-10-08 | Knoll Gesellschaft Mit Beschraenkter Haftung | Pyrrolopyrimidines as tyrosine kinase inhibitors |
| US6680324B2 (en) | 2000-12-01 | 2004-01-20 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptors and uses thereof |
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| PL363245A1 (en) | 2000-12-01 | 2004-11-15 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine a1 |
| DE10060388A1 (de) * | 2000-12-05 | 2002-06-06 | Merck Patent Gmbh | Verwendung von Pyrazolo [4,3-d]pyrimidinen |
| AR035885A1 (es) | 2001-05-14 | 2004-07-21 | Novartis Ag | Derivados de 4-amino-5-fenil-7-ciclobutilpirrolo (2,3-d)pirimidina, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos derivados para la preparacion de una composicion farmaceutica |
| US20030114467A1 (en) | 2001-06-21 | 2003-06-19 | Shakespeare William C. | Novel pyrazolo- and pyrrolo-pyrimidines and uses thereof |
| GB0115393D0 (en) | 2001-06-23 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
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| KR20050067383A (ko) | 2002-08-06 | 2005-07-01 | 아스트라제네카 아베 | Ｔｉｅ2(ｔｅｋ) 활성을 갖는 축합 피리딘 및 피리미딘 |
| US20040138238A1 (en) | 2002-08-08 | 2004-07-15 | Dhanoa Dale S. | Substituted aminopyrimidine compounds as neurokinin antagonists |
-
2009
- 2009-01-12 CN CN2009801083051A patent/CN101965350A/zh active Pending
- 2009-01-12 WO PCT/IN2009/000037 patent/WO2009098715A2/en active Application Filing
- 2009-01-12 KR KR1020107017777A patent/KR20100116607A/ko not_active Application Discontinuation
- 2009-01-12 EP EP09761144A patent/EP2247596A2/en not_active Withdrawn
- 2009-01-12 JP JP2010541891A patent/JP2011509290A/ja active Pending
- 2009-01-12 NZ NZ586642A patent/NZ586642A/en not_active IP Right Cessation
- 2009-01-12 AU AU2009211004A patent/AU2009211004C1/en not_active Ceased
- 2009-01-12 CA CA2711777A patent/CA2711777A1/en not_active Abandoned
- 2009-01-12 GE GEAP200911914A patent/GEP20135780B/en unknown
- 2009-01-12 EA EA201070841A patent/EA201070841A1/ru unknown
- 2009-01-12 BR BRPI0906475-3A patent/BRPI0906475A2/pt not_active IP Right Cessation
- 2009-01-12 US US12/812,405 patent/US8349847B2/en not_active Expired - Fee Related
- 2009-01-12 AP AP2010005347A patent/AP2010005347A0/en unknown
- 2009-01-12 MX MX2010007523A patent/MX2010007523A/es not_active Application Discontinuation
-
2010
- 2010-07-05 IL IL206811A patent/IL206811A0/en unknown
- 2010-07-08 ZA ZA2010/04823A patent/ZA201004823B/en unknown
- 2010-07-09 MA MA33007A patent/MA32009B1/fr unknown
- 2010-08-11 CO CO10098749A patent/CO6382174A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EA201070841A1 (ru) | 2011-02-28 |
| KR20100116607A (ko) | 2010-11-01 |
| IL206811A0 (en) | 2010-12-30 |
| US20100298351A1 (en) | 2010-11-25 |
| MX2010007523A (es) | 2010-08-18 |
| GEP20135780B (en) | 2013-03-11 |
| CN101965350A (zh) | 2011-02-02 |
| WO2009098715A3 (en) | 2009-10-15 |
| JP2011509290A (ja) | 2011-03-24 |
| AU2009211004A1 (en) | 2009-08-13 |
| AU2009211004C1 (en) | 2013-08-01 |
| WO2009098715A2 (en) | 2009-08-13 |
| CA2711777A1 (en) | 2009-08-13 |
| US8349847B2 (en) | 2013-01-08 |
| EP2247596A2 (en) | 2010-11-10 |
| AU2009211004B2 (en) | 2011-09-01 |
| WO2009098715A4 (en) | 2009-12-10 |
| MA32009B1 (fr) | 2011-01-03 |
| ZA201004823B (en) | 2011-09-28 |
| BRPI0906475A2 (pt) | 2015-07-14 |
| AU2009211004A2 (en) | 2011-01-27 |
| NZ586642A (en) | 2012-04-27 |
| AP2010005347A0 (en) | 2010-08-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Application granted | ||
| FD | Application lapsed |