AR086254A1 - Derivados de imidazol utiles para el tratamiento de artritis - Google Patents
Derivados de imidazol utiles para el tratamiento de artritisInfo
- Publication number
- AR086254A1 AR086254A1 ARP120101556A ARP120101556A AR086254A1 AR 086254 A1 AR086254 A1 AR 086254A1 AR P120101556 A ARP120101556 A AR P120101556A AR P120101556 A ARP120101556 A AR P120101556A AR 086254 A1 AR086254 A1 AR 086254A1
- Authority
- AR
- Argentina
- Prior art keywords
- arthritis
- useful
- treatment
- imidazol derivatives
- chf2
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
Una sal farmacéutica del mismo, y una composición farmacéutica que contiene este compuesto; métodos para tratar dolor asociado con osteoartritis usando uno de los compuestos o una sal del mismo farmacéuticamente aceptable, y procesos para preparar los compuestos.Reivindicación 1: Un compuesto de la fórmula (1) caracterizado porque R1 se selecciona de: -alquilo C1-4; R2 es Cl o -CHF2; R3 es H o -CH3; R4 se selecciona de: H, F, Cl, -CH3, -CHF2, y -CF3; R5 se selecciona de: H, F, Cl, y -CH3; R6 se selecciona de: H, F, Cl, y -CH3; y uno de X y A es N y el otro de X y A es CH; siempre que cuando A es N, R4 no sea F o Cl y cuando X es N, R2 no sea Cl; o una sal del mismo farmacéuticamente aceptable.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161490222P | 2011-05-26 | 2011-05-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR086254A1 true AR086254A1 (es) | 2013-11-27 |
Family
ID=46148987
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120101556A AR086254A1 (es) | 2011-05-26 | 2012-05-03 | Derivados de imidazol utiles para el tratamiento de artritis |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US8648200B2 (es) |
| EP (1) | EP2714679A1 (es) |
| JP (1) | JP2014518886A (es) |
| KR (1) | KR20130143138A (es) |
| CN (1) | CN103562200A (es) |
| AR (1) | AR086254A1 (es) |
| AU (1) | AU2012259234A1 (es) |
| BR (1) | BR112013029692A2 (es) |
| CA (1) | CA2836240A1 (es) |
| CO (1) | CO6811858A2 (es) |
| CR (1) | CR20130534A (es) |
| DO (1) | DOP2013000276A (es) |
| EA (1) | EA201391568A1 (es) |
| EC (1) | ECSP13013047A (es) |
| IL (1) | IL229318A0 (es) |
| MA (1) | MA35128B1 (es) |
| MX (1) | MX2013013859A (es) |
| SG (1) | SG195020A1 (es) |
| TN (1) | TN2013000434A1 (es) |
| TW (1) | TW201311658A (es) |
| WO (1) | WO2012161965A1 (es) |
| ZA (1) | ZA201308609B (es) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8871947B2 (en) | 2013-02-04 | 2014-10-28 | KingChem LLC | Preparation of alkyl 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid ester |
| CN103467379A (zh) * | 2013-08-23 | 2013-12-25 | 江苏恒安化工有限公司 | 3-三氟甲基-1-甲基吡唑-4-甲酸的制备方法 |
| CN103601675B (zh) * | 2013-10-08 | 2015-10-28 | 南京复兴生物科技有限公司 | 一种5-氨甲基烟酸的制备方法 |
| CN103483250B (zh) * | 2013-10-08 | 2015-07-22 | 南京复兴生物科技有限公司 | 一种5-氨甲基烟酸的制备方法 |
| US9139507B2 (en) | 2013-12-09 | 2015-09-22 | KingChem LLC. | Process for the preparation of alkyl 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylate and its analogs |
| TWI651310B (zh) | 2014-02-20 | 2019-02-21 | 日商日本煙草產業股份有限公司 | 三化合物及其醫藥用途 |
| WO2015143240A2 (en) * | 2014-03-19 | 2015-09-24 | Curza Global, Llc | Compositions and methods comprising 2-(acylamino)imidazoles |
| PT3133068T (pt) | 2014-04-14 | 2021-01-06 | Shanghai hengrui pharmaceutical co ltd | Derivados de amida e sais farmacêuticos destes, método de preparação destes e aplicação medicinal destes |
