MA30075B1 - Derives de pyrimidine pour le traitement d'une croissance cellulaire anormale - Google Patents
Derives de pyrimidine pour le traitement d'une croissance cellulaire anormaleInfo
- Publication number
- MA30075B1 MA30075B1 MA31059A MA31059A MA30075B1 MA 30075 B1 MA30075 B1 MA 30075B1 MA 31059 A MA31059 A MA 31059A MA 31059 A MA31059 A MA 31059A MA 30075 B1 MA30075 B1 MA 30075B1
- Authority
- MA
- Morocco
- Prior art keywords
- treatment
- cell growth
- abnormal cell
- pyrimidine derivatives
- mammals
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pyridine Compounds (AREA)
Abstract
Dérivés de pyrimidine pour le traitement d'une croissance cellulaire anormale La présente invention concerne un composé de formule (I), ou un de ses sels pharmaceutiquement acceptables, formule dans laquelle Ar représente un groupe de formule (III), et R1, R2, R13, A, K, M, L1, L2, X, Y1, Y2, Q, un de ses sels, où R1, R2, R13, A, K, L1, L2, W, X, Z1, Z2, Y1, Y2, Z1, Z2, M, Q, W, X, m, p et q répondent aux définitions figurant dans le présent mémoire. Ces dérivés de pyrimidine nouveaux sont utiles dans le traitement d'une croissance cellulaire anormale, telle qu'un cancer, chez des mammifères. La présente invention concerne également une méthode d'utilisation de ces composés dans le traitement d'une croissance cellulaire anormale chez des mammifères, notamment des êtres humains, et des compositions pharmaceutiques contenant ces composés.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75270805P | 2005-12-21 | 2005-12-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA30075B1 true MA30075B1 (fr) | 2008-12-01 |
Family
ID=38038639
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA31059A MA30075B1 (fr) | 2005-12-21 | 2008-06-20 | Derives de pyrimidine pour le traitement d'une croissance cellulaire anormale |
Country Status (30)
Country | Link |
---|---|
US (1) | US7820648B2 (fr) |
EP (1) | EP1966207A2 (fr) |
JP (1) | JP4332590B2 (fr) |
KR (1) | KR101060051B1 (fr) |
CN (1) | CN101346380B (fr) |
AP (1) | AP2008004488A0 (fr) |
AR (1) | AR058399A1 (fr) |
AU (1) | AU2006327871A1 (fr) |
BR (1) | BRPI0620324A2 (fr) |
CA (1) | CA2634646C (fr) |
CR (1) | CR10095A (fr) |
DO (1) | DOP2006000289A (fr) |
EA (1) | EA014551B1 (fr) |
EC (1) | ECSP088563A (fr) |
GT (1) | GT200600517A (fr) |
HN (1) | HN2006042221A (fr) |
IL (1) | IL191555A0 (fr) |
MA (1) | MA30075B1 (fr) |
ME (1) | MEP0908A (fr) |
NL (1) | NL2000375C2 (fr) |
NO (1) | NO20082338L (fr) |
PE (1) | PE20071138A1 (fr) |
RS (1) | RS20080272A (fr) |
SV (1) | SV2008002969A (fr) |
TN (1) | TNSN08270A1 (fr) |
TW (1) | TW200736258A (fr) |
UA (1) | UA89123C2 (fr) |
UY (1) | UY30051A1 (fr) |
WO (1) | WO2007072158A2 (fr) |
ZA (1) | ZA200804488B (fr) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL1656372T3 (pl) | 2003-07-30 | 2013-08-30 | Rigel Pharmaceuticals Inc | Związki 2,4-pirymidynodiaminy do stosowania w leczeniu lub zapobieganiu chorobom autoimmunologicznym |
US20070032514A1 (en) * | 2005-07-01 | 2007-02-08 | Zahn Stephan K | 2,4-diamino-pyrimidines as aurora inhibitors |
JP2009542604A (ja) * | 2006-07-06 | 2009-12-03 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 4−ヘテロシクロアルキルピリミジン、それらの調製方法及び医薬としての使用 |
CA2669111C (fr) | 2006-10-23 | 2016-04-12 | Cephalon, Inc. | Derives bicycliques fusionnes de 2,4-diaminopyrimidine utilises comme inhibiteurs de alk et c-met |
