MA33239B1 - 3h-imidazo [4,5-c] pyridine-6-carboxamides en tant qu'anti-inflammatoires - Google Patents

3h-imidazo [4,5-c] pyridine-6-carboxamides en tant qu'anti-inflammatoires

Info

Publication number
MA33239B1
MA33239B1 MA34131A MA34131A MA33239B1 MA 33239 B1 MA33239 B1 MA 33239B1 MA 34131 A MA34131 A MA 34131A MA 34131 A MA34131 A MA 34131A MA 33239 B1 MA33239 B1 MA 33239B1
Authority
MA
Morocco
Prior art keywords
compounds
inflammatory
imidazo
carboxamide
pyridine
Prior art date
Application number
MA34131A
Other languages
Arabic (ar)
English (en)
Inventor
Roland Pfau
Kirsten Arndt
Henri Doods
Klaus Klinder
Raimund Kuelzer
Dimitrijs Lubriks
Juergen Mack
Benjamin Pelcman
Henning Priepke
Robert Roenn
Dirk Stenkamp
Edgars Suna
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42111729&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA33239(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of MA33239B1 publication Critical patent/MA33239B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA PRÉSENTE INVENTION CONCERNE DES COMPOSÉS DE FORMULE GÉNÉRALE (I) DANS LAQUELLE A, L, M, Q2, Q3, Q4, R1, R5, RA, RB, RC, W, X, Y, Z1, Z2, Z3 SONT DÉFINIS DANS LA DESCRIPTION, LEURS SELS, EN PARTICULIÈR LEURS SELS PHYSIOLOGIQUEMENT ACCEPTABLES. LES COMPOSÉS SONT D'UNE UTILITÉ POTENTIELLE DANS LE TRAITEMENT ET/OU LA PRÉVENTION DE MALADIES INFLAMMATOIRES ET D'AFFECTIONS ASSOCIÉES, EN PARTICULIER, DANS LE TRAITEMENT ET/OU LA PRÉVENTION DE LA DOULEUR. L'INVENTION CONCERNE ÉGALEMENT L'UTILISATION DE CES COMPOSÉS EN TANT QUE MÉDICAMENTS, DES COMPOSITIONS PHARMACEUTIQUES LES CONTENANT , ET LEUR PRÉPARATION.
MA34131A 2009-03-05 2010-03-05 3h-imidazo [4,5-c] pyridine-6-carboxamides en tant qu'anti-inflammatoires MA33239B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09154414 2009-03-05
EP09179618 2009-12-17
PCT/EP2010/052799 WO2010100249A1 (fr) 2009-03-05 2010-03-05 3h-imidazo[4,5-c]pyridine-6-carboxamides en tant qu'anti-inflammatoires

Publications (1)

Publication Number Publication Date
MA33239B1 true MA33239B1 (fr) 2012-05-02

Family

ID=42111729

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34131A MA33239B1 (fr) 2009-03-05 2010-03-05 3h-imidazo [4,5-c] pyridine-6-carboxamides en tant qu'anti-inflammatoires

Country Status (37)

