MX2010007523A - Nuevos derivados de pirazolo[3,4-d]pirimidina como farmacos anticancer. - Google Patents

Nuevos derivados de pirazolo[3,4-d]pirimidina como farmacos anticancer.

Info

Publication number
MX2010007523A
MX2010007523A MX2010007523A MX2010007523A MX2010007523A MX 2010007523 A MX2010007523 A MX 2010007523A MX 2010007523 A MX2010007523 A MX 2010007523A MX 2010007523 A MX2010007523 A MX 2010007523A MX 2010007523 A MX2010007523 A MX 2010007523A
Authority
MX
Mexico
Prior art keywords
pyrimidine derivatives
cancer agents
novel pyrazolo
manufacture
relates
Prior art date
Application number
MX2010007523A
Other languages
English (en)
Inventor
Bhujanga Rao Adibhatla Kali Satya
Nannapaneni Venkaiah Chowdary
Durga Prasad Konakanchi
Subba Rao Pula
Lakshmi Ananthaneni
Muddasani Pulla Reddy
Ramakrishna Pilli
Original Assignee
Natco Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Natco Pharma Ltd filed Critical Natco Pharma Ltd
Publication of MX2010007523A publication Critical patent/MX2010007523A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invención se refiere a derivados de pirazolo[3,4-D]pirimidina sustituida de la fórmula (I), o sales farmacéuticamente aceptables de los mimos, que poseen actividad anti-proliferativa tal como actividad anti-cáncer y por consiguiente son útiles en métodos de tratamiento del cuerpo humano o animal. La invención también se refiere a procesos para la elaboración de derivados de pirazolo[3,4-D]pirimidina sustituida, composiciones farmacéuticas que contienen el compuesto y a su uso en la elaboración de medicamentos para la producción de un efecto anti proliferativo en un animal de sangre caliente tal como el hombre.
MX2010007523A 2008-01-11 2009-01-12 Nuevos derivados de pirazolo[3,4-d]pirimidina como farmacos anticancer. MX2010007523A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN109CH2008 2008-01-11
PCT/IN2009/000037 WO2009098715A2 (en) 2008-01-11 2009-01-12 Novel pyrazolo [3, 4 -d] pyrimidine derivatives as anti -cancer agents

Publications (1)

Publication Number Publication Date
MX2010007523A true MX2010007523A (es) 2010-08-18

Family

ID=40933862

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010007523A MX2010007523A (es) 2008-01-11 2009-01-12 Nuevos derivados de pirazolo[3,4-d]pirimidina como farmacos anticancer.

Country Status (18)

Country Link
US (1) US8349847B2 (es)
EP (1) EP2247596A2 (es)
JP (1) JP2011509290A (es)
KR (1) KR20100116607A (es)
CN (1) CN101965350A (es)
AP (1) AP2010005347A0 (es)
AU (1) AU2009211004C1 (es)
BR (1) BRPI0906475A2 (es)
CA (1) CA2711777A1 (es)
CO (1) CO6382174A2 (es)
EA (1) EA201070841A1 (es)
GE (1) GEP20135780B (es)
IL (1) IL206811A0 (es)
MA (1) MA32009B1 (es)
MX (1) MX2010007523A (es)
NZ (1) NZ586642A (es)
WO (1) WO2009098715A2 (es)
ZA (1) ZA201004823B (es)

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RS53494B9 (sr) 2009-06-29 2020-11-30 Incyte Holdings Corp Pirimidinoni kao inhibitori pi3k
WO2011075630A1 (en) * 2009-12-18 2011-06-23 Incyte Corporation Substituted fused aryl and heteroaryl derivatives as pi3k inhibitors
WO2011075643A1 (en) * 2009-12-18 2011-06-23 Incyte Corporation Substituted heteroaryl fused derivatives as pi3k inhibitors
EP2558463A1 (en) 2010-04-14 2013-02-20 Incyte Corporation Fused derivatives as i3 inhibitors
US9062055B2 (en) 2010-06-21 2015-06-23 Incyte Corporation Fused pyrrole derivatives as PI3K inhibitors
AR084366A1 (es) 2010-12-20 2013-05-08 Incyte Corp N-(1-(fenil sustituido)etil)-9h-purin-6-aminas como inhibidores de pi3k
WO2012125629A1 (en) 2011-03-14 2012-09-20 Incyte Corporation Substituted diamino-pyrimidine and diamino-pyridine derivatives as pi3k inhibitors
WO2012135009A1 (en) 2011-03-25 2012-10-04 Incyte Corporation Pyrimidine-4,6-diamine derivatives as pi3k inhibitors
HUE043703T2 (hu) 2011-09-02 2019-09-30 Incyte Holdings Corp Heterociklusos aminok PI3K inhibitorokként
AR090548A1 (es) 2012-04-02 2014-11-19 Incyte Corp Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
CN102746307B (zh) * 2012-07-09 2013-07-31 四川大学 1-n-苄基别嘌醇衍生物及其制备方法和用途
CN102746309B (zh) * 2012-07-09 2013-06-05 四川大学 1-N-乙基-4-N-2′-取代酰基肼-1H-吡唑[3,4-d]嘧啶类衍生物及其制备方法和用途
CN103965202B (zh) * 2014-05-21 2016-01-20 邹宏丽 二环稠合杂环化合物、其制备方法及用途
US10077277B2 (en) 2014-06-11 2018-09-18 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors
PL3262046T3 (pl) 2015-02-27 2021-05-04 Incyte Corporation Sole inhibitora pi3k i sposoby ich wytwarzania
WO2016183060A1 (en) 2015-05-11 2016-11-17 Incyte Corporation Process for the synthesis of a phosphoinositide 3-kinase inhibitor
WO2016183063A1 (en) 2015-05-11 2016-11-17 Incyte Corporation Crystalline forms of a pi3k inhibitor
CN106008527B (zh) * 2016-06-29 2018-05-15 四川大学华西医院 吡唑并[3,4-d]嘧啶衍生物
CN107698596A (zh) * 2017-11-15 2018-02-16 双鹤药业（商丘）有限责任公司 一种别嘌醇的合成方法
CN115304607B (zh) * 2022-07-06 2023-06-27 华南农业大学 吡唑并嘧啶衍生物的制备方法

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Also Published As

Publication number Publication date
EP2247596A2 (en) 2010-11-10
ZA201004823B (en) 2011-09-28
AU2009211004A1 (en) 2009-08-13
MA32009B1 (fr) 2011-01-03
US20100298351A1 (en) 2010-11-25
KR20100116607A (ko) 2010-11-01
NZ586642A (en) 2012-04-27
BRPI0906475A2 (pt) 2015-07-14
US8349847B2 (en) 2013-01-08
GEP20135780B (en) 2013-03-11
CA2711777A1 (en) 2009-08-13
WO2009098715A2 (en) 2009-08-13
WO2009098715A3 (en) 2009-10-15
JP2011509290A (ja) 2011-03-24
CN101965350A (zh) 2011-02-02
AU2009211004B2 (en) 2011-09-01
AU2009211004C1 (en) 2013-08-01
AU2009211004A2 (en) 2011-01-27
IL206811A0 (en) 2010-12-30
WO2009098715A4 (en) 2009-12-10
AP2010005347A0 (en) 2010-08-31
CO6382174A2 (es) 2012-02-15
EA201070841A1 (ru) 2011-02-28

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