MX345238B - (aralquilamino y heteroarilalquilamino alfa-substituidos)pirimidin ilo y 1,3,5-triazinilbenzimidazoles, composiciones farmacéuticas que los contienen, y estos compuestos para su uso en el tratamiento de enfermedades proliferativas. - Google Patents
(aralquilamino y heteroarilalquilamino alfa-substituidos)pirimidin ilo y 1,3,5-triazinilbenzimidazoles, composiciones farmacéuticas que los contienen, y estos compuestos para su uso en el tratamiento de enfermedades proliferativas.Info
- Publication number
- MX345238B MX345238B MX2013011086A MX2013011086A MX345238B MX 345238 B MX345238 B MX 345238B MX 2013011086 A MX2013011086 A MX 2013011086A MX 2013011086 A MX2013011086 A MX 2013011086A MX 345238 B MX345238 B MX 345238B
- Authority
- MX
- Mexico
- Prior art keywords
- heteroarylalkylamino
- pyrimidinyl
- alpha
- pharmaceutical compositions
- proliferative diseases
- Prior art date
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract
Se proporcionan en la presente (aralquilamino o heteroarilalquilamino alfa-sustituido)pirimidinilo y 1,3,5-triazinilbenzimidazoles, por ejemplo, un compuesto de la Fórmula I, y sus composiciones farmacéuticas, preparación y uso como agentes o fármacos para el tratamiento de enfermedades proliferativas.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161468502P | 2011-03-28 | 2011-03-28 | |
US201161530859P | 2011-09-02 | 2011-09-02 | |
US201161560699P | 2011-11-16 | 2011-11-16 | |
PCT/US2012/030640 WO2012135160A1 (en) | 2011-03-28 | 2012-03-27 | (alpha- substituted aralkylamino and heteroarylalkylamino) pyrimidinyl and 1,3,5 -triazinyl benzimidazoles, pharmaceutical compositions containing them, and these compounds for use in treating proliferative diseases |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013011086A MX2013011086A (es) | 2014-04-14 |
MX345238B true MX345238B (es) | 2017-01-23 |
Family
ID=45922860
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013011086A MX345238B (es) | 2011-03-28 | 2012-03-27 | (aralquilamino y heteroarilalquilamino alfa-substituidos)pirimidin ilo y 1,3,5-triazinilbenzimidazoles, composiciones farmacéuticas que los contienen, y estos compuestos para su uso en el tratamiento de enfermedades proliferativas. |
Country Status (17)
Country | Link |
---|---|
US (6) | US9056852B2 (es) |
EP (1) | EP2691384B1 (es) |
JP (1) | JP6042406B2 (es) |
KR (1) | KR101940831B1 (es) |
CN (2) | CN103582636B (es) |
AU (2) | AU2012236834B2 (es) |
BR (1) | BR112013024907A2 (es) |
CA (1) | CA2831582C (es) |
DK (1) | DK2691384T3 (es) |
ES (1) | ES2608967T3 (es) |
IL (1) | IL228600B (es) |
MX (1) | MX345238B (es) |
RU (1) | RU2608742C2 (es) |
SG (1) | SG193982A1 (es) |
TW (1) | TWI572599B (es) |
WO (1) | WO2012135160A1 (es) |
ZA (1) | ZA201307224B (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2831582C (en) | 2011-03-28 | 2019-01-08 | Mei Pharma, Inc. | (alpha-substituted aralkylamino and heteroarylalkylamino) pyrimidinyl and 1,3,5-triazinyl benzimidazoles, pharmaceutical compositions thereof, and their use in treating proliferative diseases |
EP2691389A1 (en) * | 2011-03-28 | 2014-02-05 | MEI Pharma, Inc. | (alpha-substituted cycloalkylamino and heterocyclylamino) pyrimidinyl and 1,3,5-triazinyl benzimidazoles, pharmaceutical compositions thereof, and their use in treating proliferative diseases |
KR20210010958A (ko) | 2012-11-08 | 2021-01-28 | 리젠 파마슈티컬스 소시에떼 아노님 | Pde4 억제제 및 pi3 델타 또는 이중 pi3 델타-감마 키나아제 억제제를 함유하는 약제학적 조성물 |
CN105102448B (zh) | 2013-02-28 | 2018-03-06 | 百时美施贵宝公司 | 作为rock1和rock2抑制剂的苯基吡唑衍生物 |
AR094929A1 (es) | 2013-02-28 | 2015-09-09 | Bristol Myers Squibb Co | Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2 |
JP6441910B2 (ja) | 2013-09-30 | 2018-12-19 | シャンハイ インリ ファーマシューティカル カンパニー リミティド | 縮合ピリミジン化合物、中間体、その調製方法、組成物及び使用 |
WO2015055071A1 (zh) | 2013-10-16 | 2015-04-23 | 上海璎黎药业有限公司 | 稠合杂环化合物、其制备方法、药物组合物和用途 |
CN103992228A (zh) * | 2014-05-26 | 2014-08-20 | 南京工业大学 | 一种盐酸芬特明的合成方法 |
WO2018053437A1 (en) * | 2016-09-19 | 2018-03-22 | Mei Pharma, Inc. | Combination therapy |
US11304953B2 (en) * | 2017-05-23 | 2022-04-19 | Mei Pharma, Inc. | Combination therapy |
MX2020001727A (es) * | 2017-08-14 | 2020-03-20 | Mei Pharma Inc | Terapia de combinacion. |
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