AR049830A1 - Derivados de piperidina - Google Patents

Derivados de piperidina

Info

Publication number
AR049830A1
AR049830A1 ARP050102573A ARP050102573A AR049830A1 AR 049830 A1 AR049830 A1 AR 049830A1 AR P050102573 A ARP050102573 A AR P050102573A AR P050102573 A ARP050102573 A AR P050102573A AR 049830 A1 AR049830 A1 AR 049830A1
Authority
AR
Argentina
Prior art keywords
alkyl
4alkyl
optionally substituted
halo
cyano
Prior art date
Application number
ARP050102573A
Other languages
English (en)
Inventor
Howard Tucker
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32733687&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR049830(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR049830A1 publication Critical patent/AR049830A1/es

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    • C—CHEMISTRY; METALLURGY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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Abstract

Composiciones que los comprenden, procesos para prepararlos y su uso en terapia médica (por ejemplo para modular la actividad del receptor CCR5 en un animal de sangre caliente). Reivindicacion 1: Un compuesto de formula (1), caracterizado porque: R1 es S(O)2R6, S(O)2NR10R11, C(O)R7 o C(O)NHR7; R2 es 3,5-difluorofenilo, 3-trifluorometilfenilo o 3-fluoro-5-clorofenilo; R3 es hidrogeno o alquilo C1-4; R4 es hidrogeno, metilo, etilo, alilo o ciclopropilo; R5 es fenil-alquiloC1-2 o fenil(alquiloC1-2)NH; donde los anillos fenilo están sustituidos opcionalmente con halo, ciano, nitro, hidroxi, alquilo C1-4, alcoxi C1-4, S(O)kalquiloC1-4, S(O)2NR8R9, NHS(O)2alquiloC1-4, NH2, NHalquiloC1-4, N(alquiloC1-4)2, NHC(O)NH2, C(O)NH2, C(O)NHalquiloC1-4, C(O)N(alquiloC1-4)2, NHC(O)alquiloC1-4, CO2H, CO2alquiloC1-4, C(O)alquiloC1-4, CF3, CHF2, CH2F, CH2CF3 u OCF3; k es 0, 1 o 2; R6 es alquilo C1-6 [opcionalmente sustituido con alcoxi C1-4, fenilo {que en sí está sustituido opcionalmente con halo, alquilo C1-4, alcoxi C1-4, ciano, nitro, CF3, OCF3, alquiloC1-4C(O)NH, S(O)2NH2, alquiltio C1-4, S(O)alquiloC1-4 o S(O)2alquiloC1-4} o heteroarilo {que en sí está sustituido opcionalmente con halo, alquilo C1-4, alcoxi C1-4, ciano, nitro, CF3, alquiloC1-4C(O)NH, S(O)2NH2, alquiltio C1-4, S(O)alquiloC1-4 o S(O)2alquiloC1-4}], cicloalquilo C3-7, tetrahidropiranilo, fenilo {opcionalmente sustituido con halo, alquilo C1-4, alcoxi C1-4, ciano, nitro, CF3, OCF3, alquiloC1- 4C(O)NH, S(O)2NH2, alquiltio C1-4, S(O)alquiloC1-4 o S(O)2alquiloC1-4} o heteroarilo {opcionalmente sustituido con halo, alquilo C1-4, alcoxi C1-4, ciano, nitro, CF3, alquiloC1-4C(O)NH, S(O)2NH2, alquiltio C1-4, S(O)alquiloC1-4 o S(O)2alquiloC1-4}; R7 es hidrogeno, alquilo 1-6 [opcionalmente sustituido con halogeno (como por ejemplo fluor), alcoxi C1-4, fenilo {que en sí está sustituido opcionalmente con halo, alquilo C1-4, alcoxi C1-4, ciano, nitro, CF3, OCF3, alquiloC1-4C(O)NH, S(O)2NH2, alquiltio C1-4, S(O)alquiloC1-4 o S(O)2alquiloC1-4} o heteroarilo {que en sí está sustituido opcionalmente con halo, alquilo C1-4, alcoxi C1-4, ciano, nitro, CF3, alquiloC1-4C(O)NH, S(O)2NH2, alquiltio C1-4, S(O)alquiloC1-4 o S(O)2alquiloC1-4}], cicloalquilo C3-7, tetrahidropiranilo, fenilo {opcionalmente sustituido con halo, alquilo C1-4, alcoxi C1-4, ciano, nitro, CF3, OCF3, alquiloC1-4C(O)NH, S(O)2NH2, alquiltio C1-4, S(O)alquiloC1-4 o S(O)2alquiloC1-4} o heteroarilo {opcionalmente sustituido con halo, alquilo C1-4, alcoxi C1-4, ciano, nitro, CF3, alquiloC1-4C(O)NH, S(O)2NH2, alquiltio C1-4, S(O)alquiloC1-4 o S(O)2alquiloC1-4}; R8 y R9 son, independientemente, hidrogeno o alquilo C1-4, o junto con un átomo de nitrogeno u oxígeno, se pueden unir para formar un anillo de 5 o 6 miembros que opcionalmente está sustituido con alquilo C1-4, C(O)H o C(O)alquiloC1-4; R10 y R11 son, independientemente, hidrogeno o alquilo C1-4, o se pueden unir para formar un anillo de 5 o 6 miembros que opcionalmente está sustituido con alquilo C1-4 o fenilo (donde el anillo fenilo está sustituido opcionalmente con halo, ciano, nitro, hidroxi, alquilo C1-4, alcoxi C1-4,, S(O)malquiloC1-4, S(O)2NH2, S(O)2NHalquiloC1-4, S(O)2N(alquiloC1- 4)2, NHS(O)2alquiloC1-4, NH2, NHalquiloC1-4, N(alquiloC1-4)2, NHC(O)NH2, C(O)NH2, C(O)NalquiloC1-4, NHC(O)alquiloC1-4, CO2H, CO2alquiloC1-4, C(O)alquiloC1-4, CF3, CHF2, CHF, CH2CF3 u OCF3); o una sal de los mismos aceptables para uso farmacéutico.
ARP050102573A 2004-06-24 2005-06-22 Derivados de piperidina AR049830A1 (es)

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