AR039125A1 - Derivados de piperidina o 8-aza-biciclo(3.2.1.)octa-3-il derivados, utiles como moduladores de receptores de actividad de quemoquinas - Google Patents
Derivados de piperidina o 8-aza-biciclo(3.2.1.)octa-3-il derivados, utiles como moduladores de receptores de actividad de quemoquinasInfo
- Publication number
- AR039125A1 AR039125A1 ARP030101026A ARP030101026A AR039125A1 AR 039125 A1 AR039125 A1 AR 039125A1 AR P030101026 A ARP030101026 A AR P030101026A AR P030101026 A ARP030101026 A AR P030101026A AR 039125 A1 AR039125 A1 AR 039125A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- derivatives
- substituted
- phenyl
- independently
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Reivindicación 1: Un compuesto caracterizado porque responde a la fórmula (1) donde: A es CH2CH2 o A está ausente, R1 es C3-7 cicloalquilo (sustituido por uno o dos átomos de F y opcionalmente también sustituido por C1-4 alquilo) o heterociclilo unido a N (sustituido por uno o dos átomos de F y opcionalmente también sustituido por C1-4 alquilo); R2 es C3-6 alquilo o C3-6 cicloalquilo, o fenilo o heteroarilo cualquiera de los cuales es opcionalmente sustituido por halógeno, C1-4 alquilo, C1-4 alcoxi, S(O)n(C1-4 alquilo), nitro, ciano o CF3; R2a, R4 y R4a son, en forma independiente, H o C1-4 alquilo; R3 y R3a son, en forma independiente, H o C1-4 alquilo o C1-4 alcoxi; R5 es H, C1-4 alquilo (opcionalmente sustituido por halógeno, hidroxi, C1-4 alcoxi, C3-7 cicloalquilo, SH, C1-4 alquiltio, ciano o S(O)q(C1-4 alquilo), C3-4 alquenilo, C3-4 alquinilo o C3-7 cicloalquilo; R6 es fenilo, heteroarilo, fenilNH, heteroarilNH, fenil(C1-2)alquilo, heteroaril (C1-2)alquilo, fenil (C1-2 alquil)NH o heteroaril (C1-2 alquil)NH; donde los anillos fenilo y heteroarilo de cualquiera de los anteriores son, a menos que se especifique lo contrario, en forma independiente opcionalmente sustituido por halo, ciano, nitro, hidroxi, C1-4 alquilo, C1-4 alcoxi, S(O)m(C1-4 alquilo), S(O)2NR7R8, NHS(O)2(C1-4 alquilo), NH2, NH(C1-4 alquilo), N(C1-4 alquil)2, NHC(O)NH2, C(O)NH2, C(O)NH(C1-4 alquilo), NHC(O)(C1-4 alquilo), CO2H, CO2(C1-4 alquilo), C(O)(C1-4 alquilo), CF3, CHF2, CH2F, CH2CF3 o OCF3; R7 y R8 son, en forma independiente, H o C1-4 alquilo, o junto con un átomo de N u O, pueden unirse para formar un anillo de 5 o 6 miembros que está opcionalmente sustituido con C1-4 alquilo, C(O)H o C(O)(C1-4 alquilo); m, n y q son, en forma independiente 0, 1, o 2; o una sal aceptable para uso farmacéutico del mismo o un solvato del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0200919A SE0200919D0 (sv) | 2002-03-25 | 2002-03-25 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR039125A1 true AR039125A1 (es) | 2005-02-09 |
Family
ID=20287391
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030101026A AR039125A1 (es) | 2002-03-25 | 2003-03-25 | Derivados de piperidina o 8-aza-biciclo(3.2.1.)octa-3-il derivados, utiles como moduladores de receptores de actividad de quemoquinas |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20050171353A1 (es) |
| EP (1) | EP1490336A1 (es) |
| JP (1) | JP2005526797A (es) |
| KR (1) | KR20040094876A (es) |
| CN (1) | CN1642913A (es) |
| AR (1) | AR039125A1 (es) |
| AU (1) | AU2003216012A1 (es) |
| BR (1) | BR0308592A (es) |
| CA (1) | CA2479887A1 (es) |
| IL (1) | IL163896A0 (es) |
| MX (1) | MXPA04009162A (es) |
| NO (1) | NO20044545L (es) |
| SE (1) | SE0200919D0 (es) |
| TW (1) | TW200305417A (es) |
| WO (1) | WO2003080574A1 (es) |
| ZA (1) | ZA200407414B (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR028948A1 (es) | 2000-06-20 | 2003-05-28 | Astrazeneca Ab | Compuestos novedosos |
| SE0301369D0 (sv) * | 2003-05-09 | 2003-05-09 | Astrazeneca Ab | Chemical compounds |
| SE0302090D0 (sv) * | 2003-07-16 | 2003-07-16 | Astrazeneca Ab | Chemical compounds |
| US7498346B2 (en) * | 2003-12-11 | 2009-03-03 | Genzyme Corporation | Chemokine receptor binding compounds |
| SE0303396D0 (sv) * | 2003-12-16 | 2003-12-16 | Astrazeneca Ab | Chemical compounds |
| TW200538098A (en) * | 2004-03-22 | 2005-12-01 | Astrazeneca Ab | Therapeutic agents |
| ES2277745B1 (es) * | 2005-06-14 | 2008-06-01 | Laboratorios Almirall S.A. | Derivados n-amida de 8-azabiciclo /3.2.1/oct-3-ilo como antagonistas de ccr1. |