Country Link
US (3) US20100256188A1 (fr)
EP (1) EP2403852B8 (fr)
JP (1) JP5433708B2 (fr)
KR (1) KR20110123764A (fr)
CN (1) CN102341395B (fr)
AP (1) AP2806A (fr)
AR (1) AR075789A1 (fr)
AU (1) AU2010220263B2 (fr)
BR (1) BRPI1009118A2 (fr)
CA (1) CA2753149A1 (fr)
CL (1) CL2011002180A1 (fr)
CO (1) CO6450668A2 (fr)
CY (1) CY1115959T1 (fr)
DK (1) DK2403852T3 (fr)
EA (1) EA020282B1 (fr)
EC (1) ECSP11011324A (fr)
ES (1) ES2528730T3 (fr)
GE (1) GEP20146034B (fr)
HK (1) HK1163064A1 (fr)
HR (1) HRP20150096T1 (fr)
IL (1) IL214033A0 (fr)
MA (1) MA33239B1 (fr)
ME (1) ME02117B (fr)
MX (1) MX2011008948A (fr)
MY (1) MY161092A (fr)
NZ (1) NZ594589A (fr)
PE (1) PE20120589A1 (fr)
PL (1) PL2403852T3 (fr)
PT (1) PT2403852E (fr)
RS (1) RS53757B1 (fr)
SG (1) SG174250A1 (fr)
SI (1) SI2403852T1 (fr)
SM (1) SMT201500053B (fr)
TN (1) TN2011000446A1 (fr)
TW (1) TWI466869B (fr)
UY (1) UY32470A (fr)
WO (1) WO2010100249A1 (fr)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY32138A (es) 2008-09-25 2010-04-30 Boehringer Ingelheim Int Amidas sustituidas del ácido 2-(2,6-dicloro-fenilamino)-6-fluoro-1-metil-1h-bencimidazol-5-carboxílico y sus sales farmacéuticamente aceptables
UY32470A (es) 2009-03-05 2010-10-29 Boehringer Ingelheim Int Derivados de 2-{2-cloro-5-[(sustituido) metil]fenilamino} -1-metil]fenilamino}-1-metilbencimidazol-5-carboxamidas-n-(sustituidas) y sus sales fisiológicamente aceptables, composiciones conteniéndolos y aplicaciones
US8586604B2 (en) * 2010-08-20 2013-11-19 Boehringer Ingelheim International Gmbh Inhibitors of the microsomal prostaglandin E2 synthase-1
US8759537B2 (en) * 2010-08-20 2014-06-24 Boehringer Ingelheim International Gmbh 3H-imidazo [4, 5-C] pyridine-6-carboxamides as anti-inflammatory agents
TW201305178A (zh) 2010-10-29 2013-02-01 Glenmark Pharmaceuticals Sa 作為ｍＰＧＥＳ－１抑制物的三環化合物
UY33779A (es) * 2010-12-10 2012-07-31 Boehringer Ingelheim Int ?2-(fenilamino)-1H-bencimidazol-5-carboxamidas novedosas?
US8486968B2 (en) 2010-12-10 2013-07-16 Boehringer Ingelheim International Gmbh Compounds
US8466186B2 (en) 2010-12-10 2013-06-18 Boehringer Ingelheim International Gmbh Compounds
AR084174A1 (es) 2010-12-21 2013-04-24 Lilly Co Eli Compuestos de imidazol-2-benzamida utiles para el tratamiento de osteoartritis y una composicion farmaceutica
AR086254A1 (es) 2011-05-26 2013-11-27 Lilly Co Eli Derivados de imidazol utiles para el tratamiento de artritis
WO2013038308A1 (fr) 2011-09-15 2013-03-21 Glenmark Pharmaceuticals S.A. Composés à base d'hétéroaryle bicyclique substitué capables d'inhiber mpges-1
PT2766359T (pt) * 2011-10-14 2016-07-14 Ambit Biosciences Corp Compostos heterocíclicos e utilização dos mesmos como moduladores de recetores tirosina-cinase de tipo iii
WO2013072825A1 (fr) 2011-11-16 2013-05-23 Glenmark Pharmaceuticals S.A. Dérivés de phtalazinone en tant qu'inhibiteurs de mpges-1
