AR070801A1 - Derivados pirimidin -piridina - Google Patents
Derivados pirimidin -piridinaInfo
- Publication number
- AR070801A1 AR070801A1 ARP090100789A ARP090100789A AR070801A1 AR 070801 A1 AR070801 A1 AR 070801A1 AR P090100789 A ARP090100789 A AR P090100789A AR P090100789 A ARP090100789 A AR P090100789A AR 070801 A1 AR070801 A1 AR 070801A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkylamino
- formulas
- formula
- group
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Otolaryngology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Su uso como compuestos farmacéuticamente activos. Dichos compuestos actuan particularmente como agentes inmunomoduladores. Reivindicacion 1: Un compuesto de formula (1) donde A representa el grupo de formulas (2) o donde A representa el grupo de formulas (2) donde los asteriscos indican el enlace que está ligado al grupo pirimidina de la formula (1); R1 representa alcoxi C1-4, alquilamino C1-4, N-alquilo C1-4-N-alquilamino C1-3, cicloalquilamino C3-5, cicloalquilmetilamino C3-5, pirrolidina, o piperidina; R2 representa alquilo C1-2, o alquilo C3-4 y Piridina1 representa el grupos de formulas (3) donde los asteriscos indican el enlace con el cual el anillo piridina está unido al anillo A de la formula (1); y en el caso en el que R1 representa alquilamino C1-4, N-alquilo C1-4-N-alquilamino C1-3, cicloalquilamino C3-5, o cicloalquilmetilamino C3-5, piridina1 puede representar también el grupo de formulas (4) donde los asteriscos indican el enlace con el cual el anillo piridina está unido al anillo A de la formula (1); R3 representa alquilo C1-4, alcoxi C1-3, o NR3aR3b; R3a representa alquilo C1-2; R3b representa hidrogeno, o metilo; y R4 representa hidrogeno, cloro, o alquilo C1-2; R5 representa alquilo C1-4, alcoxi C1-3 o NR5aR5b; R5a representa alquilo C1-3; R5b representa hidrogeno, o alquilo C1-2; y R6 representa alquilo C1-2; R7 representa alquilo C1-4, y R8 representa alquilo C1-2, o R7 representa alquilo C1-2; y R8 representa alquilo C1-4; R9 representa alquilo C1-2; y R10 representa alquilo C1-4; y R11representa alquilo C1-4; y R12 representa alquilo C1-2 o una sal del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2008050818 | 2008-03-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR070801A1 true AR070801A1 (es) | 2010-05-05 |
Family
ID=40577803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090100789A AR070801A1 (es) | 2008-03-06 | 2009-03-05 | Derivados pirimidin -piridina |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20110046170A1 (es) |
| EP (1) | EP2262800A1 (es) |
| JP (1) | JP2011513385A (es) |
| CN (1) | CN101965346A (es) |
| AR (1) | AR070801A1 (es) |
| CA (1) | CA2714614A1 (es) |
| TW (1) | TW200940535A (es) |
| WO (1) | WO2009109907A1 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2400533T3 (es) * | 2006-09-07 | 2013-04-10 | Actelion Pharmaceuticals Ltd. | Derivados de piridin 4-ilo como agentes inmunomoduladores |
| MY150661A (en) * | 2006-09-08 | 2014-02-14 | Actelion Pharmaceuticals Ltd | Pyridin-3-yl derivatives as immunomodulating agents |
| US8044076B2 (en) * | 2006-09-21 | 2011-10-25 | Actelion Pharmaceuticals Ltd. | Phenyl derivatives and their use as immunomodulators |