| MX2018002044A (es) | 2015-08-17 | 2018-04-13 | Japan Tobacco Inc | Compuesto hidroxitriazina y su uso medico. |
| WO2018184019A1 (en) | 2017-03-31 | 2018-10-04 | Curza Global, Llc | Compositions and methods comprising substituted 2-aminoimidazoles |
| CN109293567A (zh) * | 2018-11-23 | 2019-02-01 | 上海睿腾医药科技有限公司 | 一种5-溴-2-甲基烟酸乙酯的合成方法 |
| JP2022538774A (ja) | 2019-06-14 | 2022-09-06 | ヤンセン ファーマシューティカ エヌ．ベー． | ピリジンカルバメート及びｇｌｕｎ２ｂ受容体調節因子としてのそれらの使用 |
| MX2021015452A (es) | 2019-06-25 | 2022-02-11 | Gilead Sciences Inc | Proteinas de fusion flt3l-fc y metodos de uso. |
| EP4045083B1 (en) | 2019-10-18 | 2024-01-10 | Forty Seven, Inc. | Combination therapies for treating myelodysplastic syndromes and acute myeloid leukemia |
| US20210147568A1 (en) | 2019-10-31 | 2021-05-20 | Forty Seven, Inc. | Anti-cd47 based treatment of blood cancer |
| TWI778443B (zh) | 2019-11-12 | 2022-09-21 | 美商基利科學股份有限公司 | Mcl1抑制劑 |
| CN110845426A (zh) * | 2019-11-29 | 2020-02-28 | 都创(上海)医药科技有限公司 | 一种2-氯-5-氰基嘧啶化合物制备方法 |
| CR20220303A (es) | 2019-12-24 | 2022-09-02 | Gilead Sciences Inc | Compuestos moduladores de la diacilglicerol quinasa |
| WO2021163064A2 (en) | 2020-02-14 | 2021-08-19 | Jounce Therapeutics, Inc. | Antibodies and fusion proteins that bind to ccr8 and uses thereof |
| US20240043427A1 (en) | 2020-05-01 | 2024-02-08 | Gilead Sciences, Inc. | Cd73 compounds |
| TW202302145A (zh) | 2021-04-14 | 2023-01-16 | 美商基利科學股份有限公司 | ＣＤ４７／ＳＩＲＰα結合及ＮＥＤＤ８活化酶Ｅ１調節次單元之共抑制以用於治療癌症 |
| TW202313094A (zh) | 2021-05-18 | 2023-04-01 | 美商基利科學股份有限公司 | 使用ＦＬＴ３Ｌ—Ｆｃ融合蛋白之方法 |
| CA3222277A1 (en) | 2021-06-23 | 2022-12-29 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| US11926628B2 (en) | 2021-06-23 | 2024-03-12 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| IL309378A (en) | 2021-06-23 | 2024-02-01 | Gilead Sciences Inc | DIACYLGLYERCOL KINASE MODULATING COMPOUNDS |
| WO2022271659A1 (en) | 2021-06-23 | 2022-12-29 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| WO2023076983A1 (en) | 2021-10-28 | 2023-05-04 | Gilead Sciences, Inc. | Pyridizin-3(2h)-one derivatives |
| US11919869B2 (en) | 2021-10-29 | 2024-03-05 | Gilead Sciences, Inc. | CD73 compounds |
| WO2023122615A1 (en) | 2021-12-22 | 2023-06-29 | Gilead Sciences, Inc. | Ikaros zinc finger family degraders and uses thereof |
| US20240124412A1 (en) | 2021-12-22 | 2024-04-18 | Gilead Sciences, Inc. | Ikaros zinc finger family degraders and uses thereof |
| TW202340168A (zh) | 2022-01-28 | 2023-10-16 | 美商基利科學股份有限公司 | Ｐａｒｐ７抑制劑 |
| WO2023178181A1 (en) | 2022-03-17 | 2023-09-21 | Gilead Sciences, Inc. | Ikaros zinc finger family degraders and uses thereof |
| US20230355796A1 (en) | 2022-03-24 | 2023-11-09 | Gilead Sciences, Inc. | Combination therapy for treating trop-2 expressing cancers |
| TW202345901A (zh) | 2022-04-05 | 2023-12-01 | 美商基利科學股份有限公司 | 用於治療結腸直腸癌之組合療法 |
| WO2023205719A1 (en) | 2022-04-21 | 2023-10-26 | Gilead Sciences, Inc. | Kras g12d modulating compounds |
| US20240116928A1 (en) | 2022-07-01 | 2024-04-11 | Gilead Sciences, Inc. | Cd73 compounds |
| WO2024064668A1 (en) | 2022-09-21 | 2024-03-28 | Gilead Sciences, Inc. | FOCAL IONIZING RADIATION AND CD47/SIRPα DISRUPTION ANTICANCER COMBINATION THERAPY |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006044527A1 (en) * | 2004-10-15 | 2006-04-27 | Amgen Inc. | Imidazole derivatives as vanilloid receptor ligands |