US9006257B2 (en) 2012-02-09 2015-04-14 Glenmark Pharmaceuticals S.A. Bicyclic compounds as mPGES-1 inhibitors
US9580398B2 (en) * 2012-04-02 2017-02-28 The Trustees Of Columbia University In The City Of New York Compounds, compositions, and methods for modulating ferroptosis and treating excitotoxic disorders
WO2013153535A1 (fr) 2012-04-13 2013-10-17 Glenmark Pharmaceuticals S.A. Composés tricycliques à titre d'inhibiteurs de la mpges-1
CN103450329B (zh) * 2012-05-29 2015-05-27 首都医科大学 3h-咪唑并吡啶-6-甲酰氨基酸苄酯、其合成、抗肿瘤活性和应用
TWI568722B (zh) * 2012-06-15 2017-02-01 葛蘭馬克製藥公司 作爲ｍＰＧＥＳ－１抑制劑之三唑酮化合物
WO2014167444A1 (fr) 2013-04-08 2014-10-16 Glenmark Pharmaceuticals S.A. Composés bicycliques substitués utilisés en tant qu'inhibiteurs de mpges-1
CA2916071A1 (fr) * 2013-06-20 2014-12-24 Novasaid Ab Nouveaux derives piperidinyle benzoimidazole utilises comme inhibiteurs de la mpges-1
WO2015059618A1 (fr) 2013-10-22 2015-04-30 Glenmark Pharmaceuticals S.A. Composés de pyrimidine substitués utilisés en tant qu'inhibiteurs de mpges-1
US9951027B2 (en) 2014-02-11 2018-04-24 Bayer Pharma Aktiengesellschaft Benzimidazol-2-amines as MIDH1 inhibitors
PE20170143A1 (es) 2014-02-11 2017-03-19 Bayer Pharma AG Benzimidazol-2-aminas como inhibidores de midh1
CN105294829B (zh) * 2014-06-13 2018-07-27 首都医科大学 咪唑并吡啶-6-甲酰-氨基酸苄酯，其合成，活性及应用
CN105198959B (zh) * 2014-06-13 2018-09-07 首都医科大学 咪唑并吡啶-6-甲酰-Met-Glu(OBzl)2,其合成,活性和应用
CN105198960B (zh) * 2014-06-13 2018-10-19 首都医科大学 咪唑并吡啶-6-甲酰-Met-AA-OBzl,其合成,活性和应用
CN105315325A (zh) * 2014-07-10 2016-02-10 首都医科大学 咪唑并吡啶-6-甲酰-Met-Arg(NO2)-OBzl,其合成,活性和应用
CN105315335A (zh) * 2014-07-10 2016-02-10 首都医科大学 咪唑并吡啶-6-甲酰-Met-Gln-OBzl,其合成,活性和应用
CN105315326A (zh) * 2014-07-10 2016-02-10 首都医科大学 咪唑并吡啶-6-甲酰-氨基酸苄酯,合成,活性和应用
PT3174535T (pt) 2014-08-01 2019-05-27 Glenmark Pharmaceuticals Sa Formulação nanoparticulada compreendendo um inibidor de mpges-1
EP3209660B1 (fr) 2014-10-23 2020-06-17 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts 1-cyclohexyl -2-phénylaminobenzimidazoles en tant qu'inhibiteurs de midh1 dans le traitement de tumeurs
JP6783756B2 (ja) 2014-10-23 2020-11-11 ドイチェス クレープスフォルシュングスツェントルム シュティフトゥング デス エッフェントリッヒェン レヒツ ｍＩＤＨ１阻害剤としてのベンゾイミダゾール−２−アミン
AR102361A1 (es) 2014-10-29 2017-02-22 Lilly Co Eli Compuestos de metil-quinolina útiles para inhibir la sintasa-1 de prostaglandina microsomal e2
JO3581B1 (ar) * 2014-10-29 2020-07-05 Lilly Co Eli مركبات ميثيل-بيبيريدين جديدة مفيدة لتثبيط إنزيم سينثاز -1 بروستاجلاندين e2 ميكروسومي
US10370339B2 (en) 2015-06-08 2019-08-06 Bayer Pharma Aktiengesellschaft N-Methylbenzimidazoles as mIDH1 inhibitors
JP6824954B2 (ja) 2015-07-16 2021-02-03 ドイチェス クレープスフォルシュングスツェントルム シュティフトゥング デス エッフェントリッヒェン レヒツ ｍＩＤＨ１阻害剤としての５−ヒドロキシアルキルベンズイミダゾール
GB201603311D0 (en) * 2016-02-25 2016-04-13 Jakobsson Per Johan New uses and methods
EP3713564B1 (fr) 2017-11-22 2023-11-15 Khondrion Ip B.V. Composés utilisés en tant qu'inhibiteurs de mpges-1