CN101678215B (zh) * | 2007-04-18 | 2014-10-01 | 辉瑞产品公司 | 用于治疗异常细胞生长的磺酰胺衍生物 |
KR20100049068A (ko) | 2007-07-17 | 2010-05-11 | 리겔 파마슈티칼스, 인크. | Pkc 억제제로서의 시클릭 아민 치환된 피리미딘디아민 |
CA2707653A1 (fr) * | 2007-12-03 | 2009-06-11 | Boehringer Ingelheim International Gmbh | Nouveaux composes |
UY31714A (es) * | 2008-03-20 | 2009-11-10 | Boehringer Ingelheim Int | Preparación selectiva de pirimidinas sustituidas |
CA2718858A1 (fr) * | 2008-03-20 | 2009-09-24 | Boehringer Ingelheim International Gmbh | Elaboration regioselective de pyrimidines substituees |
EA020807B1 (ru) | 2008-06-17 | 2015-01-30 | Астразенека Аб | Соединения пиридина |
EP2161259A1 (fr) | 2008-09-03 | 2010-03-10 | Bayer CropScience AG | 4-haloalkyle-diaminopyrimidines substitués |
US20110071158A1 (en) * | 2009-03-18 | 2011-03-24 | Boehringer Ingelheim International Gmbh | New compounds |
TW201100441A (en) | 2009-06-01 | 2011-01-01 | Osi Pharm Inc | Amino pyrimidine anticancer compounds |
JP5539518B2 (ja) | 2009-08-14 | 2014-07-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 2−アミノ−5−トリフルオロメチルピリミジン誘導体の位置選択的調製 |
US8933227B2 (en) | 2009-08-14 | 2015-01-13 | Boehringer Ingelheim International Gmbh | Selective synthesis of functionalized pyrimidines |
US8466155B2 (en) * | 2009-10-02 | 2013-06-18 | Boehringer Ingelheim International Gmbh | Pyrimidines |
TWI513694B (zh) | 2010-05-11 | 2015-12-21 | Amgen Inc | 抑制間變性淋巴瘤激酶的嘧啶化合物 |
US8927547B2 (en) | 2010-05-21 | 2015-01-06 | Noviga Research Ab | Pyrimidine derivatives |
US20120244141A1 (en) | 2010-09-28 | 2012-09-27 | Boehringer Ingelheim International Gmbh | Stratification of cancer patients for susceptibility to therapy with PTK2 inhibitors |
WO2012074951A1 (fr) | 2010-11-29 | 2012-06-07 | OSI Pharmaceuticals, LLC | Inhibiteurs de kinase macrocycliques |
CA2830129C (fr) | 2011-03-24 | 2016-07-19 | Chemilia Ab | Nouveaux derives de pyrimidine |
EP2788345B1 (fr) | 2011-12-09 | 2020-06-10 | Chiesi Farmaceutici S.p.A. | Derives de 4-hydroxy-1,2,3,4-tetrahydronaphtalen-1-yl uree et leur utilisation dans le traitement de, entre outre, maladies des voies respiratoires |
AU2012357038B2 (en) | 2011-12-23 | 2016-05-12 | Cellzome Limited | Pyrimidine-2,4-diamine derivatives as kinase inhibitors |
CN103655577A (zh) * | 2012-09-20 | 2014-03-26 | 杨育新 | 一类治疗创伤性脑损伤疾病的化合物及其用途 |
CN103664957A (zh) * | 2012-09-25 | 2014-03-26 | 杨子娇 | 一类治疗房角狭窄的化合物及其用途 |
CN105130907B (zh) * | 2015-07-29 | 2018-10-16 | 沈阳药科大学 | 嘧啶类化合物及其用途 |
JP6946412B2 (ja) | 2016-07-18 | 2021-10-06 | ヤンセン ファーマシューティカ エヌ.ベー. | タウpet画像化リガンド |
WO2020023851A1 (fr) * | 2018-07-26 | 2020-01-30 | Yale University | Pyrimidines substituées bifonctionnelles en tant que modulateurs du protéolyse de fak |
JP2024502174A (ja) * | 2021-01-07 | 2024-01-17 | オンタリオ・インスティテュート・フォー・キャンサー・リサーチ(オーアイシーアール) | Nuakキナーゼの阻害剤としてのチエニル及びシクロアルキルアミノピリミジン化合物、その組成物及び使用 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9828511D0 (en) | 1998-12-24 | 1999-02-17 | Zeneca Ltd | Chemical compounds |
GB0004887D0 (en) * | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
GB0004890D0 (en) * | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
WO2003030909A1 (fr) | 2001-09-25 | 2003-04-17 | Bayer Pharmaceuticals Corporation | 2- et 4-aminopyrimidines n-substituees par un noyau bicyclique utilisees comme inhibiteurs de kinases dans le traitement du cancer |