| US8084466B2 (en) * | 2007-12-18 | 2011-12-27 | Janssen Pharmaceutica Nv | Bicyclic heteroaryl-substituted imidazoles as modulators of the histamine H4 receptor |
| WO2009103778A1 (en) | 2008-02-19 | 2009-08-27 | Novasaid Ab | Compounds and methods |
| UY32470A (es) | 2009-03-05 | 2010-10-29 | Boehringer Ingelheim Int | Derivados de 2-{2-cloro-5-[(sustituido) metil]fenilamino} -1-metil]fenilamino}-1-metilbencimidazol-5-carboxamidas-n-(sustituidas) y sus sales fisiológicamente aceptables, composiciones conteniéndolos y aplicaciones |
| WO2010127152A2 (en) | 2009-04-29 | 2010-11-04 | Irm Llc | Compounds and compositions as microsomal prostaglandin e synthase-1 inhibitors |
| EP2491007B1 (en) * | 2009-10-23 | 2013-09-25 | Boehringer Ingelheim International GmbH | Inhibitors of the microsomal prostaglandin E2 synthase-1 |
| AR084174A1 (es) * | 2010-12-21 | 2013-04-24 | Lilly Co Eli | Compuestos de imidazol-2-benzamida utiles para el tratamiento de osteoartritis y una composicion farmaceutica |
-
2012
- 2012-05-03 AR ARP120101556A patent/AR086254A1/es not_active Application Discontinuation
- 2012-05-04 TW TW101116086A patent/TW201311658A/zh unknown
- 2012-05-10 KR KR1020137030893A patent/KR20130143138A/ko not_active Application Discontinuation
- 2012-05-10 BR BR112013029692A patent/BR112013029692A2/pt not_active IP Right Cessation
- 2012-05-10 JP JP2014512861A patent/JP2014518886A/ja active Pending
- 2012-05-10 US US13/468,122 patent/US8648200B2/en not_active Expired - Fee Related
- 2012-05-10 CN CN201280025230.2A patent/CN103562200A/zh active Pending
- 2012-05-10 WO PCT/US2012/037200 patent/WO2012161965A1/en active Application Filing
- 2012-05-10 AU AU2012259234A patent/AU2012259234A1/en not_active Abandoned
- 2012-05-10 EP EP12723323.7A patent/EP2714679A1/en not_active Withdrawn
- 2012-05-10 CA CA2836240A patent/CA2836240A1/en not_active Abandoned
- 2012-05-10 MX MX2013013859A patent/MX2013013859A/es unknown
- 2012-05-10 EA EA201391568A patent/EA201391568A1/ru unknown
- 2012-05-10 SG SG2013085154A patent/SG195020A1/en unknown
-
2013
- 2013-10-18 CR CR20130534A patent/CR20130534A/es unknown
- 2013-10-24 TN TNP2013000434A patent/TN2013000434A1/fr unknown
- 2013-11-07 IL IL229318A patent/IL229318A0/en unknown
- 2013-11-15 ZA ZA2013/08609A patent/ZA201308609B/en unknown
- 2013-11-15 MA MA36452A patent/MA35128B1/fr unknown
- 2013-11-22 DO DO2013000276A patent/DOP2013000276A/es unknown
- 2013-11-22 CO CO13275568A patent/CO6811858A2/es not_active Application Discontinuation
- 2013-11-25 EC ECSP13013047 patent/ECSP13013047A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL229318A0 (en) | 2014-01-30 |
| WO2012161965A1 (en) | 2012-11-29 |
| AU2012259234A1 (en) | 2013-11-14 |
| EA201391568A1 (ru) | 2014-04-30 |
| CA2836240A1 (en) | 2012-11-29 |
| US8648200B2 (en) | 2014-02-11 |
| BR112013029692A2 (pt) | 2017-01-17 |
| ZA201308609B (en) | 2015-05-27 |
| KR20130143138A (ko) | 2013-12-30 |
| EP2714679A1 (en) | 2014-04-09 |
| SG195020A1 (en) | 2013-12-30 |
| DOP2013000276A (es) | 2014-03-31 |
| CO6811858A2 (es) | 2013-12-16 |
| TN2013000434A1 (en) | 2015-03-30 |
| MA35128B1 (fr) | 2014-05-02 |
| CN103562200A (zh) | 2014-02-05 |
| TW201311658A (zh) | 2013-03-16 |
| US20120302608A1 (en) | 2012-11-29 |
| JP2014518886A (ja) | 2014-08-07 |
| MX2013013859A (es) | 2014-05-28 |
| ECSP13013047A (es) | 2014-01-31 |
| CR20130534A (es) | 2014-03-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |