WO2008036967A3 - Novel heterocyclic compounds as lasy activators - Google Patents
Novel heterocyclic compounds as lasy activators Download PDFInfo
- Publication number
- WO2008036967A3 WO2008036967A3 PCT/US2007/079286 US2007079286W WO2008036967A3 WO 2008036967 A3 WO2008036967 A3 WO 2008036967A3 US 2007079286 W US2007079286 W US 2007079286W WO 2008036967 A3 WO2008036967 A3 WO 2008036967A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- lasy
- activators
- heterocyclic compounds
- novel heterocyclic
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
This invention provides a compound of formula (I), which is a free species and/or a pharmaceutically-acceptable salt or a stereoisomer of the compound of formula (I). Another aspect of the present invention provides the compound of the formula (I) as a Lipoic acid synthase (LASY) inducer
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84649906P | 2006-09-22 | 2006-09-22 | |
US60/846,499 | 2006-09-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008036967A2 WO2008036967A2 (en) | 2008-03-27 |
WO2008036967A3 true WO2008036967A3 (en) | 2008-09-18 |
Family
ID=39201359
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/079286 WO2008036967A2 (en) | 2006-09-22 | 2007-09-24 | Novel heterocyclic compounds as lasy activators |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2008036967A2 (en) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2477279C2 (en) * | 2007-06-05 | 2013-03-10 | Санофи-Авентис | Substituted benzoylaminoindan-2-carboxylic acids and related compounds |
ES2647664T3 (en) | 2011-01-04 | 2017-12-26 | Novartis Ag | Indole compounds or analogs thereof useful for the treatment of age-related macular degeneration (AMD) |
EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
JP6273274B2 (en) | 2012-06-28 | 2018-01-31 | ノバルティス アーゲー | Complement pathway modulators and uses thereof |
JP6209605B2 (en) | 2012-06-28 | 2017-10-04 | ノバルティス アーゲー | Pyrrolidine derivatives and their use as complement pathway regulators |
ES2712190T3 (en) | 2012-06-28 | 2019-05-09 | Novartis Ag | Modulators of the complement pathway and its uses |
US9468661B2 (en) | 2012-06-28 | 2016-10-18 | Novartis Ag | Pyrrolidine derivatives and their use as complement pathway modulators |
JP6154897B2 (en) | 2012-06-28 | 2017-06-28 | ノバルティス アーゲー | Pyrrolidine derivatives and their use as complement pathway regulators |
KR20150036481A (en) | 2012-07-12 | 2015-04-07 | 노파르티스 아게 | Complement pathway modulators and uses thereof |
BR112016022785B8 (en) | 2014-04-04 | 2020-09-15 | Iomet Pharma Ltd | tryptophan-2,3-dioxigenase (tdo) and / or indoleamine-2,3-dioxigenase (acid) inhibitor compound, pharmaceutical composition, and use of tryptophan-2,3-dioxigenase (tdo) inhibitor and / or indoleamine-2,3dioxigenase (acid) or a pharmaceutically acceptable salt thereof for the manufacture of a medicinal product |
WO2017123826A1 (en) | 2016-01-14 | 2017-07-20 | Beth Israel Deaconess Medical Center, Inc. | Mast-cell modulators and uses thereof |
US10858319B2 (en) | 2016-10-03 | 2020-12-08 | Iomet Pharma Ltd. | Indole derivatives for use in medicine |
GB201704476D0 (en) | 2017-03-21 | 2017-05-03 | Antabio Sas | Chemical compounds |
AU2021215709A1 (en) | 2020-02-04 | 2022-09-01 | Mindset Pharma Inc. | 3-pyrrolidine-indole derivatives as serotonergic psychedelic agents for the treatment of CNS disorders |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7196111B2 (en) * | 2002-06-04 | 2007-03-27 | Schering Corporation | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents |
-
2007
- 2007-09-24 WO PCT/US2007/079286 patent/WO2008036967A2/en active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7196111B2 (en) * | 2002-06-04 | 2007-03-27 | Schering Corporation | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents |
Also Published As
Publication number | Publication date |
---|---|
WO2008036967A2 (en) | 2008-03-27 |
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