SMT201500053B - 2-Amminobenzimidazol-5-carbossammidi come agenti nati-infiammatori - Google Patents
2-Amminobenzimidazol-5-carbossammidi come agenti nati-infiammatoriInfo
- Publication number
- SMT201500053B SMT201500053B SM201500053T SM201500053T SMT201500053B SM T201500053 B SMT201500053 B SM T201500053B SM 201500053 T SM201500053 T SM 201500053T SM 201500053 T SM201500053 T SM 201500053T SM T201500053 B SMT201500053 B SM T201500053B
- Authority
- SM
- San Marino
- Prior art keywords
- aminobenzimidazol
- carboxamides
- native
- inflammatory agents
- inflammatory
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09154414 | 2009-03-05 | ||
| EP09179618 | 2009-12-17 | ||
| PCT/EP2010/052799 WO2010100249A1 (fr) | 2009-03-05 | 2010-03-05 | 3h-imidazo[4,5-c]pyridine-6-carboxamides en tant qu'anti-inflammatoires |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SMT201500053B true SMT201500053B (it) | 2015-05-05 |
Family
ID=42111729
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SM201500053T SMT201500053B (it) | 2009-03-05 | 2015-03-09 | 2-Amminobenzimidazol-5-carbossammidi come agenti nati-infiammatori |
Country Status (37)
| Country | Link |
|---|---|
| US (3) | US20100256188A1 (fr) |
| EP (1) | EP2403852B8 (fr) |
| JP (1) | JP5433708B2 (fr) |
| KR (1) | KR20110123764A (fr) |
| CN (1) | CN102341395B (fr) |
| AP (1) | AP2806A (fr) |
| AR (1) | AR075789A1 (fr) |
| AU (1) | AU2010220263B2 (fr) |
| BR (1) | BRPI1009118A2 (fr) |
| CA (1) | CA2753149A1 (fr) |
| CL (1) | CL2011002180A1 (fr) |
| CO (1) | CO6450668A2 (fr) |
| CY (1) | CY1115959T1 (fr) |
| DK (1) | DK2403852T3 (fr) |
| EA (1) | EA020282B1 (fr) |
| EC (1) | ECSP11011324A (fr) |
| ES (1) | ES2528730T3 (fr) |
| GE (1) | GEP20146034B (fr) |
| HK (1) | HK1163064A1 (fr) |
| HR (1) | HRP20150096T1 (fr) |
| IL (1) | IL214033A0 (fr) |
| MA (1) | MA33239B1 (fr) |
| ME (1) | ME02117B (fr) |
| MX (1) | MX2011008948A (fr) |
| MY (1) | MY161092A (fr) |
| NZ (1) | NZ594589A (fr) |
| PE (1) | PE20120589A1 (fr) |
| PL (1) | PL2403852T3 (fr) |
| PT (1) | PT2403852E (fr) |
| RS (1) | RS53757B1 (fr) |
| SG (1) | SG174250A1 (fr) |
| SI (1) | SI2403852T1 (fr) |
| SM (1) | SMT201500053B (fr) |
| TN (1) | TN2011000446A1 (fr) |
| TW (1) | TWI466869B (fr) |
| UY (1) | UY32470A (fr) |
| WO (1) | WO2010100249A1 (fr) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY32138A (es) | 2008-09-25 | 2010-04-30 | Boehringer Ingelheim Int | Amidas sustituidas del ácido 2-(2,6-dicloro-fenilamino)-6-fluoro-1-metil-1h-bencimidazol-5-carboxílico y sus sales farmacéuticamente aceptables |
| UY32470A (es) | 2009-03-05 | 2010-10-29 | Boehringer Ingelheim Int | Derivados de 2-{2-cloro-5-[(sustituido) metil]fenilamino} -1-metil]fenilamino}-1-metilbencimidazol-5-carboxamidas-n-(sustituidas) y sus sales fisiológicamente aceptables, composiciones conteniéndolos y aplicaciones |
| US8586604B2 (en) * | 2010-08-20 | 2013-11-19 | Boehringer Ingelheim International Gmbh | Inhibitors of the microsomal prostaglandin E2 synthase-1 |
| US8759537B2 (en) | 2010-08-20 | 2014-06-24 | Boehringer Ingelheim International Gmbh | 3H-imidazo [4, 5-C] pyridine-6-carboxamides as anti-inflammatory agents |
| TW201305178A (zh) | 2010-10-29 | 2013-02-01 | Glenmark Pharmaceuticals Sa | 作為ｍＰＧＥＳ－１抑制物的三環化合物 |
| US8466186B2 (en) | 2010-12-10 | 2013-06-18 | Boehringer Ingelheim International Gmbh | Compounds |
| US8486968B2 (en) | 2010-12-10 | 2013-07-16 | Boehringer Ingelheim International Gmbh | Compounds |
| UY33779A (es) | 2010-12-10 | 2012-07-31 | Boehringer Ingelheim Int | ?2-(fenilamino)-1H-bencimidazol-5-carboxamidas novedosas? |
| AR084174A1 (es) | 2010-12-21 | 2013-04-24 | Lilly Co Eli | Compuestos de imidazol-2-benzamida utiles para el tratamiento de osteoartritis y una composicion farmaceutica |
| AR086254A1 (es) | 2011-05-26 | 2013-11-27 | Lilly Co Eli | Derivados de imidazol utiles para el tratamiento de artritis |
| WO2013038308A1 (fr) | 2011-09-15 | 2013-03-21 | Glenmark Pharmaceuticals S.A. | Composés à base d'hétéroaryle bicyclique substitué capables d'inhiber mpges-1 |
| ES2586527T3 (es) | 2011-10-14 | 2016-10-17 | Ambit Biosciences Corporation | Compuestos heterocíclicos y uso de los mismos como moduladores del receptor de tirosina quinasas de tipo III |
| WO2013072825A1 (fr) | 2011-11-16 | 2013-05-23 | Glenmark Pharmaceuticals S.A. | Dérivés de phtalazinone en tant qu'inhibiteurs de mpges-1 |
| WO2013118071A1 (fr) | 2012-02-09 | 2013-08-15 | Glenmark Pharmaceuticals S.A. | Composés bicycliques en tant qu'inhibiteurs de mpges-1 |
| US9580398B2 (en) * | 2012-04-02 | 2017-02-28 | The Trustees Of Columbia University In The City Of New York | Compounds, compositions, and methods for modulating ferroptosis and treating excitotoxic disorders |
| WO2013153535A1 (fr) | 2012-04-13 | 2013-10-17 | Glenmark Pharmaceuticals S.A. | Composés tricycliques à titre d'inhibiteurs de la mpges-1 |
| CN103450329B (zh) * | 2012-05-29 | 2015-05-27 | 首都医科大学 | 3h-咪唑并吡啶-6-甲酰氨基酸苄酯、其合成、抗肿瘤活性和应用 |
| TWI568722B (zh) | 2012-06-15 | 2017-02-01 | 葛蘭馬克製藥公司 | 作爲ｍＰＧＥＳ－１抑制劑之三唑酮化合物 |
| WO2014167444A1 (fr) | 2013-04-08 | 2014-10-16 | Glenmark Pharmaceuticals S.A. | Composés bicycliques substitués utilisés en tant qu'inhibiteurs de mpges-1 |
| CN105683185A (zh) * | 2013-06-20 | 2016-06-15 | 诺瓦赛德股份公司 | 作为mpges-1抑制剂的新型哌啶基苯并咪唑衍生物 |
| WO2015059618A1 (fr) | 2013-10-22 | 2015-04-30 | Glenmark Pharmaceuticals S.A. | Composés de pyrimidine substitués utilisés en tant qu'inhibiteurs de mpges-1 |
| EP3105210B1 (fr) | 2014-02-11 | 2019-01-30 | Bayer Pharma Aktiengesellschaft | Benzimidazol-2-amines comme inhibiteurs de midh1 |
| SG11201605810WA (en) | 2014-02-11 | 2016-08-30 | Bayer Pharma AG | Benzimidazol-2-amines as midh1 inhibitors |
| CN105198960B (zh) * | 2014-06-13 | 2018-10-19 | 首都医科大学 | 咪唑并吡啶-6-甲酰-Met-AA-OBzl,其合成,活性和应用 |
| CN105294829B (zh) * | 2014-06-13 | 2018-07-27 | 首都医科大学 | 咪唑并吡啶-6-甲酰-氨基酸苄酯，其合成，活性及应用 |
| CN105198959B (zh) * | 2014-06-13 | 2018-09-07 | 首都医科大学 | 咪唑并吡啶-6-甲酰-Met-Glu(OBzl)2,其合成,活性和应用 |
| CN105315325A (zh) * | 2014-07-10 | 2016-02-10 | 首都医科大学 | 咪唑并吡啶-6-甲酰-Met-Arg(NO2)-OBzl,其合成,活性和应用 |
| CN105315335A (zh) * | 2014-07-10 | 2016-02-10 | 首都医科大学 | 咪唑并吡啶-6-甲酰-Met-Gln-OBzl,其合成,活性和应用 |
| CN105315326A (zh) * | 2014-07-10 | 2016-02-10 | 首都医科大学 | 咪唑并吡啶-6-甲酰-氨基酸苄酯,合成,活性和应用 |
| EP3517104A1 (fr) | 2014-08-01 | 2019-07-31 | Glenmark Pharmaceuticals S.A. | Formulation nanoparticulaire comprenant un inhibiteur de mpges -1 |
