CR10095A - Derivados de pirimidina para el tratamiento del crecimiento celular anormal - Google Patents

Derivados de pirimidina para el tratamiento del crecimiento celular anormal

Info

Publication number
CR10095A
CR10095A CR10095A CR10095A CR10095A CR 10095 A CR10095 A CR 10095A CR 10095 A CR10095 A CR 10095A CR 10095 A CR10095 A CR 10095A CR 10095 A CR10095 A CR 10095A
Authority
CR
Costa Rica
Prior art keywords
treatment
cellular growth
abnormal cellular
pirimidine derivatives
derivatives
Prior art date
Application number
CR10095A
Other languages
English (en)
Inventor
Thomas Arcari Joel
Kumar Bhattacharya Samit
Douglas Brosius Arthur
Joseph Luzzio Michael
Louise Nelson Kendra
Pan Gonghua
Alfred Jr Southers James
Gregory Wishka Donn
Xiao Jun
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of CR10095A publication Critical patent/CR10095A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08Bridged systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08Bridged systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/08Bridged systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyridine Compounds (AREA)

Abstract

La presente invención se refiere a un compuesto de fórmula 1 o una sal farmacéuticamente aceptable del mismo, en la que Ar es un grupo de fórmula y R1, R2, R13, A, K, M, L1, L2, X, Y1, Y2, Q, sal del mismo, en la que R1, R2, R13, A, K, L1, L2, W, X, Z, Z2, Y1, Y2, Z1, Z2, M, Q, W, X, m, p, y q son como se han definido en este documento. Dichos nuevos derivados de pirimidina son útiles en el tratamiento del crecimiento celular anormal, tal como cáncer, en mamíferos. Esta invención también se refiere a un procedimiento de uso de dichos compuestos en el tratamiento del crecimiento celular anormal en mamíferos, especialmente seres humanos, y a composiciones farmacéuticas que contienen dichos compuestos.
CR10095A 2005-12-21 2008-06-20 Derivados de pirimidina para el tratamiento del crecimiento celular anormal CR10095A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75270805P 2005-12-21 2005-12-21

Publications (1)

Publication Number Publication Date
CR10095A true CR10095A (es) 2008-07-17

Family

ID=38038639

Family Applications (1)

Application Number Title Priority Date Filing Date
CR10095A CR10095A (es) 2005-12-21 2008-06-20 Derivados de pirimidina para el tratamiento del crecimiento celular anormal

Country Status (30)

Country Link
US (1) US7820648B2 (es)
EP (1) EP1966207A2 (es)
JP (1) JP4332590B2 (es)
KR (1) KR101060051B1 (es)
CN (1) CN101346380B (es)
AP (1) AP2008004488A0 (es)
AR (1) AR058399A1 (es)
AU (1) AU2006327871A1 (es)
BR (1) BRPI0620324A2 (es)
CA (1) CA2634646C (es)
CR (1) CR10095A (es)
DO (1) DOP2006000289A (es)
EA (1) EA014551B1 (es)
EC (1) ECSP088563A (es)
GT (1) GT200600517A (es)
HN (1) HN2006042221A (es)
IL (1) IL191555A0 (es)
MA (1) MA30075B1 (es)
ME (1) MEP0908A (es)
NL (1) NL2000375C2 (es)
NO (1) NO20082338L (es)
PE (1) PE20071138A1 (es)
RS (1) RS20080272A (es)
SV (1) SV2008002969A (es)
TN (1) TNSN08270A1 (es)
TW (1) TW200736258A (es)
UA (1) UA89123C2 (es)
UY (1) UY30051A1 (es)
WO (1) WO2007072158A2 (es)
ZA (1) ZA200804488B (es)

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RS53109B (en) 2003-07-30 2014-06-30 Rigel Pharmaceuticals Inc. 2,4 PIRIMIDINDIAMINE COMPOUNDS FOR USE IN TREATMENT OR PREVENTION OF AUTOIMMUNE DISEASES
US20070032514A1 (en) * 2005-07-01 2007-02-08 Zahn Stephan K 2,4-diamino-pyrimidines as aurora inhibitors
EP2041132A2 (en) * 2006-07-06 2009-04-01 Boehringer Ingelheim International GmbH New compounds
EP2222647B1 (en) 2006-10-23 2015-08-05 Cephalon, Inc. Fused bicyclic derivatives of 2,4-diaminopyrimidine as alk and c-met inhibitors
EA016679B1 (ru) 2007-04-18 2012-06-29 Пфайзер Продактс Инк. Сульфониламидные производные для лечения аномального роста клеток
JP5586460B2 (ja) * 2007-07-17 2014-09-10 ライジェル ファーマシューティカルズ, インコーポレイテッド Pkc阻害剤としての環状アミン置換ピリミジンジアミン
CA2707653A1 (en) * 2007-12-03 2009-06-11 Boehringer Ingelheim International Gmbh Diaminopyridines for the treatment of diseases which are characterised by excessive or anomal cell proliferation
WO2009115583A1 (en) * 2008-03-20 2009-09-24 Boehringer Ingelheim International Gmbh Regioselective preparation of substituted pyrimidines
UY31714A (es) * 2008-03-20 2009-11-10 Boehringer Ingelheim Int Preparación selectiva de pirimidinas sustituidas
AU2009261764B2 (en) 2008-06-17 2013-01-10 Astrazeneca Ab Pyridine compounds
EP2161259A1 (de) 2008-09-03 2010-03-10 Bayer CropScience AG 4-Halogenalkylsubstituierte Diaminopyrimidine als Fungizide
US20110071158A1 (en) * 2009-03-18 2011-03-24 Boehringer Ingelheim International Gmbh New compounds
TW201100441A (en) * 2009-06-01 2011-01-01 Osi Pharm Inc Amino pyrimidine anticancer compounds
US8933227B2 (en) 2009-08-14 2015-01-13 Boehringer Ingelheim International Gmbh Selective synthesis of functionalized pyrimidines
WO2011018517A1 (en) 2009-08-14 2011-02-17 Boehringer Ingelheim International Gmbh Regioselective preparation of 2-amino-5-trifluoromethylpyrimidine derivatives
US8466155B2 (en) * 2009-10-02 2013-06-18 Boehringer Ingelheim International Gmbh Pyrimidines
TWI513694B (zh) * 2010-05-11 2015-12-21 Amgen Inc 抑制間變性淋巴瘤激酶的嘧啶化合物
CN103003264B (zh) 2010-05-21 2014-08-06 切米利亚股份公司 嘧啶衍生物
US20120244141A1 (en) 2010-09-28 2012-09-27 Boehringer Ingelheim International Gmbh Stratification of cancer patients for susceptibility to therapy with PTK2 inhibitors
ES2645508T3 (es) 2010-11-29 2017-12-05 OSI Pharmaceuticals, LLC Inhibidores de cinasa macrocíclica
JP5886411B2 (ja) 2011-03-24 2016-03-16 ノビガ・リサーチ・エービーNoviga Research AB 新規のピリミジン誘導体
US9458154B2 (en) 2011-12-09 2016-10-04 Chiesi Farmaceutici S.P.A. Kinase inhibitors
KR20140114344A (ko) 2011-12-23 2014-09-26 셀좀 리미티드 키나제 억제제로서의 피리미딘-2,4-디아민 유도체
CN103655577A (zh) * 2012-09-20 2014-03-26 杨育新 一类治疗创伤性脑损伤疾病的化合物及其用途
CN103664957A (zh) * 2012-09-25 2014-03-26 杨子娇 一类治疗房角狭窄的化合物及其用途
CN105130907B (zh) * 2015-07-29 2018-10-16 沈阳药科大学 嘧啶类化合物及其用途
EP3484528B1 (en) 2016-07-18 2020-11-25 Janssen Pharmaceutica NV Tau pet imaging ligands
WO2020023851A1 (en) * 2018-07-26 2020-01-30 Yale University Bifunctional substitued pyrimidines as modulators of fak proteolyse
WO2022147620A1 (en) * 2021-01-07 2022-07-14 Ontario Institute For Cancer Research (Oicr) Thienyl and cycloalkyl aminopyrimidine compounds as inhibitors of nuak kinases, compositions and uses thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9828511D0 (en) 1998-12-24 1999-02-17 Zeneca Ltd Chemical compounds
GB0004890D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
GB0004887D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
WO2003030909A1 (en) 2001-09-25 2003-04-17 Bayer Pharmaceuticals Corporation 2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
GB0206215D0 (en) 2002-03-15 2002-05-01 Novartis Ag Organic compounds
AU2003231231A1 (en) 2002-05-06 2003-11-11 Bayer Pharmaceuticals Corporation Pyridinyl amino pyrimidine derivatives useful for treating hyper-proliferative disorders
CN1717396A (zh) 2002-11-28 2006-01-04 舍林股份公司 Chk-、Pdk-和Akt-抑制嘧啶,其制备及作为药物的用途
UA80767C2 (en) 2002-12-20 2007-10-25 Pfizer Prod Inc Pyrimidine derivatives for the treatment of abnormal cell growth
DE602004022633D1 (de) 2003-01-30 2009-10-01 Boehringer Ingelheim Pharma 2,4-diaminopyrimidinderivate, die sich als inhibitoren von pkc-theta eignen
CA2566707A1 (en) * 2004-05-14 2005-11-24 Pfizer Products Inc. Pyrimidine derivatives for the treatment of abnormal cell growth
EP1758887A1 (en) * 2004-05-14 2007-03-07 Pfizer Products Incorporated Pyrimidine derivatives for the treatment of abnormal cell growth

Also Published As

Publication number Publication date
UY30051A1 (es) 2007-07-31
NL2000375C2 (nl) 2008-01-03
TNSN08270A1 (fr) 2009-10-30
KR101060051B1 (ko) 2011-08-29
HN2006042221A (es) 2010-01-18
ZA200804488B (en) 2009-05-27
RS20080272A (en) 2009-07-15
MEP0908A (xx) 2010-02-10
NO20082338L (no) 2008-06-25
JP4332590B2 (ja) 2009-09-16
ECSP088563A (es) 2008-07-30
WO2007072158A8 (en) 2008-08-14
CN101346380A (zh) 2009-01-14
BRPI0620324A2 (pt) 2011-11-08
AR058399A1 (es) 2008-01-30
CA2634646C (en) 2012-04-10
AU2006327871A1 (en) 2007-06-28
CA2634646A1 (en) 2007-06-28
JP2009520807A (ja) 2009-05-28
TW200736258A (en) 2007-10-01
CN101346380B (zh) 2012-02-29
EA014551B1 (ru) 2010-12-30
AP2008004488A0 (en) 2008-06-30
GT200600517A (es) 2007-09-13
WO2007072158A3 (en) 2007-12-27
UA89123C2 (ru) 2009-12-25
WO2007072158A2 (en) 2007-06-28
MA30075B1 (fr) 2008-12-01
IL191555A0 (en) 2008-12-29
NL2000375A1 (nl) 2007-06-25
KR20080077026A (ko) 2008-08-20
DOP2006000289A (es) 2007-07-31
EP1966207A2 (en) 2008-09-10
PE20071138A1 (es) 2007-12-29
SV2008002969A (es) 2010-08-17
US20080234303A1 (en) 2008-09-25
US7820648B2 (en) 2010-10-26
EA200801287A1 (ru) 2008-10-30

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