| ES2450750T3 (es) * | 2007-03-16 | 2014-03-25 | Actelion Pharmaceuticals Ltd. | Derivados de amino-piridina como agonistas del receptor S1P1/EDG1 |
| NZ583957A (en) * | 2007-08-17 | 2011-09-30 | Actelion Pharmaceuticals Ltd | Pyridine derivatives as s1p1/edg1 receptor modulators |
| NZ588438A (en) * | 2008-03-07 | 2012-05-25 | Actelion Pharmaceuticals Ltd | Pyridin-2-yl oxadiazole derivatives as immunomodulating agents |
| KR20120016247A (ko) * | 2009-05-19 | 2012-02-23 | 다우 아그로사이언시즈 엘엘씨 | 진균 방제를 위한 화합물 및 방법 |
| ES2441845T3 (es) | 2009-07-16 | 2014-02-06 | Actelion Pharmaceuticals Ltd. | Derivados de piridin-4-ilo como agonistas de S1P1/EDG1 |
| ES2544086T3 (es) | 2011-01-19 | 2015-08-27 | Actelion Pharmaceuticals Ltd. | Derivados de 2-metoxi-piridin-4-ilo |
| CA2900910C (en) | 2013-03-15 | 2021-03-30 | Actelion Pharmaceuticals Ltd | Pyridin-4-yl derivatives |
| EP3298008B1 (en) | 2015-05-20 | 2019-11-20 | Idorsia Pharmaceuticals Ltd | Crystalline form of the compound (s)-3-{4-[5-(2-cyclopentyl-6-methoxy-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy}-propane-1,2-diol |
| WO2017004610A1 (en) | 2015-07-02 | 2017-01-05 | Exelixis, Inc. | Tercyclic s1p3-sparing, s1p1 receptor agonists |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2547198A1 (en) * | 2003-12-17 | 2005-06-30 | Merck & Co., Inc. | (3,4-disubstituted)propanoic carboxylates as s1p (edg) receptor agonists |
| GB0601744D0 (en) * | 2006-01-27 | 2006-03-08 | Novartis Ag | Organic compounds |
| MEP43308A (en) * | 2006-05-09 | 2011-02-10 | Pfizer Prod Inc | Cycloalkylamino acid derivatives and pharmaceutical compositions thereof |
| ES2400533T3 (es) * | 2006-09-07 | 2013-04-10 | Actelion Pharmaceuticals Ltd. | Derivados de piridin 4-ilo como agentes inmunomoduladores |
| MY150661A (en) * | 2006-09-08 | 2014-02-14 | Actelion Pharmaceuticals Ltd | Pyridin-3-yl derivatives as immunomodulating agents |
| US8044076B2 (en) * | 2006-09-21 | 2011-10-25 | Actelion Pharmaceuticals Ltd. | Phenyl derivatives and their use as immunomodulators |
| ES2450750T3 (es) * | 2007-03-16 | 2014-03-25 | Actelion Pharmaceuticals Ltd. | Derivados de amino-piridina como agonistas del receptor S1P1/EDG1 |
| RU2010121969A (ru) * | 2007-11-01 | 2011-12-10 | Актелион Фармасьютиклз Лтд (Ch) | Новые производные пиримидина |
-
2009
- 2009-03-03 JP JP2010549234A patent/JP2011513385A/ja not_active Withdrawn
- 2009-03-03 CN CN2009801078585A patent/CN101965346A/zh active Pending
- 2009-03-03 US US12/920,572 patent/US20110046170A1/en not_active Abandoned
- 2009-03-03 EP EP09717044A patent/EP2262800A1/en not_active Withdrawn
- 2009-03-03 CA CA2714614A patent/CA2714614A1/en not_active Abandoned
- 2009-03-03 WO PCT/IB2009/050848 patent/WO2009109907A1/en active Application Filing
- 2009-03-05 AR ARP090100789A patent/AR070801A1/es unknown
- 2009-03-05 TW TW098107154A patent/TW200940535A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2262800A1 (en) | 2010-12-22 |
| US20110046170A1 (en) | 2011-02-24 |
| CN101965346A (zh) | 2011-02-02 |
| WO2009109907A1 (en) | 2009-09-11 |
| JP2011513385A (ja) | 2011-04-28 |
| CA2714614A1 (en) | 2009-09-11 |
| TW200940535A (en) | 2009-10-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |