MX2007010404A - Hidrazinometilo, hidrazonometilo y compuestos heterociclicos de 5 miembros que actuan como inhibidores de mtor y su uso como agentes anti-cancer. - Google Patents

Hidrazinometilo, hidrazonometilo y compuestos heterociclicos de 5 miembros que actuan como inhibidores de mtor y su uso como agentes anti-cancer.

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Publication number
MX2007010404A
MX2007010404A MX2007010404A MX2007010404A MX2007010404A MX 2007010404 A MX2007010404 A MX 2007010404A MX 2007010404 A MX2007010404 A MX 2007010404A MX 2007010404 A MX2007010404 A MX 2007010404A MX 2007010404 A MX2007010404 A MX 2007010404A
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Mexico
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sup
formula
group
halo
carbon atoms
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MX2007010404A
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English (en)
Inventor
Marc Geoffrey Hummersone
Sylvie Gomez
Keith Allan Menear
Graeme Cameron Murray Smith
Xiao-Ling Fan Cockcroft
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Kudos Pharm Ltd
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Priority claimed from GBGB0503962.3A external-priority patent/GB0503962D0/en
Application filed by Kudos Pharm Ltd filed Critical Kudos Pharm Ltd
Publication of MX2007010404A publication Critical patent/MX2007010404A/es

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    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/54—Three nitrogen atoms
    • C07D251/70—Other substituted melamines
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D239/50—Three nitrogen atoms
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    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D471/04—Ortho-condensed systems

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  • Immunology (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Compuestos de la Formula (I): A-B-C e isomeros, sales, solvatos, formas quimicamente protegidas, y profarmacos de los mismos en donde: B se selecciona del grupo que consiste de formula (i), en donde RN es H o Me; o B es un residuo heterociclico de 5 atomos de carbono divalente que contiene uno o dos atomos heterogeneos en el anillo; A es de la formula (ii), RA3 y RA5 se seleccionan independientemente de halo, ORO y RAC, donde RO es H o Me, y RAC es H o alquilo de 1 a 4 atomos de carbono; XA se selecciona de N y CRA4, en donde RA4 se selecciona de H, ORO, CH2OH, CO2H, NHSO2Me y NHCOMe; RA2 y R46 se seleccionan independientemente de H, halo y ORO; o RA3 y RA4 junto con los atomos de carbono a los cuales se unen, o RA2 y RA3 junto con los atomos de carbono a los cuales se unen, pueden formar un anillo heterociclico o heteroaromatico de 5 a 6 atomos de carbono, que contiene al menos un atomo en el anillo de nitrogeno; donde si X no es N, 1, 2, o 3 de RA2 a RA6 no son H; C es formula (iii) donde X se selecciona de N y CH, Y se selecciona de N y CH, y Z se selecciona de N y CRC6; RC3 se selecciona de II, halo y un grupo heterociclico de 5 a 7 atomos de carbono que contiene N opcionalmente sustituido; RC5 es un grupo seleccionado de la formula (iv) cuyo grupo puede seleccionarse por uno o dos grupos alquilo de 1 a 4 atomos de carbono o un grupo carboxi; RC6 es H; o, cuando X y Y son N, RC5 y RC6 (cuando Z es CRC6) junto con los atomos de carbono a los cuales se unen pueden formar un anillo aromatico de 6 atomos de carbono fusionado seleccionado del grupo que consiste de la formula (v).
MX2007010404A 2005-02-25 2006-02-24 Hidrazinometilo, hidrazonometilo y compuestos heterociclicos de 5 miembros que actuan como inhibidores de mtor y su uso como agentes anti-cancer. MX2007010404A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US65619305P 2005-02-25 2005-02-25
GBGB0503962.3A GB0503962D0 (en) 2005-02-25 2005-02-25 Compounds
PCT/GB2006/000668 WO2006090167A2 (en) 2005-02-25 2006-02-24 Hydrazinomethyl, hydr zonomethyl and 5-membered heterocylic compounds which act as mtor inhibitors and their use as anti cancer agents

Publications (1)

Publication Number Publication Date
MX2007010404A true MX2007010404A (es) 2008-01-11

Family

ID=36729293

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007010404A MX2007010404A (es) 2005-02-25 2006-02-24 Hidrazinometilo, hidrazonometilo y compuestos heterociclicos de 5 miembros que actuan como inhibidores de mtor y su uso como agentes anti-cancer.

Country Status (10)

Country Link
US (1) US20100130473A1 (es)
EP (1) EP1877388A2 (es)
JP (1) JP2008531537A (es)
KR (1) KR20070108916A (es)
AU (1) AU2006217742A1 (es)
CA (1) CA2599320A1 (es)
IL (1) IL184900A0 (es)
MX (1) MX2007010404A (es)
NO (1) NO20074071L (es)
WO (1) WO2006090167A2 (es)

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CA2599320A1 (en) 2006-08-31
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