MX2009006129A - Compuestos de n-hidroxiacrilamida. - Google Patents

Compuestos de n-hidroxiacrilamida.

Info

Publication number
MX2009006129A
MX2009006129A MX2009006129A MX2009006129A MX2009006129A MX 2009006129 A MX2009006129 A MX 2009006129A MX 2009006129 A MX2009006129 A MX 2009006129A MX 2009006129 A MX2009006129 A MX 2009006129A MX 2009006129 A MX2009006129 A MX 2009006129A
Authority
MX
Mexico
Prior art keywords
sup
alkyl
optionally substituted
hydrogen
cyclo
Prior art date
Application number
MX2009006129A
Other languages
English (en)
Inventor
Fumiyuki Shirai
Yoshikazu Inoue
Yoshiteru Eikyu
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of MX2009006129A publication Critical patent/MX2009006129A/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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Abstract

Un compuesto que tiene la fórmula (I): (ver fórmula I) en donde R1 es hidrógeno, alquilo inferior opcionalmente sustituido, cicloalquilo inferior, cicloalquilo superior, arilo opcionalmente sustituido, heterociclilo opcionalmente sustituido o cicloalquilo inferior fusionado con arilo, R2 es hidrógeno o halógeno, Z es CH o N, X es (ver fórmula I) R3 es alquilo Inferior el cual puede estar sustituido con -OH u opcionalmente arilo sustituido o alquilo inferior, Y es hidrógeno o alquilo inferior, Y es alquileno inferior opcionalmente sustituido, o una sal del mismo. El compuesto es útil como un inhibidor de histona desactilasa.
MX2009006129A 2006-12-15 2007-12-14 Compuestos de n-hidroxiacrilamida. MX2009006129A (es)

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PCT/JP2007/074605 WO2008075757A1 (en) 2006-12-15 2007-12-14 N-hydroxyacrylamide compounds

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CA2848877A1 (en) 2011-09-15 2013-03-21 Taipei Medical University Use of indolyl and indolinvl hvdroxamates for treating heart failure or neuronal injury
EP3062783B1 (en) * 2013-10-18 2020-08-12 The General Hospital Corporation Imaging histone deacetylases with a radiotracer using positron emission tomography
KR20170124602A (ko) 2015-03-13 2017-11-10 포르마 세라퓨틱스 인크. Hdac8 억제제로서의 알파-신나미드 화합물 및 조성물
CN110437661B (zh) * 2019-07-23 2021-06-01 天津大学 一种基于季铵盐与n-羟基丙烯酰胺共混物的抗菌/防污/防雾涂层及其制备方法

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WO2001038322A1 (en) * 1999-11-23 2001-05-31 Methylgene, Inc. Inhibitors of histone deacetylase
PE20020354A1 (es) * 2000-09-01 2002-06-12 Novartis Ag Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
US7148257B2 (en) * 2002-03-04 2006-12-12 Merck Hdac Research, Llc Methods of treating mesothelioma with suberoylanilide hydroxamic acid
RU2352337C2 (ru) * 2002-11-12 2009-04-20 Алькон, Инк. Ингибиторы гистондеацетилазы для лечения офтальмологических неоваскулярных нарушений и заболеваний
CN101001851B (zh) * 2004-08-09 2011-04-20 安斯泰来制药有限公司 具有作为组蛋白脱乙酰酶(hdac)抑制剂的活性的羟基酰胺化合物
GB0509225D0 (en) * 2005-05-05 2005-06-15 Chroma Therapeutics Ltd Inhibitors of enzymatic activity

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CN101583599A (zh) 2009-11-18
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JP2010513223A (ja) 2010-04-30
EP2099756A1 (en) 2009-09-16
WO2008075757A1 (en) 2008-06-26
CA2671993A1 (en) 2008-06-26
KR20090099561A (ko) 2009-09-22

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