MX2010007523A - Nuevos derivados de pirazolo[3,4-d]pirimidina como farmacos anticancer. - Google Patents
Nuevos derivados de pirazolo[3,4-d]pirimidina como farmacos anticancer.Info
- Publication number
- MX2010007523A MX2010007523A MX2010007523A MX2010007523A MX2010007523A MX 2010007523 A MX2010007523 A MX 2010007523A MX 2010007523 A MX2010007523 A MX 2010007523A MX 2010007523 A MX2010007523 A MX 2010007523A MX 2010007523 A MX2010007523 A MX 2010007523A
- Authority
- MX
- Mexico
- Prior art keywords
- pyrimidine derivatives
- cancer agents
- novel pyrazolo
- manufacture
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La invención se refiere a derivados de pirazolo[3,4-D]pirimidina sustituida de la fórmula (I), o sales farmacéuticamente aceptables de los mimos, que poseen actividad anti-proliferativa tal como actividad anti-cáncer y por consiguiente son útiles en métodos de tratamiento del cuerpo humano o animal. La invención también se refiere a procesos para la elaboración de derivados de pirazolo[3,4-D]pirimidina sustituida, composiciones farmacéuticas que contienen el compuesto y a su uso en la elaboración de medicamentos para la producción de un efecto anti proliferativo en un animal de sangre caliente tal como el hombre.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN109CH2008 | 2008-01-11 | ||
PCT/IN2009/000037 WO2009098715A2 (en) | 2008-01-11 | 2009-01-12 | Novel pyrazolo [3, 4 -d] pyrimidine derivatives as anti -cancer agents |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2010007523A true MX2010007523A (es) | 2010-08-18 |
Family
ID=40933862
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010007523A MX2010007523A (es) | 2008-01-11 | 2009-01-12 | Nuevos derivados de pirazolo[3,4-d]pirimidina como farmacos anticancer. |
Country Status (18)
Country | Link |
---|---|
US (1) | US8349847B2 (es) |
EP (1) | EP2247596A2 (es) |
JP (1) | JP2011509290A (es) |
KR (1) | KR20100116607A (es) |
CN (1) | CN101965350A (es) |
AP (1) | AP2010005347A0 (es) |
AU (1) | AU2009211004C1 (es) |
BR (1) | BRPI0906475A2 (es) |
CA (1) | CA2711777A1 (es) |
CO (1) | CO6382174A2 (es) |
EA (1) | EA201070841A1 (es) |
GE (1) | GEP20135780B (es) |
IL (1) | IL206811A0 (es) |
MA (1) | MA32009B1 (es) |
MX (1) | MX2010007523A (es) |
NZ (1) | NZ586642A (es) |
WO (1) | WO2009098715A2 (es) |
ZA (1) | ZA201004823B (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RS53494B9 (sr) | 2009-06-29 | 2020-11-30 | Incyte Holdings Corp | Pirimidinoni kao inhibitori pi3k |
WO2011075630A1 (en) * | 2009-12-18 | 2011-06-23 | Incyte Corporation | Substituted fused aryl and heteroaryl derivatives as pi3k inhibitors |
WO2011075643A1 (en) * | 2009-12-18 | 2011-06-23 | Incyte Corporation | Substituted heteroaryl fused derivatives as pi3k inhibitors |
EP2558463A1 (en) | 2010-04-14 | 2013-02-20 | Incyte Corporation | Fused derivatives as i3 inhibitors |
US9062055B2 (en) | 2010-06-21 | 2015-06-23 | Incyte Corporation | Fused pyrrole derivatives as PI3K inhibitors |
AR084366A1 (es) | 2010-12-20 | 2013-05-08 | Incyte Corp | N-(1-(fenil sustituido)etil)-9h-purin-6-aminas como inhibidores de pi3k |
