BR112013029692A2 - derivados de imidazol úteis para o tratamento da artrite - Google Patents

derivados de imidazol úteis para o tratamento da artrite

Info

Publication number
BR112013029692A2
BR112013029692A2 BR112013029692A BR112013029692A BR112013029692A2 BR 112013029692 A2 BR112013029692 A2 BR 112013029692A2 BR 112013029692 A BR112013029692 A BR 112013029692A BR 112013029692 A BR112013029692 A BR 112013029692A BR 112013029692 A2 BR112013029692 A2 BR 112013029692A2
Authority
BR
Brazil
Prior art keywords
imidazole derivatives
derivatives useful
treating arthritis
compounds
pharmaceutically acceptable
Prior art date
Application number
BR112013029692A
Other languages
English (en)
Inventor
Bryan Hurst Norman
Norman Earle Hughes
Timothy Andrew Woods
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BR112013029692A2 publication Critical patent/BR112013029692A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

resumo patente de invenção: "derivados de imidazol úteis para o tratamento da artrite". a presente invenção refere-se a compostos da fórmula abaixo: onde a, x e r1-r6 são como aqui descritos, um sal farmaceuticamente aceitável do mesmo e uma composição farmacêutica que contenha esse composto; a métodos para tratar a dor associada com a osteoartrite usando um dos compostos ou um sal farmaceuticamente aceitável dos mesmos e processos para a preparação dos compostos.
BR112013029692A 2011-05-26 2012-05-10 derivados de imidazol úteis para o tratamento da artrite BR112013029692A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161490222P 2011-05-26 2011-05-26
PCT/US2012/037200 WO2012161965A1 (en) 2011-05-26 2012-05-10 Novel imidazole derivatives useful for the treatment of arthritis

Publications (1)

Publication Number Publication Date
BR112013029692A2 true BR112013029692A2 (pt) 2017-01-17

Family

ID=46148987

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013029692A BR112013029692A2 (pt) 2011-05-26 2012-05-10 derivados de imidazol úteis para o tratamento da artrite

Country Status (22)

Country Link
US (1) US8648200B2 (pt)
EP (1) EP2714679A1 (pt)
JP (1) JP2014518886A (pt)
KR (1) KR20130143138A (pt)
CN (1) CN103562200A (pt)
AR (1) AR086254A1 (pt)
AU (1) AU2012259234A1 (pt)
BR (1) BR112013029692A2 (pt)
CA (1) CA2836240A1 (pt)
CO (1) CO6811858A2 (pt)
CR (1) CR20130534A (pt)
DO (1) DOP2013000276A (pt)
EA (1) EA201391568A1 (pt)
EC (1) ECSP13013047A (pt)
IL (1) IL229318A0 (pt)
MA (1) MA35128B1 (pt)
MX (1) MX2013013859A (pt)
SG (1) SG195020A1 (pt)
TN (1) TN2013000434A1 (pt)
TW (1) TW201311658A (pt)
WO (1) WO2012161965A1 (pt)
ZA (1) ZA201308609B (pt)

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TW202302145A (zh) 2021-04-14 2023-01-16 美商基利科學股份有限公司 ＣＤ４７／ＳＩＲＰα結合及ＮＥＤＤ８活化酶Ｅ１調節次單元之共抑制以用於治療癌症
WO2022245671A1 (en) 2021-05-18 2022-11-24 Gilead Sciences, Inc. Methods of using flt3l-fc fusion proteins
KR20240025616A (ko) 2021-06-23 2024-02-27 길리애드 사이언시즈, 인코포레이티드 다이아실글리세롤 키나제 조절 화합물
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EP4359411A1 (en) 2021-06-23 2024-05-01 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
KR20240091056A (ko) 2021-10-28 2024-06-21 길리애드 사이언시즈, 인코포레이티드 피리디진-3(2h)-온 유도체
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Also Published As

Publication number Publication date
AR086254A1 (es) 2013-11-27
ZA201308609B (en) 2015-05-27
US8648200B2 (en) 2014-02-11
CA2836240A1 (en) 2012-11-29
EA201391568A1 (ru) 2014-04-30
MX2013013859A (es) 2014-05-28
WO2012161965A1 (en) 2012-11-29
CR20130534A (es) 2014-03-12
JP2014518886A (ja) 2014-08-07
CN103562200A (zh) 2014-02-05
AU2012259234A1 (en) 2013-11-14
DOP2013000276A (es) 2014-03-31
SG195020A1 (en) 2013-12-30
MA35128B1 (fr) 2014-05-02
US20120302608A1 (en) 2012-11-29
ECSP13013047A (es) 2014-01-31
TN2013000434A1 (en) 2015-03-30
CO6811858A2 (es) 2013-12-16
IL229318A0 (en) 2014-01-30
EP2714679A1 (en) 2014-04-09
KR20130143138A (ko) 2013-12-30
TW201311658A (zh) 2013-03-16

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]