NL2000375A1 - Pyrimidinederivaten voor de behandeling van abnormale celgroei. - Google Patents

Pyrimidinederivaten voor de behandeling van abnormale celgroei.

Info

Publication number
NL2000375A1
NL2000375A1 NL2000375A NL2000375A NL2000375A1 NL 2000375 A1 NL2000375 A1 NL 2000375A1 NL 2000375 A NL2000375 A NL 2000375A NL 2000375 A NL2000375 A NL 2000375A NL 2000375 A1 NL2000375 A1 NL 2000375A1
Authority
NL
Netherlands
Prior art keywords
treatment
cell growth
abnormal cell
pyrimidine derivatives
pyrimidine
Prior art date
Application number
NL2000375A
Other languages
English (en)
Other versions
NL2000375C2 (nl
Inventor
Joel Thomas Arcari
Samit Kumar Bhattacharya
Arthur Douglas Brosius
Michael Joseph Luzzio
Kendra Louise Nelson
Gonghua Pan
James Alfred Southers
Donn Gregory Wishka
Jun Xiao
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of NL2000375A1 publication Critical patent/NL2000375A1/nl
Application granted granted Critical
Publication of NL2000375C2 publication Critical patent/NL2000375C2/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
NL2000375A 2005-12-21 2006-12-14 Pyrimidinederivaten voor de behandeling van abnormale celgroei. NL2000375C2 (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75270805P 2005-12-21 2005-12-21
US75270805 2005-12-21

Publications (2)

Publication Number Publication Date
NL2000375A1 true NL2000375A1 (nl) 2007-06-25
NL2000375C2 NL2000375C2 (nl) 2008-01-03

Family

ID=38038639

Family Applications (1)

Application Number Title Priority Date Filing Date
NL2000375A NL2000375C2 (nl) 2005-12-21 2006-12-14 Pyrimidinederivaten voor de behandeling van abnormale celgroei.

Country Status (30)

Country Link
US (1) US7820648B2 (nl)
EP (1) EP1966207A2 (nl)
JP (1) JP4332590B2 (nl)
KR (1) KR101060051B1 (nl)
CN (1) CN101346380B (nl)
AP (1) AP2008004488A0 (nl)
AR (1) AR058399A1 (nl)
AU (1) AU2006327871A1 (nl)
BR (1) BRPI0620324A2 (nl)
CA (1) CA2634646C (nl)
CR (1) CR10095A (nl)
DO (1) DOP2006000289A (nl)
EA (1) EA014551B1 (nl)
EC (1) ECSP088563A (nl)
GT (1) GT200600517A (nl)
HN (1) HN2006042221A (nl)
IL (1) IL191555A0 (nl)
MA (1) MA30075B1 (nl)
ME (1) MEP0908A (nl)
NL (1) NL2000375C2 (nl)
NO (1) NO20082338L (nl)
PE (1) PE20071138A1 (nl)
RS (1) RS20080272A (nl)
SV (1) SV2008002969A (nl)
TN (1) TNSN08270A1 (nl)
TW (1) TW200736258A (nl)
UA (1) UA89123C2 (nl)
UY (1) UY30051A1 (nl)
WO (1) WO2007072158A2 (nl)
ZA (1) ZA200804488B (nl)

Families Citing this family (29)

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Publication number Priority date Publication date Assignee Title
JP4886511B2 (ja) 2003-07-30 2012-02-29 ライジェル ファーマシューティカルズ， インコーポレイテッド ２，４−ピリミジンジアミン化合物による自己免疫疾患の治療または予防方法
US20070032514A1 (en) * 2005-07-01 2007-02-08 Zahn Stephan K 2,4-diamino-pyrimidines as aurora inhibitors
EP2041132A2 (en) * 2006-07-06 2009-04-01 Boehringer Ingelheim International GmbH New compounds
ES2633318T3 (es) 2006-10-23 2017-09-20 Cephalon, Inc. Derivados bicíclicos fusionados de 2,4-diaminopirimidina como inhibidores de ALK y c-Met
DK2146779T3 (en) 2007-04-18 2016-11-28 Pfizer Prod Inc Sulfonylamid derivatives to treat abnormal cell growth.
EP2183225A1 (en) * 2007-07-17 2010-05-12 Rigel Pharmaceuticals, Inc. Cyclic amine substituted pyrimidinediamines as pkc inhibitors
US8461147B2 (en) * 2007-12-03 2013-06-11 Boehringer Ingelheim International Gmbh Diaminopyridines for the treatment of diseases which are characterised by excessive or anomal cell proliferation
JP2011515372A (ja) * 2008-03-20 2011-05-19 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 置換ピリミジン類の位置選択的製造法
UY31714A (es) * 2008-03-20 2009-11-10 Boehringer Ingelheim Int Preparación selectiva de pirimidinas sustituidas
CN102124000B (zh) 2008-06-17 2014-09-17 阿斯利康(瑞典)有限公司 吡啶化合物
EP2161259A1 (de) 2008-09-03 2010-03-10 Bayer CropScience AG 4-Halogenalkylsubstituierte Diaminopyrimidine als Fungizide
US20110071158A1 (en) * 2009-03-18 2011-03-24 Boehringer Ingelheim International Gmbh New compounds
TW201100441A (en) 2009-06-01 2011-01-01 Osi Pharm Inc Amino pyrimidine anticancer compounds
WO2011018517A1 (en) 2009-08-14 2011-02-17 Boehringer Ingelheim International Gmbh Regioselective preparation of 2-amino-5-trifluoromethylpyrimidine derivatives
US8933227B2 (en) 2009-08-14 2015-01-13 Boehringer Ingelheim International Gmbh Selective synthesis of functionalized pyrimidines
US8466155B2 (en) * 2009-10-02 2013-06-18 Boehringer Ingelheim International Gmbh Pyrimidines
TWI513694B (zh) * 2010-05-11 2015-12-21 Amgen Inc 抑制間變性淋巴瘤激酶的嘧啶化合物
CA2798578C (en) 2010-05-21 2015-12-29 Chemilia Ab Novel pyrimidine derivatives
US20120244141A1 (en) 2010-09-28 2012-09-27 Boehringer Ingelheim International Gmbh Stratification of cancer patients for susceptibility to therapy with PTK2 inhibitors
PT2646448T (pt) 2010-11-29 2017-10-04 Osi Pharmaceuticals Llc Inibidores macrocíclicos de cinases
RU2013147417A (ru) 2011-03-24 2015-04-27 Кемилиа Аб Новые производные пиримидина
CA2858420A1 (en) 2011-12-09 2013-06-13 Chiesi Farmaceutici S.P.A. Derivatives of 4-hydroxy-1,2,3,4-tetrahydronaphthalen-1-yl urea and their use in the treatment of, inter alia, diseases of the respiratory tract
JP2015500862A (ja) 2011-12-23 2015-01-08 セルゾーム リミティッド キナーゼ阻害剤としてのピリミジン−２，４−ジアミン誘導体
CN103655577A (zh) * 2012-09-20 2014-03-26 杨育新 一类治疗创伤性脑损伤疾病的化合物及其用途
CN103664957A (zh) * 2012-09-25 2014-03-26 杨子娇 一类治疗房角狭窄的化合物及其用途
CN105130907B (zh) * 2015-07-29 2018-10-16 沈阳药科大学 嘧啶类化合物及其用途
JP6946412B2 (ja) 2016-07-18 2021-10-06 ヤンセン ファーマシューティカ エヌ．ベー． タウｐｅｔ画像化リガンド
US20200038513A1 (en) * 2018-07-26 2020-02-06 Arvinas Operations, Inc. Modulators of fak proteolysis and associated methods of use
US20240025887A1 (en) * 2021-01-07 2024-01-25 Ontario Institute For Cancer Research (Oicr) Thienyl and cycloalkyl aminopyrimidine compounds as inhibitors of nuak kinases, compositions and uses thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9828511D0 (en) 1998-12-24 1999-02-17 Zeneca Ltd Chemical compounds
GB0004890D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
GB0004887D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
WO2003030909A1 (en) 2001-09-25 2003-04-17 Bayer Pharmaceuticals Corporation 2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
GB0206215D0 (en) 2002-03-15 2002-05-01 Novartis Ag Organic compounds
AU2003231231A1 (en) 2002-05-06 2003-11-11 Bayer Pharmaceuticals Corporation Pyridinyl amino pyrimidine derivatives useful for treating hyper-proliferative disorders
NZ539823A (en) 2002-11-28 2008-04-30 Schering Aktiengessellschaft Chk-, Pdk- and Akt-inhibitory pyrimidines, their production and use as pharmaceutical agents
UA80767C2 (en) * 2002-12-20 2007-10-25 Pfizer Prod Inc Pyrimidine derivatives for the treatment of abnormal cell growth
WO2004067516A1 (en) 2003-01-30 2004-08-12 Boehringer Ingelheim Pharmaceuticals, Inc. 2,4-diaminopyrimidine derivatives useful as inhibitors of pkc-theta
CA2564199A1 (en) * 2004-05-14 2005-11-24 Pfizer Products Inc. Pyrimidine derivatives for the treatment of abnormal cell growth
EP1751143A1 (en) * 2004-05-14 2007-02-14 Pfizer Products Incorporated Pyrimidine derivatives for the treatment of abnormal cell growth

Also Published As

Publication number Publication date
JP4332590B2 (ja) 2009-09-16
AP2008004488A0 (en) 2008-06-30
CR10095A (es) 2008-07-17
WO2007072158A2 (en) 2007-06-28
MA30075B1 (fr) 2008-12-01
CA2634646C (en) 2012-04-10
US7820648B2 (en) 2010-10-26
AR058399A1 (es) 2008-01-30
KR101060051B1 (ko) 2011-08-29
RS20080272A (en) 2009-07-15
AU2006327871A1 (en) 2007-06-28
UY30051A1 (es) 2007-07-31
SV2008002969A (es) 2010-08-17
EA014551B1 (ru) 2010-12-30
CA2634646A1 (en) 2007-06-28
UA89123C2 (ru) 2009-12-25
WO2007072158A3 (en) 2007-12-27
WO2007072158A8 (en) 2008-08-14
ZA200804488B (en) 2009-05-27
TNSN08270A1 (fr) 2009-10-30
GT200600517A (es) 2007-09-13
BRPI0620324A2 (pt) 2011-11-08
NO20082338L (no) 2008-06-25
NL2000375C2 (nl) 2008-01-03
EA200801287A1 (ru) 2008-10-30
ECSP088563A (es) 2008-07-30
DOP2006000289A (es) 2007-07-31
US20080234303A1 (en) 2008-09-25
KR20080077026A (ko) 2008-08-20
TW200736258A (en) 2007-10-01
JP2009520807A (ja) 2009-05-28
HN2006042221A (es) 2010-01-18
PE20071138A1 (es) 2007-12-29
CN101346380B (zh) 2012-02-29
IL191555A0 (en) 2008-12-29
EP1966207A2 (en) 2008-09-10
MEP0908A (xx) 2010-02-10
CN101346380A (zh) 2009-01-14

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Legal Events

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AD1A A request for search or an international type search has been filed
RD2N Patents in respect of which a decision has been taken or a report has been made (novelty report)
PD2B A search report has been drawn up
V1 Lapsed because of non-payment of the annual fee

Effective date: 20100701