EP3990476A1 (fr) 2019-06-25 2022-05-04 Gilead Sciences, Inc. Protéines de fusion flt3l-fc et procédés d'utilisation
EP4023638A4 (fr) * 2019-08-26 2023-10-04 Kukje Pharma Co., Ltd. Dérivé d'indole carboxamide et composition pharmaceutique le contenant
CN118178645A (zh) 2019-10-18 2024-06-14 四十七公司 用于治疗骨髓增生异常综合征和急性髓系白血病的联合疗法
JP2022552748A (ja) 2019-10-31 2022-12-19 フォーティ セブン， インコーポレイテッド 抗ｃｄ４７及び抗ｃｄ２０による血液癌の治療
TWI778443B (zh) 2019-11-12 2022-09-21 美商基利科學股份有限公司 Mcl1抑制劑
PE20230376A1 (es) 2019-12-24 2023-03-06 Carna Biosciences Inc Compuestos moduladores de la diacilglicerol quinasa
US11692038B2 (en) 2020-02-14 2023-07-04 Gilead Sciences, Inc. Antibodies that bind chemokine (C-C motif) receptor 8 (CCR8)
CR20220547A (es) 2020-05-01 2022-12-15 Gilead Sciences Inc Compuestos de 2,4-dioxopirimidina inhibidores de cd73
WO2021226261A1 (fr) 2020-05-06 2021-11-11 Ajax Therapeutics, Inc. 6-hétéroaryloxy benzimidazoles et azabenzimidazoles en tant qu'inhibiteurs de jak2
TW202302145A (zh) 2021-04-14 2023-01-16 美商基利科學股份有限公司 ＣＤ４７／ＳＩＲＰα結合及ＮＥＤＤ８活化酶Ｅ１調節次單元之共抑制以用於治療癌症
WO2022245671A1 (fr) 2021-05-18 2022-11-24 Gilead Sciences, Inc. Méthodes d'utilisation de protéines de fusion flt3l-fc
US20220378771A1 (en) * 2021-05-25 2022-12-01 Louis Habash Modifying the expression level of a gene encoding an cyclooxygenase enzyme by treating a human subject with a nitroxide
EP4359415A1 (fr) 2021-06-23 2024-05-01 Gilead Sciences, Inc. Composés modulant les diacylglycérol kinases
WO2022271650A1 (fr) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Composés de modulation de la diacylglycérol kinase
CN117480155A (zh) 2021-06-23 2024-01-30 吉利德科学公司 二酰基甘油激酶调节化合物
CA3222439A1 (fr) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Composes modulant les diacylglycerol kinases
CA3235986A1 (fr) 2021-10-29 2023-05-04 Gilead Science, Inc. Composes cd73
AU2022388555A1 (en) 2021-11-09 2024-05-02 Ajax Therapeutics, Inc. 6-he tero aryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors
AU2022417491A1 (en) 2021-12-22 2024-05-23 Gilead Sciences, Inc. Ikaros zinc finger family degraders and uses thereof
AU2022419982A1 (en) 2021-12-22 2024-06-06 Gilead Sciences, Inc. Ikaros zinc finger family degraders and uses thereof
TW202340168A (zh) 2022-01-28 2023-10-16 美商基利科學股份有限公司 Ｐａｒｐ７抑制劑
TW202346277A (zh) 2022-03-17 2023-12-01 美商基利科學股份有限公司 Ｉｋａｒｏｓ鋅指家族降解劑及其用途
US20230355796A1 (en) 2022-03-24 2023-11-09 Gilead Sciences, Inc. Combination therapy for treating trop-2 expressing cancers
TW202345806A (zh) 2022-03-31 2023-12-01 美商艾伯維有限公司 噻唑并〔５，４－ｂ〕吡啶ｍａｌｔ－１抑制劑
TW202345901A (zh) 2022-04-05 2023-12-01 美商基利科學股份有限公司 用於治療結腸直腸癌之組合療法
TW202400138A (zh) 2022-04-21 2024-01-01 美商基利科學股份有限公司 Ｋｒａｓ ｇ１２ｄ調節化合物
WO2024006929A1 (fr) 2022-07-01 2024-01-04 Gilead Sciences, Inc. Composés cd73
WO2024064668A1 (fr) 2022-09-21 2024-03-28 Gilead Sciences, Inc. POLYTHÉRAPIE ANTICANCÉREUSE PAR RAYONNEMENT IONISANT FOCAL ET PERTURBATION CD47/SIRPα