TWI329105B (en) * | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
GB0206215D0 (en) | 2002-03-15 | 2002-05-01 | Novartis Ag | Organic compounds |
AU2003231231A1 (en) | 2002-05-06 | 2003-11-11 | Bayer Pharmaceuticals Corporation | Pyridinyl amino pyrimidine derivatives useful for treating hyper-proliferative disorders |
US7504410B2 (en) * | 2002-11-28 | 2009-03-17 | Schering Aktiengesellschaft | Chk-, Pdk- and Akt-inhibitory pyrimidines, their production and use as pharmaceutical agents |
UA80767C2 (en) * | 2002-12-20 | 2007-10-25 | Pfizer Prod Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
DE602004022633D1 (de) * | 2003-01-30 | 2009-10-01 | Boehringer Ingelheim Pharma | 2,4-diaminopyrimidinderivate, die sich als inhibitoren von pkc-theta eignen |
GEP20104875B (en) * | 2004-05-14 | 2010-01-11 | Pfizer Prod Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
BRPI0510963A (pt) * | 2004-05-14 | 2007-11-20 | Pfizer Prod Inc | derivados pirimidina para o tratamento do crescimento anormal de células |
-
2006
- 2006-12-11 EP EP06831737A patent/EP1966207A2/fr not_active Withdrawn
- 2006-12-11 ME MEP-09/08A patent/MEP0908A/xx unknown
- 2006-12-11 KR KR1020087017637A patent/KR101060051B1/ko not_active IP Right Cessation
- 2006-12-11 EA EA200801287A patent/EA014551B1/ru not_active IP Right Cessation
- 2006-12-11 CN CN2006800487340A patent/CN101346380B/zh not_active Expired - Fee Related
- 2006-12-11 CA CA2634646A patent/CA2634646C/fr not_active Expired - Fee Related
- 2006-12-11 AP AP2008004488A patent/AP2008004488A0/xx unknown
- 2006-12-11 JP JP2008546669A patent/JP4332590B2/ja not_active Expired - Fee Related
- 2006-12-11 BR BRPI0620324-8A patent/BRPI0620324A2/pt not_active IP Right Cessation
- 2006-12-11 RS RSP-2008/0272A patent/RS20080272A/sr unknown
- 2006-12-11 WO PCT/IB2006/003655 patent/WO2007072158A2/fr active Application Filing
- 2006-12-11 UA UAA200807169A patent/UA89123C2/ru unknown
- 2006-12-11 AU AU2006327871A patent/AU2006327871A1/en not_active Abandoned
- 2006-12-14 NL NL2000375A patent/NL2000375C2/nl not_active IP Right Cessation
- 2006-12-19 GT GT200600517A patent/GT200600517A/es unknown
- 2006-12-19 DO DO2006000289A patent/DOP2006000289A/es unknown
- 2006-12-20 US US11/613,390 patent/US7820648B2/en not_active Expired - Fee Related
- 2006-12-20 HN HN2006042221A patent/HN2006042221A/es unknown
- 2006-12-20 PE PE2006001661A patent/PE20071138A1/es not_active Application Discontinuation
- 2006-12-20 AR ARP060105660A patent/AR058399A1/es not_active Application Discontinuation
- 2006-12-20 TW TW095147907A patent/TW200736258A/zh unknown
- 2006-12-21 UY UY30051A patent/UY30051A1/es not_active Application Discontinuation
-
2008
- 2008-05-19 IL IL191555A patent/IL191555A0/en unknown
- 2008-05-22 NO NO20082338A patent/NO20082338L/no not_active Application Discontinuation
- 2008-05-23 ZA ZA200804488A patent/ZA200804488B/xx unknown
- 2008-06-19 EC EC2008008563A patent/ECSP088563A/es unknown
- 2008-06-20 SV SV2008002969A patent/SV2008002969A/es not_active Application Discontinuation
- 2008-06-20 CR CR10095A patent/CR10095A/es unknown
- 2008-06-20 MA MA31059A patent/MA30075B1/fr unknown
- 2008-06-20 TN TNP2008000270A patent/TNSN08270A1/fr unknown
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