WO2012125629A1 (en) | 2011-03-14 | 2012-09-20 | Incyte Corporation | Substituted diamino-pyrimidine and diamino-pyridine derivatives as pi3k inhibitors |
WO2012135009A1 (en) | 2011-03-25 | 2012-10-04 | Incyte Corporation | Pyrimidine-4,6-diamine derivatives as pi3k inhibitors |
HUE043703T2 (hu) | 2011-09-02 | 2019-09-30 | Incyte Holdings Corp | Heterociklusos aminok PI3K inhibitorokként |
AR090548A1 (es) | 2012-04-02 | 2014-11-19 | Incyte Corp | Azaheterociclobencilaminas biciclicas como inhibidores de pi3k |
CN102746307B (zh) * | 2012-07-09 | 2013-07-31 | 四川大学 | 1-n-苄基别嘌醇衍生物及其制备方法和用途 |
CN102746309B (zh) * | 2012-07-09 | 2013-06-05 | 四川大学 | 1-N-乙基-4-N-2′-取代酰基肼-1H-吡唑[3,4-d]嘧啶类衍生物及其制备方法和用途 |
CN103965202B (zh) * | 2014-05-21 | 2016-01-20 | 邹宏丽 | 二环稠合杂环化合物、其制备方法及用途 |
US10077277B2 (en) | 2014-06-11 | 2018-09-18 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors |
PL3262046T3 (pl) | 2015-02-27 | 2021-05-04 | Incyte Corporation | Sole inhibitora pi3k i sposoby ich wytwarzania |
WO2016183060A1 (en) | 2015-05-11 | 2016-11-17 | Incyte Corporation | Process for the synthesis of a phosphoinositide 3-kinase inhibitor |
WO2016183063A1 (en) | 2015-05-11 | 2016-11-17 | Incyte Corporation | Crystalline forms of a pi3k inhibitor |
CN106008527B (zh) * | 2016-06-29 | 2018-05-15 | 四川大学华西医院 | 吡唑并[3,4-d]嘧啶衍生物 |
CN107698596A (zh) * | 2017-11-15 | 2018-02-16 | 双鹤药业(商丘)有限责任公司 | 一种别嘌醇的合成方法 |
CN115304607B (zh) * | 2022-07-06 | 2023-06-27 | 华南农业大学 | 吡唑并嘧啶衍生物的制备方法 |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3000688A (en) | 1961-09-19 | Process for vatting of vat dyestuffs | ||
US3551428A (en) | 1956-02-10 | 1970-12-29 | Ciba Geigy Corp | New 1- (or 2-) substituted 4-mercapto-pyrazolo(3,4-d)pyrimidines |
JPS5439096A (en) | 1977-08-27 | 1979-03-24 | Lion Dentifrice Co Ltd | 11phenyll1hhpyrazolo*3*44d*pyrimidinee44 carbonitrile |
US5877178A (en) | 1991-04-08 | 1999-03-02 | Duquesne University Of The Holy Ghost | Pyrimidine derivatives and methods of making and using these derivatives |
US5958930A (en) | 1991-04-08 | 1999-09-28 | Duquesne University Of The Holy Ghost | Pyrrolo pyrimidine and furo pyrimidine derivatives |
US5593997A (en) * | 1995-05-23 | 1997-01-14 | Pfizer Inc. | 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors |
DE69619114T2 (de) | 1995-07-06 | 2002-10-02 | Novartis Ag, Basel | Pyrolopyrimidine und verfahren zu ihrer herstellung |
ATE217873T1 (de) | 1996-01-23 | 2002-06-15 | Novartis Erfind Verwalt Gmbh | Pyrrolopyrimidinen und verfahren zu deren herstellung |
CH690773A5 (de) | 1996-02-01 | 2001-01-15 | Novartis Ag | Pyrrolo(2,3-d)pyrimide und ihre Verwendung. |
US6537999B2 (en) | 1996-06-06 | 2003-03-25 | Duquesne University Of The Holy Ghost | Pyrimidine derivatives and methods of making and using these derivatives |
DE69738468T2 (de) | 1996-08-23 | 2009-01-08 | Novartis Ag | Substituierte pyrrolopyrimidine und verfahren zu ihrer herstellung |
DE19709488A1 (de) | 1997-03-07 | 1998-09-10 | Basf Ag | Verfahren zur N-Alkylierung von Aminen |
AU7927498A (en) | 1997-08-05 | 1999-03-01 | Pfizer Products Inc. | 4-aminopyrrole(3,2-d) pyrimidines as neuropeptide y receptor antagonists |