| EP1942890A4 (en) * | 2005-06-15 | 2009-08-26 | Genzyme Corp | CHEMOKINE RECEPTOR BINDING COMPOUNDS |
| EP1912942A1 (en) * | 2005-08-01 | 2008-04-23 | AstraZeneca AB | Novel piperidine derivatives as chemokine receptor modulators useful for the treatment of respiratory diseases. |
| BRPI0617720A2 (pt) | 2005-10-19 | 2011-08-02 | Hoffmann La Roche | compostos inibidores de nnrt de fenil-acetamida, usos dos referidos compostos e composição farmacêutica que os contém |
| PT2057125E (pt) | 2006-08-16 | 2011-05-31 | Hoffmann La Roche | Inibidores n?o nucle?sidos de transcriptase inversa |
| JP5415957B2 (ja) | 2006-12-13 | 2014-02-12 | エフ．ホフマン−ラ ロシュ アーゲー | 非ヌクレオシド逆転写酵素阻害剤としての２−（ピペリジン−４−イル）−４−フェノキシ−又はフェニルアミノ−ピリミジン誘導体 |
| EP2173715A2 (en) * | 2007-07-13 | 2010-04-14 | Euroscreen S.A. | Use of piperidine derivatives as agonists of chemokine receptor activity |
| CN101412692B (zh) * | 2007-10-18 | 2012-10-17 | 中国科学院上海药物研究所 | 1-(3-氨基丙基)哌啶-4-氨基酰胺类化合物、其药物组合物及其制备方法和用途 |
| CN101712679B (zh) * | 2008-10-08 | 2013-04-10 | 中国科学院上海药物研究所 | 一种酰胺类化合物、其药物组合物及其制备方法和用途 |
| CN102140104B (zh) * | 2010-02-03 | 2014-11-12 | 中国科学院上海药物研究所 | 1-(3-(s)-氨基丙基)-哌啶-4-氨基酰胺类化合物、其药物组合物及其制备方法和用途 |
| WO2012113103A1 (en) | 2011-02-25 | 2012-08-30 | Helsinn Healthcare S.A. | Asymmetric ureas and medical uses thereof |
| CN103159754A (zh) * | 2011-12-19 | 2013-06-19 | 中国科学院上海药物研究所 | 一种氨基丙基取代托烷胺类化合物、其药物组合物及其制备方法和用途 |
| RS64027B1 (sr) | 2016-03-22 | 2023-03-31 | Helsinn Healthcare Sa | Benzenesulfonil-asimetrične uree i njihove medicinske upotrebe |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1013276A1 (en) * | 1998-12-23 | 2000-06-28 | Pfizer Inc. | Aminoazacycloalkanes as CCR5 modulators |
| US6506777B1 (en) * | 1999-06-11 | 2003-01-14 | Merck & Co., Inc. | Cyclopentyl modulators of chemokine receptor activity |
| SE9902987D0 (sv) * | 1999-08-24 | 1999-08-24 | Astra Pharma Prod | Novel compounds |
| GB0011838D0 (en) * | 2000-05-17 | 2000-07-05 | Astrazeneca Ab | Chemical compounds |
| ES2215129T3 (es) * | 2000-05-26 | 2004-10-01 | Pfizer Inc. | Derivados de triazolil tropano como modulares de ccr5. |
| EP1368314A1 (en) * | 2001-03-01 | 2003-12-10 | AstraZeneca AB | N-4-piperidinyl compounds as ccr5 modulators |
| GB0107228D0 (en) * | 2001-03-22 | 2001-05-16 | Astrazeneca Ab | Chemical compounds |
-
2002
- 2002-03-25 SE SE0200919A patent/SE0200919D0/xx unknown
-
2003
- 2003-03-17 TW TW092105784A patent/TW200305417A/zh unknown
- 2003-03-24 CA CA002479887A patent/CA2479887A1/en not_active Abandoned
- 2003-03-24 CN CNA038064642A patent/CN1642913A/zh active Pending
- 2003-03-24 AU AU2003216012A patent/AU2003216012A1/en not_active Abandoned
- 2003-03-24 KR KR10-2004-7015310A patent/KR20040094876A/ko not_active Application Discontinuation
- 2003-03-24 JP JP2003578329A patent/JP2005526797A/ja active Pending
- 2003-03-24 MX MXPA04009162A patent/MXPA04009162A/es not_active Application Discontinuation
- 2003-03-24 IL IL16389603A patent/IL163896A0/xx unknown
- 2003-03-24 BR BR0308592-9A patent/BR0308592A/pt not_active Application Discontinuation
- 2003-03-24 EP EP03745059A patent/EP1490336A1/en not_active Withdrawn
- 2003-03-24 WO PCT/SE2003/000480 patent/WO2003080574A1/en active Application Filing
- 2003-03-24 US US10/508,895 patent/US20050171353A1/en not_active Abandoned
- 2003-03-25 AR ARP030101026A patent/AR039125A1/es unknown
-
2004
- 2004-09-15 ZA ZA200407414A patent/ZA200407414B/en unknown
- 2004-10-22 NO NO20044545A patent/NO20044545L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003216012A1 (en) | 2003-10-08 |
| EP1490336A1 (en) | 2004-12-29 |
| SE0200919D0 (sv) | 2002-03-25 |
| WO2003080574A1 (en) | 2003-10-02 |
| CN1642913A (zh) | 2005-07-20 |
| BR0308592A (pt) | 2005-02-09 |
| JP2005526797A (ja) | 2005-09-08 |
| MXPA04009162A (es) | 2004-12-07 |
| IL163896A0 (en) | 2005-12-18 |
| KR20040094876A (ko) | 2004-11-10 |
| NO20044545L (no) | 2004-12-13 |
| TW200305417A (en) | 2003-11-01 |
| US20050171353A1 (en) | 2005-08-04 |
| ZA200407414B (en) | 2005-08-29 |
| CA2479887A1 (en) | 2003-10-02 |
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Legal Events
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|---|---|---|---|
| FB | Suspension of granting procedure |