| JP6672288B2 (ja) | 2014-10-23 | 2020-03-25 | バイエル・ファルマ・アクティエンゲゼルシャフト | 腫瘍の治療のためのｍｉｄｈ１阻害剤としての１−シクロヘキシル−２−フェニルアミノベンゾイミダゾール |
| CA2965201A1 (fr) | 2014-10-23 | 2016-04-28 | Bayer Pharma Aktiengesellschaft | Benzimidazol-2-amines en tant qu'inhibiteurs midh1 |
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| MX2020005238A (es) | 2017-11-22 | 2020-08-24 | Khondrion Ip B V | Compuestos novedosos como inhibidores mpges-1. |
| CA3142513A1 (fr) | 2019-06-25 | 2020-12-30 | Gilead Sciences, Inc. | Proteines de fusion flt3l-fc et procedes d'utilisation |
| KR102711104B1 (ko) * | 2019-08-26 | 2024-09-27 | 국제약품 주식회사 | 인돌 카복사미드 유도체 및 그를 포함하는 약제학적 조성물 |
| CN114555123B (zh) | 2019-10-18 | 2024-04-02 | 四十七公司 | 用于治疗骨髓增生异常综合征和急性髓系白血病的联合疗法 |
| AU2020374947A1 (en) | 2019-10-31 | 2022-03-31 | Forty Seven, Inc. | Anti-CD47 and anti-CD20 based treatment of blood cancer |
| TWI778443B (zh) | 2019-11-12 | 2022-09-21 | 美商基利科學股份有限公司 | Mcl1抑制劑 |
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| TWI832035B (zh) | 2020-02-14 | 2024-02-11 | 美商基利科學股份有限公司 | 結合ccr8之抗體及融合蛋白及其用途 |
| MX2022013619A (es) | 2020-05-01 | 2022-11-16 | Gilead Sciences Inc | Compuestos de 2,4-dioxopirimidina que inhiben cd73. |
| EP4146639A1 (fr) | 2020-05-06 | 2023-03-15 | Ajax Therapeutics, Inc. | 6-hétéroaryloxy benzimidazoles et azabenzimidazoles en tant qu'inhibiteurs de jak2 |
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| TW202302145A (zh) | 2021-04-14 | 2023-01-16 | 美商基利科學股份有限公司 | ＣＤ４７／ＳＩＲＰα結合及ＮＥＤＤ８活化酶Ｅ１調節次單元之共抑制以用於治療癌症 |
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| TW202334139A (zh) | 2021-11-09 | 2023-09-01 | 美商雅捷可斯治療公司 | 作為ｊａｋ２抑制劑之６－雜芳氧基苯并咪唑及氮雜苯并咪唑 |
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2010
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- 2010-03-04 AR ARP100100651A patent/AR075789A1/es unknown
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- 2010-03-05 NZ NZ594589A patent/NZ594589A/en not_active IP Right Cessation
- 2010-03-05 KR KR1020117020598A patent/KR20110123764A/ko not_active Application Discontinuation
- 2010-03-05 EP EP10706659.9A patent/EP2403852B8/fr active Active
- 2010-03-05 MY MYPI2011004122A patent/MY161092A/en unknown
- 2010-03-05 PT PT107066599T patent/PT2403852E/pt unknown
- 2010-03-05 WO PCT/EP2010/052799 patent/WO2010100249A1/fr active Application Filing
- 2010-03-05 PE PE2011001560A patent/PE20120589A1/es not_active Application Discontinuation
- 2010-03-05 ES ES10706659.9T patent/ES2528730T3/es active Active
- 2010-03-05 ME MEP-2015-11A patent/ME02117B/me unknown
- 2010-03-05 CN CN201080010352.5A patent/CN102341395B/zh not_active Expired - Fee Related
- 2010-03-05 AU AU2010220263A patent/AU2010220263B2/en not_active Ceased
- 2010-03-05 JP JP2011552460A patent/JP5433708B2/ja active Active
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- 2010-03-05 AP AP2011005807A patent/AP2806A/xx active
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- 2010-03-05 BR BRPI1009118A patent/BRPI1009118A2/pt not_active IP Right Cessation
- 2010-03-05 CA CA2753149A patent/CA2753149A1/fr not_active Abandoned
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- 2010-03-05 MX MX2011008948A patent/MX2011008948A/es active IP Right Grant
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