US6686366B1 (en) | 1998-06-02 | 2004-02-03 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
US6423871B1 (en) | 1999-02-26 | 2002-07-23 | University Of South Florida | Efficient synthesis of secondary amines by selective alkylation of primary amines |
IL144977A0 (en) | 1999-05-21 | 2002-06-30 | Bristol Myers Squibb Co | Pyrrolotriazine derivatives and pharmaceutical compositions containing the same |
ITMI992711A1 (it) | 1999-12-27 | 2001-06-27 | Novartis Ag | Composti organici |
AU2000240570A1 (en) | 2000-03-29 | 2001-10-08 | Knoll Gesellschaft Mit Beschraenkter Haftung | Pyrrolopyrimidines as tyrosine kinase inhibitors |
US6680324B2 (en) | 2000-12-01 | 2004-01-20 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptors and uses thereof |
BR0115847A (pt) | 2000-12-01 | 2004-02-25 | Osi Pharm Inc | Compostos especìficos para receptor para adenosina a1, a2a, e a3 e usos dos mesmos |
US6673802B2 (en) | 2000-12-01 | 2004-01-06 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
DE10060388A1 (de) | 2000-12-05 | 2002-06-06 | Merck Patent Gmbh | Verwendung von Pyrazolo [4,3-d]pyrimidinen |
TWI238824B (en) | 2001-05-14 | 2005-09-01 | Novartis Ag | 4-amino-5-phenyl-7-cyclobutyl-pyrrolo[2,3-d]pyrimidine derivatives |
EP1463742A4 (en) | 2001-06-21 | 2006-05-10 | Ariad Pharma Inc | NEW PYRAZOLO AND PYRROLO PYRIMIDINES AND THEIR USES |
GB0115393D0 (en) | 2001-06-23 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
US6939874B2 (en) | 2001-08-22 | 2005-09-06 | Amgen Inc. | Substituted pyrimidinyl derivatives and methods of use |
US7115617B2 (en) | 2001-08-22 | 2006-10-03 | Amgen Inc. | Amino-substituted pyrimidinyl derivatives and methods of use |
AU2003246972A1 (en) | 2002-08-06 | 2004-02-23 | Astrazeneca Ab | Condensed pyridines and pyrimidines with tie2 (tek) activity |
US20040138238A1 (en) | 2002-08-08 | 2004-07-15 | Dhanoa Dale S. | Substituted aminopyrimidine compounds as neurokinin antagonists |
-
2009
- 2009-01-12 BR BRPI0906475-3A patent/BRPI0906475A2/pt not_active IP Right Cessation
- 2009-01-12 EP EP09761144A patent/EP2247596A2/en not_active Withdrawn
- 2009-01-12 MX MX2010007523A patent/MX2010007523A/es not_active Application Discontinuation
- 2009-01-12 AP AP2010005347A patent/AP2010005347A0/en unknown
- 2009-01-12 AU AU2009211004A patent/AU2009211004C1/en not_active Ceased
- 2009-01-12 CN CN2009801083051A patent/CN101965350A/zh active Pending
- 2009-01-12 WO PCT/IN2009/000037 patent/WO2009098715A2/en active Application Filing
- 2009-01-12 CA CA2711777A patent/CA2711777A1/en not_active Abandoned
- 2009-01-12 EA EA201070841A patent/EA201070841A1/ru unknown
- 2009-01-12 KR KR1020107017777A patent/KR20100116607A/ko not_active Application Discontinuation
- 2009-01-12 NZ NZ586642A patent/NZ586642A/en not_active IP Right Cessation
- 2009-01-12 JP JP2010541891A patent/JP2011509290A/ja active Pending
- 2009-01-12 GE GEAP200911914A patent/GEP20135780B/en unknown
- 2009-01-12 US US12/812,405 patent/US8349847B2/en not_active Expired - Fee Related
-
2010
- 2010-07-05 IL IL206811A patent/IL206811A0/en unknown
- 2010-07-08 ZA ZA2010/04823A patent/ZA201004823B/en unknown
