MA32009B1 - Nouveaux derives de pyrazolo [3,4-d]pyrimidine en tant qu'agents anticancereux - Google Patents
Nouveaux derives de pyrazolo [3,4-d]pyrimidine en tant qu'agents anticancereuxInfo
- Publication number
- MA32009B1 MA32009B1 MA33007A MA33007A MA32009B1 MA 32009 B1 MA32009 B1 MA 32009B1 MA 33007 A MA33007 A MA 33007A MA 33007 A MA33007 A MA 33007A MA 32009 B1 MA32009 B1 MA 32009B1
- Authority
- MA
- Morocco
- Prior art keywords
- pyrazolo
- pyrimidine
- anticancer agents
- novel derivatives
- human
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention concerne des dérivés substitutes de pyrazolo [3,4-d] pyrimidine de formule (i), ou leurs sels pharmaceutiquement acceptables, qui possèdent une activité anti-proliférante telle qu'une activité anticancéreuse et sont donc utiles dans des procédés de traitement de l'organisme humain ou animal. L'invention concerne également des procédés de fabrication de dérivés substitués de pyrazolo [3,4-d] pyrimidine, des compositions pharmaceutiques contenant le composé et son utilisation dans la fabrication de médicaments pour la production d'un effet anti-proliférant dans un animal à sang chaud tel qu'un humain.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN109CH2008 | 2008-01-11 | ||
PCT/IN2009/000037 WO2009098715A2 (fr) | 2008-01-11 | 2009-01-12 | Nouveaux dérivés de pyrazolo [3, 4 -d] pyrimidine en tant qu’agents anticancéreux |
Publications (1)
Publication Number | Publication Date |
---|---|
MA32009B1 true MA32009B1 (fr) | 2011-01-03 |
Family
ID=40933862
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA33007A MA32009B1 (fr) | 2008-01-11 | 2010-07-09 | Nouveaux derives de pyrazolo [3,4-d]pyrimidine en tant qu'agents anticancereux |
Country Status (18)
Country | Link |
---|---|
US (1) | US8349847B2 (fr) |
EP (1) | EP2247596A2 (fr) |
JP (1) | JP2011509290A (fr) |
KR (1) | KR20100116607A (fr) |
CN (1) | CN101965350A (fr) |
AP (1) | AP2010005347A0 (fr) |
AU (1) | AU2009211004C1 (fr) |
BR (1) | BRPI0906475A2 (fr) |
CA (1) | CA2711777A1 (fr) |
CO (1) | CO6382174A2 (fr) |
EA (1) | EA201070841A1 (fr) |
GE (1) | GEP20135780B (fr) |
IL (1) | IL206811A0 (fr) |
MA (1) | MA32009B1 (fr) |
MX (1) | MX2010007523A (fr) |
NZ (1) | NZ586642A (fr) |
WO (1) | WO2009098715A2 (fr) |
ZA (1) | ZA201004823B (fr) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ597050A (en) | 2009-06-29 | 2014-02-28 | Incyte Corp | Pyrimidinones as pi3k inhibitors |
US8680108B2 (en) * | 2009-12-18 | 2014-03-25 | Incyte Corporation | Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors |
US8759359B2 (en) * | 2009-12-18 | 2014-06-24 | Incyte Corporation | Substituted heteroaryl fused derivatives as PI3K inhibitors |
EP2558463A1 (fr) | 2010-04-14 | 2013-02-20 | Incyte Corporation | Dérivés condensés en tant qu'inhibiteurs de i3 |
WO2011163195A1 (fr) | 2010-06-21 | 2011-12-29 | Incyte Corporation | Dérivés condensés de pyrrole en tant qu'inhibiteurs de pi3k |
AR084366A1 (es) | 2010-12-20 | 2013-05-08 | Incyte Corp | N-(1-(fenil sustituido)etil)-9h-purin-6-aminas como inhibidores de pi3k |
US9108984B2 (en) | 2011-03-14 | 2015-08-18 | Incyte Corporation | Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors |
WO2012135009A1 (fr) | 2011-03-25 | 2012-10-04 | Incyte Corporation | Dérivés de pyrimidine-4,6-diamine en tant qu'inhibiteurs de pi3k |
BR122019020716B1 (pt) | 2011-09-02 | 2021-02-17 | Incyte Holdings Corporation | heterociclilaminas como inibidores de pi3k e composição farmacêutica que as compreende |
AR090548A1 (es) | 2012-04-02 | 2014-11-19 | Incyte Corp | Azaheterociclobencilaminas biciclicas como inhibidores de pi3k |
CN102746307B (zh) * | 2012-07-09 | 2013-07-31 | 四川大学 | 1-n-苄基别嘌醇衍生物及其制备方法和用途 |
CN102746309B (zh) * | 2012-07-09 | 2013-06-05 | 四川大学 | 1-N-乙基-4-N-2′-取代酰基肼-1H-吡唑[3,4-d]嘧啶类衍生物及其制备方法和用途 |
CN103965202B (zh) * | 2014-05-21 | 2016-01-20 | 邹宏丽 | 二环稠合杂环化合物、其制备方法及用途 |
US10077277B2 (en) | 2014-06-11 | 2018-09-18 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors |
MD3262046T2 (ro) | 2015-02-27 | 2021-03-31 | Incyte Corp | Săruri de inhibitori ai PI3K și procedee pentru prepararea lor |
US9732097B2 (en) | 2015-05-11 | 2017-08-15 | Incyte Corporation | Process for the synthesis of a phosphoinositide 3-kinase inhibitor |
WO2016183063A1 (fr) | 2015-05-11 | 2016-11-17 | Incyte Corporation | Formes cristallines d'un inhibiteur de pi3k |
CN106008527B (zh) * | 2016-06-29 | 2018-05-15 | 四川大学华西医院 | 吡唑并[3,4-d]嘧啶衍生物 |
CN107698596A (zh) * | 2017-11-15 | 2018-02-16 | 双鹤药业(商丘)有限责任公司 | 一种别嘌醇的合成方法 |
CN115304607B (zh) * | 2022-07-06 | 2023-06-27 | 华南农业大学 | 吡唑并嘧啶衍生物的制备方法 |
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US3000688A (en) | 1961-09-19 | Process for vatting of vat dyestuffs | ||
US3551428A (en) | 1956-02-10 | 1970-12-29 | Ciba Geigy Corp | New 1- (or 2-) substituted 4-mercapto-pyrazolo(3,4-d)pyrimidines |
JPS5439096A (en) | 1977-08-27 | 1979-03-24 | Lion Dentifrice Co Ltd | 11phenyll1hhpyrazolo*3*44d*pyrimidinee44 carbonitrile |
US5958930A (en) | 1991-04-08 | 1999-09-28 | Duquesne University Of The Holy Ghost | Pyrrolo pyrimidine and furo pyrimidine derivatives |
US5877178A (en) | 1991-04-08 | 1999-03-02 | Duquesne University Of The Holy Ghost | Pyrimidine derivatives and methods of making and using these derivatives |
US5593997A (en) * | 1995-05-23 | 1997-01-14 | Pfizer Inc. | 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors |
JP4146514B2 (ja) | 1995-07-06 | 2008-09-10 | ノバルティス アクチエンゲゼルシャフト | ピロロピリミジン類およびその製造方法 |
JP4275733B2 (ja) | 1996-01-23 | 2009-06-10 | ノバルティス アクチエンゲゼルシャフト | ピロロピリミジンおよびその製造法 |
CH690773A5 (de) | 1996-02-01 | 2001-01-15 | Novartis Ag | Pyrrolo(2,3-d)pyrimide und ihre Verwendung. |
US6537999B2 (en) | 1996-06-06 | 2003-03-25 | Duquesne University Of The Holy Ghost | Pyrimidine derivatives and methods of making and using these derivatives |
WO1998007726A1 (fr) | 1996-08-23 | 1998-02-26 | Novartis Ag | Pyrrolopyrimidines substituees et procede pour leur preparation |
DE19709488A1 (de) | 1997-03-07 | 1998-09-10 | Basf Ag | Verfahren zur N-Alkylierung von Aminen |
JP3711238B2 (ja) | 1997-08-05 | 2005-11-02 | ファイザー・プロダクツ・インク | 神経ペプチドY受容体アンタゴニストとしての4−アミノピロ−ル(3,2−d)ピリミジン |
US6686366B1 (en) | 1998-06-02 | 2004-02-03 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
US6423871B1 (en) | 1999-02-26 | 2002-07-23 | University Of South Florida | Efficient synthesis of secondary amines by selective alkylation of primary amines |
WO2000071129A1 (fr) | 1999-05-21 | 2000-11-30 | Bristol-Myers Squibb Company | Pyrrolotriazines inhibiteurs de kinases |
ITMI992711A1 (it) | 1999-12-27 | 2001-06-27 | Novartis Ag | Composti organici |
WO2001072751A1 (fr) | 2000-03-29 | 2001-10-04 | Knoll Gesellschaft Mit Beschraenkter Haftung | Pyrrolopyrimidines utilisees comme inhibiteurs de tyrosine kinases |
US6673802B2 (en) | 2000-12-01 | 2004-01-06 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
HUP0400692A3 (en) | 2000-12-01 | 2007-09-28 | Osi Pharmaceuticals | Substituted 7h-pyrrolo[2,3-d]pyrimidine derivatives, their use and pharmaceutical compositions containing them |
US6680324B2 (en) | 2000-12-01 | 2004-01-20 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptors and uses thereof |
DE10060388A1 (de) * | 2000-12-05 | 2002-06-06 | Merck Patent Gmbh | Verwendung von Pyrazolo [4,3-d]pyrimidinen |
AR035885A1 (es) | 2001-05-14 | 2004-07-21 | Novartis Ag | Derivados de 4-amino-5-fenil-7-ciclobutilpirrolo (2,3-d)pirimidina, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos derivados para la preparacion de una composicion farmaceutica |
WO2003000187A2 (fr) | 2001-06-21 | 2003-01-03 | Ariad Pharmaceuticals, Inc. | Nouvelles pyrazolo-pyrimidines et pyrrolo-pyrimidines et leur utilisation |
GB0115393D0 (en) | 2001-06-23 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
US6939874B2 (en) | 2001-08-22 | 2005-09-06 | Amgen Inc. | Substituted pyrimidinyl derivatives and methods of use |
US7115617B2 (en) | 2001-08-22 | 2006-10-03 | Amgen Inc. | Amino-substituted pyrimidinyl derivatives and methods of use |
BR0313078A (pt) | 2002-08-06 | 2005-07-12 | Astrazeneca Ab | Composto ou um sal deste farmaceuticamente aceitável, composição farmacêutica, e, uso do composto ou de um sal deste farmaceuticamente aceitável |
US20040138238A1 (en) | 2002-08-08 | 2004-07-15 | Dhanoa Dale S. | Substituted aminopyrimidine compounds as neurokinin antagonists |
-
2009
- 2009-01-12 JP JP2010541891A patent/JP2011509290A/ja active Pending
- 2009-01-12 GE GEAP200911914A patent/GEP20135780B/en unknown
- 2009-01-12 EP EP09761144A patent/EP2247596A2/fr not_active Withdrawn
- 2009-01-12 NZ NZ586642A patent/NZ586642A/en not_active IP Right Cessation
- 2009-01-12 AU AU2009211004A patent/AU2009211004C1/en not_active Ceased
- 2009-01-12 WO PCT/IN2009/000037 patent/WO2009098715A2/fr active Application Filing
- 2009-01-12 BR BRPI0906475-3A patent/BRPI0906475A2/pt not_active IP Right Cessation
- 2009-01-12 AP AP2010005347A patent/AP2010005347A0/en unknown
- 2009-01-12 MX MX2010007523A patent/MX2010007523A/es not_active Application Discontinuation
- 2009-01-12 EA EA201070841A patent/EA201070841A1/ru unknown
- 2009-01-12 CA CA2711777A patent/CA2711777A1/fr not_active Abandoned
- 2009-01-12 CN CN2009801083051A patent/CN101965350A/zh active Pending
- 2009-01-12 US US12/812,405 patent/US8349847B2/en not_active Expired - Fee Related
- 2009-01-12 KR KR1020107017777A patent/KR20100116607A/ko not_active Application Discontinuation
-
2010
- 2010-07-05 IL IL206811A patent/IL206811A0/en unknown
- 2010-07-08 ZA ZA2010/04823A patent/ZA201004823B/en unknown
- 2010-07-09 MA MA33007A patent/MA32009B1/fr unknown
- 2010-08-11 CO CO10098749A patent/CO6382174A2/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CO6382174A2 (es) | 2012-02-15 |
WO2009098715A2 (fr) | 2009-08-13 |
US8349847B2 (en) | 2013-01-08 |
JP2011509290A (ja) | 2011-03-24 |
EP2247596A2 (fr) | 2010-11-10 |
AP2010005347A0 (en) | 2010-08-31 |
NZ586642A (en) | 2012-04-27 |
CA2711777A1 (fr) | 2009-08-13 |
WO2009098715A4 (fr) | 2009-12-10 |
US20100298351A1 (en) | 2010-11-25 |
MX2010007523A (es) | 2010-08-18 |
AU2009211004C1 (en) | 2013-08-01 |
ZA201004823B (en) | 2011-09-28 |
IL206811A0 (en) | 2010-12-30 |
WO2009098715A3 (fr) | 2009-10-15 |
AU2009211004A1 (en) | 2009-08-13 |
AU2009211004A2 (en) | 2011-01-27 |
AU2009211004B2 (en) | 2011-09-01 |
EA201070841A1 (ru) | 2011-02-28 |
CN101965350A (zh) | 2011-02-02 |
GEP20135780B (en) | 2013-03-11 |
KR20100116607A (ko) | 2010-11-01 |
BRPI0906475A2 (pt) | 2015-07-14 |
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