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3006671A1 (de) 1980-02-22 1981-08-27 Dr. Karl Thomae Gmbh, 7950 Biberach Neue benzoxazole, deren herstellung und deren verwendung als arzneumittel
FI91859C (fi) 1987-06-17 1994-08-25 Eisai Co Ltd Analogiamenetelmä antiallergisena aineena aktiivisen bentsotiatsolijohdannaisen valmistamiseksi
JPH06759B2 (ja) 1989-09-22 1994-01-05 ファイザー製薬株式会社 新規なベンゾイミダゾール化合物
KR20010085630A (ko) 1998-08-26 2001-09-07 앤드류 앵뉴 세포 접착 억제를 조절하는 아자-비사이클
ES2263447T3 (es) * 1999-02-16 2006-12-16 Aventis Pharma Limited Compuestos biciclicos y su uso como ligandos en los receptores de integrinas.
SK14372001A3 (sk) * 1999-04-12 2002-06-04 Aventis Pharma Limited Substituované bicyklické heteroarylové zlúčeniny ako antagonisty integrínu a farmaceutický prostriedok, ktorý ich obsahuje
CA2372840C (fr) * 1999-05-05 2008-07-22 Aventis Pharma Limited Composes bicycliques substitues
US6340681B1 (en) 1999-07-16 2002-01-22 Pfizer Inc 2-benzimidazolylamine compounds as ORL-1-receptor agonists
ATE277044T1 (de) * 1999-10-06 2004-10-15 Boehringer Ingelheim Pharma Heterocyclische verbindungen verwendbar als tyrosinkinase inhibitoren
FR2833948B1 (fr) * 2001-12-21 2004-02-06 Sod Conseils Rech Applic Nouveaux derives de benzimidazole et leur utilisation en tant que medicament
CA2477505A1 (fr) 2002-03-01 2003-09-12 Smithkline Beecham Corporation Diamino-pyrimidines et leurs utilisations en tant qu'inhibiteurs de l'angiogenese
US7071216B2 (en) 2002-03-29 2006-07-04 Chiron Corporation Substituted benz-azoles and methods of their use as inhibitors of Raf kinase
US7037902B2 (en) 2002-07-03 2006-05-02 Receptron, Inc. Affinity small molecules for the EPO receptor
US7122665B2 (en) 2002-10-15 2006-10-17 Synta Pharmaceuticals Corp. Heterocyclic compounds
US7265138B2 (en) 2003-02-10 2007-09-04 Amgen Inc. Vanilloid receptor ligands and their use in treatments
FR2851563B1 (fr) * 2003-02-26 2005-04-22 Sod Conseils Rech Applic Nouveaux derives de benzimidazole et d'imidazo-pyridine et leur utilisation en tant que medicament
US7531553B2 (en) * 2003-03-21 2009-05-12 Amgen Inc. Heterocyclic compounds and methods of use
FR2852957B1 (fr) * 2003-03-31 2005-06-10 Sod Conseils Rech Applic Nouveaux derives d'imidazo-pyridine et leur utilisation en tant que medicament
US7329682B2 (en) * 2003-04-03 2008-02-12 Ewha University-Industry Collaboration Foundation Method for inhibiting 5-lipoxygenase using a benzoxazole derivative
EP1677791A4 (fr) 2003-10-31 2007-08-15 Takeda Pharmaceutical Composes heterocycliques accoles contenant de l'azote
GB0401334D0 (en) * 2004-01-21 2004-02-25 Novartis Ag Organic compounds
US7470712B2 (en) * 2004-01-21 2008-12-30 Bristol-Myers Squibb Company Amino-benzazoles as P2Y1 receptor inhibitors
US20080188473A1 (en) 2004-06-18 2008-08-07 Kristofer Olofsson Indoles Useful in the Treatment of Inflammation
US7521446B2 (en) 2005-01-13 2009-04-21 Signal Pharmaceuticals, Llc Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith
US7723340B2 (en) * 2005-01-13 2010-05-25 Signal Pharmaceuticals, Llc Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith
CN101142185A (zh) * 2005-01-19 2008-03-12 比奥里波克斯公司 用于炎症治疗的吲哚
CA2599320A1 (fr) 2005-02-25 2006-08-31 Kudos Pharmaceuticals Limited Composes
US7820821B2 (en) * 2006-02-10 2010-10-26 Transtech Pharma, Inc. Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitors
WO2007124589A1 (fr) 2006-05-02 2007-11-08 Merck Frosst Canada Ltd. Procédés permettant de traiter ou de prévenir des néoplasies
WO2008009924A2 (fr) * 2006-07-18 2008-01-24 Biolipox Ab Indoles utiles dans le traitement de l'inflammation
WO2008035956A1 (fr) 2006-09-22 2008-03-27 Ewha University - Industry Collaboration Foundation Nouveau dérivé de benzoxazole, son procédé de préparation et composition pharmaceutique le renfermant
WO2008071944A1 (fr) * 2006-12-14 2008-06-19 Boehringer Ingelheim International Gmbh Benzoxasoles utiles dans le traitement de l'inflammation
WO2008129276A1 (fr) 2007-04-19 2008-10-30 Boehringer Ingelheim International Gmbh Disulfonamides utiles dans le traitement de l'inflammation
UY32138A (es) 2008-09-25 2010-04-30 Boehringer Ingelheim Int Amidas sustituidas del ácido 2-(2,6-dicloro-fenilamino)-6-fluoro-1-metil-1h-bencimidazol-5-carboxílico y sus sales farmacéuticamente aceptables
UY32470A (es) 2009-03-05 2010-10-29 Boehringer Ingelheim Int Derivados de 2-{2-cloro-5-[(sustituido) metil]fenilamino} -1-metil]fenilamino}-1-metilbencimidazol-5-carboxamidas-n-(sustituidas) y sus sales fisiológicamente aceptables, composiciones conteniéndolos y aplicaciones
US8586604B2 (en) 2010-08-20 2013-11-19 Boehringer Ingelheim International Gmbh Inhibitors of the microsomal prostaglandin E2 synthase-1
US8759537B2 (en) 2010-08-20 2014-06-24 Boehringer Ingelheim International Gmbh 3H-imidazo [4, 5-C] pyridine-6-carboxamides as anti-inflammatory agents
US8466186B2 (en) 2010-12-10 2013-06-18 Boehringer Ingelheim International Gmbh Compounds
UY33779A (es) 2010-12-10 2012-07-31 Boehringer Ingelheim Int ?2-(fenilamino)-1H-bencimidazol-5-carboxamidas novedosas?
US8486968B2 (en) 2010-12-10 2013-07-16 Boehringer Ingelheim International Gmbh Compounds

Also Published As

Publication number Publication date
RS53757B1 (en) 2015-06-30
GEP20146034B (en) 2014-02-10
US20130303571A1 (en) 2013-11-14
HK1163064A1 (en) 2012-09-07
DK2403852T3 (en) 2015-01-26
CL2011002180A1 (es) 2012-01-20
CY1115959T1 (el) 2017-01-25
UY32470A (es) 2010-10-29
MX2011008948A (es) 2011-09-27
SMT201500053B (it) 2015-05-05
PE20120589A1 (es) 2012-05-26
EP2403852A1 (fr) 2012-01-11
SG174250A1 (en) 2011-10-28
TWI466869B (zh) 2015-01-01
EA201101243A1 (ru) 2012-04-30
ME02117B (me) 2015-10-20
AP2806A (en) 2013-11-30
JP5433708B2 (ja) 2014-03-05
TW201043604A (en) 2010-12-16
CA2753149A1 (fr) 2010-09-10
AP2011005807A0 (en) 2011-08-31
EA020282B1 (ru) 2014-10-30
IL214033A0 (en) 2011-08-31
CN102341395B (zh) 2014-07-30
US20100256188A1 (en) 2010-10-07
BRPI1009118A2 (pt) 2016-12-06
SI2403852T1 (sl) 2015-04-30
US20120196897A1 (en) 2012-08-02
EP2403852B1 (fr) 2014-10-29
PL2403852T3 (pl) 2015-04-30
ECSP11011324A (es) 2011-10-31
CN102341395A (zh) 2012-02-01
AR075789A1 (es) 2011-04-27
PT2403852E (pt) 2015-02-06
JP2012519205A (ja) 2012-08-23
NZ594589A (en) 2014-01-31
ES2528730T3 (es) 2015-02-12
CO6450668A2 (es) 2012-05-31
KR20110123764A (ko) 2011-11-15
WO2010100249A1 (fr) 2010-09-10
AU2010220263A1 (en) 2011-08-11
TN2011000446A1 (en) 2013-03-27
EP2403852B8 (fr) 2014-12-17
US8921405B2 (en) 2014-12-30
HRP20150096T1 (hr) 2015-02-27
AU2010220263B2 (en) 2016-07-14
MY161092A (en) 2017-04-14

Similar Documents

Publication Publication Date Title
MA33239B1 (fr) 3h-imidazo [4,5-c] pyridine-6-carboxamides en tant qu'anti-inflammatoires
MA34655B1 (fr) Dérivés de 2,3- dihydroimidazo[1,2-c]quinazoléine substitués par un aminoalcool utiles pour traiter des troubles hyperprolifératifs et des maladies associées à l'angiogenèse
MA44674B1 (fr) Inhibiteurs de bromodomaine
MA40111A1 (fr) Dérivés du tétrahydronaphtalène inhibant la protéine mcl-1
MA31283B1 (fr) Produits dérivés de 2,3-dihydroimidazo[1,2-c]quinazoline substitués, utiles pour le traitement de troubles hyperlifératifs et de maladies associées à une angiogénèse
MA35193B1 (fr) Halogeno-alkyl-1,3 oxazines en tant qu'inhibiteurs de bace1 et/ou bace2
MA38138A1 (fr) Dérivés inédits de quinolone
MA35246B1 (fr) 1,3-oxazines en tant qu'inhibiteurs de bace1 et/ou de bace2
MA33920B1 (fr) Modulateurs allosteriques positifs du recepteur m1 a base de quinolinamide
TN2009000471A1 (fr) Composes amino-heterocycliques
MA30514B1 (fr) Nouveaux composes.
MA41179A (fr) Composés inhibiteurs de parg
MA35191B1 (fr) Spiro-[1,3]-oxazines et spiro-[1,4]-oxazepines en tant qu'inhibiteurs de baec1 et/ou bace2
MA34234B1 (fr) Composes pyrazol-4-yl-heterocyclyle-carboxamide et leurs procedes d'utilisation
MA38391A1 (fr) Dérivés de pyridinyl et triazolone pyridinyl de fusion
MA35748B1 (fr) Fluorométhyl-5,6-dihydro-4h-[1,3]oxazines
MA33332B1 (fr) Dérivés de la 1h-imidazo[4,5-c]quinolinone
MA31117B1 (fr) Composes tricycliques et leur utilisation comme modulateurs du recepteur de glucocorticoïdes
MA37691B1 (fr) 5-amino[1,4]thiazines comme inhibiteurs de bace1
EP2091328A4 (fr) Composés de spiropipéridine inhibiteurs de la bêta-sécrétase pour le traitement de la maladie d'alzheimer
MA37763A1 (fr) Difluoro-hexahydro-cyclopentaoxazinyles et difluoro-hexahydro-benzooxazinyles en tant qu'inhibiteurs de bace1
MA38556A1 (fr) Inhibiteurs de bace1
MA33533B1 (fr) Compositions pharmaceutiques pour le traitement du cancer et d'autres maladies ou troubles
MA31170B1 (fr) Dérivés de 2-amino-5,7-dihydro-6h-pyrrolo[3,4-d]pyrimidine servant d'inhibiteurs de la hsp-90 pour le traitement du cancer
TNSN00235A1 (fr) Derives d'heterocyclo-alkylsulfonylpyrazole nouveaux, procede pour leur preparation et compositions les contenant