- 2010-07-09 MA MA33007A patent/MA32009B1/fr unknown
- 2010-08-11 CO CO10098749A patent/CO6382174A2/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP2247596A2 (en) | 2010-11-10 |
ZA201004823B (en) | 2011-09-28 |
AU2009211004A1 (en) | 2009-08-13 |
MA32009B1 (fr) | 2011-01-03 |
US20100298351A1 (en) | 2010-11-25 |
KR20100116607A (ko) | 2010-11-01 |
NZ586642A (en) | 2012-04-27 |
BRPI0906475A2 (pt) | 2015-07-14 |
US8349847B2 (en) | 2013-01-08 |
GEP20135780B (en) | 2013-03-11 |
CA2711777A1 (en) | 2009-08-13 |
WO2009098715A2 (en) | 2009-08-13 |
WO2009098715A3 (en) | 2009-10-15 |
JP2011509290A (ja) | 2011-03-24 |
CN101965350A (zh) | 2011-02-02 |
AU2009211004B2 (en) | 2011-09-01 |
AU2009211004C1 (en) | 2013-08-01 |
AU2009211004A2 (en) | 2011-01-27 |
IL206811A0 (en) | 2010-12-30 |
WO2009098715A4 (en) | 2009-12-10 |
AP2010005347A0 (en) | 2010-08-31 |
CO6382174A2 (es) | 2012-02-15 |
EA201070841A1 (ru) | 2011-02-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2010007523A (es) | Nuevos derivados de pirazolo[3,4-d]pirimidina como farmacos anticancer. | |
MX2007008924A (es) | Compuestos quimicos. | |
TW200635899A (en) | Chemical compounds | |
TW200634003A (en) | Chemical compounds | |
TW200616974A (en) | Chemical compounds | |
TW200736234A (en) | Chemical compounds | |
TW200621259A (en) | Chemical compounds | |
TW200621730A (en) | Chemical compounds | |
WO2007071963A3 (en) | Quinazoline derivatives, process for their preparation and their use as anti-cancer agents | |
TN2015000368A1 (en) | Quinazoline inhibitors of activating mutant forms of epidermal growth factor receptor | |
CA2918938C (en) | Substituted aminopyrimidine compounds and methods of use | |
WO2007113558A3 (en) | Quinazolinone derivatives having b-raf inhibitory activity | |
MY164274A (en) | Salt(s) of 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7h-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide and processes of making thereof | |
MY148072A (en) | Oxygen linked pyrimidine derivatives | |
TW200606162A (en) | Pyrazolopyridine derivatives | |
MY164730A (en) | Aminoalcohol substituted 2,3-dihydroimidazo[1,2-c]quinazoline derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | |
MX2009004906A (es) | Sulfonamidas heterociclicas que tienen actividad antagonistica del edg-1. | |
MX2009004908A (es) | Compuestos quimicos. | |
TW200618801A (en) | Pyrimidine derivatives | |
WO2008068507A3 (en) | 2 -phenylamino, 6- (pyrid-3-yl) quinazoline derivatives as raf-protein kinase inhibitors in cancer treatment | |
MX2012002327A (es) | Inhibidores de cinasa, formas de profarmaco de los mismos y su uso en terapia. | |
MX2014003194A (es) | 3-(quinolin-6-il-tio)-[1,2,4]-triazolo-[4,3-a]-piridinas 6-sustituidas como cinasas de tirosina. | |
PT1869038E (pt) | Compostos de 5,6,7,8-tetra-hidro-imidazo[1,2-a]piridin-2- ilamina substituída e sua utilização para produzir fármacos | |
MY150054A (en) | Novel 4-(tetrazol-5-yl)-quinazoline derivatives as anti cancer agents | |
MX2009007889A (es) | Derivados de 3-cinnolincarboxamida y su uso para el tratamiento del cancer. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |